SANDY S CHANG
Affiliation: The University of Texas
- Multiple roles for MRE11 at uncapped telomeresYibin Deng
Department of Genetics, Box 1010, The M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Nature 460:914-8. 2009..MRE11 can also protect newly replicated leading strand telomeres from NHEJ by promoting 5' strand resection to generate POT1a-TPP1-bound 3' overhangs...
- Modeling premature aging syndromes with the telomerase knockout mouseSandy Chang
Department of Molecular Genetics, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Curr Mol Med 5:153-8. 2005..Insights into the molecular pathways of the aging process may offer unprecedented opportunities to delay the deleterious effects of the aging process...
- Modeling aging and cancer in the telomerase knockout mouseSandy Chang
Department of Molecular Genetics, MD Anderson Cancer Center, Houston, TX 77030, USA
Mutat Res 576:39-53. 2005..Here, I discuss the use of the telomerase null mouse for understanding the contrasting roles of telomeres and telomerase in organismal aging and cancer...
- A mouse model of Werner Syndrome: what can it tell us about aging and cancer?Sandy Chang
Department of Molecular Genetics, Box 11, The M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Int J Biochem Cell Biol 37:991-9. 2005..This mouse model thus provides a unique genetic platform to explore molecular mechanisms by which telomere dysfunction and loss of WRN gene function leads to the onset of premature aging and cancer...
- Essential role of limiting telomeres in the pathogenesis of Werner syndromeSandy Chang
Department of Molecular Genetics, M D Anderson Cancer Center, Box 11, 1515 Holcombe Blvd, Houston, Texas 77030, USA
Nat Genet 36:877-82. 2004..These genetic data indicate that the delayed manifestation of the complex pleiotropic of Wrn deficiency relates to telomere shortening...
- Inflammatory breast cancer survival: the role of obesity and menopausal status at diagnosisS Chang
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston 77030 4095, USA
Breast Cancer Res Treat 64:157-63. 2000....
- Leptin and prostate cancerS Chang
Department of Epidemiology, Box 189, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4095, USA
Prostate 46:62-7. 2001..Higher prostate cancer mortality rates among US immigrants from countries with lower rates suggest environmental influences on prostate carcinogenesis (e.g., diet, body composition)...
- Inflammatory breast cancer and body mass indexS Chang
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030 4095, USA
J Clin Oncol 16:3731-5. 1998..Because high body mass index (BMI) is associated with decreased risk of premenopausal breast cancer but increased risk of postmenopausal breast cancer, we evaluated whether high BMI was a risk factor for IBC...
- A case-control study of diet and testicular carcinomaA J Sigurdson
Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Nutr Cancer 34:20-6. 1999....
- Breast cancer survival and the timing of tumor removal during the menstrual cycleS Chang
Department of Epidemiology, University of North Carolina at Chapel Hill 27599 7400, USA
Cancer Epidemiol Biomarkers Prev 6:881-6. 1997..57; 95% CI, 0.82-3.03). Prospective studies using hormone measurements to define menstrual cycle status more accurately than the reported day of the menstrual cycle could provide further insight about the postulated association...
- A pilot study for a screening trial of cervical fluorescence spectroscopyA Nath
Biomedical Engineering Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Int J Gynecol Cancer 14:1097-107. 2004..Fluorescence spectroscopy is a promising technology for the detection of epithelial precancers and cancers. The screening trial of fluorescence and reflectance spectroscopy was successful...
- GENOMIC INSTABILITY IN TELOMERASE AND AGING MOUSE MODELSSandy Chang; Fiscal Year: 2003..Guarente s lab. The hypotheses are that these mice will represent models for human aging, and that the combination of both strains will generate animals with increased genomic instability. ..
- Characterization of a Mouse Model of Werner SyndromeSandy Chang; Fiscal Year: 2005..These studies should establish a role for WRN function in mammalian telomere biology and lend support to the notion that telomeres play a causative role in mammalian aging. ..
- Telomere Induced Genomic Instability in Premature AgingSandy Chang; Fiscal Year: 2006..These studies should illuminate the roles of Wrn and dysfunctional telomeres during human aging. [unreadable] [unreadable]..
- The role of the telomere capping protein POT1 in mammalian agingSandy Chang; Fiscal Year: 2009..Given increasing evidence that telomere attrition reduces lifespan in humans, we believe our findings will be relevant to human aging as well. ..