Anthony Brown

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Rapid movement of microtubules in axons
    Lei Wang
    Graduate Program in Biological Sciences, Ohio University, Athens 45701, USA
    Curr Biol 12:1496-1501. 2002
  2. pmc Severing and end-to-end annealing of neurofilaments in neurons
    Atsuko Uchida
    Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 110:E2696-705. 2013
  3. pmc A critical reevaluation of the stationary axonal cytoskeleton hypothesis
    Anthony Brown
    Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Cytoskeleton (Hoboken) 70:1-11. 2013
  4. pmc Axonal transport of membranous and nonmembranous cargoes: a unified perspective
    Anthony Brown
    The Ohio State University, Neurobiotechnology Center, Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
    J Cell Biol 160:817-21. 2003
  5. pmc Stochastic simulation of neurofilament transport in axons: the "stop-and-go" hypothesis
    Anthony Brown
    Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 16:4243-55. 2005
  6. pmc A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport
    Lina Wang
    Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Mol Neurodegener 5:52. 2010
  7. pmc Neurofilament polymer transport in axons
    Yanping Yan
    Center for Molecular Neurobiology, Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 25:7014-21. 2005
  8. doi request reprint Axonal transport of neurofilaments: a single population of intermittently moving polymers
    Yinyun Li
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 32:746-58. 2012
  9. pmc The polypeptide composition of moving and stationary neurofilaments in cultured sympathetic neurons
    Yanping Yan
    Department of Neuroscience, Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio 43210, USA
    Cell Motil Cytoskeleton 64:299-309. 2007
  10. pmc Arrival, reversal, and departure of neurofilaments at the tips of growing axons
    Atsuko Uchida
    Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 15:4215-25. 2004

Research Grants

  1. AXONAL TRANSPORT OF NEUROFILAMENTS
    Anthony Brown; Fiscal Year: 2007
  2. ASSEMBLY AND AXONAL TRANSPORT OF NEUROFILAMENT PROTEINS
    Anthony Brown; Fiscal Year: 2002
  3. Assembly and Axonal Transport of Neurofilaments
    Anthony Brown; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Rapid movement of microtubules in axons
    Lei Wang
    Graduate Program in Biological Sciences, Ohio University, Athens 45701, USA
    Curr Biol 12:1496-1501. 2002
    ..The rapid, infrequent, and highly asynchronous nature of the movement may explain why the axonal transport of tubulin has eluded detection in so many other studies...
  2. pmc Severing and end-to-end annealing of neurofilaments in neurons
    Atsuko Uchida
    Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 110:E2696-705. 2013
    ..We propose that the length of intermediate filaments in cells is regulated by the opposing actions of severing and end-to-end annealing, and we speculate that this regulatory mechanism may influence neurofilament transport within axons. ..
  3. pmc A critical reevaluation of the stationary axonal cytoskeleton hypothesis
    Anthony Brown
    Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Cytoskeleton (Hoboken) 70:1-11. 2013
    ....
  4. pmc Axonal transport of membranous and nonmembranous cargoes: a unified perspective
    Anthony Brown
    The Ohio State University, Neurobiotechnology Center, Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
    J Cell Biol 160:817-21. 2003
    ..A Flash feature (http://www.jcb.org/cgi/content/full/jcb.200212017/DC1) accompanies this Mini-Review...
  5. pmc Stochastic simulation of neurofilament transport in axons: the "stop-and-go" hypothesis
    Anthony Brown
    Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 16:4243-55. 2005
    ..The model predicts that axonal neurofilaments spend approximately 8% of their time on track and approximately 97% of their time pausing during their journey along the axon...
  6. pmc A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport
    Lina Wang
    Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Mol Neurodegener 5:52. 2010
    ..One of the dominantly inherited forms of this disease (spastic gait type 10, or SPG10) is caused by point mutations in kinesin-1A (also known as KIF5A), which is thought to be an anterograde motor for neurofilaments...
  7. pmc Neurofilament polymer transport in axons
    Yanping Yan
    Center for Molecular Neurobiology, Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 25:7014-21. 2005
    ..Thus, neurofilament polymers are one of the cargo structures of slow axonal transport...
  8. doi request reprint Axonal transport of neurofilaments: a single population of intermittently moving polymers
    Yinyun Li
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 32:746-58. 2012
    ..We conclude that all of the neurofilaments move and that they do so with a single broad and continuous distribution of average rates that is dictated by their intermittent and stochastic motile behavior...
  9. pmc The polypeptide composition of moving and stationary neurofilaments in cultured sympathetic neurons
    Yanping Yan
    Department of Neuroscience, Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio 43210, USA
    Cell Motil Cytoskeleton 64:299-309. 2007
    ....
  10. pmc Arrival, reversal, and departure of neurofilaments at the tips of growing axons
    Atsuko Uchida
    Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 15:4215-25. 2004
    ....
  11. pmc Myosin Va increases the efficiency of neurofilament transport by decreasing the duration of long-term pauses
    Nael H Alami
    Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 29:6625-34. 2009
    ....
  12. pmc Tight functional coupling of kinesin-1A and dynein motors in the bidirectional transport of neurofilaments
    Atsuko Uchida
    Center for Molecular Neurobiology and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 20:4997-5006. 2009
    ....
  13. pmc FluoroMyelin™ Red is a bright, photostable and non-toxic fluorescent stain for live imaging of myelin
    Paula C Monsma
    Department of Neuroscience, The Ohio State University, Columbus, OH 43210, United States
    J Neurosci Methods 209:344-50. 2012
    ..Thus FluoroMyelin™ Red is a useful reagent for live fluorescence imaging studies on myelinated axons...
  14. pmc Neurofilaments switch between distinct mobile and stationary states during their transport along axons
    Niraj Trivedi
    Center for Molecular Neurobiology and Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 27:507-16. 2007
    ....
  15. pmc Intermediate filaments exchange subunits along their length and elongate by end-to-end annealing
    Gulsen Colakoglu
    Center for Molecular Neurobiology, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 185:769-77. 2009
    ....
  16. pmc Neurofilaments are flexible polymers that often fold and unfold, but they move in a fully extended configuration
    Nicholas J Taylor
    Department of Neuroscience, Wexner Medical Center, Ohio State University, Columbus, Ohio 43210, USA
    Cytoskeleton (Hoboken) 69:535-44. 2012
    ..Thus, we speculate that motors may bind to the leading ends of neurofilaments polymers during both anterograde and retrograde motion...
  17. pmc A dynamical system model of neurofilament transport in axons
    Gheorghe Craciun
    Mathematical Biosciences Institute, Ohio State University, Columbus, OH 43210, USA
    J Theor Biol 237:316-22. 2005
    ..We show that we can choose this last remaining parameter such that the results of our model agree with pulse-labeling experiments from three different nerve cell types, and also agree with stochastic simulation results...
  18. pmc Live-cell imaging of slow axonal transport in cultured neurons
    Anthony Brown
    Neurobiotechnology Center, Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA
    Methods Cell Biol 71:305-23. 2003
    ..In particular, the author describes how to culture these neurons, how to transfect them by nuclear injection, and how to detect the rapid and infrequent movement of cytoskeletal polymers using time-lapse fluorescence imaging...

Research Grants14

  1. AXONAL TRANSPORT OF NEUROFILAMENTS
    Anthony Brown; Fiscal Year: 2007
    ..The long-term goal of our research is to determine the mechanism and regulation of neurofilament protein transport along axons and the mechanisms that lead to the accumulation of neurofilaments in neurofilamentous neuropathies. ..
  2. ASSEMBLY AND AXONAL TRANSPORT OF NEUROFILAMENT PROTEINS
    Anthony Brown; Fiscal Year: 2002
    ..By testing specific hypotheses on the assembly and axonal transport of neurofilaments, the studies proposed here represent an important step toward this goal. ..
  3. Assembly and Axonal Transport of Neurofilaments
    Anthony Brown; Fiscal Year: 2010
    ....