Jonathan P Butchar
Affiliation: The Ohio State University
Ren L, Campbell A, Fang H, Gautam S, Elavazhagan S, Fatehchand K, et al
. Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte FcÎ³ Receptor (FcÎ³R) Function. J Biol Chem. 2016;291:3043-52 pubmed publisher
..These results suggest that combining ibrutinib with monoclonal antibody therapy could enhance chronic lymphocytic leukemia cell killing without affecting macrophage effector function. ..
Fatehchand K, Ren L, Elavazhagan S, Fang H, Mo X, Vasilakos J, et al
. Toll-like Receptor 4 Ligands Down-regulate FcÎ³ Receptor IIb (FcÎ³RIIb) via MARCH3 Protein-mediated Ubiquitination. J Biol Chem. 2016;291:3895-904 pubmed publisher
..These data suggest that activation of TLR4 on monocytes can induce a rapid down-regulation of FcÎ³RIIb protein and that this involves ubiquitination. ..
Gautam S, Fatehchand K, Elavazhagan S, Reader B, Ren L, Mo X, et al
. Reprogramming Nurse-like Cells with Interferon ? to Interrupt Chronic Lymphocytic Leukemia Cell Survival. J Biol Chem. 2016;291:14356-62 pubmed publisher
..These results suggest that IFN? can re-educate NLCs and shift them toward an effector-like state and that therapies promoting local IFN? production may be effective adjuvants for antibody therapy in CLL. ..
Fatehchand K, McMichael E, Reader B, Fang H, Santhanam R, Gautam S, et al
. Interferon-Î³ Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells. J Biol Chem. 2016;291:25656-25666 pubmed
..Taken together, these studies show a novel mechanism of daratumumab-mediated killing and a possible new therapeutic strategy for AML. ..