Long Sheng Chang
Affiliation: The Ohio State University
- Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor geneKseniya Golovnina
Institute of Cytology and Genetics, Russian Academy of Sciences, 630090, Novosibirsk, Russia
BMC Evol Biol 5:69. 2005..While merlin's functional activity has been examined in mammalian and Drosophila models, little is understood about its evolution, diversity, and overall distribution among different taxa...
- The role of Drosophila Merlin in spermatogenesisNatalia V Dorogova
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia
BMC Cell Biol 9:1. 2008..Male flies carrying a Mer3 allele, a missense mutation (Met177-->Ile) in the Merlin gene, are viable but sterile; however, the cause of sterility is unknown...
- Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcriptsLong Sheng Chang
Children s Research Institute, Children s Hospital, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
Genomics 79:63-76. 2002..Cotransfection studies in Drosophila melanogaster SL2 cells showed that Sp1 could activate the NF2 promoter through the GC-rich sequence...
- Growth of benign and malignant schwannoma xenografts in severe combined immunodeficiency miceLong Sheng Chang
Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
Laryngoscope 116:2018-26. 2006..Models for the development of new treatment options in vestibular schwannoma (VS) treatment are lacking. The purpose of this study is to establish a quantifiable human VS xenograft model in mice...
- Induction of apoptosis by the p53-related p73 and partial inhibition by the baculovirus-encoded p35 in neuronal cellsWarren D Lo
Department of Pediatrics, Children s Hospital, The Ohio State University, Columbus, USA
Brain Res Mol Brain Res 113:1-12. 2003..Taken together, our results suggest that the N-terminal structure of p35 is critical for its anti-apoptotic activity on p73-induced apoptosis in neuronal cells...
- Treatment of vestibular schwannoma cells with ErbB inhibitorsMatthew L Bush
Department of Otolaryngology Head and Neck Surgery, The Ohio State University Eye and Ear Institute, Columbus, Ohio 43212, USA
Otol Neurotol 33:244-57. 2012..Aberrant phosphorylation of ErbB family receptor tyrosine kinases (RTK) in human vestibular schwannomas (VSs) renders them susceptible to growth suppression by RTK inhibitors...
- The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular levelBrian A Neff
Department of Otolaryngology, The Ohio State University College of Medicine and Children s Hospital, Columbus, Ohio, USA
Otol Neurotol 27:197-208. 2006..The goal of this article was to review concisely what is currently known about the tumorigenesis of vestibular schwannomas...
- Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomasAbraham Jacob
Department of Surgery, Division of Otolaryngology, University of Arizona, Tucson, Arizona 85724, USA
Laryngoscope 122:174-89. 2012....
- Retinoblastoma-cyclin-dependent kinase pathway deregulation in vestibular schwannomasJohn M Lasak
Department of Otolaryngology, The Ohio State University and Children s Hospital, Columbus, USA
Laryngoscope 112:1555-61. 2002..The purpose of the study was to identify genes of the retinoblastoma protein (pRb)-cyclin-dependent kinase (CDK) pathway that are deregulated in vestibular schwannomas when compared with normal vestibular nerve tissues...
- Cyclin D(1) and D(3) expression in vestibular schwannomasBrian A Neff
Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43205, USA
Laryngoscope 116:423-6. 2006..The purpose of this study is to evaluate cyclin D(1) and D(3) protein expression and the corresponding clinical characteristics of vestibular schwannomas...
- Molecular studies of vestibular schwannomas: a reviewD Bradley Welling
Department of Otolaryngology, The Ohio State University College of Medicine and Children s Hospital, Columbus, Ohio 43210, USA
Curr Opin Otolaryngol Head Neck Surg 15:341-6. 2007..To summarize advances in understanding the molecular biology of vestibular schwannomas over the past year...
- Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannomaAbraham Jacob
Department of Otolaryngology, The Ohio State University, Columbus, and Center for Childhood Cancer, Research Institute at Nationwide Children s Hospital, Department of Pediatrics 43210, USA
Otol Neurotol 29:58-68. 2008..Merlin can inhibit phosphatidylinositol 3 kinase (PI3 kinase) by binding to PI3 kinase enhancer long isoform. Therefore, we hypothesized that the PI3 kinase/AKT pathway is activated in VS...
- Regulation of the neurofibromatosis 2 gene promoter expression during embryonic developmentElena M Akhmametyeva
Center for Childhood Cancer, Children s Research Institute, Children s Hospital, Columbus, Ohio, USA
Dev Dyn 235:2771-85. 2006....
- AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomasMatthew L Bush
Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, OH 43212, USA
Neuro Oncol 13:983-99. 2011..The potent growth inhibitory activity of AR42 in schwannoma and meningioma cells suggests that AR42 should be further evaluated as a potential treatment for NF2-associated tumors...
- Molecular biology of vestibular schwannomasLong Sheng Chang
Department of Pediatrics, The Ohio State University College of Medicine, Center for Childhood Cancer Research Institute at National Childen s Hospital, Columbus, OH, USA
Methods Mol Biol 493:163-77. 2009..Nf2-transgenic and knockout mice as well as vestibular schwannoma xenograft models are now ready for novel therapeutic testing. Hopefully, better treatment options will be forthcoming soon...
- Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cellsTina X Lee
Department of Otolaryngology, The Ohio State University College of Medicine, Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
Eur J Cancer 45:1709-20. 2009..Vestibular schwannomas (VS) frequently express high levels of activated AKT. Small-molecule inhibitors of AKT signalling may have therapeutic potential in suppressing the growth of benign VS and malignant schwannomas...
- cDNA microarray analysis of vestibular schwannomasD Bradley Welling
Department of Otolaryngology, Ohio State University College of Medicine, Ohio, USA
Otol Neurotol 23:736-48. 2002..Identification of genes differentially expressed in normal and diseased tissues through the use of a large-scale, cDNA microarray approach may lead to increased understanding of pathways that lead to tumor formation...
- Over-expression of p73beta results in apoptotic death of post-mitotic hNT neuronsYuying Jiang
Center for Childhood Cancer, Children s Research Institute, Division of Neurology, Children s Hospital, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Columbus, OH 43205 2696, United States
J Neurol Sci 240:1-6. 2006..Understanding the regulation of p73 expression will be important for understanding the development of the nervous system and may have implications for the treatment of neurological diseases...
- Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiationZhixiong Xu
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
Mol Cell Biol 23:7585-99. 2003..2 and beta-globin mRNAs. These studies define a physiologic target for a TAL1- and GATA-1-containing ternary complex and reveal a positive role for Ldb1 in erythroid gene expression and differentiation...
- Cell cycle-related transformation of the E2F4-p130 repressor complexBoris Popov
Institute of Cytology, Russian Academy of Sciences, 4, Tikhoretsky Ave, St Petersburg 194064, Russia
Biochem Biophys Res Commun 336:762-9. 2005..In contrast to T98G cells, transformation of the p130 containing cyc/cdk-pp-E2F4 complex into the p130-pp-E2F4 repressor does not occur in HeLa cells under growth restriction conditions...