Edgar D Charles

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Hepatitis C virus-induced cryoglobulinemia
    Edgar D Charles
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Kidney Int 76:818-24. 2009
  2. pmc Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures
    Svetlana Marukian
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065, USA
    Hepatology 54:1913-23. 2011
  3. pmc Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Blood 117:5425-37. 2011
  4. pmc Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10021, USA
    Blood 111:1344-56. 2008
  5. pmc Somatic hypermutations confer rheumatoid factor activity in hepatitis C virus-associated mixed cryoglobulinemia
    Edgar D Charles
    Rockefeller University, New York, New York
    Arthritis Rheum 65:2430-40. 2013
  6. pmc Primary, post-primary and non-specific immunoglobulin M responses in HCV infection
    Lynn B Dustin
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
    Antivir Ther 17:1449-52. 2012
  7. pmc Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells
    Svetlana Marukian
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
    Hepatology 48:1843-50. 2008
  8. pmc A flow cytometry-based strategy to identify and express IgM from VH1-69+ clonal peripheral B cells
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA
    J Immunol Methods 363:210-20. 2011
  9. pmc Selection of apoptotic cell specific human antibodies from adult bone marrow
    Caroline Grönwall
    School of Medicine, New York University, New York, New York, United States of America
    PLoS ONE 9:e95999. 2014
  10. pmc Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C
    David Butera
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, Box 64, 1230 York Ave, New York, NY 10021, USA
    Blood 106:1175-82. 2005

Collaborators

Detail Information

Publications11

  1. pmc Hepatitis C virus-induced cryoglobulinemia
    Edgar D Charles
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Kidney Int 76:818-24. 2009
    ..It is unclear how B cells become dysregulated during the course of chronic HCV infection, and continued patient-centered research is necessary to elucidate the pathogenesis of HCV-related B-cell dysregulation...
  2. pmc Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures
    Svetlana Marukian
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065, USA
    Hepatology 54:1913-23. 2011
    ..Induction of ISGs and λ IFNs may limit the growth and spread of HCV in primary cell cultures and in the infected liver. HCV infection of HFLC may provide a useful model for the study of gene induction by HCV in vivo...
  3. pmc Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Blood 117:5425-37. 2011
    ..Down-regulation of multiple activation pathways may represent a homeostatic mechanism attenuating otherwise uncontrolled stimulation of circulating HCV-containing immune complexes...
  4. pmc Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10021, USA
    Blood 111:1344-56. 2008
    ..This study was registered at www.clinicaltrials.gov as NCT00219999...
  5. pmc Somatic hypermutations confer rheumatoid factor activity in hepatitis C virus-associated mixed cryoglobulinemia
    Edgar D Charles
    Rockefeller University, New York, New York
    Arthritis Rheum 65:2430-40. 2013
    ..This study was undertaken to test the hypothesis that SHM augments RF activity...
  6. pmc Primary, post-primary and non-specific immunoglobulin M responses in HCV infection
    Lynn B Dustin
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
    Antivir Ther 17:1449-52. 2012
    ..More study is required to identify the antigens that drive the development of MC...
  7. pmc Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cells
    Svetlana Marukian
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
    Hepatology 48:1843-50. 2008
    ..Supernatants from HCV RNA-transfected macrophages inhibited HCV replication in Huh-7.5 cells. Conclusion: We conclude that multiple blocks prevent blood cells from supporting HCV infection...
  8. pmc A flow cytometry-based strategy to identify and express IgM from VH1-69+ clonal peripheral B cells
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA
    J Immunol Methods 363:210-20. 2011
    ..We anticipate that this system will be useful for the cloning and expression of mAbs partially encoded by VH1-69 and for determination of the reactivity patterns of polyspecific, low-affinity IgMs of human pathogenic importance...
  9. pmc Selection of apoptotic cell specific human antibodies from adult bone marrow
    Caroline Grönwall
    School of Medicine, New York University, New York, New York, United States of America
    PLoS ONE 9:e95999. 2014
    ..Our findings may have implication for improved prognostic testing and therapeutic interventions in human inflammatory disease. ..
  10. pmc Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C
    David Butera
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, Box 64, 1230 York Ave, New York, NY 10021, USA
    Blood 106:1175-82. 2005
    ..This observation has implications for understanding the pathogenesis of HCV infection...
  11. pmc Chemokine antagonism in chronic hepatitis C virus infection
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York 10065, USA
    J Clin Invest 121:25-7. 2011
    ..These findings introduce a role for chemokine antagonism during HCV infection and unveil new avenues for improved HCV diagnosis and therapy...