Carol Bult

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. ncbi The mouse genome database: genotypes, phenotypes, and models of human disease
    Carol J Bult
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA
    Nucleic Acids Res 41:D885-91. 2013
  2. ncbi Bioinformatics resources for behavior studies in the laboratory mouse
    Carol J Bult
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Int Rev Neurobiol 104:71-90. 2012
  3. ncbi JAX Colony Management System (JCMS): an extensible colony and phenotype data management system
    Chuck J Donnelly
    The Jackson Laboratory, 610 Main Street, Bar Harbor, ME 04609, USA
    Mamm Genome 21:205-15. 2010
  4. ncbi MouseCyc: a curated biochemical pathways database for the laboratory mouse
    Alexei V Evsikov
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genome Biol 10:R84. 2009
  5. ncbi Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers
    Kamila Naxerova
    Children s Hospital Informatics Program, Harvard MIT Division of Health Sciences and Technology, Longwood Avenue, Boston, MA 02115, USA
    Genome Biol 9:R108. 2008
  6. ncbi Expression of the transcription factor, TFII-I, during post-implantation mouse embryonic development
    Iwona Fijalkowska
    Johns Hopkins University School of Medicine, Department of Medicine, Cardiopulmonary and Critical Care Division, 1830 E, Monument Street, Baltimore, MD 21205, USA
    BMC Res Notes 3:203. 2010
  7. ncbi The Mouse Genome Database (MGD): mouse biology and model systems
    Carol J Bult
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 36:D724-8. 2008
  8. ncbi From information to understanding: the role of model organism databases in comparative and functional genomics
    C J Bult
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Anim Genet 37:28-40. 2006
  9. ncbi The representation of protein complexes in the Protein Ontology (PRO)
    Carol J Bult
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    BMC Bioinformatics 12:371. 2011
  10. ncbi The Mouse Genome Database: enhancements and updates
    Carol J Bult
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA
    Nucleic Acids Res 38:D586-92. 2010

Research Grants

  1. Annual Conference on Computational Genomics
    Carol Bult; Fiscal Year: 2007
  2. MouseCyc: A Biochemical Pathway Database for the Mouse
    Carol Bult; Fiscal Year: 2007
  3. Computational Biology Resources
    Carol Bult; Fiscal Year: 2007
  4. Genome Sequence Analysis: Theory and Practice
    Carol Bult; Fiscal Year: 2006
  5. Computational Biology Resources
    Carol J Bult; Fiscal Year: 2010

Detail Information

Publications46

  1. ncbi The mouse genome database: genotypes, phenotypes, and models of human disease
    Carol J Bult
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA
    Nucleic Acids Res 41:D885-91. 2013
    ....
  2. ncbi Bioinformatics resources for behavior studies in the laboratory mouse
    Carol J Bult
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Int Rev Neurobiol 104:71-90. 2012
    ..MGI collects and integrates information about function, phenotype, disease associations, and developmental gene expression for all genome features in the laboratory mouse...
  3. ncbi JAX Colony Management System (JCMS): an extensible colony and phenotype data management system
    Chuck J Donnelly
    The Jackson Laboratory, 610 Main Street, Bar Harbor, ME 04609, USA
    Mamm Genome 21:205-15. 2010
    ..Recent advances in handheld computers with integrated barcode readers, middleware technologies, web browsers, and wireless networks add to the utility of JCMS by allowing real-time access to the database from any networked computer...
  4. ncbi MouseCyc: a curated biochemical pathways database for the laboratory mouse
    Alexei V Evsikov
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genome Biol 10:R84. 2009
    ..jax.org. MouseCyc has been integrated with genetic and genomic data for the laboratory mouse available from the Mouse Genome Informatics database and with pathway data from other organisms, including human...
  5. ncbi Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers
    Kamila Naxerova
    Children s Hospital Informatics Program, Harvard MIT Division of Health Sciences and Technology, Longwood Avenue, Boston, MA 02115, USA
    Genome Biol 9:R108. 2008
    ....
  6. ncbi Expression of the transcription factor, TFII-I, during post-implantation mouse embryonic development
    Iwona Fijalkowska
    Johns Hopkins University School of Medicine, Department of Medicine, Cardiopulmonary and Critical Care Division, 1830 E, Monument Street, Baltimore, MD 21205, USA
    BMC Res Notes 3:203. 2010
    ..We sought to define the timing and pattern of expression of TFII-I in post-implantation embryos at a time during which many putative TFII-I target genes are expressed...
  7. ncbi The Mouse Genome Database (MGD): mouse biology and model systems
    Carol J Bult
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 36:D724-8. 2008
    ..Recent improvements in MGD described here include the association of gene trap data with mouse genes and a new batch query capability for customized data access and retrieval...
  8. ncbi From information to understanding: the role of model organism databases in comparative and functional genomics
    C J Bult
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Anim Genet 37:28-40. 2006
    ....
  9. ncbi The representation of protein complexes in the Protein Ontology (PRO)
    Carol J Bult
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    BMC Bioinformatics 12:371. 2011
    ....
  10. ncbi The Mouse Genome Database: enhancements and updates
    Carol J Bult
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA
    Nucleic Acids Res 38:D586-92. 2010
    ....
  11. ncbi The mouse genome database (MGD): new features facilitating a model system
    Janan T Eppig
    The Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 35:D630-7. 2007
    ....
  12. ncbi The Mouse Genome Database (MGD): from genes to mice--a community resource for mouse biology
    Janan T Eppig
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 33:D471-5. 2005
    ....
  13. ncbi The Mouse Genome Database (MGD): integrating biology with the genome
    Carol J Bult
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 32:D476-81. 2004
    ..Recent developments in MGD discussed here include an extensive integration of the mouse sequence data and substantial revisions in the presentation, query and visualization of sequence data...
  14. ncbi Mouse phenome database
    Stephen C Grubb
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 37:D720-30. 2009
    ..jax.org/phenome/trytools)...
  15. ncbi Mutation discovery in mice by whole exome sequencing
    Heather Fairfield
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Genome Biol 12:R86. 2011
    ..We found strong candidate mutations for the majority of mutant exomes sequenced, including new models of orofacial clefting, urogenital dysmorphology, kyphosis and autoimmune hepatitis...
  16. ncbi The Mouse Tumor Biology Database: integrated access to mouse cancer biology data
    Debra Krupke
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Exp Lung Res 31:259-70. 2005
    ....
  17. ncbi The mouse as a model for human biology: a resource guide for complex trait analysis
    Luanne L Peters
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Genet 8:58-69. 2007
    ..This review summarizes those resources and provides practical guidelines for their use, particularly in the analysis of quantitative traits...
  18. ncbi Mouse genome informatics (MGI) resources for pathology and toxicology
    Janan T Eppig
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Toxicol Pathol 35:456-7. 2007
  19. ncbi The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics
    Judith A Blake
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 39:D842-8. 2011
    ....
  20. ncbi The Mouse Tumor Biology database
    Debra M Krupke
    Jackson Laboratory, Mouse Tumour Biology Database, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Cancer 8:459-65. 2008
    ..Tools to integrate, locate and visualize these data are crucial to aid researchers in their investigations. The Mouse Tumor Biology database (http://tumor.informatics.jax.org) seeks to address that need...
  21. ncbi The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium
    Martin Ringwald
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 39:D849-55. 2011
    ..The IKMC database provides data to, and features extensive interconnections with, other community databases...
  22. ncbi The Mouse Genome Database genotypes::phenotypes
    Judith A Blake
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 37:D712-9. 2009
    ..Recent improvements in MGD described here include the unified mouse gene catalog for NCBI Build 37 of the reference genome assembly, and improved representation of mouse mutants and phenotypes...
  23. ncbi Mouse Phenome Database (MPD)
    Molly A Bogue
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 35:D643-9. 2007
    ..The laboratory mouse is a premier genetic model for understanding human biology and pathology; MPD facilitates research that uses the mouse to identify and determine the function of genes participating in normal and disease pathways...
  24. ncbi Genome function and nuclear architecture: from gene expression to nanoscience
    TIMOTHY P O'BRIEN
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 13:1029-41. 2003
    ..Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists...
  25. ncbi Mouse Tumor Biology Database (MTB): status update and future directions
    Dale A Begley
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
    Nucleic Acids Res 35:D638-42. 2007
    ..A new pathology data submission tool allows users to submit, edit and release data to the MTB system...
  26. ncbi The Mouse Genome Database (MGD): the model organism database for the laboratory mouse
    Judith A Blake
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 30:113-5. 2002
    ....
  27. ncbi The Mouse Tumor Biology Database: a public resource for cancer genetics and pathology of the mouse
    Dieter Naf
    Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Cancer Res 62:1235-40. 2002
    ..We outline current content, data acquisition strategies, and query mechanisms for MTB. MTB is accessible on-line at http://tumor.informatics.jax.org...
  28. ncbi MGD: the Mouse Genome Database
    Judith A Blake
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 31:193-5. 2003
    ..Recent developments include a general implementation of database structures for controlled vocabularies and the integration of a phenotype classification system...
  29. ncbi Integrating computationally assembled mouse transcript sequences with the Mouse Genome Informatics (MGI) database
    Yunxia Zhu
    Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genome Biol 4:R16. 2003
    ..We present the analysis and results of a semi-automated process of connecting transcript assemblies with highly curated biological information for mouse genes that is available through the Mouse Genome Informatics (MGI) database...
  30. ncbi Connecting sequence and biology in the laboratory mouse
    Richard M Baldarelli
    Mouse Genome Informatics Group, The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 13:1505-19. 2003
    ..In particular, we describe the methods and results of integration of 60,770 FANTOM2 mouse cDNAs with gene records in the databases of MGI and LocusLink...
  31. ncbi Mice and more
    Carol J Bult
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genome Biol 4:340. 2003
    ..A report on the Mouse Initiatives V meeting 'Genomics of Complex Systems in Biomedical Research', The Jackson Laboratory, Bar Harbor, USA, 30 July-2 August 2003...
  32. ncbi Antibodies that label paraffin-embedded mouse tissues: a collaborative endeavor
    Igor Mikaelian
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Toxicol Pathol 32:181-91. 2004
    ..Regularly updated information on immunohistochemistry of normal and neoplastic mouse tissues is accessible online at (http://tumor.informatics.jax.org); links to antibody suppliers' web sites are provided...
  33. ncbi The Mouse Genome Database (MGD): updates and enhancements
    Judith A Blake
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Nucleic Acids Res 34:D562-7. 2006
    ..informatics.jax.org. Recent improvements in MGD described here include the incorporation of an interactive genome browser, the enhancement of phenotype resources and the further development of functional annotation resources...
  34. ncbi Beyond the data deluge: data integration and bio-ontologies
    Judith A Blake
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Biomed Inform 39:314-20. 2006
    ....
  35. ncbi Genomes as geography: using GIS technology to build interactive genome feature maps
    Mary E Dolan
    National Center for Geographic Information and Analysis, University of Maine, Orono, ME 04469, USA
    BMC Bioinformatics 7:416. 2006
    ....
  36. ncbi A new standard genetic map for the laboratory mouse
    Allison Cox
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Genetics 182:1335-44. 2009
    ..We demonstrate that utilization of the revised genetic map improves QTL mapping, partially due to the resolution of previously undetected errors in marker ordering along the chromosome...
  37. ncbi Clusters of internally primed transcripts reveal novel long noncoding RNAs
    Masaaki Furuno
    Mouse Genome Informatics Consortium, The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 2:e37. 2006
    ..Taken together, the data not only identify multiple new ncRNAs but also suggest the existence of many more macro ncRNAs like Xist and Air...
  38. ncbi Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence
    Lindsay S Shopland
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 174:27-38. 2006
    ..Together, these data suggest dynamic, probabilistic 3D folding states for a contiguous megabase-scale chromosomal region, supporting the diverse activities of multiple genes and their conserved primary sequence organization...
  39. ncbi A genome end-game: understanding gene function in the nervous system
    Carol Bult
    Neuroscience Mutagenesis Facility, The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Neurosci 7:484-5. 2004
  40. ncbi A mouse model of conditional lipodystrophy
    Suyeon Kim
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 104:16627-32. 2007
    ..Thus, the Pparg(ldi/+) mouse provides a conditional animal model for studying lipodystrophy and its associated physiology and gene expression...
  41. ncbi Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14
    Kevin A Peterson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 80:172-84. 2002
    ..Our studies combining computational gene prediction with genetic and comparative genomic analyses provide insight regarding the functional composition and organization of this defined chromosomal region...
  42. ncbi Transcriptional profile of mouse pre-granulosa and Sertoli cells isolated from early-differentiated fetal gonads
    Gerrit J Bouma
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Gene Expr Patterns 7:113-23. 2007
    ..Among the newly identified differentially expressed transcripts are potential GSD genes involved in unexplained human sex reversal cases...
  43. ncbi Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
    Rong Yuan
    The Jackson Aging Center at The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Aging Cell 8:277-87. 2009
    ..53, P < 0.01). These results support the hypothesis that the IGF1 pathway plays a key role in regulating longevity in mice and indicates that common genetic mechanisms may exist for regulating IGF1 levels and lifespan...
  44. ncbi Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs
    Norihiro Maeda
    Genome Science Laboratory, Discovery Research Institute, RIKEN Wako Institute, Wako, Japan
    PLoS Genet 2:e62. 2006
    ....
  45. ncbi A genomewide functional network for the laboratory mouse
    Yuanfang Guan
    Lewis Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey, United States of America
    PLoS Comput Biol 4:e1000165. 2008
    ..princeton.edu...
  46. ncbi Discrimination of non-protein-coding transcripts from protein-coding mRNA
    Martin C Frith
    Genome Exploration Research Group Genome Network Project Core Group, RIKEN Genomic Sciences Center GSC, RIKEN Yokohama Institute, Kanagawa, Japan
    RNA Biol 3:40-8. 2006
    ..Conversely and surprisingly, our analyses also provide evidence that as much as approximately 10% of entries in the manually curated protein database Swiss-Prot are erroneous translations of actually non-coding transcripts...

Research Grants10

  1. Annual Conference on Computational Genomics
    Carol Bult; Fiscal Year: 2007
    ..In subsequent years, The Conference will alternate between the Northeast (Boston/Cambridge) and the Mid-Atlantic Region (Virginia/Maryland). ..
  2. MouseCyc: A Biochemical Pathway Database for the Mouse
    Carol Bult; Fiscal Year: 2007
    ..The visualization and query interfaces for MouseCyc will further enhance the value of the mouse as a model system for understanding human biology and disease processes. ..
  3. Computational Biology Resources
    Carol Bult; Fiscal Year: 2007
    ..The software development group at TJL operates under a highly disciplined system development process that will ensure the production of robust and well-documented software products. ..
  4. Genome Sequence Analysis: Theory and Practice
    Carol Bult; Fiscal Year: 2006
    ..Biological questions will be framed largely around a variety of human diseases and biological processes for which comparative sequence analysis using genomes of model organisms (especially mouse) is yielding insights. ..
  5. Computational Biology Resources
    Carol J Bult; Fiscal Year: 2010
    ....