David G Brooks

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Effect of latent human immunodeficiency virus infection on cell surface phenotype
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 76:1673-81. 2002
  2. pmc Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
  3. pmc Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection
    David G Brooks
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:10514-27. 2005
  4. pmc IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
    David G Brooks
    Viral Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:533-41. 2008
  5. pmc Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California, USA
    J Clin Invest 116:1675-85. 2006
  6. pmc Networking at the level of host immunity: immune cell interactions during persistent viral infections
    Cherie T Ng
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Host Microbe 13:652-64. 2013
  7. pmc Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
    Yoko Kidani
    Institute for Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nat Immunol 14:489-99. 2013
  8. pmc Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
    David G Brooks
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:12955-60. 2003
  9. pmc Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    Yael D Korin
    Department of Medicine, UCLA School of Medicine, and UCLA AIDS Institute, 90095 1678, USA
    J Virol 76:8118-23. 2002
  10. pmc CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection
    Scott G Kitchen
    Department of Medicine and Microbiology, David Geffen School of Medicine, University of California, 11 934 Factor Building, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8727-32. 2004

Research Grants

  1. Novel Molecules that Define Viral Persistence
    David Brooks; Fiscal Year: 2007

Collaborators

  • Dorian B McGavern
  • Luc Teyton
  • Steven J Bensinger
  • Andrew M Lee
  • M B A Oldstone
  • BETH DEIRDRE JAMIESON KARAVODIN
  • Dean H Hamer
  • O O Yang
  • Jerome A Zack
  • Yoko Kidani
  • Cherie T Ng
  • Yael D Korin
  • Philip A Arlen
  • Scott G Kitchen
  • Ayub Ali
  • Prasad S Koka
  • Deirdre D Scripture-Adams
  • Laura M Snell
  • Heidi Elsaesser
  • M Benjamin Hock
  • Kevin J Williams
  • Joseph P Argus
  • Beth N Marbois
  • Timothy F Osborne
  • Karen Reue
  • Thomas G Graeber
  • Evangelia Komisopoulou
  • Laurent Vergnes
  • Elizabeth B Wilson
  • Dimitrios Vatakis
  • Lian Y Gao
  • Helen J Brown
  • Stephen J Brown
  • Stuart LaForge
  • Nicole R Jones
  • Christina M R Kitchen
  • Zoran Galic
  • Rachel Lubong
  • Bien Aimee Vu
  • Hwee Ng
  • Jason K Whitmire
  • Ali Razai
  • Christina M Kitchen
  • Andrew Korotzer
  • Stephen Brown

Detail Information

Publications16

  1. pmc Effect of latent human immunodeficiency virus infection on cell surface phenotype
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 76:1673-81. 2002
    ..The apparently normal phenotype and lack of HIV expression in latently infected cells could prevent recognition by the immune response and contribute to the long-lived nature of this reservoir...
  2. pmc Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
    ..Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence...
  3. pmc Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection
    David G Brooks
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:10514-27. 2005
    ....
  4. pmc IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
    David G Brooks
    Viral Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:533-41. 2008
    ..Consequently, blocking key suppressive factors could render ineffective vaccines more efficient at improving T cell immunity, and thereby allow immune-mediated control of persistent viral infection...
  5. pmc Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California, USA
    J Clin Invest 116:1675-85. 2006
    ..Thus, dysfunctional antiviral T cells can regain activity, providing a basis for future therapeutic strategies to treat persistent viral infections...
  6. pmc Networking at the level of host immunity: immune cell interactions during persistent viral infections
    Cherie T Ng
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Host Microbe 13:652-64. 2013
    ..Ultimately, these findings will further our understanding of the immunologic basis of persistent viral infection and likely lead to strategies to treat human viral infections...
  7. pmc Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
    Yoko Kidani
    Institute for Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nat Immunol 14:489-99. 2013
    ..Our studies provide insights into the molecular signals that underlie the metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation...
  8. pmc Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
    David G Brooks
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:12955-60. 2003
    ..Thus, we define several molecular pathways that trigger HIV reactivation from latency and provide evidence that latent HIV infection is maintained by the functional lack of particular transcription factors in quiescent cells...
  9. pmc Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    Yael D Korin
    Department of Medicine, UCLA School of Medicine, and UCLA AIDS Institute, 90095 1678, USA
    J Virol 76:8118-23. 2002
    ....
  10. pmc CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection
    Scott G Kitchen
    Department of Medicine and Microbiology, David Geffen School of Medicine, University of California, 11 934 Factor Building, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8727-32. 2004
    ..Thus, the CD4 molecule plays a direct role in CD8 T cell function, and infection of these cells by HIV provides an additional reservoir for the virus and also may contribute to the immunodeficiency seen in HIV disease...
  11. ncbi request reprint Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development
    David G Brooks
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine and AIDS Institute, University of California, Los Angeles, 90095, USA
    Curr HIV Res 3:377-92. 2005
    ....
  12. ncbi request reprint Molecular characterization, reactivation, and depletion of latent HIV
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Immunity 19:413-23. 2003
    ..We demonstrate that activation of latent virus is required for targeting by antiviral agents and provide the basis for future therapeutic strategies to eradicate the latent reservoir...
  13. ncbi request reprint HIV type 1 infection alters cytokine mRNA expression in thymus
    Prasad S Koka
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine and UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    AIDS Res Hum Retroviruses 19:1-12. 2003
    ..These results indicate that HIV-1 infection can greatly distort the cytokine profiles in Thy/Liv implants, and suggest that cytokine perturbation could be involved in virus-induced inhibition of hematopoiesis...
  14. pmc Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype
    Deirdre D Scripture-Adams
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Virol 76:13077-82. 2002
    ..Thus, IL-7 is a viable candidate to activate expression of latent HIV and may facilitate immune clearance of latently infected cells...
  15. pmc Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes
    Ayub Ali
    Department of Medicine, AIDS Institute, Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Virol 78:561-7. 2004
    ..The epitope targeting of CTL and viral control of class I therefore likely play important roles in the ability of CTL to exert pressure on HIV-1...
  16. pmc Rapid expression of human immunodeficiency virus following activation of latently infected cells
    Philip A Arlen
    David Geffen School of Medicine, University of California Los Angeles, 11 934 Factor Building, 650 Charles Young Drive South, Los Angeles, CA 90095, USA
    J Virol 80:1599-603. 2006
    ..This hierarchy also held true for viral protein production. These results may explain the rapid reemergence of viremia following termination of therapy...

Research Grants1

  1. Novel Molecules that Define Viral Persistence
    David Brooks; Fiscal Year: 2007
    ....