Nancy Bunin

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: persistent immune deficiency in pediatric transplant survivors
    Nancy Bunin
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Biol Blood Marrow Transplant 18:6-15. 2012
  2. ncbi request reprint Unrelated donor bone marrow transplantation for children with severe aplastic anemia: minimal GVHD and durable engraftment with partial T cell depletion
    N Bunin
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Bone Marrow Transplant 35:369-73. 2005
  3. ncbi request reprint Outcomes of transplantation with partial T-cell depletion of matched or mismatched unrelated or partially matched related donor bone marrow in children and adolescents with leukemias
    N Bunin
    Division of Oncology, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 35:151-8. 2005
  4. ncbi request reprint Randomized trial of busulfan vs total body irradiation containing conditioning regimens for children with acute lymphoblastic leukemia: a Pediatric Blood and Marrow Transplant Consortium study
    N Bunin
    The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 32:543-8. 2003
  5. ncbi request reprint Residual leukaemia after bone marrow transplant in children with acute lymphoblastic leukaemia after first haematological relapse or with poor initial presenting features
    Nancy Bunin
    Children s Hospital of Philadelphia, University of Pennsylvania, PA 19104, USA
    Br J Haematol 120:711-5. 2003
  6. doi request reprint Solid organ transplants following hematopoietic stem cell transplant in children
    Nancy Bunin
    Divisions of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Transplant 14:1030-5. 2010
  7. doi request reprint Donor leukocyte infusions to treat hematologic malignancy relapse following allo-SCT in a pediatric population
    J E Levine
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 5941, USA
    Bone Marrow Transplant 42:201-5. 2008
  8. doi request reprint Sirolimus pharmacokinetics in early postmyeloablative pediatric blood and marrow transplantation
    Rakesh K Goyal
    Division of Blood and Marrow Transplantation and Cellular Therapies, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Biol Blood Marrow Transplant 19:569-75. 2013
  9. doi request reprint Bone density and structure in long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation
    Sogol Mostoufi-Moab
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Bone Miner Res 27:760-9. 2012
  10. ncbi request reprint A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation
    David L Porter
    Stem Cell Transplant Program, Division of Hematology Oncology, 16 Penn Tower, 3400 Spruce St, Philadelphia, PA 19104, USA
    Blood 107:1325-31. 2006

Detail Information

Publications35

  1. pmc NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: persistent immune deficiency in pediatric transplant survivors
    Nancy Bunin
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Biol Blood Marrow Transplant 18:6-15. 2012
    ..Additional studies are needed in children post-HCT to evaluate the impact of differing stem cell sources upon immune reconstitution, infectious risks, and immunization responses...
  2. ncbi request reprint Unrelated donor bone marrow transplantation for children with severe aplastic anemia: minimal GVHD and durable engraftment with partial T cell depletion
    N Bunin
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Bone Marrow Transplant 35:369-73. 2005
    ..This series suggests that an aggressive immunosuppressive conditioning regimen with PTCD results in successful engraftment and minimal GVHD in pediatric patients with SAA, even with HLA mismatched donors...
  3. ncbi request reprint Outcomes of transplantation with partial T-cell depletion of matched or mismatched unrelated or partially matched related donor bone marrow in children and adolescents with leukemias
    N Bunin
    Division of Oncology, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 35:151-8. 2005
    ..8% of AML/MDS patients. Grades III-IV GVHD was observed in only 6.7% of patients. Partial TCD allows use of matched or mismatched URD, or PMRD with little mortality from GVHD, durable engraftment, and no increase in relapse risk...
  4. ncbi request reprint Randomized trial of busulfan vs total body irradiation containing conditioning regimens for children with acute lymphoblastic leukemia: a Pediatric Blood and Marrow Transplant Consortium study
    N Bunin
    The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 32:543-8. 2003
    ..3). However, for URD, EFS was 20% for Bu and 57% for TBI (P=0.04). Relapses were similar in both arms. This randomized prospective study suggests that Bu is inferior to TBI for pediatric patients with ALL undergoing allogeneic SCT...
  5. ncbi request reprint Residual leukaemia after bone marrow transplant in children with acute lymphoblastic leukaemia after first haematological relapse or with poor initial presenting features
    Nancy Bunin
    Children s Hospital of Philadelphia, University of Pennsylvania, PA 19104, USA
    Br J Haematol 120:711-5. 2003
    ..Both the rate of this increase and its timing were variable. These results suggest that residual leukaemia measurements can be used to direct post-transplant interventions and measure their effects...
  6. doi request reprint Solid organ transplants following hematopoietic stem cell transplant in children
    Nancy Bunin
    Divisions of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Transplant 14:1030-5. 2010
    ..Children who have undergone HSCT and develop single organ failure should be considered for an SOT if there is a high likelihood of cure of the primary disease...
  7. doi request reprint Donor leukocyte infusions to treat hematologic malignancy relapse following allo-SCT in a pediatric population
    J E Levine
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 5941, USA
    Bone Marrow Transplant 42:201-5. 2008
    ..Although a few children achieved durable remissions when DLI was used as part of a post-relapse treatment strategy, DLI was unsuccessful in the majority of cases. Strategies may be better directed at preempting post transplant relapse...
  8. doi request reprint Sirolimus pharmacokinetics in early postmyeloablative pediatric blood and marrow transplantation
    Rakesh K Goyal
    Division of Blood and Marrow Transplantation and Cellular Therapies, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Biol Blood Marrow Transplant 19:569-75. 2013
    ....
  9. doi request reprint Bone density and structure in long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation
    Sogol Mostoufi-Moab
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Bone Miner Res 27:760-9. 2012
    ..Future studies are needed to determine the metabolic and fracture implications of these deficits, and to identify therapies to improve bone accrual following alloHSCT during childhood...
  10. ncbi request reprint A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation
    David L Porter
    Stem Cell Transplant Program, Division of Hematology Oncology, 16 Penn Tower, 3400 Spruce St, Philadelphia, PA 19104, USA
    Blood 107:1325-31. 2006
    ..Adoptive transfer of costimulated activated allogeneic T cells is feasible, does not result in excessive GVHD, and may contribute to durable remissions in diseases where conventional DLI has been disappointing...
  11. doi request reprint A single-center study of hematopoietic stem cell transplantation for primary immune deficiencies (PIDD)
    Laura Dinardo
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Transplant 16:63-72. 2012
    ..This study encourages greater use of transplantation...
  12. doi request reprint Donor T-cell-mediated pancytopenia after haploidentical hematopoietic stem cell transplant for severe combined immunodeficiency
    Robin Norris
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Hematol Oncol 31:148-50. 2009
    ..His pancytopenia resolved after thymoglobulin and a stem cell boost. Thrombocytopenia resolved with rituximab...
  13. ncbi request reprint Unrelated marrow transplantation for children with acute lymphoblastic leukemia in second remission
    Nancy Bunin
    National Marrow Donor Program, Minneapolis, MN, USA
    Blood 99:3151-7. 2002
    ..However, innovative approaches are needed for patients with initial remissions of less than 6 months and for older teenagers...
  14. ncbi request reprint Isolated extramedullary relapse in acute myeloid leukemia: A retrospective analysis
    Jill P Ginsberg
    Division of Oncology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Med Pediatr Oncol 38:387-90. 2002
    ..Little is known about the characteristics and outcome of children with acute myeloid leukemia (AML) experiencing an isolated extramedullary relapse (IEMR)...
  15. ncbi request reprint Cognitive, behavioral, and social outcome in survivors of childhood stem cell transplantation
    Steven Simms
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Pediatr Hematol Oncol 24:115-9. 2002
    ..To evaluate prospectively the cognitive functioning and to obtain ratings of cognitive, behavioral, and social functioning for children receiving stem cell transplantation (SCT)...
  16. ncbi request reprint Unrelated donor or partially matched related donor peripheral stem cell transplant with CD34+ selection and CD3+ addback for pediatric patients with leukemias
    N Bunin
    Dept Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 37:143-9. 2006
    ..Two patients relapsed, and 10 patients died of non-relapse causes. This study demonstrates that PSCT with CD34+ selection and a defined dose of CD3+ results in prompt engraftment and may limit development of extensive chronic GVHD...
  17. ncbi request reprint Daclizumab for children with corticosteroid refractory graft-versus-host disease
    D T Teachey
    Division of Oncology in the Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 37:95-9. 2006
    ..Daclizumab is a relatively safe and effective medication for corticosteroid refractory GVHD in children and larger studies are needed to evaluate its role in treatment...
  18. ncbi request reprint Tandem high-dose therapy in rapid sequence for children with high-risk neuroblastoma
    S A Grupp
    Division of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Clin Oncol 18:2567-75. 2000
    ....
  19. ncbi request reprint Rapid-sequence tandem transplant for children with high-risk neuroblastoma
    S A Grupp
    Department of Pediatrics, Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Med Pediatr Oncol 35:696-700. 2000
    ..The majority of patients with high risk neuroblastoma (NB) still relapse...
  20. ncbi request reprint Pulmonary infection with microsporidia after allogeneic bone marrow transplantation
    D T Teachey
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 33:299-302. 2004
    ..Although rare, microsporidial infection should be considered in the differential diagnosis of unexplained pulmonary infection in bone marrow transplant patients...
  21. pmc DNA-based HLA typing of nonhematopoietic tissue used to select the marrow transplant donor for successful treatment of transfusion-associated graft-versus-host disease
    D F Friedman
    Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, USA
    Clin Diagn Lab Immunol 1:590-6. 1994
    ..This case illustrates that TAGVHD can be successfully treated by allogeneic bone marrow transplantation and that DNA-based HLA typing can play a unique role in the diagnosis and management of TAGVHD...
  22. ncbi request reprint Sequential liver and bone marrow transplantation for treatment of erythropoietic protoporphyria
    Elizabeth B Rand
    Department of Pediatrics, University of Pennsylvania, Children s Hospital of Philadelphia, 324 S 34th St, Philadelphia, PA 19104, USA
    Pediatrics 118:e1896-9. 2006
    ..This combination corrected the severe phenotype, resolving the severe photosensitivity and halting erythropoietic protoporphyria associated liver graft injury. Splenectomy seemed to facilitate the successful bone marrow transplant...
  23. ncbi request reprint Nephrotic syndrome after hematopoietic cell transplantation: do glomerular lesions represent renal graft-versus-host disease?
    Kirsten Brukamp
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Clin J Am Soc Nephrol 1:685-94. 2006
    ..Glomerular lesions after hematopoietic cell transplantation may therefore represent the renal manifestation of GVHD. Further studies are warranted to delineate the pathogenesis of this complication...
  24. ncbi request reprint Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation
    Ginna G Laport
    Translational Research Program, Abramsonm Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Blood 102:2004-13. 2003
    ....
  25. doi request reprint Diagnosis of 22q11.2 deletion syndrome and artemis deficiency in two children with T-B-NK+ immunodeficiency
    Jennifer Heimall
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Clin Immunol 32:1141-4. 2012
    ..However, if the thymus is completely absent, donor stem cells from a HSCT would not be able to be educated...
  26. pmc Body composition abnormalities in long-term survivors of pediatric hematopoietic stem cell transplantation
    Sogol Mostoufi-Moab
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr 160:122-8. 2012
    ..To quantify lean mass (LM) and fat mass (FM) in survivors of childhood allogeneic hematopoietic stem-cell transplantation (alloHSCT) compared with healthy reference participants and identify risk factors for body composition abnormalities...
  27. pmc Umbilical cord blood transplantation for juvenile metachromatic leukodystrophy
    Tyler Mark Pierson
    Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 20892 3705, USA
    Ann Neurol 64:583-7. 2008
    ..To our knowledge, this report is the first to document neurological outcome of metachromatic leukodystrophy treated by umbilical cord blood transplantation...
  28. ncbi request reprint Pulmonary hypertension complicating bone marrow transplantation for idiopathic myelofibrosis
    Sadhna Shankar
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6310, USA
    J Pediatr Hematol Oncol 26:393-7. 2004
    ..After BMT, the patient's clinical course improved in all respects, but he ultimately died of progressive pulmonary hypertension...
  29. ncbi request reprint Early bacteremia in pediatric hematopoietic stem cell transplant patients on oral antibiotic prophylaxis
    Leslie S Kersun
    Department of Pediatrics, Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 45:162-9. 2005
    ..Our purpose was to determine the incidence of bacteremia and antimicrobial resistance post-HSCT in pediatric patients receiving GD, and to identify risk factors associated with infection...
  30. doi request reprint Challenges in the use of allogeneic hematopoietic SCT for ectodermal dysplasia with immune deficiency
    J D Fish
    Department of Pediatrics, Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 43:217-21. 2009
    ..These cases suggest that patients with immune deficiencies caused by NEMO or IkappaBalpha mutations may have intrinsic barriers to successful engraftment, which require further investigation...
  31. ncbi request reprint Unrelated donor bone marrow transplantation for children with juvenile myelomonocytic leukaemia
    Franklin O Smith
    Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 116:716-24. 2002
    ..With lower relapse observed in patients with chronic GVHD, new treatment strategies that focus on enhancing the graft-versus-leukaemia effect may improve survival...
  32. ncbi request reprint Prospective study of carboplatin-based chemotherapy for pediatric germ cell tumors
    Julie W Stern
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Med Pediatr Oncol 39:163-7. 2002
    ..In a prospective study, carboplatin was substituted for cisplatin in an attempt to minimize nephro- and oto-toxicities, while achieving excellent disease-free survival...
  33. doi request reprint Clinical application of DNA microarrays: molecular diagnosis and HLA matching of an Amish child with severe combined immune deficiency
    Kevin A Strauss
    Clinic for Special Children, Strasburg, Pennsylvania 17579, USA
    Clin Immunol 128:31-8. 2008
    ..Autozygosity and linkage analysis of SNP genotypes within a family narrows the search for SCID candidate genes and provides a relatively simple and inexpensive way to identify potential tissue donors among biological siblings...
  34. ncbi request reprint Successful haploidentical bone marrow transplantation in a patient with reticular dysgenesis: three-year follow-up
    Meredith Lee Heltzer
    J Allergy Clin Immunol 120:950-2. 2007
  35. ncbi request reprint Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation
    Jo Anne H van Burik
    University of Minnesota, Minneapolis, MN, USA
    Clin Infect Dis 39:1407-16. 2004
    ..73.5% in the fluconazole arm [difference, 6.5%]; 95% confidence interval, 0.9%-12%; P=.03). This randomized trial demonstrates the efficacy of an echinocandin for antifungal prophylaxis in neutropenic patients...