Greta R Bunin

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc Parental nutrient intake and risk of retinoblastoma resulting from new germline RB1 mutation
    Greta R Bunin
    Division of Oncology, Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cancer Causes Control 24:343-55. 2013
  2. doi request reprint Parental diet and risk of retinoblastoma resulting from new germline RB1 mutation
    Greta R Bunin
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Environ Mol Mutagen 53:451-61. 2012
  3. ncbi request reprint Secular trends in response rates for controls selected by random digit dialing in childhood cancer studies: a report from the Children's Oncology Group
    Greta R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Epidemiol 166:109-16. 2007
  4. ncbi request reprint Parental heat exposure and risk of childhood brain tumor: a Children's Oncology Group study
    Greta R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    Am J Epidemiol 164:222-31. 2006
  5. ncbi request reprint Unrelated donor or partially matched related donor peripheral stem cell transplant with CD34+ selection and CD3+ addback for pediatric patients with leukemias
    N Bunin
    Dept Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 37:143-9. 2006
  6. ncbi request reprint Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States)
    Greta R Bunin
    Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cancer Causes Control 16:877-91. 2005
  7. ncbi request reprint Practical aspects of sharing controls between case-control studies
    Greta R Bunin
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:523-30. 2005
  8. ncbi request reprint Nongenetic causes of childhood cancers: evidence from international variation, time trends, and risk factor studies
    Greta R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Toxicol Appl Pharmacol 199:91-103. 2004
  9. pmc Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation
    Greta R Bunin
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Int J Cancer 128:2393-404. 2011
  10. ncbi request reprint Paternal age and sporadic neurofibromatosis 1: a case-control study and consideration of the methodologic issues
    G R Bunin
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104 4318, USA
    Genet Epidemiol 14:507-16. 1997

Detail Information

Publications39

  1. pmc Parental nutrient intake and risk of retinoblastoma resulting from new germline RB1 mutation
    Greta R Bunin
    Division of Oncology, Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cancer Causes Control 24:343-55. 2013
    ..We conducted a case-control study to examine the role of parents' nutrient intake before their child's conception in the child's risk of sporadic bilateral retinoblastoma, which results from a new germline RB1 mutation...
  2. doi request reprint Parental diet and risk of retinoblastoma resulting from new germline RB1 mutation
    Greta R Bunin
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Environ Mol Mutagen 53:451-61. 2012
    ..As few human data exist on the role of diet in any condition resulting from new germ-cell mutation, additional studies will be needed to replicate or refute our findings...
  3. ncbi request reprint Secular trends in response rates for controls selected by random digit dialing in childhood cancer studies: a report from the Children's Oncology Group
    Greta R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Epidemiol 166:109-16. 2007
    ..4% per year (95% CI: -2.7, -2.0; p < 0.001). The current low response rates for RDD indicate a substantial potential for selection bias and a need to seek alternative sources of controls...
  4. ncbi request reprint Parental heat exposure and risk of childhood brain tumor: a Children's Oncology Group study
    Greta R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    Am J Epidemiol 164:222-31. 2006
    ..4, 95% CI: 1.2, 9.7, and odds ratio = 2.1, 95% CI: 1.1, 4.3, respectively). This new observation regarding paternal exposure to heat just prior to the index pregnancy deserves consideration in future animal and human studies of MB/PNET...
  5. ncbi request reprint Unrelated donor or partially matched related donor peripheral stem cell transplant with CD34+ selection and CD3+ addback for pediatric patients with leukemias
    N Bunin
    Dept Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 37:143-9. 2006
    ..Two patients relapsed, and 10 patients died of non-relapse causes. This study demonstrates that PSCT with CD34+ selection and a defined dose of CD3+ results in prompt engraftment and may limit development of extensive chronic GVHD...
  6. ncbi request reprint Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States)
    Greta R Bunin
    Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cancer Causes Control 16:877-91. 2005
    ..French fries (OR = 2.4, 95% CI: 1.2, 4.9) and chili peppers (OR = 1.8, 95% CI: 1.0, 3.0) were associated with medulloblastoma/PNET. The results suggest that some aspects of diet are worthy of further research...
  7. ncbi request reprint Practical aspects of sharing controls between case-control studies
    Greta R Bunin
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:523-30. 2005
    ..We discuss the practical advantages and challenges of sharing controls among two or more concurrently conducted case-control studies...
  8. ncbi request reprint Nongenetic causes of childhood cancers: evidence from international variation, time trends, and risk factor studies
    Greta R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Toxicol Appl Pharmacol 199:91-103. 2004
    ..The most important difference between the cancers for which there are good etiologic clues and those for which there are not may be the number of relevant studies...
  9. pmc Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation
    Greta R Bunin
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Int J Cancer 128:2393-404. 2011
    ....
  10. ncbi request reprint Paternal age and sporadic neurofibromatosis 1: a case-control study and consideration of the methodologic issues
    G R Bunin
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104 4318, USA
    Genet Epidemiol 14:507-16. 1997
    ..These and previous data are consistent with either a small paternal age effect in sporadic NF1 or a bias such as that resulting from the selection of cases and/or controls...
  11. ncbi request reprint Recall of diet during a past pregnancy
    G R Bunin
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Epidemiol 154:1136-42. 2001
    ..While the results of this study may not be generalizable to those obtained from other populations, to the authors' knowledge it is the first study of recall of diet during pregnancy...
  12. ncbi request reprint Unrelated marrow transplantation for children with acute lymphoblastic leukemia in second remission
    Nancy Bunin
    National Marrow Donor Program, Minneapolis, MN, USA
    Blood 99:3151-7. 2002
    ..However, innovative approaches are needed for patients with initial remissions of less than 6 months and for older teenagers...
  13. pmc Practical and analytical aspects of using friend controls in case-control studies: experience from a case-control study of childhood cancer
    Greta R Bunin
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, PA 19104, USA
    Paediatr Perinat Epidemiol 25:402-12. 2011
    ..Although not ideal, friend controls were convenient, had a reasonably high response rate and provided controls closely matched on race/ethnicity, education and age...
  14. pmc Impact of raloxifene or tamoxifen use on endometrial cancer risk: a population-based case-control study
    Angela DeMichele
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA
    J Clin Oncol 26:4151-9. 2008
    ....
  15. pmc Comparability and representativeness of control groups in a case-control study of infant leukemia: a report from the Children's Oncology Group
    Susan E Puumala
    Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Epidemiol 170:379-87. 2009
    ..3,317 g). Finally, participating BC mothers were likely to be older and to have more education than nonparticipants. Thus, the study's control groups were comparable but differed from the population of interest...
  16. ncbi request reprint Feasibility of nationwide birth registry control selection in the United States
    Logan G Spector
    Division of Epidemiology Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Epidemiol 166:852-6. 2007
    ..These results suggest that birth registries may be used to select controls for studies of rare childhood diseases on a national scale...
  17. doi request reprint Donor leukocyte infusions to treat hematologic malignancy relapse following allo-SCT in a pediatric population
    J E Levine
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 5941, USA
    Bone Marrow Transplant 42:201-5. 2008
    ..Although a few children achieved durable remissions when DLI was used as part of a post-relapse treatment strategy, DLI was unsuccessful in the majority of cases. Strategies may be better directed at preempting post transplant relapse...
  18. pmc Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women
    Timothy R Rebbeck
    Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Carcinogenesis 30:269-74. 2009
    ..We further report that these genes confer their effects in HER2- tumors, interact with one another to confer breast cancer susceptibility in AA women and interact with hormone exposures in AA and EA women...
  19. pmc A case-control study of childhood brain tumors and fathers' hobbies: a Children's Oncology Group study
    Andrea L Rosso
    Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA, USA
    Cancer Causes Control 19:1201-7. 2008
    ..This analysis was conducted to evaluate associations between fathers' hobbies and risk of their children developing MB/PNET. The hobbies chosen for study were those with similar exposures as occupations associated with childhood cancers...
  20. pmc Head injury, diagnostic X-rays, and risk of medulloblastoma and primitive neuroectodermal tumor: a Children's Oncology Group study
    Saira Khan
    Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA, USA
    Cancer Causes Control 21:1017-23. 2010
    ..This analysis evaluated possible associations between previous head injury and ionizing radiation exposure through diagnostic X-rays and medulloblastoma/PNET...
  21. ncbi request reprint Invited commentary: Birth certificates--a best control scenario?
    Julie A Ross
    Division of Epidemiology and Clinical Research, Department of Pediatrics, and Cancer Center, University of Minnesota, Minneapolis, 55455, USA
    Am J Epidemiol 159:922-4; discussion 925. 2004
  22. ncbi request reprint Impact of donor and recipient sex and parity on outcomes of HLA-identical sibling allogeneic hematopoietic stem cell transplantation
    Alison W Loren
    Stem Cell Transplant Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Blood Marrow Transplant 12:758-69. 2006
    ..Until the effects of pregnancy on the maternal immune system are better understood, it is appropriate whenever possible to avoid parous female donors and to choose male donors for male recipients in HLA-identical related donor SCT...
  23. ncbi request reprint A retrospective case-control study of the use of hormone-related supplements and association with breast cancer
    Timothy R Rebbeck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Int J Cancer 120:1523-8. 2007
    ..Additional confirmatory studies are required to determine whether black cohosh could be used to prevent breast cancer...
  24. ncbi request reprint Rapid-sequence tandem transplant for children with high-risk neuroblastoma
    S A Grupp
    Department of Pediatrics, Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Med Pediatr Oncol 35:696-700. 2000
    ..The majority of patients with high risk neuroblastoma (NB) still relapse...
  25. ncbi request reprint Randomized trial of busulfan vs total body irradiation containing conditioning regimens for children with acute lymphoblastic leukemia: a Pediatric Blood and Marrow Transplant Consortium study
    N Bunin
    The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 32:543-8. 2003
    ..3). However, for URD, EFS was 20% for Bu and 57% for TBI (P=0.04). Relapses were similar in both arms. This randomized prospective study suggests that Bu is inferior to TBI for pediatric patients with ALL undergoing allogeneic SCT...
  26. ncbi request reprint Outcomes of transplantation with partial T-cell depletion of matched or mismatched unrelated or partially matched related donor bone marrow in children and adolescents with leukemias
    N Bunin
    Division of Oncology, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 35:151-8. 2005
    ..8% of AML/MDS patients. Grades III-IV GVHD was observed in only 6.7% of patients. Partial TCD allows use of matched or mismatched URD, or PMRD with little mortality from GVHD, durable engraftment, and no increase in relapse risk...
  27. ncbi request reprint Unrelated donor bone marrow transplantation for children with severe aplastic anemia: minimal GVHD and durable engraftment with partial T cell depletion
    N Bunin
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Bone Marrow Transplant 35:369-73. 2005
    ..This series suggests that an aggressive immunosuppressive conditioning regimen with PTCD results in successful engraftment and minimal GVHD in pediatric patients with SAA, even with HLA mismatched donors...
  28. ncbi request reprint Daclizumab for children with corticosteroid refractory graft-versus-host disease
    D T Teachey
    Division of Oncology in the Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 37:95-9. 2006
    ..Daclizumab is a relatively safe and effective medication for corticosteroid refractory GVHD in children and larger studies are needed to evaluate its role in treatment...
  29. ncbi request reprint Tandem high-dose therapy in rapid sequence for children with high-risk neuroblastoma
    S A Grupp
    Division of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Clin Oncol 18:2567-75. 2000
    ....
  30. ncbi request reprint Pulmonary infection with microsporidia after allogeneic bone marrow transplantation
    D T Teachey
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 33:299-302. 2004
    ..Although rare, microsporidial infection should be considered in the differential diagnosis of unexplained pulmonary infection in bone marrow transplant patients...
  31. pmc DNA-based HLA typing of nonhematopoietic tissue used to select the marrow transplant donor for successful treatment of transfusion-associated graft-versus-host disease
    D F Friedman
    Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, USA
    Clin Diagn Lab Immunol 1:590-6. 1994
    ..This case illustrates that TAGVHD can be successfully treated by allogeneic bone marrow transplantation and that DNA-based HLA typing can play a unique role in the diagnosis and management of TAGVHD...
  32. doi request reprint Factors that contribute to post-treatment follow-up care for survivors of childhood cancer
    Lamia P Barakat
    Division of Oncology, The Children s Hospital of Philadelphia, 3501 Civic Center Blvd, 10303 CTRB, Philadelphia, PA 19104, USA
    J Cancer Surviv 6:155-62. 2012
    ..Relative contributions of cancer and treatment variables and sociodemographic factors in engagement with follow-up care are not fully understood. This study aimed to identify risk factors for inadequate follow-up care...
  33. pmc Risk factors for death of patients with cystic fibrosis awaiting lung transplantation
    Richard A Belkin
    Division of Pulmonary, Allergy, and Critical Care, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Am J Respir Crit Care Med 173:659-66. 2006
    ..The optimal timing for listing of cystic fibrosis patients for lung transplantation is controversial...
  34. ncbi request reprint Chemoreduction and local ophthalmic therapy for intraocular retinoblastoma
    D L Friedman
    Department of Pediatrics, Division of Oncology, The Children s Hospital of Philadelphia, PA, USA
    J Clin Oncol 18:12-7. 2000
    ..To study the effectiveness of combined systemic chemotherapy and local ophthalmic therapy for retinoblastoma with the goal of avoiding enucleation and external-beam radiation therapy (EBRT)...
  35. doi request reprint Challenges in the use of allogeneic hematopoietic SCT for ectodermal dysplasia with immune deficiency
    J D Fish
    Department of Pediatrics, Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 43:217-21. 2009
    ..These cases suggest that patients with immune deficiencies caused by NEMO or IkappaBalpha mutations may have intrinsic barriers to successful engraftment, which require further investigation...
  36. ncbi request reprint Maternal supplement, micronutrient, and cured meat intake during pregnancy and risk of medulloblastoma during childhood: a children's oncology group study
    Greta R Bunin
    c o Donna Correia, CureSearch, Children s Oncology Group, 440 East Huntington Drive, Arcadia, CA 91006, USA
    Cancer Epidemiol Biomarkers Prev 15:1660-7. 2006
    ..The results of the study add to the evidence of a protective role for multivitamins, suggest a possible role for micronutrients early in pregnancy, and generally do not support an association between cured meats and medulloblastoma/PNET...
  37. ncbi request reprint Parental occupational exposure to pesticides and childhood brain cancer
    Edwin van Wijngaarden
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Epidemiol 157:989-97. 2003
    ..Most risk estimates were around unity, and exposure-response patterns were absent. Overall, it seems unlikely that parental exposure to pesticides plays an important role in the etiology of childhood brain cancer...
  38. ncbi request reprint Breast-feeding and Wilms tumor: a report from the Children's Oncology Group
    Stephanie Saddlemire
    Department of Epidemiology, University of North Carolina, CB 7435, Chapel Hill, NC, 27599 7435, USA
    Cancer Causes Control 17:687-93. 2006
    ..We investigated the association between breast-feeding and Wilms tumor, a childhood kidney tumor...
  39. ncbi request reprint Folic acid and neuroblastoma: too soon to tell
    Bethany B Barone
    Clin Pharmacol Ther 75:489; author reply 490. 2004

Research Grants11

  1. Occupational Pesticide Exposure of Parents and Brain Tumor Risk in Children
    Greta Bunin; Fiscal Year: 2007
    ..The assessment of job tasks has been used little or not at all in studies of occupational exposure and childhood cancer. The proposed study will provide information on the usefulness of these approaches. ..
  2. CONTROL SELECTION METHODS FOR CHILDHOOD CANCER STUDIES
    Greta Bunin; Fiscal Year: 2007
    ..A feasible and valid control group is needed to ensure that studies of childhood cancer are scientifically valid and therefore, will provide results that can eventually lead to prevention of these cancers. ..
  3. PATERNAL EXPOSURE AND SPORADIC BILATERAL RETINOBLASTOMA
    Greta Bunin; Fiscal Year: 2005
    ..Sporadic heritable RBL is a childhood cancer worth studying in its own right and an ideal model for the investigation of new germline mutation. ..
  4. CONTROL SELECTION METHODS FOR CHILDHOOD CANCER STUDIES
    Greta Bunin; Fiscal Year: 2009
    ..A feasible and valid control group is needed to ensure that studies of childhood cancer are scientifically valid and therefore, will provide results that can eventually lead to prevention of these cancers. ..