Mark S Chambers

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Anterior key method for indexing orbital prostheses
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    J Prosthet Dent 87:102-5. 2002
  2. ncbi request reprint Obturation of the partial soft palate defect
    Mark S Chambers
    Department of Head and Neck Surgery, M D Anderson Cancer Center, The University of Texas, Houston 77030 4009 USA
    J Prosthet Dent 91:75-9. 2004
  3. ncbi request reprint Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 1: Fluorides
    Mark S Chambers
    Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Oral Oncol 42:934-45. 2006
  4. ncbi request reprint Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 68:1102-9. 2007
  5. ncbi request reprint Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 69:1369-76. 2007
  6. ncbi request reprint Erratum to "Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study"
    Mark S Chambers
    Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Oral Oncol 43:98-105. 2007
  7. ncbi request reprint Radiation-induced xerostomia in patients with head and neck cancer: pathogenesis, impact on quality of life, and management
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA
    Head Neck 26:796-807. 2004
  8. ncbi request reprint Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study
    Mark S Chambers
    Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Oral Oncol 42:946-53. 2006
  9. ncbi request reprint Mutans streptococci in xerostomic cancer patients after pilocarpine therapy: a pilot study
    Mark S Chambers
    The University of Texas, M D Anderson Cancer Center, MDACC, Department of Head and Neck Surgery, Houston, Texas 77030 4009, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:180-4. 2005
  10. doi request reprint Salivary flow rates measured during radiation therapy in head and neck cancer patients: a pilot study assessing salivary sediment formation
    Mark S Chambers
    Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Prosthet Dent 100:142-6. 2008

Detail Information

Publications53

  1. ncbi request reprint Anterior key method for indexing orbital prostheses
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    J Prosthet Dent 87:102-5. 2002
    ..Because indexing is performed from the anterior aspect of the cast, damage is minimized, fewer modifications are required, and the mold can be preserved for repeated use...
  2. ncbi request reprint Obturation of the partial soft palate defect
    Mark S Chambers
    Department of Head and Neck Surgery, M D Anderson Cancer Center, The University of Texas, Houston 77030 4009 USA
    J Prosthet Dent 91:75-9. 2004
    ..This article presents a technique for recording the contours of a partial soft-palate defect for prosthetic obturation...
  3. ncbi request reprint Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 1: Fluorides
    Mark S Chambers
    Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Oral Oncol 42:934-45. 2006
    ..Part 1 discusses the historical and currently available fluoride preparations and Part 2 presents data of a recently completed trial investigating the benefit of an intraoral sodium fluoride releasing system...
  4. ncbi request reprint Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 68:1102-9. 2007
    ..To study the efficacy and safety of cevimeline in two double-blind trials (Studies 003 and 004) enrolling patients with head and neck cancer in whom xerostomia developed after radiotherapy...
  5. ncbi request reprint Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 69:1369-76. 2007
    ..To assess the safety of long-term cevimeline treatment of radiation-induced xerostomia in patients with head-and-neck cancer; and to assess the efficacy of cevimeline in these patients...
  6. ncbi request reprint Erratum to "Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study"
    Mark S Chambers
    Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Oral Oncol 43:98-105. 2007
    ..It would be more convenient than the daily home application of a tray of 0.4% stannous fluoride or 1.1% sodium fluoride gel, and avoids the problem of variable patient compliance...
  7. ncbi request reprint Radiation-induced xerostomia in patients with head and neck cancer: pathogenesis, impact on quality of life, and management
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA
    Head Neck 26:796-807. 2004
    ..Xerostomia is a common, debilitating complication of radiation therapy (RT) for head and neck cancer. This article reviews the pathogenesis of radiation-induced xerostomia, its impact on quality of life (QOL), and treatment options...
  8. ncbi request reprint Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study
    Mark S Chambers
    Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Oral Oncol 42:946-53. 2006
    ..It would be more convenient than the daily home application of a tray of 0.4% stannous fluoride or 1.1% sodium fluoride gel, and avoids the problem of variable patient compliance...
  9. ncbi request reprint Mutans streptococci in xerostomic cancer patients after pilocarpine therapy: a pilot study
    Mark S Chambers
    The University of Texas, M D Anderson Cancer Center, MDACC, Department of Head and Neck Surgery, Houston, Texas 77030 4009, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:180-4. 2005
    ..Opiod- and/or radiation-induced xerostomia in cancer patients is frequently associated with elevated levels of cariogenic mutans streptococci (MS)...
  10. doi request reprint Salivary flow rates measured during radiation therapy in head and neck cancer patients: a pilot study assessing salivary sediment formation
    Mark S Chambers
    Department of Head and Neck Surgery, Department of Radiation Oncology, M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Prosthet Dent 100:142-6. 2008
    ..Determining the impact that salivary sediments have on measured salivary flow rates during radiation is important for management of patients...
  11. ncbi request reprint Intensity-modulated radiotherapy: is xerostomia still prevalent?
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Curr Oncol Rep 7:131-6. 2005
    ....
  12. ncbi request reprint Radiation-induced xerostomia
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Head Neck 29:58-63. 2007
    ..Radiation-induced xerostomia is a frequent and usually permanent side effect of radiation therapy for head and neck cancer. We summarize recent developments in the prevention and treatment of radiation-induced xerostomia...
  13. doi request reprint Beam path toxicities to non-target structures during intensity-modulated radiation therapy for head and neck cancer
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 72:747-55. 2008
    ..This study estimates the doses and toxicities to nontarget structures during IMRT...
  14. ncbi request reprint Measuring head and neck cancer symptom burden: the development and validation of the M. D. Anderson symptom inventory, head and neck module
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 29:923-31. 2007
    ....
  15. doi request reprint The M. D. Anderson symptom inventory-head and neck module, a patient-reported outcome instrument, accurately predicts the severity of radiation-induced mucositis
    David I Rosenthal
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 72:1355-61. 2008
    ....
  16. ncbi request reprint Intensity-modulated radiation therapy and xerostomia
    Mark S Chambers
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Calif Dent Assoc 34:743-8. 2006
    ....
  17. ncbi request reprint Further experience with modification of an intraluminal button for hands-free tracheoesophageal speech after laryngectomy
    Jan S Lewin
    Department of Head and Neck Surgery, The University of Texas, M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    J Prosthet Dent 102:328-31. 2009
    ..A technique is presented for modification of a standard silicone laryngectomy button to facilitate hands-free TE speech after total laryngectomy...
  18. ncbi request reprint Psychosocial and economic impact of cancer
    Linda S Elting
    Section of Health Services Research, Department of Biostatistics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 447, Houston, TX 77030, USA
    Dent Clin North Am 52:231-52, x. 2008
    ....
  19. doi request reprint Acupuncture for radiation-induced xerostomia in patients with cancer: a pilot study
    M Kay Garcia
    Integrative Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Head Neck 31:1360-8. 2009
    ..This pilot study evaluated if acupuncture can alleviate radiation-induced xerostomia among patients with cancer. Secondary objectives were to assess the effects of acupuncture on salivary flow and quality of life (QOL)...
  20. ncbi request reprint Multiple regions-of-interest analysis of setup uncertainties for head-and-neck cancer radiotherapy
    Lifei Zhang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 64:1559-69. 2006
    ..To analyze three-dimensional setup uncertainties for multiple regions of interest (ROIs) in head-and-neck region...
  21. ncbi request reprint Facial prosthetic rehabilitation: preprosthetic surgical techniques and biomaterials
    James C Lemon
    Section of Oncologic Dentistry, Department of Head and Neck Surgery, MD Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Opin Otolaryngol Head Neck Surg 13:255-62. 2005
    ..Teamwork between the surgeon and maxillofacial prosthodontist will ensure an optimal surgical preparation and definitive prosthesis...
  22. ncbi request reprint A phase II study to assess the efficacy of amifostine for submandibular/sublingual salivary sparing during the treatment of head and neck cancer with intensity modulated radiation therapy for parotid salivary sparing
    David I Rosenthal
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Oncol 31:25-8. 2004
    ....
  23. ncbi request reprint How to reduce radiation-related toxicity in patients with cancer of the head and neck
    Adam S Garden
    Department of Radiation Oncology and Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston TX, 77030, USA
    Curr Oncol Rep 8:140-5. 2006
    ..Minimizing radiation dose to these tissues may lower the incidence of radiation-induced dysphagia...
  24. ncbi request reprint Custom modification of the Blom-Singer tracheostoma valve housing
    James C Lemon
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Prosthodont 12:17-20. 2003
    ..A punch biopsy instrument is used to cut uniform holes around the housing device to allow for permeation of the silicone mixture for better mechanical adherence of the materials...
  25. ncbi request reprint Oral rehabilitation of a mandibular discontinuity defect: a clinical report
    Peter J Gerngross
    Michael E DeBakey V A Medical Center, Houston, USA
    Tex Dent J 125:438-41. 2008
    ..It is important to inform them that prosthetic reconstruction may restore structures and continuity, but it may not restore function...
  26. doi request reprint Head and neck radiation and mucositis
    Adam S Garden
    Departments of Radiation Oncology and Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Opin Support Palliat Care 1:30-4. 2007
    ..We will review the recent literature that has provided new insights into the pathogenesis, metrics and therapeutics of mucositis...
  27. ncbi request reprint A technique for the fabrication of an immediate mandibular surgical stent securing a skin graft
    Kelley L Tomsett
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Prosthet Dent 93:395-7. 2005
    ..This article describes an efficient and accurate method of fabricating an immediate mandibular surgical stent in the operating room setting...
  28. ncbi request reprint A phase II study of gefitinib for aggressive cutaneous squamous cell carcinoma of the head and neck
    Carol M Lewis
    Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:1435-46. 2012
    ..To determine the disease control rate and toxicity of treating patients with aggressive cutaneous squamous cell carcinoma (CSCC) with neoadjuvant gefitinib...
  29. doi request reprint Three synchronous HPV-associated squamous cell carcinomas of Waldeyer's ring: case report and comparison with Slaughter's model of field cancerization
    Susan L McGovern
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Head Neck 32:1118-24. 2010
    ..The rate of synchronous lesions in human papillomavirus (HPV)-positive oropharyngeal cancers is unknown...
  30. ncbi request reprint Stent fabrication for graft immobilization following wide surgical excision of myofibroblastic sarcoma of the buccal mucosa: a clinical report
    Ioli Ioanna Artopoulou
    Department of Head and Neck Surgery, Section of Oncologic Dentistry and Prosthodontics, University of Texas M D Anderson Cancer Center, Houston, 77230 1402, USA
    J Prosthet Dent 95:280-5. 2006
    ..A situation of a surgically excised myofibrosarcoma of the buccal mucosa is reported. In this patient, a stent was fabricated to stabilize a split-thickness skin graft used for the buccal mucosa reconstruction...
  31. ncbi request reprint Period between completion of radiation therapy and prosthetic rehabilitation in edentulous patients: a retrospective study
    Peter J Gerngross
    Veteran s Administration Hospital, Houston, Texas, USA
    J Prosthodont 14:110-21. 2005
    ..e., denture) following radiation therapy to the head and neck and (2) to investigate whether the time between radiation therapy and denture insertion might contribute to those complications...
  32. ncbi request reprint Association between microbial flora and tissue abnormality around dental implants penetrating the skin in reconstructed oral cancer patients
    Ayman Ahmed
    Section of Oncologic Dentistry and Prosthodontics, Department of Head and Neck Surgery, M D Anderson Cancer Center, University of Texas, Houston, TX, USA
    Int J Oral Maxillofac Implants 27:684-94. 2012
    ..This pilot clinical trial identified the oral microflora of the peri-implant sulcus of cancer patients with jaw reconstruction and compared sites with and without clinical signs of inflammation...
  33. ncbi request reprint In vitro effect of microwave irradiation on the retentive force of magnets
    James C Lemon
    M D Anderson Canncer Center and University of Texas Health Science Center at Houston, Dental Branch, Houston, TX 77030, USA
    J Prosthet Dent 91:368-73. 2004
    ..Few studies have addressed the possible effect(s) of microwave irradiation on the magnetic properties of "permanent" magnets during the fabrication of dental and maxillofacial prostheses...
  34. ncbi request reprint Postsurgical use of prosthetic palatal appliances. Two case reports
    Ioli Ioanna Artopoulou
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston 77230 1402, USA
    J Clin Pediatr Dent 30:105-8. 2005
    ..Surgical and orthodontic interventions are essential and prosthetic palatal appliances play an important role not only throughout the patient's treatment course, but also in the treatment of unfavorable surgical sequelae...
  35. ncbi request reprint Locking retentive attachment for an implant-retained auricular prosthesis
    James C Lemon
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Prosthet Dent 87:336-8. 2002
    ..This article describes the use of the Slant-Lock retention system with an implant-retained auricular prosthesis...
  36. doi request reprint Customization of the voice prosthesis to prevent leakage from the enlarged tracheoesophageal puncture: results of a prospective trial
    Jan S Lewin
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Laryngoscope 122:1767-72. 2012
    ....
  37. doi request reprint Adaptive radiotherapy for head-and-neck cancer: initial clinical outcomes from a prospective trial
    David L Schwartz
    Department of Radiation Medicine, Hofstra North Shore Long Island Jewish School of Medicine, New Hyde Park, NY 11040, USA
    Int J Radiat Oncol Biol Phys 83:986-93. 2012
    ..To present pilot toxicity and survival outcomes for a prospective trial investigating adaptive radiotherapy (ART) for oropharyngeal squamous cell carcinoma...
  38. ncbi request reprint Diagnosis of premalignant lesions and early cancers of the oral cavity
    Ann M Gillenwater
    Department of Head and Neck Surgery, Anderson Cancer Center, The University of Texas, Houston, USA
    Tex Dent J 123:512-20. 2006
  39. ncbi request reprint Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies
    Linda S Elting
    Section of Health Services Research, Department of Biostatistics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 68:1110-20. 2007
    ..To study the risk, outcomes, and costs of radiation-induced oral mucositis (OM) among patients receiving radiotherapy (RT) to head and neck primary cancers...
  40. ncbi request reprint Sjögren's syndrome
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas, M D Anderson Cancer Center, Houston 77030 4009, USA
    ORL Head Neck Nurs 22:22-30; quiz 32-3. 2004
    ..This article describes saliva and salivary function, the pathogenesis of SS, the current treatment of xerostomia, and quality of life issues related to salivary dysfunction...
  41. doi request reprint The multiple oral presentations of multiple myeloma
    Richard C Cardoso
    Section of Oral Oncology, Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, USA
    Support Care Cancer 22:259-67. 2014
    ..The diagnostic criteria and prognostic features for multiple myeloma were also reviewed...
  42. doi request reprint Evaluating the impact of patient, tumor, and treatment characteristics on the development of jaw complications in patients treated for oral cancers: a SEER-Medicare analysis
    Beth M Beadle
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Head Neck 35:1599-605. 2013
    ..This study identifies the impact of patient, tumor, and treatment characteristics on the development of jaw complications in patients treated with RT...
  43. ncbi request reprint Facial moulage: the effect of a retarder on compressive strength and working and setting times of irreversible hydrocolloid impression material
    James C Lemon
    M D Anderson Cancer Center and Dental Branch, University of Texas Health Science Center at Houston, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    J Prosthet Dent 90:276-81. 2003
    ..Irreversible hydrocolloid is widely used as an impression material for fabrication of extraoral maxillofacial impressions. A disadvantage of irreversible hydrocolloid, however, is its limited working time...
  44. ncbi request reprint How I do it: a technique for oral wound irrigation following maxillectomy and mandibulectomy
    Mark S Chambers
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center MDACC, Houston, Texas, USA
    ORL Head Neck Nurs 21:27-8. 2003
    ..Numerous devices have been recommended for ensuring appropriate hygiene and care of wounds resulting from maxillectomy and mandibulectomy. This article describes an irrigation device for use in the oral cavity after these procedures...
  45. ncbi request reprint Treatment strategy for patients with ectodermal dysplasia: a case report
    Jack W Martin
    Department of Head and Neck Surgery, MDACC, Houston, TX 77030 4009, USA
    J Clin Pediatr Dent 29:113-8. 2005
    ..With any form of ED, children may display a range of symptoms and challenging rehabilitation. This clinical report presents the treatment plan for a young patient with ED and anodontia requiring prosthetic restoration...
  46. ncbi request reprint Modification of the Barton button for tracheoesophageal speech: an innovative maxillofacial prosthetic technique
    James C Lemon
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    J Prosthet Dent 87:236-9. 2002
    ..This article presents a technique for modification of the Barton button to increase its successful use by tracheoesophageal speakers...
  47. ncbi request reprint Clinical commentary on prophylactic treatment of radiation-induced xerostomia
    Mark S Chambers
    Arch Otolaryngol Head Neck Surg 129:251-2. 2003
  48. ncbi request reprint Risk of osteoradionecrosis after extraction of impacted third molars in irradiated head and neck cancer patients
    Hee Kyun Oh
    Department of Oral and Maxillofacial Surgery, College of Dentistry, Chonnam National University, South Korea
    J Oral Maxillofac Surg 62:139-44. 2004
    ..This study was performed to compare the risk of osteoradionecrosis (ORN) in head and neck cancer patients in whom 1 or more impacted third molars were extracted before radiotherapy with patients whose impacted third molars were left intact...
  49. ncbi request reprint A mold-making procedure for multiple orbital prostheses fabrication
    Trakol Mekayarajjananonth
    Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
    J Prosthet Dent 90:97-100. 2003
    ..The following method provides a mold resistant to these problems with light-polymerized resin surrounding the palpebral part of the orbital mold...
  50. ncbi request reprint Interactions of pigments and opacifiers on color stability of MDX4-4210/type A maxillofacial elastomers subjected to artificial aging
    Sudarat Kiat-Amnuay
    Department of Restorative Dentistry and Biomaterials, University of Texas Dental Branch at Houston, 77030, USA
    J Prosthet Dent 95:249-57. 2006
    ..The color instability and degradation of maxillofacial elastomers limit the function and cosmetic quality of facial prostheses...
  51. ncbi request reprint A maxillary fibro-osseous lesion: differential diagnosis and case report
    Mark S Chambers
    Department of Otolaryngology, University of West Virginia, USA
    Tex Dent J 119:12-9. 2002
  52. ncbi request reprint 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists
    Mark S Chambers
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
    J Med Chem 45:1176-9. 2002
    ..In particular, 6,6-dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one (26) has been identified as a functionally selective GABA-A alpha5 inverse agonist...
  53. ncbi request reprint Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition
    Mark S Chambers
    Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    J Med Chem 46:2227-40. 2003
    ....