David G Brooks

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi Effect of latent human immunodeficiency virus infection on cell surface phenotype
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 76:1673-81. 2002
  2. ncbi Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
  3. ncbi IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
    David G Brooks
    Viral Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:533-41. 2008
  4. ncbi Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California, USA
    J Clin Invest 116:1675-85. 2006
  5. ncbi Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection
    David G Brooks
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:10514-27. 2005
  6. ncbi CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection
    Scott G Kitchen
    Department of Medicine and Microbiology, David Geffen School of Medicine, University of California, 11-934 Factor Building, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8727-32. 2004
  7. ncbi Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
    David G Brooks
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California-Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:12955-60. 2003
  8. ncbi Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    Yael D Korin
    Department of Medicine, UCLA School of Medicine, and UCLA AIDS Institute, 90095-1678, USA
    J Virol 76:8118-23. 2002
  9. ncbi Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes
    Ayub Ali
    Department of Medicine, AIDS Institute, Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Virol 78:561-7. 2004
  10. ncbi Molecular characterization, reactivation, and depletion of latent HIV
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Immunity 19:413-23. 2003

Research Grants

  1. Novel Molecules that Define Viral Persistence
    David Brooks; Fiscal Year: 2007

Collaborators

Detail Information

Publications14

  1. ncbi Effect of latent human immunodeficiency virus infection on cell surface phenotype
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 76:1673-81. 2002
    ..The apparently normal phenotype and lack of HIV expression in latently infected cells could prevent recognition by the immune response and contribute to the long-lived nature of this reservoir...
  2. ncbi Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
    ..Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence...
  3. ncbi IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
    David G Brooks
    Viral Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:533-41. 2008
    ..Consequently, blocking key suppressive factors could render ineffective vaccines more efficient at improving T cell immunity, and thereby allow immune-mediated control of persistent viral infection...
  4. ncbi Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California, USA
    J Clin Invest 116:1675-85. 2006
    ..Thus, dysfunctional antiviral T cells can regain activity, providing a basis for future therapeutic strategies to treat persistent viral infections...
  5. ncbi Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection
    David G Brooks
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:10514-27. 2005
    ....
  6. ncbi CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection
    Scott G Kitchen
    Department of Medicine and Microbiology, David Geffen School of Medicine, University of California, 11-934 Factor Building, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8727-32. 2004
    ..Thus, the CD4 molecule plays a direct role in CD8 T cell function, and infection of these cells by HIV provides an additional reservoir for the virus and also may contribute to the immunodeficiency seen in HIV disease...
  7. ncbi Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
    David G Brooks
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California-Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:12955-60. 2003
    ..Thus, we define several molecular pathways that trigger HIV reactivation from latency and provide evidence that latent HIV infection is maintained by the functional lack of particular transcription factors in quiescent cells...
  8. ncbi Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    Yael D Korin
    Department of Medicine, UCLA School of Medicine, and UCLA AIDS Institute, 90095-1678, USA
    J Virol 76:8118-23. 2002
    ....
  9. ncbi Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes
    Ayub Ali
    Department of Medicine, AIDS Institute, Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Virol 78:561-7. 2004
    ..The epitope targeting of CTL and viral control of class I therefore likely play important roles in the ability of CTL to exert pressure on HIV-1...
  10. ncbi Molecular characterization, reactivation, and depletion of latent HIV
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Immunity 19:413-23. 2003
    ..We demonstrate that activation of latent virus is required for targeting by antiviral agents and provide the basis for future therapeutic strategies to eradicate the latent reservoir...
  11. ncbi HIV type 1 infection alters cytokine mRNA expression in thymus
    Prasad S Koka
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine and UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    AIDS Res Hum Retroviruses 19:1-12. 2003
    ..These results indicate that HIV-1 infection can greatly distort the cytokine profiles in Thy/Liv implants, and suggest that cytokine perturbation could be involved in virus-induced inhibition of hematopoiesis...
  12. ncbi Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development
    David G Brooks
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine and AIDS Institute, University of California, Los Angeles, 90095, USA
    Curr HIV Res 3:377-92. 2005
    ....
  13. ncbi Rapid expression of human immunodeficiency virus following activation of latently infected cells
    Philip A Arlen
    David Geffen School of Medicine, University of California-Los Angeles, 11-934 Factor Building, 650 Charles Young Drive South, Los Angeles, CA 90095, USA
    J Virol 80:1599-603. 2006
    ..This hierarchy also held true for viral protein production. These results may explain the rapid reemergence of viremia following termination of therapy...
  14. ncbi Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype
    Deirdre D Scripture-Adams
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Virol 76:13077-82. 2002
    ..Thus, IL-7 is a viable candidate to activate expression of latent HIV and may facilitate immune clearance of latently infected cells...

Research Grants1

  1. Novel Molecules that Define Viral Persistence
    David Brooks; Fiscal Year: 2007
    ....