B Chang

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. ncbi request reprint Identification of a missense mutation in the alphaA-crystallin gene of the lop18 mouse
    B Chang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mol Vis 5:21. 1999
  2. pmc Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure
    B Chang
    The Howard Hughes Medical Institute, USA
    BMC Genet 2:18. 2001
  3. ncbi request reprint Mouse models of ocular diseases
    B Chang
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Vis Neurosci 22:587-93. 2005
  4. ncbi request reprint Retinal degeneration mutants in the mouse
    B Chang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA
    Vision Res 42:517-25. 2002
  5. pmc Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
    M G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine, USA
    BMC Genet 2:1. 2001
  6. ncbi request reprint Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens
    N L Hawes
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Invest Ophthalmol Vis Sci 41:3149-57. 2000
  7. ncbi request reprint Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes
    N L Hawes
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mol Vis 5:22. 1999
  8. ncbi request reprint Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice
    B Chang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Genet 21:405-9. 1999
  9. ncbi request reprint Lop12, a mutation in mouse Crygd causing lens opacity similar to human Coppock cataract
    R S Smith
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 63:314-20. 2000
  10. pmc Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene
    B Chang
    The Jackson Laboratory, Bar Harbor, ME, USA
    Vision Res 47:624-33. 2007

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Identification of a missense mutation in the alphaA-crystallin gene of the lop18 mouse
    B Chang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mol Vis 5:21. 1999
    ..Here we report the identification of a missense mutation in the alphaA-crystallin gene of lop18/lop18 mutant mice...
  2. pmc Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure
    B Chang
    The Howard Hughes Medical Institute, USA
    BMC Genet 2:18. 2001
    ..Bone morphogenetic proteins (BMPs) participate in various developmental processes. We tested the importance of Bmp4 gene dosage for ocular development and developmental glaucoma...
  3. ncbi request reprint Mouse models of ocular diseases
    B Chang
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Vis Neurosci 22:587-93. 2005
    ..Because of the great similarity among mammalian genomes, these findings in mice have direct relevance to the homologous human conditions...
  4. ncbi request reprint Retinal degeneration mutants in the mouse
    B Chang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA
    Vision Res 42:517-25. 2002
    ..cpfl1 mice may provide a model for congenital achromatopsia in humans...
  5. pmc Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
    M G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine, USA
    BMC Genet 2:1. 2001
    ..The purpose of this study was to determine if the effects of the DBA/2J derived isa and ipd loci are modified in strain AKXD-28/Ty...
  6. ncbi request reprint Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens
    N L Hawes
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Invest Ophthalmol Vis Sci 41:3149-57. 2000
    ..To characterize the genetics and phenotype of a new mouse mutant with retinal degeneration, rd6, that is associated with extensive, scattered, small white retinal dots seen ophthalmoscopically...
  7. ncbi request reprint Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes
    N L Hawes
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mol Vis 5:22. 1999
    ..The purpose of this work was to develop procedures for mouse fundus photography and angiography and to use these techniques to examine several new mouse strains with ocular abnormalities...
  8. ncbi request reprint Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice
    B Chang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Genet 21:405-9. 1999
    ..Progeny homozygous for the D2 alleles of both ipd and isa develop an earlier onset and more severe disease involving pigment dispersion and iris stromal atrophy...
  9. ncbi request reprint Lop12, a mutation in mouse Crygd causing lens opacity similar to human Coppock cataract
    R S Smith
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 63:314-20. 2000
    ..It is predicted that the defective gene product alters protein folding of the gamma-crystallin(s) and results in lens opacity...
  10. pmc Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene
    B Chang
    The Jackson Laboratory, Bar Harbor, ME, USA
    Vision Res 47:624-33. 2007
    ..It may also provide a better model for experimental pharmaceutical-based therapy for RP because of its later onset and milder retinal degeneration than rd1 and nmf137...
  11. ncbi request reprint Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice
    S Ikeda
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Invest Ophthalmol Vis Sci 40:1874-8. 1999
    ..To demonstrate the importance of genetic background interaction on the development of ocular phenotypes in p53-deficient mice...
  12. ncbi request reprint Chromosomal localization of a new mouse lens opacity gene (lop18)
    B Chang
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 36:171-3. 1996
    ..It is a likely candidate mutation for the alpha-crystallin (Crya1) gene...
  13. ncbi request reprint Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
    Y Xue
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Hum Mol Genet 8:723-30. 1999
    ..These results establish the phenotype of Cm /+ mice as a contiguous gene deletion syndrome and demonstrate that Jag1 is essential for remodeling of the embryonic vasculature...
  14. pmc The bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization
    R S Smith
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 97:2191-5. 2000
    ..This represents a spontaneous, genetically determined model of SRN. Bst/+ mice offer the possibility of exploring the molecular mechanisms of SRN without the need for exogenous agents...
  15. ncbi request reprint A new dominant retinal degeneration (Rd4) associated with a chromosomal inversion in the mouse
    T H Roderick
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 42:393-6. 1997
    ..A human homolog would be expected to be located on human chromosomes 1p or 8q...
  16. ncbi request reprint Corn1: a mouse model for corneal surface disease and neovascularization
    R S Smith
    Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Invest Ophthalmol Vis Sci 37:397-404. 1996
    ..To describe a new mouse model of corneal surface disease and neovascularization...
  17. pmc Linkage and association studies of prostate cancer susceptibility: evidence for linkage at 8p22-23
    J Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA
    Am J Hum Genet 69:341-50. 2001
    ..In summary, these results provide evidence for the existence of a prostate cancer-susceptibility gene at 8p22-23. Evaluation of the PG1 gene and other candidate genes in this area appears warranted...
  18. ncbi request reprint Cortical visual function in the rd12 mouse model of Leber Congenital Amarousis (LCA) after gene replacement therapy to restore retinal function
    S Nusinowitz
    Department of Ophthalmology, Jules Stein Eye Institute, Los Angeles, CA, USA
    Vision Res 46:3926-34. 2006
    ..These results provide further support that early treatment in human LCA will have the most hope for optimal visual performance...
  19. pmc Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15
    J R Heckenlively
    Jules Stein Eye Institute, Harbor UCLA Medical Center, Torrance 90509, USA
    Proc Natl Acad Sci U S A 92:11100-4. 1995
    ..Auditory-evoked response testing demonstrates increased hearing thresholds more than control at 3 weeks of about 30 decibels (dB) that worsen to about 45 dB by 6 months...
  20. ncbi request reprint Retinal degeneration in motor neuron degeneration: a mouse model of ceroid lipofuscinosis
    B Chang
    Jackson Laboratory, Bar Harbor, Maine
    Invest Ophthalmol Vis Sci 35:1071-6. 1994
    ..To evaluate the retinal degeneration of the motor neuron degeneration (mnd) mouse, and to confirm its inheritance pattern and gene location...
  21. pmc A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse
    N B Akhmedov
    Jules Stein Eye Institute, University of California School of Medicine, Los Angeles, CA 90095 7000, USA
    Proc Natl Acad Sci U S A 97:5551-6. 2000
    ..Our findings demonstrate that mPNR expression is critical for the normal development and function of the photoreceptor cells...
  22. ncbi request reprint New mouse primary retinal degeneration (rd-3)
    B Chang
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 16:45-9. 1993
    ..5 cM distal to Akp-1. Homology mapping suggests that the homologous human locus should be on chromosome 1q...
  23. ncbi request reprint Characterization of the mouse Prox1 gene
    S I Tomarev
    Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochem Biophys Res Commun 248:684-9. 1998
    ..Immunostaining of the eyes from wild type and rd3 animals also revealed differences in the distribution of Prox1 protein in the retina and lens. These data suggest that the rd3 mutation affects expression of the mouse Prox1 gene...
  24. ncbi request reprint Identification and cloning of a truncated isoform of the cardiac sodium-calcium exchanger in the BALB/c mouse heart
    S Shi
    Columbia University, Institute of Comparative Medicine, New York, New York 10032, USA
    Biochem Genet 36:119-35. 1998
    ..Using the mouse mapping gene panel BCB, the NCX1 gene was mapped to the distal end of mouse chromosome 17 (51.3 cM), confirming the data published from the rat probe...
  25. pmc Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer
    J Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Hum Genet 68:901-11. 2001
    ..Nor can we rule out a prostate cancer-modifier gene that confers a lower-than-reported risk. Additional larger studies are needed to more fully evaluate the role of this gene in prostate cancer risk...
  26. ncbi request reprint Biotechnology applications of amino acids in protein purification and formulations
    T Arakawa
    Alliance Protein Laboratories, Thousand Oaks, CA, USA
    Amino Acids 33:587-605. 2007
    ..This review covers various biotechnology applications of amino acids, in particular arginine...
  27. ncbi request reprint Characterization of the mouse Myoc/Tigr gene
    S I Tomarev
    Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochem Biophys Res Commun 245:887-93. 1998
    ..The mouse Myoc/Tigr gene was mapped to Chromosome 1 at position 82.8 cM from the centromere. All residues, which were identified in the human MYOC/TIGR protein as critical for glaucoma development, are conserved in the mouse Myoc/Tigr...
  28. pmc Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci
    W M Brown
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Cancer 90:510-4. 2004
    ..Continued collection and analysis of African American prostate cancer families will lead to an improved understanding of inherited susceptibility in this high-risk group...
  29. ncbi request reprint Vitreous cyst and a cataract in a toddler
    B Chang
    Eye (Lond) 17:1034-6. 2003
  30. ncbi request reprint Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer
    B Chang
    University of Maryland School of Medicine, Baltimore, MD, USA
    Int J Cancer 95:354-9. 2001
    ....
  31. ncbi request reprint Evidence for a prostate cancer linkage to chromosome 20 in 159 hereditary prostate cancer families
    S L Zheng
    University of Maryland School of Medicine, Baltimore, USA
    Hum Genet 108:430-5. 2001
    ..01, P=0.15 at D20S117). The region with positive linkage scores spanned approximately 60 cM from 20pter to 20q11 in these subsets of families. Our results are consistent with a prostate cancer susceptibility locus on chromosome 20...
  32. ncbi request reprint Linkage of prostate cancer susceptibility loci to chromosome 1
    J Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA
    Hum Genet 108:335-45. 2001
    ..61 (P=0.09) and hlod of 0.39 (P=0.16) at D1S407 in all six families. These results are consistent with the heterogeneous nature of hereditary prostate cancer, and the existence of multiple loci on chromosome 1 for this disease...
  33. doi request reprint Spatial and temporal changes in sulphate-reducing groundwater bacterial community structure in response to Managed Aquifer Recharge
    D A Reed
    CSIRO Land and Water, Private Bag No 5 PO Wembley, Western Australia 6913, Australia
    Water Sci Technol 57:789-95. 2008
    ..Additionally, the biodiversity of these culturable bacteria was restored when aquifer geochemistry returned to ambient conditions during the recovery phase at the Adelaide Aquifer Storage and Recovery site...