Robert A Budinsky

Summary

Affiliation: The Dow Chemical Company
Country: USA

Publications

  1. doi Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran
    Robert A Budinsky
    The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 118:224-35. 2010
  2. doi Chlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyl profiles of workers with trichlorophenol and pentachlorophenol exposures
    James J Collins
    The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Chemosphere 73:S284-9. 2008
  3. ncbi Factors related to dioxin and furan body levels among Michigan workers
    Carol J Burns
    The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Environ Res 106:250-6. 2008
  4. doi Effects of aging and sediment composition on hexachlorobenzene desorption resistance compared to oral bioavailability in rats
    Yunzhou Chai
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Chemosphere 72:432-41. 2008
  5. ncbi Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former Michigan trichlorophenol and pentachlorophenol workers
    James J Collins
    The Dow Chemical Company, Midland, MI 48674, USA
    J Expo Sci Environ Epidemiol 17:541-8. 2007
  6. ncbi Effect of organic carbon content, clay type, and aging on the oral bioavailability of hexachlorobenzene in rats
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Environ Toxicol Chem 26:2420-9. 2007
  7. ncbi Serum dioxin levels in former chlorophenol workers
    James J Collins
    The Dow Chemical Company, Midland, MI 48674, USA
    J Expo Sci Environ Epidemiol 16:76-84. 2006
  8. ncbi Mode of mutagenic action for the biocide Bioban CS-1246 in mouse lymphoma cells and implications for its in vivo mutagenic potential
    Grantley D Charles
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 84:73-80. 2005
  9. ncbi Recommended relative potency factors for 2,3,4,7,8-pentachlorodibenzofuran: the impact of different dose metrics
    Robert A Budinsky
    The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 91:275-85. 2006
  10. ncbi Effects of black carbon and montmorillonite clay on multiphasic hexachlorobenzene desorption from sediments
    Yunzhou Chai
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Chemosphere 69:1204-12. 2007

Detail Information

Publications12

  1. doi Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran
    Robert A Budinsky
    The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 118:224-35. 2010
    ..Overall, these data support the position that humans are less sensitive than rats to these AHR-dependent end points and support the use of a data-derived adjustment factor of 1.0 or less for extrapolating between rats and humans...
  2. doi Chlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyl profiles of workers with trichlorophenol and pentachlorophenol exposures
    James J Collins
    The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Chemosphere 73:S284-9. 2008
    ..We were effectively able to distinguish past trichlorophenol exposures from pentachlorophenol exposures based on differing serum dioxin profiles among workers...
  3. ncbi Factors related to dioxin and furan body levels among Michigan workers
    Carol J Burns
    The Dow Chemical Company, 1803 Building, Midland, MI 48674, USA
    Environ Res 106:250-6. 2008
    ..Other factors such as diet and jobs outside of the chlorophenol plant exposures had only a very minor impact on dioxin and furan concentrations in these workers...
  4. doi Effects of aging and sediment composition on hexachlorobenzene desorption resistance compared to oral bioavailability in rats
    Yunzhou Chai
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Chemosphere 72:432-41. 2008
    ..These results showed that montmorillonite clay, black carbon and aging reduced physicochemical availability and ultimately bioavailability of sediment-bound HCB...
  5. ncbi Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former Michigan trichlorophenol and pentachlorophenol workers
    James J Collins
    The Dow Chemical Company, Midland, MI 48674, USA
    J Expo Sci Environ Epidemiol 17:541-8. 2007
    ..These data can be used to better assess dioxin exposures in future health studies...
  6. ncbi Effect of organic carbon content, clay type, and aging on the oral bioavailability of hexachlorobenzene in rats
    Shakil A Saghir
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Environ Toxicol Chem 26:2420-9. 2007
    ..Increase in the fecal elimination and decrease in oral bioavailability of (14)C-HCB was related to the increase in clay and black carbon...
  7. ncbi Serum dioxin levels in former chlorophenol workers
    James J Collins
    The Dow Chemical Company, Midland, MI 48674, USA
    J Expo Sci Environ Epidemiol 16:76-84. 2006
    ..We conclude that our findings are consistent with other studies reporting high serum dioxin levels among chlorophenol workers after occupational exposures...
  8. ncbi Mode of mutagenic action for the biocide Bioban CS-1246 in mouse lymphoma cells and implications for its in vivo mutagenic potential
    Grantley D Charles
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 84:73-80. 2005
    ..The extensive literature on FA would therefore be of value in assessing the carcinogenic risk to humans and animals from CS-1246 exposure...
  9. ncbi Recommended relative potency factors for 2,3,4,7,8-pentachlorodibenzofuran: the impact of different dose metrics
    Robert A Budinsky
    The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 91:275-85. 2006
    ..In summary, our analyses support an administered dose TEF no greater than 0.25 and one in the 0.05-0.1 range for internal dose metrics such as lifetime average liver concentration or body burden...
  10. ncbi Effects of black carbon and montmorillonite clay on multiphasic hexachlorobenzene desorption from sediments
    Yunzhou Chai
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland, MI 48674, United States
    Chemosphere 69:1204-12. 2007
    ....
  11. ncbi Body mass index and serum chlorinated dibenzo-p-dioxin and dibenzofuran levels
    James J Collins
    The Dow Chemical Company, Epidemiology Department, 1803 Building Midland, MI 48674, USA
    Chemosphere 66:1079-85. 2007
    ..Further, age and BMI may also be important in epidemiology studies where back-extrapolation from current dioxin levels is used to assess historical chlorophenol exposure...
  12. ncbi An evaluation of single nucleotide polymorphisms in the human aryl hydrocarbon receptor-interacting protein (AIP) gene
    J Craig Rowlands
    The Dow Chemical Company, Midland, MI 48574, USA
    Drug Metab Pharmacokinet 26:431-9. 2011
    ..To date, no non-synonymous SNPs have been detected in the AHR-binding region of AIP...