Huei Sheng Vincent Chen

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
    Changsung Kim
    Del E Webb Neuroscience, Aging and Stem Cell Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Nature 494:105-10. 2013
  2. ncbi request reprint Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels
    Huei Sheng Vincent Chen
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 314:961-71. 2005
  3. ncbi request reprint Spontaneous migration of the site of 2:1 atrioventricular block during atrioventricular nodal reentrant tachycardia
    Huei Sheng Vincent Chen
    Cardiac Electrophysiology Program, Division of Cardiology, University of California San Diego Medical Center, San Diego, CA, USA
    Heart Rhythm 2:1256-60. 2005
  4. ncbi request reprint The chemical biology of clinically tolerated NMDA receptor antagonists
    Huei Sheng Vincent Chen
    Burnham Institute for Medical Research and the University of California San Diego, La Jolla, California 92037, USA
    J Neurochem 97:1611-26. 2006
  5. pmc Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses
    Peng Xia
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:11246-50. 2010
  6. pmc Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation
    Changsung Kim
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Stem Cells Dev 19:783-95. 2010
  7. pmc MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts
    Padmini Sirish
    Division of Cardiovascular Medicine, University of California, Davis, CA, USA
    J Mol Cell Cardiol 52:264-72. 2012
  8. pmc Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif
    Hiroto Takahashi
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 53:53-64. 2007

Research Grants

Collaborators

Detail Information

Publications8

  1. pmc Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
    Changsung Kim
    Del E Webb Neuroscience, Aging and Stem Cell Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Nature 494:105-10. 2013
    ..Using this model, we revealed crucial pathogenic insights that metabolic derangement in adult-like metabolic milieu underlies ARVD/C pathologies, enabling us to propose novel disease-modifying therapeutic strategies...
  2. ncbi request reprint Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels
    Huei Sheng Vincent Chen
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 314:961-71. 2005
    ..In the future, these parameters should be considered in searching for improved neuroprotective agents in this class...
  3. ncbi request reprint Spontaneous migration of the site of 2:1 atrioventricular block during atrioventricular nodal reentrant tachycardia
    Huei Sheng Vincent Chen
    Cardiac Electrophysiology Program, Division of Cardiology, University of California San Diego Medical Center, San Diego, CA, USA
    Heart Rhythm 2:1256-60. 2005
  4. ncbi request reprint The chemical biology of clinically tolerated NMDA receptor antagonists
    Huei Sheng Vincent Chen
    Burnham Institute for Medical Research and the University of California San Diego, La Jolla, California 92037, USA
    J Neurochem 97:1611-26. 2006
    ..These second-generation memantine derivatives are designed as pathologically activated therapeutics, and in preliminary studies appear to have even greater neuroprotective properties than memantine...
  5. pmc Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses
    Peng Xia
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:11246-50. 2010
    ..At therapeutic concentrations, memantine effectively blocks excessive extrasynaptic NMDAR-mediated currents, while relatively sparing normal synaptic activity...
  6. pmc Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation
    Changsung Kim
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Stem Cells Dev 19:783-95. 2010
    ..Defining the nature of these extrinsic signals will aid in the directed maturation of immature hESC-CMs to mitigate arrhythmogenic risks of cell-based therapies...
  7. pmc MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts
    Padmini Sirish
    Division of Cardiovascular Medicine, University of California, Davis, CA, USA
    J Mol Cell Cardiol 52:264-72. 2012
    ..Our study provides new insights that may enhance the utilization of adult CPCs for regenerative therapy of the injured myocardium...
  8. pmc Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif
    Hiroto Takahashi
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 53:53-64. 2007
    ..These thiols may be nitrosylated preferentially during increasing hypoxia or stroke conditions, thus preventing excessive activity associated with cytotoxicity while avoiding blockade of physiologically active NMDARs...

Research Grants1