Long Sheng Chang

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Evolution and Origin of HRS, a Protein Interacting with Merlin, the Neurofibromatosis 2 Gene Product
    Leonid V Omelyanchuk
    Institute of Cytology and Genetics, Russian Academy of Sciences, 10 Lavrent ev Ave, 630090, Novosibirsk, Russia
    Gene Regul Syst Bio 3:143-57. 2009
  2. pmc Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene
    Kseniya Golovnina
    Institute of Cytology and Genetics, Russian Academy of Sciences, 630090, Novosibirsk, Russia
    BMC Evol Biol 5:69. 2005
  3. pmc The role of Drosophila Merlin in spermatogenesis
    Natalia V Dorogova
    Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia
    BMC Cell Biol 9:1. 2008
  4. ncbi request reprint Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcripts
    Long Sheng Chang
    Children s Research Institute, Children s Hospital, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Genomics 79:63-76. 2002
  5. ncbi request reprint Growth of benign and malignant schwannoma xenografts in severe combined immunodeficiency mice
    Long Sheng Chang
    Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
    Laryngoscope 116:2018-26. 2006
  6. ncbi request reprint Induction of apoptosis by the p53-related p73 and partial inhibition by the baculovirus-encoded p35 in neuronal cells
    Warren D Lo
    Department of Pediatrics, Children s Hospital, The Ohio State University, Columbus, USA
    Brain Res Mol Brain Res 113:1-12. 2003
  7. pmc Treatment of vestibular schwannoma cells with ErbB inhibitors
    Matthew L Bush
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University Eye and Ear Institute, Columbus, Ohio 43212, USA
    Otol Neurotol 33:244-57. 2012
  8. ncbi request reprint The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level
    Brian A Neff
    Department of Otolaryngology, The Ohio State University College of Medicine and Children s Hospital, Columbus, Ohio, USA
    Otol Neurotol 27:197-208. 2006
  9. pmc Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas
    Abraham Jacob
    Department of Surgery, Division of Otolaryngology, University of Arizona, Tucson, Arizona 85724, USA
    Laryngoscope 122:174-89. 2012
  10. ncbi request reprint Cyclin D(1) and D(3) expression in vestibular schwannomas
    Brian A Neff
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43205, USA
    Laryngoscope 116:423-6. 2006

Collaborators

  • D B Welling
  • Brian A Neff
  • Ching Shih Chen
  • Jie Huang
  • J Yamate
  • Abraham Jacob
  • Elena M Akhmametyeva
  • Matthew L Bush
  • Leonid V Omelyanchuk
  • Sarah S Burns
  • Janet Oblinger
  • Tina X Lee
  • Natalia V Dorogova
  • Yuying Jiang
  • Kseniya Golovnina
  • Boris Popov
  • Zhixiong Xu
  • Warren D Lo
  • John M Lasak
  • Sholpan Davletova
  • Griffin Santarelli
  • Jeremy Davis
  • Charles W Yates
  • Victoria Brendel
  • Justin Wheeler
  • Abhik R Chaudhury
  • Samuel Kulp
  • Marco Giovannini
  • Mark D Packer
  • Julia A Pertseva
  • Samuel K Kulp
  • Olga S Yudina
  • Sergei A Kopyl
  • Natalia V Gubanova
  • Warren Lo
  • Huijun Luo
  • Maria M Mihaylova
  • Sadeq Kharzai
  • Alexander Blinov
  • Vladimir Serikov
  • Suming Huang
  • Stephen J Brandt
  • Paul D Friesen
  • Alan D Agulnick
  • Lingyun Zhu
  • Mariah Salloum

Detail Information

Publications21

  1. pmc Evolution and Origin of HRS, a Protein Interacting with Merlin, the Neurofibromatosis 2 Gene Product
    Leonid V Omelyanchuk
    Institute of Cytology and Genetics, Russian Academy of Sciences, 10 Lavrent ev Ave, 630090, Novosibirsk, Russia
    Gene Regul Syst Bio 3:143-57. 2009
    ..As these domains appear during the transition to multicellularity, their functional roles may be related to cell-cell interaction...
  2. pmc Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene
    Kseniya Golovnina
    Institute of Cytology and Genetics, Russian Academy of Sciences, 630090, Novosibirsk, Russia
    BMC Evol Biol 5:69. 2005
    ..While merlin's functional activity has been examined in mammalian and Drosophila models, little is understood about its evolution, diversity, and overall distribution among different taxa...
  3. pmc The role of Drosophila Merlin in spermatogenesis
    Natalia V Dorogova
    Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia
    BMC Cell Biol 9:1. 2008
    ..Male flies carrying a Mer3 allele, a missense mutation (Met177-->Ile) in the Merlin gene, are viable but sterile; however, the cause of sterility is unknown...
  4. ncbi request reprint Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcripts
    Long Sheng Chang
    Children s Research Institute, Children s Hospital, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Genomics 79:63-76. 2002
    ..Cotransfection studies in Drosophila melanogaster SL2 cells showed that Sp1 could activate the NF2 promoter through the GC-rich sequence...
  5. ncbi request reprint Growth of benign and malignant schwannoma xenografts in severe combined immunodeficiency mice
    Long Sheng Chang
    Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
    Laryngoscope 116:2018-26. 2006
    ..Models for the development of new treatment options in vestibular schwannoma (VS) treatment are lacking. The purpose of this study is to establish a quantifiable human VS xenograft model in mice...
  6. ncbi request reprint Induction of apoptosis by the p53-related p73 and partial inhibition by the baculovirus-encoded p35 in neuronal cells
    Warren D Lo
    Department of Pediatrics, Children s Hospital, The Ohio State University, Columbus, USA
    Brain Res Mol Brain Res 113:1-12. 2003
    ..Taken together, our results suggest that the N-terminal structure of p35 is critical for its anti-apoptotic activity on p73-induced apoptosis in neuronal cells...
  7. pmc Treatment of vestibular schwannoma cells with ErbB inhibitors
    Matthew L Bush
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University Eye and Ear Institute, Columbus, Ohio 43212, USA
    Otol Neurotol 33:244-57. 2012
    ..Aberrant phosphorylation of ErbB family receptor tyrosine kinases (RTK) in human vestibular schwannomas (VSs) renders them susceptible to growth suppression by RTK inhibitors...
  8. ncbi request reprint The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level
    Brian A Neff
    Department of Otolaryngology, The Ohio State University College of Medicine and Children s Hospital, Columbus, Ohio, USA
    Otol Neurotol 27:197-208. 2006
    ..The goal of this article was to review concisely what is currently known about the tumorigenesis of vestibular schwannomas...
  9. pmc Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas
    Abraham Jacob
    Department of Surgery, Division of Otolaryngology, University of Arizona, Tucson, Arizona 85724, USA
    Laryngoscope 122:174-89. 2012
    ....
  10. ncbi request reprint Cyclin D(1) and D(3) expression in vestibular schwannomas
    Brian A Neff
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43205, USA
    Laryngoscope 116:423-6. 2006
    ..The purpose of this study is to evaluate cyclin D(1) and D(3) protein expression and the corresponding clinical characteristics of vestibular schwannomas...
  11. ncbi request reprint Molecular studies of vestibular schwannomas: a review
    D Bradley Welling
    Department of Otolaryngology, The Ohio State University College of Medicine and Children s Hospital, Columbus, Ohio 43210, USA
    Curr Opin Otolaryngol Head Neck Surg 15:341-6. 2007
    ..To summarize advances in understanding the molecular biology of vestibular schwannomas over the past year...
  12. ncbi request reprint Retinoblastoma-cyclin-dependent kinase pathway deregulation in vestibular schwannomas
    John M Lasak
    Department of Otolaryngology, The Ohio State University and Children s Hospital, Columbus, USA
    Laryngoscope 112:1555-61. 2002
    ..The purpose of the study was to identify genes of the retinoblastoma protein (pRb)-cyclin-dependent kinase (CDK) pathway that are deregulated in vestibular schwannomas when compared with normal vestibular nerve tissues...
  13. ncbi request reprint Regulation of the neurofibromatosis 2 gene promoter expression during embryonic development
    Elena M Akhmametyeva
    Center for Childhood Cancer, Children s Research Institute, Children s Hospital, Columbus, Ohio, USA
    Dev Dyn 235:2771-85. 2006
    ....
  14. doi request reprint Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma
    Abraham Jacob
    Department of Otolaryngology, The Ohio State University, Columbus, and Center for Childhood Cancer, Research Institute at Nationwide Children s Hospital, Department of Pediatrics 43210, USA
    Otol Neurotol 29:58-68. 2008
    ..Merlin can inhibit phosphatidylinositol 3 kinase (PI3 kinase) by binding to PI3 kinase enhancer long isoform. Therefore, we hypothesized that the PI3 kinase/AKT pathway is activated in VS...
  15. doi request reprint Molecular biology of vestibular schwannomas
    Long Sheng Chang
    Department of Pediatrics, The Ohio State University College of Medicine, Center for Childhood Cancer Research Institute at National Childen s Hospital, Columbus, OH, USA
    Methods Mol Biol 493:163-77. 2009
    ..Nf2-transgenic and knockout mice as well as vestibular schwannoma xenograft models are now ready for novel therapeutic testing. Hopefully, better treatment options will be forthcoming soon...
  16. pmc AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas
    Matthew L Bush
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, OH 43212, USA
    Neuro Oncol 13:983-99. 2011
    ..The potent growth inhibitory activity of AR42 in schwannoma and meningioma cells suggests that AR42 should be further evaluated as a potential treatment for NF2-associated tumors...
  17. pmc Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells
    Tina X Lee
    Department of Otolaryngology, The Ohio State University College of Medicine, Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
    Eur J Cancer 45:1709-20. 2009
    ..Vestibular schwannomas (VS) frequently express high levels of activated AKT. Small-molecule inhibitors of AKT signalling may have therapeutic potential in suppressing the growth of benign VS and malignant schwannomas...
  18. ncbi request reprint cDNA microarray analysis of vestibular schwannomas
    D Bradley Welling
    Department of Otolaryngology, Ohio State University College of Medicine, Ohio, USA
    Otol Neurotol 23:736-48. 2002
    ..Identification of genes differentially expressed in normal and diseased tissues through the use of a large-scale, cDNA microarray approach may lead to increased understanding of pathways that lead to tumor formation...
  19. ncbi request reprint Over-expression of p73beta results in apoptotic death of post-mitotic hNT neurons
    Yuying Jiang
    Center for Childhood Cancer, Children s Research Institute, Division of Neurology, Children s Hospital, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Columbus, OH 43205 2696, United States
    J Neurol Sci 240:1-6. 2006
    ..Understanding the regulation of p73 expression will be important for understanding the development of the nervous system and may have implications for the treatment of neurological diseases...
  20. pmc Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation
    Zhixiong Xu
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Mol Cell Biol 23:7585-99. 2003
    ..2 and beta-globin mRNAs. These studies define a physiologic target for a TAL1- and GATA-1-containing ternary complex and reveal a positive role for Ldb1 in erythroid gene expression and differentiation...
  21. ncbi request reprint Cell cycle-related transformation of the E2F4-p130 repressor complex
    Boris Popov
    Institute of Cytology, Russian Academy of Sciences, 4, Tikhoretsky Ave, St Petersburg 194064, Russia
    Biochem Biophys Res Commun 336:762-9. 2005
    ..In contrast to T98G cells, transformation of the p130 containing cyc/cdk-pp-E2F4 complex into the p130-pp-E2F4 repressor does not occur in HeLa cells under growth restriction conditions...