George J Chang

..MR imaging permits precise delineation of tumor anatomy and assessment of mesorectal tumor penetration and radial margin risk...

..To better understand the reasons for decreased survival rates in elderly patients with rectal cancer by performing an epidemiologic evaluation of age-related differences in treatment and survival...

..Adenocarcinoma of the anal canal is a rare malignancy with limited data regarding treatment and outcomes. The purpose of this study is to evaluate disease control and survival outcomes in patients with adenocarcinoma of the anal canal...

..The purpose of this study was to perform a population-based evaluation of the impact of pathologic LN status (ypN) after neoadjuvant radiotherapy on survival...

..We performed a systematic review of the evidence for the association between lymph node evaluation and oncologic outcomes in patients with colon cancer...

..Despite these limitations, patient recovery benefits may offset the increased operative costs and result in improved outcome overall...

..In this study we performed a contemporary evaluation of conditional survival among colon cancer patients and created a browser-based tool for real-time determination of conditional survival expectancies...

..To retrospectively determine rates of toxicity, freedom from local progression, and survival in rectal cancer patients treated with reirradiation...

..The purpose of this study was to assess and compare oncologic outcomes associated with the degree of pathologic response after chemoradiotherapy...

..We designed this Phase II trial to assess the efficacy and safety of the addition of bevacizumab to concurrent neoadjuvant capecitabine-based chemoradiation in locally advanced rectal cancer...

..To evaluate patterns of locoregional failure, and predictors of recurrence and survival in patients treated with chemoradiation for anal cancer...

..An increasing number of patients with synchronous colorectal liver metastases (CLM) are candidates for resection. The optimal treatment sequence in these patients has not been defined...

..Our goal was to determine the incidence, risk factors, and clinical course of SI fractures in patients treated with preoperative chemoradiation for rectal cancer...

..To identify patterns of locoregional recurrence in patients treated with surgery and preoperative or postoperative radiotherapy or chemoradiation for rectal cancer...

..The objective of this study was to identify predictive factors for pathologic complete response and tumor downstaging after preoperative chemoradiation for rectal cancer...

..We evaluated clinical features and survival outcomes among patients with signet ring and mucinous histologies of colorectal adenocarcinoma by using data from the National Cancer Data Base (NCDB)...

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..To assist in patient selection for radical surgery, we sought to determine clinicopathologic factors influencing recurrence and disease-free survival (DFS) of LARC...

..Conditional survival estimates provide useful prognostic information for cancer survivors. The objective of this study was to determine conditional survival estimates for melanoma patients with substages of stage III disease...

..Therefore, tumor response in the bowel wall has been proposed to be used to identify patients for organ-preserving strategies...

..We therefore evaluated whether neoadjuvant BV is associated with an increase in postoperative complications in patients undergoing surgery for CRC liver metastases...

..Neuroendocrine tumors (NETs) of the appendix include malignant carcinoid tumor (MCT), goblet cell carcinoid (GCT), and composite goblet cell carcinoid-adenocarcinoma (CGCC-A)...

..However, the safety and efficacy of simultaneous resection have been demonstrated in selected patients. The purpose of this study was to evaluate outcomes and economic implications of simultaneous and staged resections...

..Local excision, alone or in combination with chemoradiation, is increasingly considered for rectal cancer. Higher risks of disease recurrence have been demonstrated after local excision...

..Because of its rarity, adenocarcinoma of the small intestine is frequently compared to adenocarcinoma of the colon, although the validity of this comparison is not known...

..To identify predictive factors for locoregional recurrence (LR), distant metastasis (DM), and overall survival (OS) in patients treated with chemoradiation and surgery for rectal cancer...

..The pathologic response rate is comparable to our previous experience using protracted venous infusion 5-FU for LARC...

..While curative resection offers survival benefits, significant trade-offs exist for the patient. Knowledge of patient-reported outcomes will help inform treatment decisions...

..We retrospectively investigated whether the timing of radiotherapy affects rates of acute toxicity, pathologic response, and relapse in rectal cancer patients receiving capecitabine...

..We sought to evaluate the surgical morbidity of proctectomy for colorectal cancer after previous liver surgery...

..Three-dimensional T2-weighted imaging provides multiplanar capability with a superior signal-to-noise ratio compared with two-dimensional T2-weighted imaging...

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..The objective of this study was to determine the prevalence and prognostic significance of acellular mucin within resected specimens of rectal cancer patients with a pCR following preoperative chemoradiation...

..The purpose of this study is to evaluate operative and pathologic factors associated with long-term survival and local recurrence outcomes in patients treated for distal rectal cancer...

..The objective of the current study was to evaluate the impact of the number of positive and negative lymph nodes on survival after curative resection...

..For patients who present with persistent or locally recurrent disease, salvage abdominoperineal resection is the treatment of choice. The purpose of this study is to review our experience with salvage surgery in this group of patients...

..The National Comprehensive Cancer Network (NCCN) has established working, expert consensus, and evidence-based guidelines for organ-specific cancer care, including care of patients with colon cancer...

..With increasing interest in neuroendocrine tumors (NETs), three staging systems for NETs of the colon and rectum have been published. Their prognostic relevance has not been examined and compared in an independent clinical database...

..We sought to determine rates of and factors associated with adherence to the National Comprehensive Cancer Network (NCCN) treatment guidelines for colon cancer...

..Here we evaluated the sensitivity, predictive value, and accuracy of SLN evaluation for determining lymph node status in resectable colon cancer...

..The objective of this analysis was to provide melanoma-specific CS estimates to help clinicians promote more informed patient decision making...

..To calculate conditional survival estimates for patients with pancreatic adenocarcinoma...

..The morbidity of these procedures is high and at times may compromise quality of life. Palliative surgical procedures can be considered; however, in some cases, palliative resections may not be better than nonsurgical palliation...

..In addition, we seek to identify factors which are associated with surgical intervention...

..Despite increased demand for contralateral prophylactic mastectomy (CPM), the survival benefit of this procedure remains uncertain...

..For rectal cancer, stage-related treatment (eg, neoadjuvant radiotherapy) affects pathologic stage and therefore stage-associated survival estimates...

..Since 1993 there has been a decrease in colorectal cancer mortality. Thus, there are more cancer survivors. In this manuscript potential barriers encountered during the rehabilitation of the colorectal cancer patient will be discussed...

..Resection of sacral tumors is difficult due to the proximity of neurovascular and visceral structures, and complete, or even partial, sacrectomy often results in functional loss for the patient...

..To evaluate the evidence for interventions to decrease surgical site infections (SSIs) in colorectal operations using Bayesian meta-analysis...

..The purpose of this study was to characterize clinical presentations and management strategy for pneumoperitoneum in cancer patients...

..The authors review the most common and clinically relevant extracolonic manifestations for each of these syndromes focusing on incidence, presentation, genotype/phenotype correlations, and management (including surveillance) strategies...

..This article discusses a practical approach for some of the issues likely to be encountered by the surgeon...

..We describe two cases of primary peritoneal cancer after BSO in women with Lynch syndrome or HNPCC...

..The high persistence or recurrence rate in human immunodeficiency virus-positive patients suggests that multiple staged procedures and continued surveillance may be necessary...

..The high Spanish organ donation rates are largely attributable to increased use of older donors. Utilizing similar proportions of older donors in the US would increase the donor pool by almost 40%...

..Despite these limitations, patient recovery benefits may offset the increased operative costs and result in improved cost-effectiveness overall...