E R Butelman

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates
    Eduardo R Butelman
    The Rockefeller University, Box 171, 1230 York Ave, New York, NY 10021, USA
    J Pharmacol Exp Ther 311:155-63. 2004
  2. ncbi request reprint Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic kappa-opioid agonists in rhesus monkeys
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, Rockefeller University Box 171, 1230 York Avenue, New York, NY 10021, USA
    Psychoneuroendocrinology 29:307-26. 2004
  3. ncbi request reprint The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys
    Eduardo R Butelman
    The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Psychopharmacology (Berl) 172:220-4. 2004
  4. ncbi request reprint kappa-Opioid receptor agonist-induced prolactin release in primates is blocked by dopamine D(2)-like receptor agonists
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University Box 171, 1230 York Avenue, New York, NY 10021, USA
    Eur J Pharmacol 423:243-9. 2001
  5. ncbi request reprint Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation
    Eduardo R Butelman
    Rockefeller University, New York, NY 10021, USA
    J Pharmacol Exp Ther 306:1106-14. 2003
  6. ncbi request reprint Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York NY 10021, USA
    J Pharmacol Exp Ther 320:300-6. 2007
  7. ncbi request reprint Comparison of the discriminative and neuroendocrine effects of centrally penetrating kappa-opioid agonists in rhesus monkeys
    Eduardo R Butelman
    The Rockefeller University Box 171, 1230 York Avenue, New York, NY 10021, USA
    Psychopharmacology (Berl) 164:115-20. 2002
  8. ncbi request reprint Systemic effects of E-2078, a stabilized dynorphin A(1-8) analog, in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 143:190-6. 1999
  9. ncbi request reprint Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 147:73-80. 1999
  10. ncbi request reprint GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    J Pharmacol Exp Ther 298:1049-59. 2001

Research Grants

  1. kappa-agonist effects of the hallucinogen Salvinorin A
    Eduardo Butelman; Fiscal Year: 2007
  2. EFFECTS OF SYSTEMICALLY ADMINISTERED DYNORPHINS
    Eduardo Butelman; Fiscal Year: 2002

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates
    Eduardo R Butelman
    The Rockefeller University, Box 171, 1230 York Ave, New York, NY 10021, USA
    J Pharmacol Exp Ther 311:155-63. 2004
    ..These studies show that loperamide, acting as a peripherally selective micro-agonist after systemic administration, can prevent capsaicin-induced thermal allodynia in primates in vivo, in the absence of thermal antinociceptive effects...
  2. ncbi request reprint Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic kappa-opioid agonists in rhesus monkeys
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, Rockefeller University Box 171, 1230 York Avenue, New York, NY 10021, USA
    Psychoneuroendocrinology 29:307-26. 2004
    ..0032 mg/kg, s.c. and i.v., respectively). Overall, these findings are consistent with the hypothesis that the dynorphins act as high efficacy, peripherally selective kappa-agonists following systemic administration in primates...
  3. ncbi request reprint The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys
    Eduardo R Butelman
    The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Psychopharmacology (Berl) 172:220-4. 2004
    ..It was postulated that salvinorin A would produce discriminative stimulus effects similar to those of a high efficacy kappa-agonist (U69,593) in rhesus monkeys...
  4. ncbi request reprint kappa-Opioid receptor agonist-induced prolactin release in primates is blocked by dopamine D(2)-like receptor agonists
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University Box 171, 1230 York Avenue, New York, NY 10021, USA
    Eur J Pharmacol 423:243-9. 2001
    ....
  5. ncbi request reprint Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation
    Eduardo R Butelman
    Rockefeller University, New York, NY 10021, USA
    J Pharmacol Exp Ther 306:1106-14. 2003
    ....
  6. ncbi request reprint Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York NY 10021, USA
    J Pharmacol Exp Ther 320:300-6. 2007
    ..The present studies indicate that the hallucinogen salvinorin A acts as a high-efficacy kappa-agonist in nonhuman primates in a translationally viable neuroendocrine biomarker assay...
  7. ncbi request reprint Comparison of the discriminative and neuroendocrine effects of centrally penetrating kappa-opioid agonists in rhesus monkeys
    Eduardo R Butelman
    The Rockefeller University Box 171, 1230 York Avenue, New York, NY 10021, USA
    Psychopharmacology (Berl) 164:115-20. 2002
    ..The potency of centrally penetrating kappa-agonists could be similar in these two assays, due to their ability to occupy kappa-receptor pools inside and outside the blood-brain barrier, following SC administration...
  8. ncbi request reprint Systemic effects of E-2078, a stabilized dynorphin A(1-8) analog, in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 143:190-6. 1999
    ..E-2078 has been found to produce kappa-opioid agonist effects in vivo in rodents...
  9. ncbi request reprint Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 147:73-80. 1999
    ..The dynorphins are endogenous opioid peptides with relative binding selectivity for kappa-receptors. It is unclear whether the dynorphins share the pharmacological profile observed with synthetic kappa-agonists in primates...
  10. ncbi request reprint GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    J Pharmacol Exp Ther 298:1049-59. 2001
    ..GR89,696 was less sensitive than U50,488 and U69,593 to naltrexone or nor-BNI antagonism, consistent with an action through the proposed kappa(2) receptor subtype...
  11. ncbi request reprint Effects of systemically administered dynorphin A(1-17) in rhesus monkeys
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, Rockefeller University, New York, USA
    J Pharmacol Exp Ther 290:678-86. 1999
    ..The present studies show that serum prolactin levels are a sensitive quantitative endpoint to study the systemic effects of the endogenous opioid peptide, dynorphin A(1-17), in primates...
  12. ncbi request reprint Apparent efficacy of kappa-opioid receptor ligands on serum prolactin levels in rhesus monkeys
    E R Butelman
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue Box 171, New York, NY 10021, USA
    Eur J Pharmacol 383:305-9. 1999
    ..Prolactin may therefore be a quantitative marker of the apparent efficacy of kappa-opioid receptor ligands in primates...
  13. ncbi request reprint kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception
    E R Butelman
    Department of Pharmacology, College of Pharmacy, University of Michigan, Ann Arbor, USA
    J Pharmacol Exp Ther 285:595-601. 1998
    ..Overall, the present results suggest that at least two functional kappa receptor populations may be present in rhesus monkey brain...
  14. doi request reprint Self administration of oxycodone by adolescent and adult mice affects striatal neurotransmitter receptor gene expression
    B Mayer-Blackwell
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuroscience 258:280-91. 2014
    ..Overall, this study demonstrates that repeated oxycodone self administration alters neurotransmitter receptors gene expression in the dorsal striatum of adolescent and adult mice. ..
  15. pmc Bidirectional translational research: Progress in understanding addictive diseases
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 56:32-43. 2009
    ....
  16. ncbi request reprint Nicotine addiction: insights from recent animal studies
    A M Mathieu-Kia
    Rockefeller University, Laboratory on the Biology of Addictive Diseases, Box 171, 1230 York Avenue, New York, NY 10021 6399, USA
    Psychopharmacology (Berl) 162:102-18. 2002
    ..Recent preclinical behavioral and neurobiological research has characterized important behavioral features and has identified neurobiological substrates that may underlie nicotine reinforcement and addiction...
  17. pmc The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates
    Eduardo R Butelman
    The Rockefeller University, Box 171, 1230 York Ave, New York, NY 10065, USA
    J Pharmacol Exp Ther 327:154-60. 2008
    ..c.) caused approximately 70% reduction in the peak effect of herkinorin (0.32 mg/kg) in females, indicating that this effect of herkinorin is prominently mediated outside the blood-brain barrier...
  18. pmc Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Psychoneuroendocrinology 33:292-304. 2008
    ..v. administration. Thus, the relative ineffectiveness of i.v. beta-endorphin in this assay does not appear to be principally due to rapid generation of non-opioid fragments of this neuropeptide...
  19. ncbi request reprint Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958
    Jon E Hawkinson
    Lead Discovery and Optimization, Elan Pharmaceuticals, South San Francisco, CA 94080, USA
    J Pharmacol Exp Ther 322:619-30. 2007
    ..ELN441958 is a novel small molecule bradykinin B(1) receptor antagonist exhibiting high oral bioavailability and potent systemic efficacy in rhesus monkey inflammatory pain...
  20. ncbi request reprint Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    Nat Neurosci 8:1450-7. 2005
    ..Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases...
  21. ncbi request reprint Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates
    Matthew D Schmidt
    Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, Iowa 52242
    Synapse 58:208-10. 2005
    ..Salvinorin B, the presumed major metabolite, is observed to accumulate ex vivo; however, in this study it never reached the limit of detection...
  22. ncbi request reprint Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands
    Wayne W Harding
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
    J Med Chem 48:4765-71. 2005
    ..This represents the identification of a novel structural class of mu opioid receptor agonists...
  23. ncbi request reprint Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization
    Mark S Schmidt
    College of Pharmacy, Division of Clinical and Administrative Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 818:221-5. 2005
    ..The method has been used to establish that Salvinorin B is the principal metabolite of Salvinorin A ex vivo and to establish the analytical method to study in vivo samples...
  24. ncbi request reprint Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors
    Yong Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171 New York, NY 10021, USA
    Psychopharmacology (Berl) 179:551-8. 2005
    ..It has been shown that kappa agonists decrease dopamine levels in the caudate putamen and nucleus accumbens and cause conditioned place aversion in rodents...
  25. ncbi request reprint Evolving perspectives on neurobiological research on the addictions: celebration of the 30th anniversary of NIDA
    Mary Jeanne Kreek
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Neuropharmacology 47:324-44. 2004
    ..g., in the hypothalamic-pituitary-adrenal axis) plays a role in vulnerability and relapse to specific addictive diseases. This atypical responsivity may be drug-induced, environmentally acquired, and/or due to genetic variation...
  26. ncbi request reprint Effect of the endogenous kappa opioid agonist dynorphin A(1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice
    Yong Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Psychopharmacology (Berl) 172:422-9. 2004
    ..Effects of synthetic kappa opioid receptor agonists on cocaine-induced reward have been studied extensively in rats but relatively few studies have used the endogenous kappa agonist dynorphin A(1-17)...
  27. ncbi request reprint Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice
    Yong Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Psychopharmacology (Berl) 173:146-52. 2004
    ....
  28. ncbi request reprint Biological clock: biological clocks may modulate drug addiction
    Vadim Yuferov
    The Rockefeller University, New York, NY, USA
    Eur J Hum Genet 13:1101-3. 2005
  29. ncbi request reprint 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 46:484-94. 2005
    ..The (-)-isomer, GR103545, is the active enantiomer of GR89696. The aim of this study was to characterize the potential of 11C-GR103545 to image kappa-OR in vivo with PET...

Research Grants11

  1. kappa-agonist effects of the hallucinogen Salvinorin A
    Eduardo Butelman; Fiscal Year: 2007
    ....
  2. EFFECTS OF SYSTEMICALLY ADMINISTERED DYNORPHINS
    Eduardo Butelman; Fiscal Year: 2002
    ....