Matthew E R Butchbach

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Effect of diet on the survival and phenotype of a mouse model for spinal muscular atrophy
    Matthew E R Butchbach
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH, USA
    Biochem Biophys Res Commun 391:835-40. 2010
  2. pmc Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy
    Matthew E R Butchbach
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA
    Hum Mol Genet 19:454-67. 2010
  3. pmc Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy
    Matthew E R Butchbach
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH, USA
    Neurobiol Dis 27:207-19. 2007
  4. pmc A novel method for oral delivery of drug compounds to the neonatal SMNDelta7 mouse model of spinal muscular atrophy
    Matthew E R Butchbach
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, 363 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
    J Neurosci Methods 161:285-90. 2007
  5. ncbi request reprint Translational control of glial glutamate transporter EAAT2 expression
    Guilian Tian
    Department of Neuroscience and Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 282:1727-37. 2007
  6. ncbi request reprint Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function
    Matthew E R Butchbach
    Department of Neuroscience, Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
    J Biol Chem 279:34388-96. 2004
  7. ncbi request reprint SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN
    Thanh T Le
    Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 14:845-57. 2005
  8. ncbi request reprint Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
    Hong Guo
    Department of Neuroscience, The Ohio State University, Columbus, 43210, USA
    Hum Mol Genet 12:2519-32. 2003
  9. ncbi request reprint Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia
    Swarnali Acharyya
    Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Cell 8:421-32. 2005
  10. pmc Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs
    Francesca Gabanella
    Dulbecco Telethon Institute, Institute of Cell Biology, Monterotondo Scalo, Rome, Italy
    PLoS ONE 2:e921. 2007

Collaborators

Detail Information

Publications12

  1. pmc Effect of diet on the survival and phenotype of a mouse model for spinal muscular atrophy
    Matthew E R Butchbach
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH, USA
    Biochem Biophys Res Commun 391:835-40. 2010
    ..These findings indicate that maternal diet alone can have considerable impact on the SMA phenotype...
  2. pmc Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy
    Matthew E R Butchbach
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA
    Hum Mol Genet 19:454-67. 2010
    ..In summary, the C5-quinazoline derivative D156844 increases SMN expression in neonatal mouse neural tissues, delays motor neuron loss at PND11 and ameliorates the motor phenotype of SMNDelta7 SMA mice...
  3. pmc Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy
    Matthew E R Butchbach
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH, USA
    Neurobiol Dis 27:207-19. 2007
    ..In summary, we have demonstrated an impairment of neonatal motor responses in SMNDelta7 SMA mice. This phenotype characterization could be used to assess the effectiveness of potential therapies for SMA...
  4. pmc A novel method for oral delivery of drug compounds to the neonatal SMNDelta7 mouse model of spinal muscular atrophy
    Matthew E R Butchbach
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, 363 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
    J Neurosci Methods 161:285-90. 2007
    ..This approach offers a simple and rapid means by which potential therapeutics for SMA can be identified...
  5. ncbi request reprint Translational control of glial glutamate transporter EAAT2 expression
    Guilian Tian
    Department of Neuroscience and Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 282:1727-37. 2007
    ....
  6. ncbi request reprint Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function
    Matthew E R Butchbach
    Department of Neuroscience, Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
    J Biol Chem 279:34388-96. 2004
    ....
  7. ncbi request reprint SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN
    Thanh T Le
    Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 14:845-57. 2005
    ..The increased survival of the SMNDelta7 SMA mice we report will facilitate testing of therapies and indicates the importance of considering co-complexes of SMN and SMNDelta7 when analyzing SMN function...
  8. ncbi request reprint Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
    Hong Guo
    Department of Neuroscience, The Ohio State University, Columbus, 43210, USA
    Hum Mol Genet 12:2519-32. 2003
    ..These results suggest that the loss of EAAT2 may contribute to, but does not cause, motor neuron degeneration in ALS...
  9. ncbi request reprint Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia
    Swarnali Acharyya
    Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Cell 8:421-32. 2005
    ..Based on these results, we propose that, similar to muscular dystrophy, DGC dysfunction plays a critical role in cancer-induced wasting...
  10. pmc Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs
    Francesca Gabanella
    Dulbecco Telethon Institute, Institute of Cell Biology, Monterotondo Scalo, Rome, Italy
    PLoS ONE 2:e921. 2007
    ..These findings are consistent with the hypothesis that SMN deficiency affects the splicing machinery and in particular the minor splicing pathway of a rare class of introns in SMA...
  11. ncbi request reprint Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing
    Tatyana Novoyatleva
    University of Erlangen, Institute for Biochemistry, Germany
    Hum Mol Genet 17:52-70. 2008
    ..Our data indicate that the binding of PP1 to evolutionary conserved motifs in several RRMs is the link between known signal transduction pathways regulating PP1 activity and pre-mRNA processing...
  12. doi request reprint Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy
    John Thurmond
    deCODE Chemistry Inc, Woodridge, IL 60517, USA
    J Med Chem 51:449-69. 2008
    ..The compound restored gems numbers in type I SMA patient fibroblasts to levels near unaffected genetic carriers of SMA...