SANDY S CHANG

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Modeling premature aging syndromes with the telomerase knockout mouse
    Sandy Chang
    Department of Molecular Genetics, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Curr Mol Med 5:153-8. 2005
  2. ncbi request reprint Modeling aging and cancer in the telomerase knockout mouse
    Sandy Chang
    Department of Molecular Genetics, MD Anderson Cancer Center, Houston, TX 77030, USA
    Mutat Res 576:39-53. 2005
  3. ncbi request reprint A mouse model of Werner Syndrome: what can it tell us about aging and cancer?
    Sandy Chang
    Department of Molecular Genetics, Box 11, The M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Int J Biochem Cell Biol 37:991-9. 2005
  4. ncbi request reprint Essential role of limiting telomeres in the pathogenesis of Werner syndrome
    Sandy Chang
    Department of Molecular Genetics, M D Anderson Cancer Center, Box 11, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Nat Genet 36:877-82. 2004
  5. ncbi request reprint Inflammatory breast cancer survival: the role of obesity and menopausal status at diagnosis
    S Chang
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston 77030 4095, USA
    Breast Cancer Res Treat 64:157-63. 2000
  6. ncbi request reprint Leptin and prostate cancer
    S Chang
    Department of Epidemiology, Box 189, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4095, USA
    Prostate 46:62-7. 2001
  7. ncbi request reprint Inflammatory breast cancer and body mass index
    S Chang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030 4095, USA
    J Clin Oncol 16:3731-5. 1998
  8. ncbi request reprint A case-control study of diet and testicular carcinoma
    A J Sigurdson
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nutr Cancer 34:20-6. 1999
  9. ncbi request reprint Breast cancer survival and the timing of tumor removal during the menstrual cycle
    S Chang
    Department of Epidemiology, University of North Carolina at Chapel Hill 27599 7400, USA
    Cancer Epidemiol Biomarkers Prev 6:881-6. 1997
  10. ncbi request reprint A pilot study for a screening trial of cervical fluorescence spectroscopy
    A Nath
    Biomedical Engineering Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Gynecol Cancer 14:1097-107. 2004

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Modeling premature aging syndromes with the telomerase knockout mouse
    Sandy Chang
    Department of Molecular Genetics, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Curr Mol Med 5:153-8. 2005
    ..Insights into the molecular pathways of the aging process may offer unprecedented opportunities to delay the deleterious effects of the aging process...
  2. ncbi request reprint Modeling aging and cancer in the telomerase knockout mouse
    Sandy Chang
    Department of Molecular Genetics, MD Anderson Cancer Center, Houston, TX 77030, USA
    Mutat Res 576:39-53. 2005
    ..Here, I discuss the use of the telomerase null mouse for understanding the contrasting roles of telomeres and telomerase in organismal aging and cancer...
  3. ncbi request reprint A mouse model of Werner Syndrome: what can it tell us about aging and cancer?
    Sandy Chang
    Department of Molecular Genetics, Box 11, The M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Int J Biochem Cell Biol 37:991-9. 2005
    ..This mouse model thus provides a unique genetic platform to explore molecular mechanisms by which telomere dysfunction and loss of WRN gene function leads to the onset of premature aging and cancer...
  4. ncbi request reprint Essential role of limiting telomeres in the pathogenesis of Werner syndrome
    Sandy Chang
    Department of Molecular Genetics, M D Anderson Cancer Center, Box 11, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Nat Genet 36:877-82. 2004
    ..These genetic data indicate that the delayed manifestation of the complex pleiotropic of Wrn deficiency relates to telomere shortening...
  5. ncbi request reprint Inflammatory breast cancer survival: the role of obesity and menopausal status at diagnosis
    S Chang
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston 77030 4095, USA
    Breast Cancer Res Treat 64:157-63. 2000
    ....
  6. ncbi request reprint Leptin and prostate cancer
    S Chang
    Department of Epidemiology, Box 189, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4095, USA
    Prostate 46:62-7. 2001
    ..Higher prostate cancer mortality rates among US immigrants from countries with lower rates suggest environmental influences on prostate carcinogenesis (e.g., diet, body composition)...
  7. ncbi request reprint Inflammatory breast cancer and body mass index
    S Chang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030 4095, USA
    J Clin Oncol 16:3731-5. 1998
    ..Because high body mass index (BMI) is associated with decreased risk of premenopausal breast cancer but increased risk of postmenopausal breast cancer, we evaluated whether high BMI was a risk factor for IBC...
  8. ncbi request reprint A case-control study of diet and testicular carcinoma
    A J Sigurdson
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nutr Cancer 34:20-6. 1999
    ....
  9. ncbi request reprint Breast cancer survival and the timing of tumor removal during the menstrual cycle
    S Chang
    Department of Epidemiology, University of North Carolina at Chapel Hill 27599 7400, USA
    Cancer Epidemiol Biomarkers Prev 6:881-6. 1997
    ..57; 95% CI, 0.82-3.03). Prospective studies using hormone measurements to define menstrual cycle status more accurately than the reported day of the menstrual cycle could provide further insight about the postulated association...
  10. ncbi request reprint A pilot study for a screening trial of cervical fluorescence spectroscopy
    A Nath
    Biomedical Engineering Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Gynecol Cancer 14:1097-107. 2004
    ..Fluorescence spectroscopy is a promising technology for the detection of epithelial precancers and cancers. The screening trial of fluorescence and reflectance spectroscopy was successful...

Research Grants10

  1. GENOMIC INSTABILITY IN TELOMERASE AND AGING MOUSE MODELS
    Sandy Chang; Fiscal Year: 2003
    ..Guarente s lab. The hypotheses are that these mice will represent models for human aging, and that the combination of both strains will generate animals with increased genomic instability. ..
  2. Telomere induced senescence as a supressor of tumorigenesis
    Sandy Chang; Fiscal Year: 2009
    ..It is likely that up regulation of p53 function by compounds currently undergoing clinical trials would favor the activation of the cellular senescence program, resulting in suppression of breast cancer. ..
  3. The role of the telomere capping protein POT1 in mammalian aging
    Sandy Chang; Fiscal Year: 2009
    ..Given increasing evidence that telomere attrition reduces lifespan in humans, we believe our findings will be relevant to human aging as well. ..
  4. The role of the telomere capping protein POT1 in mammalian aging
    Sandy Chang; Fiscal Year: 2007
    ..Given increasing evidence that telomere attrition reduces lifespan in humans, we believe our findings will be relevant to human aging as well. ..
  5. Telomere induced senescence as a supressor of tumorigenesis
    Sandy Chang; Fiscal Year: 2007
    ..It is likely that up regulation of p53 function by compounds currently undergoing clinical trials would favor the activation of the cellular senescence program, resulting in suppression of breast cancer. ..
  6. Telomere Induced Genomic Instability in Premature Aging
    Sandy Chang; Fiscal Year: 2006
    ..We are also probing for molecular mechanisms that may be responsible for the observed aging phenotypes in our mouse model. These studies should illuminate the roles of Wrn and dysfunctional telomeres during human aging. ..
  7. Characterization of a Mouse Model of Werner Syndrome
    Sandy Chang; Fiscal Year: 2005
    ..These studies should establish a role for WRN function in mammalian telomere biology and lend support to the notion that telomeres play a causative role in mammalian aging. ..