SERGIO DANIEL CATZ

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Gene transfer and expression in human neutrophils. The phox homology domain of p47phox translocates to the plasma membrane but not to the membrane of mature phagosomes
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA
    BMC Immunol 7:28. 2006
  2. ncbi request reprint BCL-2 in prostate cancer: a minireview
    S D Catz
    Biochemistry Division, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Apoptosis 8:29-37. 2003
  3. pmc Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Infect Immun 79:3607-18. 2011
  4. doi request reprint Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells
    Sergio D Catz
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Methods Enzymol 438:25-40. 2008
  5. pmc Cross-talk between IRAK-4 and the NADPH oxidase
    Sandrine Pacquelet
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 403:451-61. 2007
  6. pmc Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes
    Daniela B Munafo
    Department of Molecular and Experimental Medicine, Division of Biochemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 402:229-39. 2007
  7. pmc The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase
    Jennifer L Johnson
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 391:699-710. 2005
  8. pmc JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells
    Sergio D Catz
    Biochemistry Division, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 367:791-9. 2002
  9. ncbi request reprint Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation
    Jennifer L Johnson
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Traffic 6:667-81. 2005
  10. pmc Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase
    Carolyn R Hoyal
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:5130-5. 2003

Research Grants

  1. FUNCTION OF NORMAL AND MALIGNANT PHAGOCYTES
    SERGIO CATZ; Fiscal Year: 2007
  2. Role of Rab27 in Granulocyte Function
    SERGIO CATZ; Fiscal Year: 2009
  3. Role of Rab27 in Granulocyte Function
    SERGIO DANIEL CATZ; Fiscal Year: 2010
  4. Role of Rab27 in Granulocyte Function
    SERGIO DANIEL CATZ; Fiscal Year: 2011

Collaborators

Detail Information

Publications11

  1. pmc Gene transfer and expression in human neutrophils. The phox homology domain of p47phox translocates to the plasma membrane but not to the membrane of mature phagosomes
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA
    BMC Immunol 7:28. 2006
    ..Consequently, exogenous gene expression in neutrophils is challenging. We report here the transfection of genes and expression of active proteins in human primary peripheral neutrophils using nucleofection...
  2. ncbi request reprint BCL-2 in prostate cancer: a minireview
    S D Catz
    Biochemistry Division, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Apoptosis 8:29-37. 2003
    ..The way in which hormone ablation influences this survival pathway and the potential application of novel therapeutic strategies to overcome this anti-apoptotic mechanism is examined...
  3. pmc Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation
    Jennifer L Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Infect Immun 79:3607-18. 2011
    ....
  4. doi request reprint Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells
    Sergio D Catz
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Methods Enzymol 438:25-40. 2008
    ..Here, we present methods for the characterization of Rab27a and its effector JFC1/Slp1 as key components of the secretory machinery that regulates exocytosis in prostate carcinoma cells...
  5. pmc Cross-talk between IRAK-4 and the NADPH oxidase
    Sandrine Pacquelet
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 403:451-61. 2007
    ..We conclude that IRAK-4 phosphorylates p47phox and regulates NADPH oxidase activation after LPS stimulation...
  6. pmc Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes
    Daniela B Munafo
    Department of Molecular and Experimental Medicine, Division of Biochemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 402:229-39. 2007
    ..Our results suggest that the granules implicated in cargo release towards the surrounding milieu are molecularly and mechanistically different from those involved in their release towards the phagolysosome...
  7. pmc The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase
    Jennifer L Johnson
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 391:699-710. 2005
    ..In conclusion, we present evidence that JFC1 differentially regulates the secretion of PSAP and PSA, and that Rab27a and PI3K play a central role in the exocytosis of prostate-specific markers...
  8. pmc JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells
    Sergio D Catz
    Biochemistry Division, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 367:791-9. 2002
    ....
  9. ncbi request reprint Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation
    Jennifer L Johnson
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Traffic 6:667-81. 2005
    ..Our results suggest that Akt regulates JFC1/Slp1 function by phosphorylation and may have implications on Rab27a-containing vesicle secretion...
  10. pmc Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase
    Carolyn R Hoyal
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:5130-5. 2003
    ..We now find that Akt activates the oxidase in vitro by phosphorylating serines S304 and S328 of p47(PHOX). These results suggest that Akt could participate in the activation of the leukocyte NADPH oxidase...
  11. pmc The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells
    Sergio D Catz
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:11652-7. 2002
    ..We also show that the association of the C2A domain to the membrane is modulated by calcium. From these results we analyze possible mechanisms for the role of JFC1 in cellular trafficking...

Research Grants7

  1. FUNCTION OF NORMAL AND MALIGNANT PHAGOCYTES
    SERGIO CATZ; Fiscal Year: 2007
    ..Further study will be carried out on the possibility that p67PHOX carries NADPH to the electron transport chain. Finally, X-ray crystallography of the oxidase components will be done. ..
  2. Role of Rab27 in Granulocyte Function
    SERGIO CATZ; Fiscal Year: 2009
    ..The study of the mechanism that controls the release of toxic products by neutrophils will lead to the design of therapeutic strategies for the control of diseases like arthritis and other inflammatory disorders. ..
  3. Role of Rab27 in Granulocyte Function
    SERGIO DANIEL CATZ; Fiscal Year: 2010
    ..The study of the mechanism that controls the release of toxic products by neutrophils will lead to the design of therapeutic strategies for the control of diseases like arthritis and other inflammatory disorders. ..
  4. Role of Rab27 in Granulocyte Function
    SERGIO DANIEL CATZ; Fiscal Year: 2011
    ..The study of the mechanism that controls the release of toxic products by neutrophils will lead to the design of therapeutic strategies for the control of diseases like arthritis and other inflammatory disorders. ..