Jane Carlton

Summary

Affiliation: The Institute for Genomic Research
Country: USA

Publications

  1. ncbi request reprint Rodent models of malaria in the genomics era
    Jane M Carlton
    Parasite Genomics Group, The Institute for Genomic Research, Rockville20850, USA
    Trends Parasitol 18:100-2. 2002
  2. pmc Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax
    Xiaorong Feng
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:8502-7. 2003
  3. ncbi request reprint Comparative genomics of trypanosomatid parasitic protozoa
    Najib M El-Sayed
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:404-9. 2005
  4. ncbi request reprint Gene discovery in Plasmodium vivax through sequencing of ESTs from mixed blood stages
    Liwang Cui
    Department of Entomology, The Pennsylvania State University, 501 ASI, University Park, PA 16802, USA
    Mol Biochem Parasitol 144:1-9. 2005
  5. ncbi request reprint Toward a malaria haplotype map
    Jane M Carlton
    Nat Genet 39:5-6. 2007
  6. pmc Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites
    Tobias J Sargeant
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Genome Biol 7:R12. 2006
  7. ncbi request reprint Profiling the malaria genome: a gene survey of three species of malaria parasite with comparison to other apicomplexan species
    J M Carlton
    Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biochem Parasitol 118:201-10. 2001
  8. ncbi request reprint The genome of model malaria parasites, and comparative genomics
    Jane Carlton
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Curr Issues Mol Biol 7:23-37. 2005
  9. ncbi request reprint Genome sequencing and comparative genomics of tropical disease pathogens
    Jane M Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Cell Microbiol 5:861-73. 2003
  10. ncbi request reprint The Plasmodium vivax genome sequencing project
    Jane Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Trends Parasitol 19:227-31. 2003

Detail Information

Publications33

  1. ncbi request reprint Rodent models of malaria in the genomics era
    Jane M Carlton
    Parasite Genomics Group, The Institute for Genomic Research, Rockville20850, USA
    Trends Parasitol 18:100-2. 2002
    ..The Rodent Malaria Genomics Symposium: Current Status and Future Directions was held on 15-16 November 2001 in Atlanta, GA, USA...
  2. pmc Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax
    Xiaorong Feng
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:8502-7. 2003
    ..These data show that P. vivax has a highly diverse genome, and provide useful information for further understanding the genome diversity of the parasite...
  3. ncbi request reprint Comparative genomics of trypanosomatid parasitic protozoa
    Najib M El-Sayed
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:404-9. 2005
    ..Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont...
  4. ncbi request reprint Gene discovery in Plasmodium vivax through sequencing of ESTs from mixed blood stages
    Liwang Cui
    Department of Entomology, The Pennsylvania State University, 501 ASI, University Park, PA 16802, USA
    Mol Biochem Parasitol 144:1-9. 2005
    ..This study should facilitate our understanding of the gene expression in P. vivax asexual stages and provide valuable data for gene prediction and annotation of the P. vivax genome sequence...
  5. ncbi request reprint Toward a malaria haplotype map
    Jane M Carlton
    Nat Genet 39:5-6. 2007
  6. pmc Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites
    Tobias J Sargeant
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Genome Biol 7:R12. 2006
    ..Previously, we have reported identification and functional analysis of a short motif necessary for export of proteins out of the parasite and into the red blood cell...
  7. ncbi request reprint Profiling the malaria genome: a gene survey of three species of malaria parasite with comparison to other apicomplexan species
    J M Carlton
    Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biochem Parasitol 118:201-10. 2001
    ..Thus a partial predicted proteome was created for each species. This first comparative analysis of Plasmodium protein coding sequences represents a valuable resource for further studies on the biology of this important pathogen...
  8. ncbi request reprint The genome of model malaria parasites, and comparative genomics
    Jane Carlton
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Curr Issues Mol Biol 7:23-37. 2005
    ..This is a stimulating time for comparative genomics of model and human malaria parasites, which promises to produce useful results for the development of antimalarial drugs and vaccines...
  9. ncbi request reprint Genome sequencing and comparative genomics of tropical disease pathogens
    Jane M Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Cell Microbiol 5:861-73. 2003
    ....
  10. ncbi request reprint The Plasmodium vivax genome sequencing project
    Jane Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Trends Parasitol 19:227-31. 2003
    ..Here, an update on the Plasmodium vivax genome sequencing project is presented, as part of the Trends in Parasitology series of reviews expanding on various aspects of P. vivax research...
  11. ncbi request reprint Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
    Jane M Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:512-9. 2002
    ..This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease...
  12. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
    ..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species...
  13. pmc Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
    ..The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria...
  14. ncbi request reprint Comparative genomics of malaria parasites
    Neil Hall
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20851, USA
    Curr Opin Genet Dev 15:609-13. 2005
    ..Recent research has led to the description of a motif that is conserved across Plasmodium species and which plays a central role in protein export into the host cell...
  15. ncbi request reprint Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
    Malcolm J Gardner
    Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:134-7. 2005
    ..Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated...
  16. ncbi request reprint A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses
    Neil Hall
    Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 307:82-6. 2005
    ..We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3' untranslated region motif is implicated in this process...
  17. pmc A potentially functional mariner transposable element in the protist Trichomonas vaginalis
    Joana C Silva
    The Institute for Genomic Research, Rockville, Maryland, USA
    Mol Biol Evol 22:126-34. 2005
    ..The considerable genetic distance between Tvmar1 and other mariners may have valuable implications for the design of new, high-efficiency vectors to be used in transfection studies in protists...
  18. ncbi request reprint Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:531-4. 2002
    ..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome...
  19. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    ..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
  20. ncbi request reprint Immune responses to Plasmodium vivax pre-erythrocytic stage antigens in naturally exposed Duffy-negative humans: a potential model for identification of liver-stage antigens
    Ruobing Wang
    The Institute for Genomic Research, Rockville, USA
    Eur J Immunol 35:1859-68. 2005
    ..These results suggest that differential immune responses observed in naturally exposed Fy(-) and Fy(+) individuals can be exploited to identify P. vivax stage-specific antigens...
  21. ncbi request reprint Host switch leads to emergence of Plasmodium vivax malaria in humans
    Jianbing Mu
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    Mol Biol Evol 22:1686-93. 2005
    ..Taken together, a haplotype network, parasite migration patterns, demographic history, and cophylogeny mapping support an Asian origin via a host switch from macaque monkeys...
  22. pmc Local adaptation and vector-mediated population structure in Plasmodium vivax malaria
    Deirdre A Joy
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biol Evol 25:1245-52. 2008
    ....
  23. pmc Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote
    Jonathan A Eisen
    The Institute for Genomic Research, Rockville, Maryland, United States of America
    PLoS Biol 4:e286. 2006
    ..thermophila an ideal model for functional genomic studies to address biological, biomedical, and biotechnological questions of fundamental importance...
  24. ncbi request reprint Mind the gap: bridging the divide between clinical and molecular studies of the trichomonads
    Emily J Lyons
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Trends Parasitol 20:204-7. 2004
  25. ncbi request reprint Identification of a very large Rab GTPase family in the parasitic protozoan Trichomonas vaginalis
    Kalpana Lal
    Department of Zoology, The Natural History Museum, South Kensington, London SW7 5BD, UK
    Mol Biochem Parasitol 143:226-35. 2005
    ..vaginalis both an amoeboid life cycle stage and very large Rab gene families...
  26. ncbi request reprint Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting man
    John B Dame
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Box 110880, Gainesville, FL 32611 0880, USA
    Mol Biochem Parasitol 130:1-12. 2003
    ..falciparum as compared with the other three species causing malaria in man will impact efforts to rationally design antimalarials targeting the food vacuole plasmepsins...
  27. pmc Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalis
    Stepanka Vanacova
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:4430-5. 2005
    ....
  28. pmc Identification of a polymorphic Plasmodium vivax microsatellite marker
    John C Gomez
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 4983, USA
    Am J Trop Med Hyg 69:377-9. 2003
    ..falciparum). The marker was polymorphic in P. vivax-infected field isolates obtained from Papua New Guinea, Indonesia and Guyana. This microsatellite marker may be useful in genetic and epidemiologic studies of P. vivax malaria...
  29. pmc Novel antigen identification method for discovery of protective malaria antigens by rapid testing of DNA vaccines encoding exons from the parasite genome
    Diana Haddad
    Naval Medical Research Center, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Infect Immun 72:1594-602. 2004
    ..We conclude that high-throughput cloning of exons into DNA vaccines and their screening is feasible and can rapidly identify new malaria vaccine candidate antigens...
  30. pmc A Plasmodium whole-genome synteny map: indels and synteny breakpoints as foci for species-specific genes
    Taco W A Kooij
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Pathog 1:e44. 2005
    ..A majority of these genes are expressed in blood stages, suggesting that the vertebrate host exerts a greater selective pressure than the mosquito vector, resulting in the acquisition of diversity...
  31. pmc The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites
    Zbynek Bozdech
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    Proc Natl Acad Sci U S A 105:16290-5. 2008
    ..These data provide insights into the biology of P. vivax and constitute an important resource for the development of therapeutic approaches...
  32. ncbi request reprint Contrasting genetic structure in Plasmodium vivax populations from Asia and South America
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Int J Parasitol 37:1013-22. 2007
    ..falciparum, and have important implications for the design of association mapping studies, and interpretation of P. vivax epidemiology...
  33. ncbi request reprint Plasmodium vivax in India
    Hema Joshi
    National Institute of Malaria Research, Delhi 110054, India
    Trends Parasitol 24:228-35. 2008
    ..The unique epidemiology of malaria in India, where P. vivax predominates over Plasmodium falciparum, renders this location ideal for studying the dynamics of co-infection...