R F Chemaly

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc An adaptive randomized trial of an intermittent dosing schedule of aerosolized ribavirin in patients with cancer and respiratory syncytial virus infection
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Infect Dis 206:1367-71. 2012
  2. pmc Characteristics and outcomes of methicillin-resistant staphylococcus aureus bloodstream infections in patients with cancer treated with vancomycin: 9-year experience at a comprehensive cancer center
    Sminil N Mahajan
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 1460, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Oncologist 17:1329-36. 2012
  3. doi request reprint A multicenter study of pandemic influenza A (H1N1) infection in patients with solid tumors in 3 countries: early therapy improves outcomes
    Roy F Chemaly
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 118:4627-33. 2012
  4. doi request reprint The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Blood 119:2738-45; quiz 2969. 2012
  5. ncbi request reprint Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational study
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Clin Infect Dis 44:964-7. 2007
  6. doi request reprint Tigecycline use in cancer patients with serious infections: a report on 110 cases from a single institution
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas77030 4009, USA
    Medicine (Baltimore) 88:211-20. 2009
  7. doi request reprint The efficacy of catheters coated with minocycline and rifampin in the prevention of catheter-related bacteremia in cancer patients receiving high-dose interleukin-2
    R F Chemaly
    Department of Infectious Diseases, Unit 402, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Int J Infect Dis 14:e548-52. 2010
  8. ncbi request reprint Cytomegalovirus pneumonia in patients with lymphoma
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, 77230, USA
    Cancer 104:1213-20. 2005
  9. doi request reprint Serratia marcescens bacteremia because of contaminated prefilled heparin and saline syringes: a multi-state report
    Roy F Chemaly
    University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Infect Control 39:521-4. 2011
  10. doi request reprint Characteristics and outcomes of methicillin-resistant Staphylococcus aureus surgical-site infections in patients with cancer: a case-control study
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 17:1499-506. 2010

Collaborators

Detail Information

Publications43

  1. pmc An adaptive randomized trial of an intermittent dosing schedule of aerosolized ribavirin in patients with cancer and respiratory syncytial virus infection
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Infect Dis 206:1367-71. 2012
    ..Because the intermittent schedule is easy to administer and has a higher efficacy than the continuous schedule, we recommend the intermittent schedule for patients who are at risk for RSV LRTI. Clinical Trials Registration. NCT00500578...
  2. pmc Characteristics and outcomes of methicillin-resistant staphylococcus aureus bloodstream infections in patients with cancer treated with vancomycin: 9-year experience at a comprehensive cancer center
    Sminil N Mahajan
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 1460, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Oncologist 17:1329-36. 2012
    ..Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs) can cause significant morbidity and mortality in patients with cancer. However, data on outcomes of patients treated with vancomycin are lacking...
  3. doi request reprint A multicenter study of pandemic influenza A (H1N1) infection in patients with solid tumors in 3 countries: early therapy improves outcomes
    Roy F Chemaly
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 118:4627-33. 2012
    ..Herein, the authors describe a series of influenza 2009/H1N1 in patients with solid malignancies at 3 major cancer hospitals worldwide...
  4. doi request reprint The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Blood 119:2738-45; quiz 2969. 2012
    ..Patients with leukemia and HSCT are at risk for serious PIV infections, including PIV pneumonia, with a significant mortality rate. We identified multiple risk factors for progression to pneumonia and death...
  5. ncbi request reprint Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational study
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Clin Infect Dis 44:964-7. 2007
    ..001). The use of neuraminidase inhibitor therapy seems to improve the outcome of influenza in patients with leukemia...
  6. doi request reprint Tigecycline use in cancer patients with serious infections: a report on 110 cases from a single institution
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas77030 4009, USA
    Medicine (Baltimore) 88:211-20. 2009
    ..Patients with refractory pneumonia had a relatively low clinical response rate in our study...
  7. doi request reprint The efficacy of catheters coated with minocycline and rifampin in the prevention of catheter-related bacteremia in cancer patients receiving high-dose interleukin-2
    R F Chemaly
    Department of Infectious Diseases, Unit 402, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Int J Infect Dis 14:e548-52. 2010
    ..06). The use of M/R-C in patients on HDIL-2 therapy for advanced melanoma and renal cell carcinoma may have reduced the risk of CRB to nil. CRB still occurred despite antibiotic prophylaxis in patients with NC-C...
  8. ncbi request reprint Cytomegalovirus pneumonia in patients with lymphoma
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, 77230, USA
    Cancer 104:1213-20. 2005
    ..Even when treated with antiviral therapy, cytomegalovirus pneumonia (CMVp) is associated with high morbidity and mortality in immunocompromised patients. CMVp has been rarely reported in patients with lymphoma...
  9. doi request reprint Serratia marcescens bacteremia because of contaminated prefilled heparin and saline syringes: a multi-state report
    Roy F Chemaly
    University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Infect Control 39:521-4. 2011
    ..We evaluated the clinical impact of this outbreak in 57 patients at 3 centers. All patients were symptomatic and were treated with intravenous antibiotics with a fatal outcome in 1 patient...
  10. doi request reprint Characteristics and outcomes of methicillin-resistant Staphylococcus aureus surgical-site infections in patients with cancer: a case-control study
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 17:1499-506. 2010
    ..We experienced an increased incidence of MRSA surgical-site infections (MRSA SSIs) at our institution. However, to our knowledge, no studies have evaluated the risk factors and outcomes of MRSA SSIs in cancer patients...
  11. ncbi request reprint Microbiology of liver abscesses and the predictive value of abscess gram stain and associated blood cultures
    Roy F Chemaly
    Department of Clinical Pathology, Section of Clinical Microbiology, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Diagn Microbiol Infect Dis 46:245-8. 2003
    ..Although, Gram stains and blood cultures offer incomplete detection of the microbial contents of pyogenic liver abscesses, both tests should always accompany liver abscess cultures...
  12. ncbi request reprint Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 85:278-87. 2006
    ..HSCT recipients and patients with hematologic malignancies who develop upper respiratory infection due to CRVs should be considered for antiviral therapy of proven efficacy to reduce the risk of pneumonia and death...
  13. doi request reprint Fatal cytomegalovirus pneumonia in patients with haematological malignancies: an autopsy-based case-control study
    H A Torres
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Clin Microbiol Infect 14:1160-6. 2008
    ..Complete remission of an HM does not preclude the development of CMV pneumonia among patients with prolonged lymphopenia...
  14. doi request reprint Fungal endophthalmitis in a tertiary care cancer center: a review of 23 cases
    G A Lamaris
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Clin Microbiol Infect Dis 27:343-7. 2008
    ..FE in cancer patients occurs in the setting of severe, frequently disseminated opportunistic mycoses, is caused predominantly by hyalohyphomycetes, and is a marker for high 4-week mortality...
  15. ncbi request reprint Outcomes for and risk factors associated with vancomycin-resistant Enterococcus faecalis and vancomycin-resistant Enterococcus faecium bacteremia in cancer patients
    G Ghanem
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Infect Control Hosp Epidemiol 28:1054-9. 2007
    ....
  16. pmc Utility of galactomannan enzyme immunoassay and (1,3) beta-D-glucan in diagnosis of invasive fungal infections: low sensitivity for Aspergillus fumigatus infection in hematologic malignancy patients
    R Y Hachem
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Microbiol 47:129-33. 2009
    ..The diagnostic marker BG was shown to have a higher sensitivity than that of GM in detecting IA and other mold infections in hematologic malignancy patients...
  17. doi request reprint Infections in non-myeloablative hematopoietic stem cell transplantation patients with lymphoid malignancies: spectrum of infections, predictors of outcome and proposed guidelines for fungal infection prevention
    A Safdar
    Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Bone Marrow Transplant 45:339-47. 2010
    ..On the basis of our results, we propose that NST recipients with lymphoma treated with high-dose corticosteroids for GVHD be considered for antifungal prophylaxis or pre-emptive antifungal therapy...
  18. ncbi request reprint Sources and outcome of bloodstream infections in cancer patients: the role of central venous catheters
    I Raad
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77230 1402, USA
    Eur J Clin Microbiol Infect Dis 26:549-56. 2007
    ..In addition to critical illness and persistent neutropenia, quantitative blood cultures might be useful in predicting outcomes for neutropenic patients with catheter-related bloodstream infections...
  19. doi request reprint Anti-adherence activity and antimicrobial durability of anti-infective-coated catheters against multidrug-resistant bacteria
    I Raad
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Antimicrob Chemother 62:746-50. 2008
    ....
  20. ncbi request reprint Oral topical cidofovir: novel route of drug delivery in a severely immunosuppressed patient with refractory multidrug-resistant herpes simplex virus infection
    C R Sims
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Transpl Infect Dis 9:256-9. 2007
    ..The use of 3% cidofovir in a saline rinse for refractory mucosal HSV infection appears promising but needs prospective evaluation...
  21. ncbi request reprint Fungal osteoarticular infections in patients treated at a comprehensive cancer centre: a 10-year retrospective review
    P R Kumashi
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Microbiol Infect 12:621-6. 2006
    ..FOAI is a rare, yet severe, manifestation of localised or systemic mycoses, caused predominantly by moulds, and is seen typically in patients with haematological malignancies...
  22. doi request reprint The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer
    S Youssef
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Antimicrob Chemother 61:421-4. 2008
    ..Previous authors have reported that administration of vitamin B6 with linezolid reversed pancytopenia in two patients...
  23. ncbi request reprint Influence of type of cancer and hematopoietic stem cell transplantation on clinical presentation of Pneumocystis jiroveci pneumonia in cancer patients
    H A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Eur J Clin Microbiol Infect Dis 25:382-8. 2006
    ..jiroveci pneumonia in cancer patients may be affected by the category of cancer and the history of hematopoietic stem cell transplantation. P. jiroveci pneumonia remains a rare yet severe infection in cancer patients...
  24. ncbi request reprint Risk factors associated with late cytomegalovirus reactivation after allogeneic stem cell transplantation for hematological malignancies
    E Ozdemir
    Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Bone Marrow Transplant 40:125-36. 2007
    ..The remaining patients had an intermediate incidence of 32%...
  25. doi request reprint Severe parainfluenza virus type 2 supraglottitis in an immunocompetent adult host: an unusual cause of a paramyxoviridae viral infection
    K J Vigil
    Department of Internal Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at Houston Medical School, Houston, TX 77030, USA
    J Intern Med 265:397-400. 2009
    ..We report - to our knowledge - the first case of a nonimmunocompromised adult patient with human parainfluenza type 2 supraglottitis immediately after returning from China...
  26. ncbi request reprint Gastrointestinal cytomegalovirus disease in patients with cancer: a two decade experience in a tertiary care cancer center
    Harrys A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, Unit 402, M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Eur J Cancer 41:2268-79. 2005
    ..01). The presentation of GI-CMVd varies according to the type of cancer, and AIDS. GI-CMVd is associated with a high mortality among cancer patients, particularly those with disseminated CMV disease or AIDS...
  27. ncbi request reprint Extrapulmonary tuberculosis active infection misdiagnosed as cancer: Mycobacterium tuberculosis disease in patients at a Comprehensive Cancer Center (2001-2005)
    Gabriel M Aisenberg
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer 104:2882-7. 2005
    ..S., even in immunosuppressed cancer patients. This study evaluated characteristics and frequency of extrapulmonary tuberculosis in patients at a tertiary care referral cancer center...
  28. ncbi request reprint Cytomegalovirus infection in patients with lymphoma: an important cause of morbidity and mortality
    Harrys A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Clin Lymphoma Myeloma 6:393-8. 2006
    ..We sought to determine the risk factors and outcome of CMV-A and CMV-D among patients with lymphoma...
  29. pmc Colistin is effective in treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa in cancer patients
    Ray Y Hachem
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, P O Box 301402, Houston, TX 77230 1402, USA
    Antimicrob Agents Chemother 51:1905-11. 2007
    ..aeruginosa and, hence, may be a useful or preferred alternative therapy for this infection in cancer patients...
  30. ncbi request reprint Characteristics and outcome of respiratory syncytial virus infection in patients with leukemia
    Harrys A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Haematologica 92:1216-23. 2007
    ..The aim of this study was to determine the characteristics, and the outcome of RSV infection with or without therapy with aerosolized ribavirin in leukemia patients...
  31. ncbi request reprint Risk of bioaerosol contamination with Aspergillus species before and after cleaning in rooms filtered with high-efficiency particulate air filters that house patients with hematologic malignancy
    Linda D Lee
    Department of Environmental Health and Safety, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Infect Control Hosp Epidemiol 28:1066-70. 2007
    ....
  32. ncbi request reprint Infections in 100 cord blood transplantations: spectrum of early and late posttransplant infections in adult and pediatric patients 1996-2005
    Amar Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 86:324-33. 2007
    ..47; p < 0.007) were less likely to die from infection. More effective measures for surveillance and prevention of late cytomegalovirus and varicella zoster virus infections in children with CBT and chronic GVHD are needed...
  33. ncbi request reprint Common community respiratory viruses in patients with cancer: more than just "common colds"
    Krystal L Hicks
    Department of Bone Marrow Transplantation, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 97:2576-87. 2003
    ..Control requires a multifaceted approach combining vaccination, chemoprophylaxis, and aggressive early antiviral treatment of high-risk individuals, as well as education of all populations affected by these viruses...
  34. ncbi request reprint Rotaviral and bacterial gastroenteritis in children during winter: an evaluation of physician ordering patterns
    Roy F Chemaly
    Department of Clinical Pathology, Section of Clinical Microbiology, The Cleveland Clinic Foundation, 9500 Euclid Avenue L40, Cleveland, OH 44185, USA
    J Clin Virol 28:44-50. 2003
    ..Identification of the agents of infectious diarrhea may facilitate appropriate therapy and prevent inappropriate antibiotic use...
  35. ncbi request reprint Hospitalization of an oncology patient suspected of having severe acute respiratory syndrome: a setup for an infection control quagmire at a comprehensive cancer center
    Amar Safdar
    Cancer 98:2738-9. 2003
  36. ncbi request reprint Clinical utility of cytomegalovirus viral load in bronchoalveolar lavage in lung transplant recipients
    Roy F Chemaly
    Department of Pathology, Section of Clinical Microbiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Transplant 5:544-8. 2005
    ..High CMV VL in BAL in lung transplant recipients is strongly associated with CMV pneumonitis, and may be more predictive than peripheral blood viral load...
  37. ncbi request reprint Viral infection or reactivation in patients during treatment with dasatinib: a call for screening?
    Harrys A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Leuk Lymphoma 48:2308-9. 2007
  38. pmc Correlation between viral loads of cytomegalovirus in blood and bronchoalveolar lavage specimens from lung transplant recipients determined by histology and immunohistochemistry
    Roy F Chemaly
    Department of Clinical Pathology, Section of Clinical Microbiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Microbiol 42:2168-72. 2004
    ..Both IHC and determination of the CMV viral load in BAL samples may be useful for the detection of individuals at risk for the development of fulminant invasive CMV disease...
  39. ncbi request reprint Posaconazole: a broad-spectrum triazole antifungal
    Harrys A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Lancet Infect Dis 5:775-85. 2005
    ..Posaconazole has shown promising clinical efficacy against life-threatening fungal infections that are often refractory to the currently available antifungal therapies-eg, invasive aspergillosis, fusariosis, and the emerging zygomycosis...
  40. ncbi request reprint Culture-positive and culture-negative endocarditis in patients with cancer: a retrospective observational study, 1994-2004
    Syed Wamique Yusuf
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 85:86-94. 2006
    ..The clinical spectrums of CPE and CNE differed in these patients with cancer. In patients with CNE, embolic cerebrovascular and fatal myocardial infarction were relatively common...
  41. doi request reprint Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study
    Drew J Winston
    University of California, Los Angeles Medical Center, Los Angeles, CA 90095, USA
    Blood 111:5403-10. 2008
    ..Maribavir had no adverse effect on neutrophil or platelet counts. These results show that maribavir can reduce the incidence of CMV infection and, unlike ganciclovir, does not cause myelosuppression...
  42. doi request reprint Human herpesvirus-6 DNAemia in immunosuppressed adult patients with leukemia at risk for mold infection
    Roy F Chemaly
    Haematologica 93:157-8. 2008
    ..HHV-6 DNA was detected from whole blood specimens in 11 patients (30%). History of granulocyte transfusions (p=0.05) and prior relapse of leukemia (p=0.07) were the only independent predictors of HHV-6 DNAemia...
  43. ncbi request reprint A case of zygomycosis and invasive candidiasis involving the epiglottis and tongue in an immunocompromised patient
    Roy F Chemaly
    Department of Infectious Diseases, The Cleveland Clinic Foundation, Ohio 44195, USA
    Scand J Infect Dis 34:149-51. 2002
    ....