Long Sheng Chang
Affiliation: The Ohio State University
- Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor geneKseniya Golovnina
Institute of Cytology and Genetics, Russian Academy of Sciences, 630090, Novosibirsk, Russia
BMC Evol Biol 5:69. 2005..While merlin's functional activity has been examined in mammalian and Drosophila models, little is understood about its evolution, diversity, and overall distribution among different taxa...
- The role of Drosophila Merlin in spermatogenesisNatalia V Dorogova
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia
BMC Cell Biol 9:1. 2008..Male flies carrying a Mer3 allele, a missense mutation (Met177-->Ile) in the Merlin gene, are viable but sterile; however, the cause of sterility is unknown...
- Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcriptsLong Sheng Chang
Children s Research Institute, Children s Hospital, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
Genomics 79:63-76. 2002..Cotransfection studies in Drosophila melanogaster SL2 cells showed that Sp1 could activate the NF2 promoter through the GC-rich sequence...
- Growth of benign and malignant schwannoma xenografts in severe combined immunodeficiency miceLong Sheng Chang
Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
Laryngoscope 116:2018-26. 2006..Models for the development of new treatment options in vestibular schwannoma (VS) treatment are lacking. The purpose of this study is to establish a quantifiable human VS xenograft model in mice...
- Treatment of vestibular schwannoma cells with ErbB inhibitorsMatthew L Bush
Department of Otolaryngology Head and Neck Surgery, The Ohio State University Eye and Ear Institute, Columbus, Ohio 43212, USA
Otol Neurotol 33:244-57. 2012..Aberrant phosphorylation of ErbB family receptor tyrosine kinases (RTK) in human vestibular schwannomas (VSs) renders them susceptible to growth suppression by RTK inhibitors...
- Molecular studies of vestibular schwannomas: a reviewD Bradley Welling
Department of Otolaryngology, The Ohio State University College of Medicine and Children s Hospital, Columbus, Ohio 43210, USA
Curr Opin Otolaryngol Head Neck Surg 15:341-6. 2007..To summarize advances in understanding the molecular biology of vestibular schwannomas over the past year...
- Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomasAbraham Jacob
Department of Surgery, Division of Otolaryngology, University of Arizona, Tucson, Arizona 85724, USA
Laryngoscope 122:174-89. 2012....
- Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannomaAbraham Jacob
Department of Otolaryngology, The Ohio State University, Columbus, and Center for Childhood Cancer, Research Institute at Nationwide Children s Hospital, Department of Pediatrics 43210, USA
Otol Neurotol 29:58-68. 2008..Merlin can inhibit phosphatidylinositol 3 kinase (PI3 kinase) by binding to PI3 kinase enhancer long isoform. Therefore, we hypothesized that the PI3 kinase/AKT pathway is activated in VS...
- Regulation of the neurofibromatosis 2 gene promoter expression during embryonic developmentElena M Akhmametyeva
Center for Childhood Cancer, Children s Research Institute, Children s Hospital, Columbus, Ohio, USA
Dev Dyn 235:2771-85. 2006....
- Molecular biology of vestibular schwannomasLong Sheng Chang
Department of Pediatrics, The Ohio State University College of Medicine, Center for Childhood Cancer Research Institute at National Childen s Hospital, Columbus, OH, USA
Methods Mol Biol 493:163-77. 2009..Nf2-transgenic and knockout mice as well as vestibular schwannoma xenograft models are now ready for novel therapeutic testing. Hopefully, better treatment options will be forthcoming soon...
- AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomasMatthew L Bush
Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, OH 43212, USA
Neuro Oncol 13:983-99. 2011..The potent growth inhibitory activity of AR42 in schwannoma and meningioma cells suggests that AR42 should be further evaluated as a potential treatment for NF2-associated tumors...
- Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cellsTina X Lee
Department of Otolaryngology, The Ohio State University College of Medicine, Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
Eur J Cancer 45:1709-20. 2009..Vestibular schwannomas (VS) frequently express high levels of activated AKT. Small-molecule inhibitors of AKT signalling may have therapeutic potential in suppressing the growth of benign VS and malignant schwannomas...
- cDNA microarray analysis of vestibular schwannomasD Bradley Welling
Department of Otolaryngology, Ohio State University College of Medicine, Ohio, USA
Otol Neurotol 23:736-48. 2002..Identification of genes differentially expressed in normal and diseased tissues through the use of a large-scale, cDNA microarray approach may lead to increased understanding of pathways that lead to tumor formation...
- Retinoblastoma-cyclin-dependent kinase pathway deregulation in vestibular schwannomasJohn M Lasak
Department of Otolaryngology, The Ohio State University and Children's Hospital, Columbus, USA
Laryngoscope 112:1555-61. 2002..Further investigation into the regulatory mechanisms governing CDK2 expression may lead to a better understanding of vestibular schwannoma tumorigenesis...
- The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular levelBrian A Neff
Department of Otolaryngology, The Ohio State University College of Medicine and Children's Hospital, Columbus, Ohio, USA
Otol Neurotol 27:197-208. 2006..CONCLUSION: Great strides have been made to identify why vestibular schwannomas develop at the molecular level. Continued research is needed to find targeted therapies with which to treat these tumors...
- Over-expression of p73beta results in apoptotic death of post-mitotic hNT neuronsYuying Jiang
Center for Childhood Cancer, Children's Research Institute, Division of Neurology, Children's Hospital, The Ohio State University, College of Medicine and Public Health, 700 Children's Drive, Columbus, OH 43205-2696, United States
J Neurol Sci 240:1-6. 2006..Understanding the regulation of p73 expression will be important for understanding the development of the nervous system and may have implications for the treatment of neurological diseases...
- Cyclin D(1) and D(3) expression in vestibular schwannomasBrian A Neff
Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio 43205, USA
Laryngoscope 116:423-6. 2006..In contrast, cyclin D(3) expression was seen in nearly half of the tumors examined, suggesting that it may have a growth-promoting role in some schwannomas. Further studies are needed to define its cellular mechanism...
- Induction of apoptosis by the p53-related p73 and partial inhibition by the baculovirus-encoded p35 in neuronal cellsWarren D Lo
Department of Pediatrics, Children's Hospital, The Ohio State University, Columbus, USA
Brain Res Mol Brain Res 113:1-12. 2003..Taken together, our results suggest that the N-terminal structure of p35 is critical for its anti-apoptotic activity on p73-induced apoptosis in neuronal cells...
- Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiationZhixiong Xu
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
Mol Cell Biol 23:7585-99. 2003..2 and beta-globin mRNAs. These studies define a physiologic target for a TAL1- and GATA-1-containing ternary complex and reveal a positive role for Ldb1 in erythroid gene expression and differentiation...
- Cell cycle-related transformation of the E2F4-p130 repressor complexBoris Popov
Institute of Cytology, Russian Academy of Sciences, 4, Tikhoretsky Ave, St Petersburg 194064, Russia
Biochem Biophys Res Commun 336:762-9. 2005..In contrast to T98G cells, transformation of the p130 containing cyc/cdk-pp-E2F4 complex into the p130-pp-E2F4 repressor does not occur in HeLa cells under growth restriction conditions...