Genomes and Genes
Affiliation: The Ohio State University
- White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axisLei Cao
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
Cell Metab 14:324-38. 2011....
- Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibitionLei Cao
Department of Molecular Virology, Immunology and Medical Genetics, and Neuroscience and Neurological Surgery and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Cell 142:52-64. 2010..These results suggest that genetic or environmental activation of this BDNF/leptin axis may have therapeutic significance for cancer...
- What is the brain-cancer connection?Lei Cao
College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Annu Rev Neurosci 35:331-45. 2012..We summarize this work and discuss how these data integrate into the body of literature regarding stress, the environment, and cancer...
- Molecular therapy of obesity and diabetes by a physiological autoregulatory approachLei Cao
Cancer Genetics and Neuroscience Program, Department of Molecular Virology, Immunology and Medical Genetics, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
Nat Med 15:447-54. 2009..This strategy mimics the body's endogenous physiological feedback mechanisms, thereby resetting the hypothalamic set point to reverse obesity and metabolic syndrome...