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Species | Edgar D CharlesSummaryAffiliation: The Rockefeller University Country: USA Publications
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Publications
Hepatitis C virus-induced cryoglobulinemiaEdgar D Charles
Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
Kidney Int 76:818-24. 2009..It is unclear how B cells become dysregulated during the course of chronic HCV infection, and continued patient-centered research is necessary to elucidate the pathogenesis of HCV-related B-cell dysregulation...- Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver culturesSvetlana Marukian
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065, USA
Hepatology 54:1913-23. 2011..Induction of ISGs and λ IFNs may limit the growth and spread of HCV in primary cell cultures and in the infected liver. HCV infection of HFLC may provide a useful model for the study of gene induction by HCV in vivo... - Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subsetEdgar D Charles
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Blood 117:5425-37. 2011..Down-regulation of multiple activation pathways may represent a homeostatic mechanism attenuating otherwise uncontrolled stimulation of circulating HCV-containing immune complexes... - Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemiaEdgar D Charles
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10021, USA
Blood 111:1344-56. 2008..This study was registered at www.clinicaltrials.gov as NCT00219999... - Cell culture-produced hepatitis C virus does not infect peripheral blood mononuclear cellsSvetlana Marukian
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
Hepatology 48:1843-50. 2008..Supernatants from HCV RNA-transfected macrophages inhibited HCV replication in Huh-7.5 cells. Conclusion: We conclude that multiple blocks prevent blood cells from supporting HCV infection... - A flow cytometry-based strategy to identify and express IgM from VH1-69+ clonal peripheral B cellsEdgar D Charles
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA
J Immunol Methods 363:210-20. 2011..We anticipate that this system will be useful for the cloning and expression of mAbs partially encoded by VH1-69 and for determination of the reactivity patterns of polyspecific, low-affinity IgMs of human pathogenic importance... - Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis CDavid Butera
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, Box 64, 1230 York Ave, New York, NY 10021, USA
Blood 106:1175-82. 2005..This observation has implications for understanding the pathogenesis of HCV infection... 
Primary, post-primary and non-specific immunoglobulin M responses in HCV infectionLynn B Dustin
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA
Antivir Ther 17:1449-52. 2012..More study is required to identify the antigens that drive the development of MC...- Chemokine antagonism in chronic hepatitis C virus infectionEdgar D Charles
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York 10065, USA
J Clin Invest 121:25-7. 2011..These findings introduce a role for chemokine antagonism during HCV infection and unveil new avenues for improved HCV diagnosis and therapy...