Affiliation: The Children's Hospital of Philadelphia
- NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: persistent immune deficiency in pediatric transplant survivorsNancy Bunin
Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
Biol Blood Marrow Transplant 18:6-15. 2012..Additional studies are needed in children post-HCT to evaluate the impact of differing stem cell sources upon immune reconstitution, infectious risks, and immunization responses...
- Unrelated donor bone marrow transplantation for children with severe aplastic anemia: minimal GVHD and durable engraftment with partial T cell depletionN Bunin
The Children s Hospital of Philadelphia, Philadelphia, PA, USA
Bone Marrow Transplant 35:369-73. 2005..This series suggests that an aggressive immunosuppressive conditioning regimen with PTCD results in successful engraftment and minimal GVHD in pediatric patients with SAA, even with HLA mismatched donors...
- Outcomes of transplantation with partial T-cell depletion of matched or mismatched unrelated or partially matched related donor bone marrow in children and adolescents with leukemiasN Bunin
Division of Oncology, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
Bone Marrow Transplant 35:151-8. 2005..8% of AML/MDS patients. Grades III-IV GVHD was observed in only 6.7% of patients. Partial TCD allows use of matched or mismatched URD, or PMRD with little mortality from GVHD, durable engraftment, and no increase in relapse risk...
- Randomized trial of busulfan vs total body irradiation containing conditioning regimens for children with acute lymphoblastic leukemia: a Pediatric Blood and Marrow Transplant Consortium studyN Bunin
The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Bone Marrow Transplant 32:543-8. 2003..3). However, for URD, EFS was 20% for Bu and 57% for TBI (P=0.04). Relapses were similar in both arms. This randomized prospective study suggests that Bu is inferior to TBI for pediatric patients with ALL undergoing allogeneic SCT...
- Residual leukaemia after bone marrow transplant in children with acute lymphoblastic leukaemia after first haematological relapse or with poor initial presenting featuresNancy Bunin
Children s Hospital of Philadelphia, University of Pennsylvania, PA 19104, USA
Br J Haematol 120:711-5. 2003..Both the rate of this increase and its timing were variable. These results suggest that residual leukaemia measurements can be used to direct post-transplant interventions and measure their effects...
- Solid organ transplants following hematopoietic stem cell transplant in childrenNancy Bunin
Divisions of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Pediatr Transplant 14:1030-5. 2010..Children who have undergone HSCT and develop single organ failure should be considered for an SOT if there is a high likelihood of cure of the primary disease...
- Donor leukocyte infusions to treat hematologic malignancy relapse following allo-SCT in a pediatric populationJ E Levine
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 5941, USA
Bone Marrow Transplant 42:201-5. 2008..Although a few children achieved durable remissions when DLI was used as part of a post-relapse treatment strategy, DLI was unsuccessful in the majority of cases. Strategies may be better directed at preempting post transplant relapse...
- Immunologic recovery in children after alternative donor allogeneic transplantation for hematologic malignancies: comparison of recipients of partially T cell-depleted peripheral blood stem cells and umbilical cord bloodBenjamin R Oshrine
Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Electronic address
Biol Blood Marrow Transplant 19:1581-9. 2013..Efforts to enhance IR after partial TCD-PBSC transplantation, such as selective αβ T cell depletion, hold promise for further improvement of this transplantation approach. ..
- Sirolimus pharmacokinetics in early postmyeloablative pediatric blood and marrow transplantationRakesh K Goyal
Division of Blood and Marrow Transplantation and Cellular Therapies, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
Biol Blood Marrow Transplant 19:569-75. 2013....
- Bone density and structure in long-term survivors of pediatric allogeneic hematopoietic stem cell transplantationSogol Mostoufi-Moab
Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Bone Miner Res 27:760-9. 2012..Future studies are needed to determine the metabolic and fracture implications of these deficits, and to identify therapies to improve bone accrual following alloHSCT during childhood...
- A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulationDavid L Porter
Stem Cell Transplant Program, Division of Hematology Oncology, 16 Penn Tower, 3400 Spruce St, Philadelphia, PA 19104, USA
Blood 107:1325-31. 2006..Adoptive transfer of costimulated activated allogeneic T cells is feasible, does not result in excessive GVHD, and may contribute to durable remissions in diseases where conventional DLI has been disappointing...
- A single-center study of hematopoietic stem cell transplantation for primary immune deficiencies (PIDD)Laura Dinardo
Division of Oncology, Children s Hospital of Philadelphia, PA 19104, USA
Pediatr Transplant 16:63-72. 2012..This study encourages greater use of transplantation...
- Donor T-cell-mediated pancytopenia after haploidentical hematopoietic stem cell transplant for severe combined immunodeficiencyRobin Norris
Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Hematol Oncol 31:148-50. 2009..His pancytopenia resolved after thymoglobulin and a stem cell boost. Thrombocytopenia resolved with rituximab...
- Unrelated marrow transplantation for children with acute lymphoblastic leukemia in second remissionNancy Bunin
National Marrow Donor Program, Minneapolis, MN, USA
Blood 99:3151-7. 2002..However, innovative approaches are needed for patients with initial remissions of less than 6 months and for older teenagers...
- Cognitive, behavioral, and social outcome in survivors of childhood stem cell transplantationSteven Simms
Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
J Pediatr Hematol Oncol 24:115-9. 2002..To evaluate prospectively the cognitive functioning and to obtain ratings of cognitive, behavioral, and social functioning for children receiving stem cell transplantation (SCT)...
- Isolated extramedullary relapse in acute myeloid leukemia: A retrospective analysisJill P Ginsberg
Division of Oncology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Med Pediatr Oncol 38:387-90. 2002..Little is known about the characteristics and outcome of children with acute myeloid leukemia (AML) experiencing an isolated extramedullary relapse (IEMR)...
- Unrelated donor or partially matched related donor peripheral stem cell transplant with CD34+ selection and CD3+ addback for pediatric patients with leukemiasN Bunin
Dept Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Bone Marrow Transplant 37:143-9. 2006..Two patients relapsed, and 10 patients died of non-relapse causes. This study demonstrates that PSCT with CD34+ selection and a defined dose of CD3+ results in prompt engraftment and may limit development of extensive chronic GVHD...
- Daclizumab for children with corticosteroid refractory graft-versus-host diseaseD T Teachey
Division of Oncology in the Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Bone Marrow Transplant 37:95-9. 2006..Daclizumab is a relatively safe and effective medication for corticosteroid refractory GVHD in children and larger studies are needed to evaluate its role in treatment...
- Pulmonary infection with microsporidia after allogeneic bone marrow transplantationD T Teachey
Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Bone Marrow Transplant 33:299-302. 2004..Although rare, microsporidial infection should be considered in the differential diagnosis of unexplained pulmonary infection in bone marrow transplant patients...
- Rapid-sequence tandem transplant for children with high-risk neuroblastomaS A Grupp
Department of Pediatrics, Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
Med Pediatr Oncol 35:696-700. 2000..The majority of patients with high risk neuroblastoma (NB) still relapse...
- Tandem high-dose therapy in rapid sequence for children with high-risk neuroblastomaS A Grupp
Division of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
J Clin Oncol 18:2567-75. 2000....
- Effect of body mass in children with hematologic malignancies undergoing allogeneic bone marrow transplantationRichard Aplenc
Children s Hospital of Philadelphia, Philadelphia, PA
Blood 123:3504-11. 2014..Obese children experience less relapse posttransplant compared with children with normal BMI; however, this benefit is offset by excess in TRM. ..
- DNA-based HLA typing of nonhematopoietic tissue used to select the marrow transplant donor for successful treatment of transfusion-associated graft-versus-host diseaseD F Friedman
Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, USA
Clin Diagn Lab Immunol 1:590-6. 1994..This case illustrates that TAGVHD can be successfully treated by allogeneic bone marrow transplantation and that DNA-based HLA typing can play a unique role in the diagnosis and management of TAGVHD...
- Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantationGinna G Laport
Translational Research Program, Abramsonm Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
Blood 102:2004-13. 2003....
- Sequential liver and bone marrow transplantation for treatment of erythropoietic protoporphyriaElizabeth B Rand
Department of Pediatrics, University of Pennsylvania, Children s Hospital of Philadelphia, 324 S 34th St, Philadelphia, PA 19104, USA
Pediatrics 118:e1896-9. 2006..This combination corrected the severe phenotype, resolving the severe photosensitivity and halting erythropoietic protoporphyria associated liver graft injury. Splenectomy seemed to facilitate the successful bone marrow transplant...
- Nephrotic syndrome after hematopoietic cell transplantation: do glomerular lesions represent renal graft-versus-host disease?Kirsten Brukamp
Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Clin J Am Soc Nephrol 1:685-94. 2006..Glomerular lesions after hematopoietic cell transplantation may therefore represent the renal manifestation of GVHD. Further studies are warranted to delineate the pathogenesis of this complication...
- Mixed chimerism and graft loss in pediatric recipients of an alemtuzumab-based reduced-intensity conditioning regimen for non-malignant diseaseBenjamin R Oshrine
Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
Pediatr Blood Cancer 61:1852-9. 2014..Intervention with donor lymphocytes or stem cell boosts (DLI/boost) may be necessary, but there is limited information about timing and results of intervention...
- Paraphyseal changes on bone-age studies predict risk of delayed radiation-associated skeletal complications following total body irradiationMary T Kitazono Hammell
Department of Radiology, The Children s Hospital of Philadelphia, Philadelphia, PA19104, USA
Pediatr Radiol 43:1152-8. 2013..Bone-age studies in these children often reveal subtle paraphyseal changes including physeal widening, metaphyseal irregularity and paraphyseal exostoses...
- Kidney and bladder outcomes in children with hemorrhagic cystitis and BK virus infection after allogeneic hematopoietic stem cell transplantationBenjamin Oshrine
Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Electronic address
Biol Blood Marrow Transplant 19:1702-7. 2013..BKV infection is common after pediatric allogeneic HSCT, and plasma testing in those with HC may predict patients who will develop severe bladder injury...
- Diagnosis of 22q11.2 deletion syndrome and artemis deficiency in two children with T-B-NK+ immunodeficiencyJennifer Heimall
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Clin Immunol 32:1141-4. 2012..However, if the thymus is completely absent, donor stem cells from a HSCT would not be able to be educated...
- Body composition abnormalities in long-term survivors of pediatric hematopoietic stem cell transplantationSogol Mostoufi-Moab
Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
J Pediatr 160:122-8. 2012..To quantify lean mass (LM) and fat mass (FM) in survivors of childhood allogeneic hematopoietic stem-cell transplantation (alloHSCT) compared with healthy reference participants and identify risk factors for body composition abnormalities...
- Umbilical cord blood transplantation for juvenile metachromatic leukodystrophyTyler Mark Pierson
Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 20892 3705, USA
Ann Neurol 64:583-7. 2008..To our knowledge, this report is the first to document neurological outcome of metachromatic leukodystrophy treated by umbilical cord blood transplantation...
- Early bacteremia in pediatric hematopoietic stem cell transplant patients on oral antibiotic prophylaxisLeslie S Kersun
Department of Pediatrics, Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pediatr Blood Cancer 45:162-9. 2005..Our purpose was to determine the incidence of bacteremia and antimicrobial resistance post-HSCT in pediatric patients receiving GD, and to identify risk factors associated with infection...
- Pulmonary hypertension complicating bone marrow transplantation for idiopathic myelofibrosisSadhna Shankar
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6310, USA
J Pediatr Hematol Oncol 26:393-7. 2004..After BMT, the patient's clinical course improved in all respects, but he ultimately died of progressive pulmonary hypertension...
- Challenges in the use of allogeneic hematopoietic SCT for ectodermal dysplasia with immune deficiencyJ D Fish
Department of Pediatrics, Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Bone Marrow Transplant 43:217-21. 2009..These cases suggest that patients with immune deficiencies caused by NEMO or IkappaBalpha mutations may have intrinsic barriers to successful engraftment, which require further investigation...
- Unrelated donor bone marrow transplantation for children with juvenile myelomonocytic leukaemiaFranklin O Smith
Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Br J Haematol 116:716-24. 2002..With lower relapse observed in patients with chronic GVHD, new treatment strategies that focus on enhancing the graft-versus-leukaemia effect may improve survival...
- Prospective study of carboplatin-based chemotherapy for pediatric germ cell tumorsJulie W Stern
Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Med Pediatr Oncol 39:163-7. 2002..In a prospective study, carboplatin was substituted for cisplatin in an attempt to minimize nephro- and oto-toxicities, while achieving excellent disease-free survival...
- Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantationJo Anne H van Burik
University of Minnesota, Minneapolis, MN, USA
Clin Infect Dis 39:1407-16. 2004..73.5% in the fluconazole arm [difference, 6.5%]; 95% confidence interval, 0.9%-12%; P=.03). This randomized trial demonstrates the efficacy of an echinocandin for antifungal prophylaxis in neutropenic patients...
- Successful haploidentical bone marrow transplantation in a patient with reticular dysgenesis: three-year follow-upMeredith Lee Heltzer
J Allergy Clin Immunol 120:950-2. 2007
- Clinical application of DNA microarrays: molecular diagnosis and HLA matching of an Amish child with severe combined immune deficiencyKevin A Strauss
Clinic for Special Children, Strasburg, Pennsylvania 17579, USA
Clin Immunol 128:31-8. 2008..Autozygosity and linkage analysis of SNP genotypes within a family narrows the search for SCID candidate genes and provides a relatively simple and inexpensive way to identify potential tissue donors among biological siblings...