Lei Cao

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis
    Lei Cao
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Cell Metab 14:324-38. 2011
  2. pmc The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma
    Travis McMurphy
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 9:e89895. 2014
  3. pmc Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition
    Lei Cao
    Department of Molecular Virology, Immunology and Medical Genetics, and Neuroscience and Neurological Surgery and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Cell 142:52-64. 2010
  4. doi request reprint What is the brain-cancer connection?
    Lei Cao
    College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Annu Rev Neurosci 35:331-45. 2012
  5. pmc Molecular therapy of obesity and diabetes by a physiological autoregulatory approach
    Lei Cao
    Cancer Genetics and Neuroscience Program, Department of Molecular Virology, Immunology and Medical Genetics, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Nat Med 15:447-54. 2009
  6. pmc Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice
    Xianglan Liu
    1 Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA 2 The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Mol Ther 22:1275-84. 2014

Collaborators

Detail Information

Publications6

  1. pmc White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis
    Lei Cao
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Cell Metab 14:324-38. 2011
    ....
  2. pmc The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma
    Travis McMurphy
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 9:e89895. 2014
    ..The blockade of central actions of leptin by systemic delivery of nanobody may compromise its anticancer effect, underscoring the need to develop peripherally acting leptin antagonists coupled with efficient cancer-targeting delivery. ..
  3. pmc Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition
    Lei Cao
    Department of Molecular Virology, Immunology and Medical Genetics, and Neuroscience and Neurological Surgery and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Cell 142:52-64. 2010
    ..These results suggest that genetic or environmental activation of this BDNF/leptin axis may have therapeutic significance for cancer...
  4. doi request reprint What is the brain-cancer connection?
    Lei Cao
    College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Annu Rev Neurosci 35:331-45. 2012
    ..We summarize this work and discuss how these data integrate into the body of literature regarding stress, the environment, and cancer...
  5. pmc Molecular therapy of obesity and diabetes by a physiological autoregulatory approach
    Lei Cao
    Cancer Genetics and Neuroscience Program, Department of Molecular Virology, Immunology and Medical Genetics, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Nat Med 15:447-54. 2009
    ..This strategy mimics the body's endogenous physiological feedback mechanisms, thereby resetting the hypothalamic set point to reverse obesity and metabolic syndrome...
  6. pmc Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice
    Xianglan Liu
    1 Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA 2 The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Mol Ther 22:1275-84. 2014
    ..Our results suggest that manipulating a single gene in the brain may influence multiple mechanisms implicated in obesity-cancer association and provide a target for the prevention and treatment of both obesity and cancer. ..