Research Topics
Species | Jane CarltonSummaryAffiliation: The Institute for Genomic Research Country: USA Publications
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Detail Information
Publications
Rodent models of malaria in the genomics eraJane M Carlton
Parasite Genomics Group, The Institute for Genomic Research, Rockville20850, USA
Trends Parasitol 18:100-2. 2002..The Rodent Malaria Genomics Symposium: Current Status and Future Directions was held on 15-16 November 2001 in Atlanta, GA, USA...
Single-nucleotide polymorphisms and genome diversity in Plasmodium vivaxXiaorong Feng
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:8502-7. 2003..These data show that P. vivax has a highly diverse genome, and provide useful information for further understanding the genome diversity of the parasite...- Comparative genomics of trypanosomatid parasitic protozoaNajib M El-Sayed
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 309:404-9. 2005..Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont... - Gene discovery in Plasmodium vivax through sequencing of ESTs from mixed blood stagesLiwang Cui
Department of Entomology, The Pennsylvania State University, 501 ASI, University Park, PA 16802, USA
Mol Biochem Parasitol 144:1-9. 2005..This study should facilitate our understanding of the gene expression in P. vivax asexual stages and provide valuable data for gene prediction and annotation of the P. vivax genome sequence... - Toward a malaria haplotype mapJane M Carlton
Nat Genet 39:5-6. 2007 
Lineage-specific expansion of proteins exported to erythrocytes in malaria parasitesTobias J Sargeant
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Genome Biol 7:R12. 2006..Previously, we have reported identification and functional analysis of a short motif necessary for export of proteins out of the parasite and into the red blood cell...- Profiling the malaria genome: a gene survey of three species of malaria parasite with comparison to other apicomplexan speciesJ M Carlton
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA
Mol Biochem Parasitol 118:201-10. 2001..Thus a partial predicted proteome was created for each species. This first comparative analysis of Plasmodium protein coding sequences represents a valuable resource for further studies on the biology of this important pathogen... - The genome of model malaria parasites, and comparative genomicsJane Carlton
The Institute for Genomic Research, Rockville, MD 20850, USA
Curr Issues Mol Biol 7:23-37. 2005..This is a stimulating time for comparative genomics of model and human malaria parasites, which promises to produce useful results for the development of antimalarial drugs and vaccines... - Genome sequencing and comparative genomics of tropical disease pathogensJane M Carlton
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Cell Microbiol 5:861-73. 2003.... - The Plasmodium vivax genome sequencing projectJane Carlton
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Trends Parasitol 19:227-31. 2003..Here, an update on the Plasmodium vivax genome sequencing project is presented, as part of the Trends in Parasitology series of reviews expanding on various aspects of P. vivax research... - Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoeliiJane M Carlton
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:512-9. 2002..This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease... - Comparative genomics of the neglected human malaria parasite Plasmodium vivaxJane M Carlton
The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Nature 455:757-63. 2008..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species... - Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalisJane M Carlton
Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
Science 315:207-12. 2007..The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria... - Comparative genomics of malaria parasitesNeil Hall
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20851, USA
Curr Opin Genet Dev 15:609-13. 2005..Recent research has led to the description of a motif that is conserved across Plasmodium species and which plays a central role in protein export into the host cell... - Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytesMalcolm J Gardner
Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 309:134-7. 2005..Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated... - A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analysesNeil Hall
Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Science 307:82-6. 2005..We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3' untranslated region motif is implicated in this process... - A potentially functional mariner transposable element in the protist Trichomonas vaginalisJoana C Silva
The Institute for Genomic Research, Rockville, Maryland, USA
Mol Biol Evol 22:126-34. 2005..The considerable genetic distance between Tvmar1 and other mariners may have valuable implications for the design of new, high-efficiency vectors to be used in transfection studies in protists... - Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14Malcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:531-4. 2002..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome... - Genome sequence of the human malaria parasite Plasmodium falciparumMalcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:498-511. 2002..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria... - Immune responses to Plasmodium vivax pre-erythrocytic stage antigens in naturally exposed Duffy-negative humans: a potential model for identification of liver-stage antigensRuobing Wang
The Institute for Genomic Research, Rockville, USA
Eur J Immunol 35:1859-68. 2005..These results suggest that differential immune responses observed in naturally exposed Fy(-) and Fy(+) individuals can be exploited to identify P. vivax stage-specific antigens... - Host switch leads to emergence of Plasmodium vivax malaria in humansJianbing Mu
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
Mol Biol Evol 22:1686-93. 2005..Taken together, a haplotype network, parasite migration patterns, demographic history, and cophylogeny mapping support an Asian origin via a host switch from macaque monkeys... - Local adaptation and vector-mediated population structure in Plasmodium vivax malariaDeirdre A Joy
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Mol Biol Evol 25:1245-52. 2008.... - Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryoteJonathan A Eisen
The Institute for Genomic Research, Rockville, Maryland, United States of America
PLoS Biol 4:e286. 2006..thermophila an ideal model for functional genomic studies to address biological, biomedical, and biotechnological questions of fundamental importance... - Mind the gap: bridging the divide between clinical and molecular studies of the trichomonadsEmily J Lyons
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Trends Parasitol 20:204-7. 2004 - Identification of a very large Rab GTPase family in the parasitic protozoan Trichomonas vaginalisKalpana Lal
Department of Zoology, The Natural History Museum, South Kensington, London SW7 5BD, UK
Mol Biochem Parasitol 143:226-35. 2005..vaginalis both an amoeboid life cycle stage and very large Rab gene families... - Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting manJohn B Dame
Department of Pathobiology, College of Veterinary Medicine, University of Florida, Box 110880, Gainesville, FL 32611 0880, USA
Mol Biochem Parasitol 130:1-12. 2003..falciparum as compared with the other three species causing malaria in man will impact efforts to rationally design antimalarials targeting the food vacuole plasmepsins... - Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalisStepanka Vanacova
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 102:4430-5. 2005.... - Identification of a polymorphic Plasmodium vivax microsatellite markerJohn C Gomez
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-4983, USA
Am J Trop Med Hyg 69:377-9. 2003..falciparum). The marker was polymorphic in P. vivax-infected field isolates obtained from Papua New Guinea, Indonesia and Guyana. This microsatellite marker may be useful in genetic and epidemiologic studies of P. vivax malaria... - Novel antigen identification method for discovery of protective malaria antigens by rapid testing of DNA vaccines encoding exons from the parasite genomeDiana Haddad
Naval Medical Research Center, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Infect Immun 72:1594-602. 2004..We conclude that high-throughput cloning of exons into DNA vaccines and their screening is feasible and can rapidly identify new malaria vaccine candidate antigens... - A Plasmodium whole-genome synteny map: indels and synteny breakpoints as foci for species-specific genesTaco W A Kooij
Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
PLoS Pathog 1:e44. 2005..A majority of these genes are expressed in blood stages, suggesting that the vertebrate host exerts a greater selective pressure than the mosquito vector, resulting in the acquisition of diversity... - The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasitesZbynek Bozdech
School of Biological Sciences, Nanyang Technological University, Singapore 637551
Proc Natl Acad Sci U S A 105:16290-5. 2008..These data provide insights into the biology of P. vivax and constitute an important resource for the development of therapeutic approaches... - Contrasting genetic structure in Plasmodium vivax populations from Asia and South AmericaMallika Imwong
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Int J Parasitol 37:1013-22. 2007..falciparum, and have important implications for the design of association mapping studies, and interpretation of P. vivax epidemiology... 
Plasmodium vivax in IndiaHema Joshi
National Institute of Malaria Research, Delhi 110054, India
Trends Parasitol 24:228-35. 2008..The unique epidemiology of malaria in India, where P. vivax predominates over Plasmodium falciparum, renders this location ideal for studying the dynamics of co-infection...