GARRETT BRODEUR

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Therapeutic targets for neuroblastomas
    Garrett M Brodeur
    Children s Hospital of Philadelphia, Division of Oncology, CTRB Rm 3018, 3501 Civic Center Blvd, Philadelphia, PA 19104 4302, USA 1 215 590 2817 1 215 590 3770
    Expert Opin Ther Targets 18:277-92. 2014
  2. ncbi request reprint Significance of intratumoral genetic heterogeneity in neuroblastomas
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia, Abramson Research Center, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 38:112-3. 2002
  3. ncbi request reprint Biological aspects of neuroblastomas identified by mass screening in Quebec
    G M Brodeur
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104 4318, USA
    Med Pediatr Oncol 36:157-9. 2001
  4. ncbi request reprint Neuroblastoma: biological insights into a clinical enigma
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Rev Cancer 3:203-16. 2003
  5. ncbi request reprint Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma
    P M Thompson
    Division of Oncology, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:679-86. 2001
  6. ncbi request reprint Comprehensive analysis of chromosome 1p deletions in neuroblastoma
    J M Maris
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4138, USA
    Med Pediatr Oncol 36:32-6. 2001
  7. ncbi request reprint Loss of heterozygosity for chromosome 14q in neuroblastoma
    P M Thompson
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4318, USA
    Med Pediatr Oncol 36:28-31. 2001
  8. ncbi request reprint High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas
    A Eggert
    Division of Oncology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 6:1900-8. 2000
  9. ncbi request reprint TrkA signal transduction pathways in neuroblastoma
    A Eggert
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104, USA
    Med Pediatr Oncol 36:108-10. 2001
  10. ncbi request reprint Human Krüppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene?
    J M Maris
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania, USA
    Eur J Cancer 33:1991-6. 1997

Research Grants

  1. Effect of Trk Expression and Inhibition in Neuroblastoma
    GARRETT BRODEUR; Fiscal Year: 2005
  2. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2005
  3. Effect of Trk Expression and Inhibition in Neuroblastoma
    GARRETT BRODEUR; Fiscal Year: 2006
  4. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2006
  5. Cancer center research training program
    GARRETT BRODEUR; Fiscal Year: 2007
  6. Neuroblastoma Biology and Therapy
    GARRETT BRODEUR; Fiscal Year: 2007
  7. Trk Expression and Inhibition in Human Neuroblastomas
    GARRETT BRODEUR; Fiscal Year: 2009
  8. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2009
  9. Trk Expression and Inhibition in Human Neuroblastomas
    Garrett M Brodeur; Fiscal Year: 2010
  10. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2004

Collaborators

Detail Information

Publications50

  1. doi request reprint Therapeutic targets for neuroblastomas
    Garrett M Brodeur
    Children s Hospital of Philadelphia, Division of Oncology, CTRB Rm 3018, 3501 Civic Center Blvd, Philadelphia, PA 19104 4302, USA 1 215 590 2817 1 215 590 3770
    Expert Opin Ther Targets 18:277-92. 2014
    ..Further, there is considerable short- and long-term toxicity. More effective, less toxic therapy is needed, and the development of targeted therapies offers great promise...
  2. ncbi request reprint Significance of intratumoral genetic heterogeneity in neuroblastomas
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia, Abramson Research Center, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 38:112-3. 2002
  3. ncbi request reprint Biological aspects of neuroblastomas identified by mass screening in Quebec
    G M Brodeur
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104 4318, USA
    Med Pediatr Oncol 36:157-9. 2001
    ..Therefore, the Quebec Neuroblastoma Screening Project was undertaken from 1989 to 1994 to examine infants at 3 weeks and 6 months by measuring urinary catecholamine metabolites...
  4. ncbi request reprint Neuroblastoma: biological insights into a clinical enigma
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Rev Cancer 3:203-16. 2003
    ..Future therapies will focus increasingly on the genes and biological pathways that contribute to malignant transformation or progression...
  5. ncbi request reprint Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma
    P M Thompson
    Division of Oncology, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:679-86. 2001
    ..These results suggest that for neuroblastoma, large HDs do not occur within 1p36, most known TSGs are not homozygously deleted, and biallelic inactivation of CDKN2A may contribute to tumorigenicity in a subset of cases...
  6. ncbi request reprint Comprehensive analysis of chromosome 1p deletions in neuroblastoma
    J M Maris
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4138, USA
    Med Pediatr Oncol 36:32-6. 2001
    ..CONCLUSIONS: These data support the hypothesis that inactivation of a tumor suppressor gene within 1p36.3 is associated with an increased risk for disease relapse...
  7. ncbi request reprint Loss of heterozygosity for chromosome 14q in neuroblastoma
    P M Thompson
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4318, USA
    Med Pediatr Oncol 36:28-31. 2001
    ..These findings suggest that a tumor suppressor gene involved in the initiation or progression of neuroblastoma is located within distal 14q...
  8. ncbi request reprint High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas
    A Eggert
    Division of Oncology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 6:1900-8. 2000
    ..04). The redundancy in angiogenic factor expression suggests that inhibition of VEGF bioactivity alone might not be a sufficient approach for antiangiogenic therapy of human NB...
  9. ncbi request reprint TrkA signal transduction pathways in neuroblastoma
    A Eggert
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104, USA
    Med Pediatr Oncol 36:108-10. 2001
    ..This suggests differences from TrkA pathways identified in PC12 cells...
  10. ncbi request reprint Human Krüppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene?
    J M Maris
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania, USA
    Eur J Cancer 33:1991-6. 1997
    ..We conclude that HKR3 is a novel zinc finger gene that maps to a region of the genome commonly rearranged or deleted in neuroblastoma and other human cancers...
  11. ncbi request reprint Cloning, chromosomal localization, physical mapping, and genomic characterization of HKR3
    J M Maris
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA
    Genomics 35:289-98. 1996
    ..HKR3 is a novel zinc finger gene that maps to a region of the genome commonly rearranged or deleted in human cancers...
  12. ncbi request reprint Identification of a 1-megabase consensus region of deletion at 1p36.3 in primary neuroblastomas
    M D Hogarty
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 35:512-5. 2000
    ..In addition, neuroblastoma has been described in children with constitutional deletions within 1p36, supporting the existence of one or more neuroblastoma suppressor genes within this region...
  13. ncbi request reprint Allelic deletion at chromosome bands 11q14-23 is common in neuroblastoma
    J M Maris
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104 4138, USA
    Med Pediatr Oncol 36:24-7. 2001
    ..Neuroblastoma tumorigenesis may involve the differential inactivation of multiple tumor suppressor genes. Recent data have suggested that a neuroblastoma suppressor gene may be located on the long arm of chromosome 11 (11q)...
  14. ncbi request reprint Effect of CEP-751 (KT-6587) on neuroblastoma xenografts expressing TrkB
    A E Evans
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Med Pediatr Oncol 36:181-4. 2001
    ..The compound CEP-751 (KT-6587), a potent and selective inhibitor of the Trk family of tyrosine kinases, has been shown to inhibit the growth of human neuroblastoma (NB) xenografts in nude mice [1]...
  15. ncbi request reprint Detailed molecular analysis of 1p36 in neuroblastoma
    P S White
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 36:37-41. 2001
    ..Several lines of evidence es tablish that chromosome band 1p36 is frequently deleted in neuroblastoma primary tumors and cell lines, suggesting that a tumor suppressor gene within this region is involved in the development of this tumor...
  16. ncbi request reprint Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2
    P S White
    Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA USA
    Cytogenet Cell Genet 81:60-4. 1998
    ..This information should facilitate the mapping of tumor suppressor and genetic disease loci that have been localized to this region...
  17. ncbi request reprint Expression of the neurotrophin receptor TrkB is associated with unfavorable outcome in Wilms' tumor
    A Eggert
    Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Clin Oncol 19:689-96. 2001
    ..Conversely, TrkBtrunc expression is associated with excellent outcome, perhaps as a result of a dominant negative effect...
  18. ncbi request reprint BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification
    M D Hogarty
    Department of Pediatrics, University of Pennsylvania School of Medicine and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 35:559-62. 2000
    ..We hypothesized that BIN1, a MYC interacting protein capable of inducing apoptosis, may be an important regulator of MYCN in neuroblastoma...
  19. ncbi request reprint Analysis of genomic imprinting at 1p35-36 in neuroblastoma
    M D Hogarty
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 36:52-5. 2001
    ..2-36.3. Indirect evidence suggests the presence of an imprinted neuroblastoma suppressor gene within this region, as well as an additional nonimprinted, proximal suppressor gene, inactivation of which correlates with MYCN amplification...
  20. ncbi request reprint MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma
    M A Grotzer
    Division of Oncology, The Children s Hospital of Philadelphia, PA 19104, USA
    Clin Cancer Res 7:2425-33. 2001
    ....
  21. ncbi request reprint Expression of Apo-3 and Apo-3L in primitive neuroectodermal tumours of the central and peripheral nervous system
    A Eggert
    Division of Oncology and Biostatistics, The Children s Hospital of Philadelphia, PA 19104, USA
    Eur J Cancer 38:92-8. 2002
    ..01). Expression of Apo-3 was significantly associated with survival in PNET/medulloblastomas (P=0.03). Thus, the Apo-3 receptor/ligand system might be involved in the regulation of apoptosis in neuroblastomas and PNET...
  22. ncbi request reprint Expression and sequence analysis of candidates for the 1p36.31 tumor suppressor gene deleted in neuroblastomas
    E R Okawa
    Division of Oncology, The Children s Hospital of Philadelphia, Department of Pediatrics, The University of Pennsylvania, Philadelphia, PA 19104 4318, USA
    Oncogene 27:803-10. 2008
    ....
  23. ncbi request reprint Association among EPHB2, TrkA, and MYCN expression in low-stage neuroblastomas
    X X Tang
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4318, USA
    Med Pediatr Oncol 36:80-2. 2001
    ..Moreover, MYCN expression was correlated with TrkA expression (P < 0.01) in the low-stage NBs. CONCLUSIONS: This observation points to the possibility that MYCN expression might contribute to favorable outcome of low-stage NBs...
  24. pmc Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma
    X X Tang
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Proc Natl Acad Sci U S A 97:10936-41. 2000
    ....
  25. ncbi request reprint cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain
    X X Tang
    Division of Neurology Research, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 29:426-37. 1995
    ..Since the NET mRNA expression in human brain is developmentally regulated and is induced during neuronal differentiation, NET potentially plays important roles in human neurogenesis...
  26. ncbi request reprint Localization of a hereditary neuroblastoma predisposition gene to 16p12-p13
    M J Weiss
    Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 35:526-30. 2000
    ..Hereditary predisposition to develop neuroblastoma segregates as an autosomal dominant Mendelian trait...
  27. ncbi request reprint Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression
    A Eggert
    Division of Oncology, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:1314-9. 2001
    ..Because many cytotoxic drugs induce caspase-dependent apoptosis, failure to express caspase-8 and/or caspase-10 might be an important mechanism of resistance to chemotherapy in NB...
  28. ncbi request reprint Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)
    A Nakagawara
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 25:538-46. 1995
    ..5-kb band encodes the full-length TRK-B mRNA and the 8.0-kb band encodes the truncated form of TRK-B mRNA. By fluorescence in situ hybridization and somatic cell hybrid mapping, the human TRK-B gene was localized to chromosome 9q22.1...
  29. ncbi request reprint Physical mapping and genomic structure of the human TNFR2 gene
    C P Beltinger
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104 4318, USA
    Genomics 35:94-100. 1996
    ....
  30. ncbi request reprint ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers
    E P Sulman
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 40:371-4. 1997
    ..Taken together, the data suggest that ECK maps to 1p36.1, a region that is frequently deleted in neuroblastoma, melanoma, and other neuroectodermal tumors...
  31. ncbi request reprint Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family
    N Ikegaki
    Division of Oncology, Children s Hospital of Philadelphia, Abramson Research Center, PA 19104 4318, USA
    Hum Mol Genet 4:2033-45. 1995
    ..Thus, the DRT gene may play a part in neuroblastoma and SCLC tumorigenesis...
  32. ncbi request reprint Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma
    X X Tang
    Division of Oncology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Clin Cancer Res 5:455-60. 1999
    ..These results suggest that the EPHB subgroup receptor kinases may modulate the biological behavior of SCLC through autocrine and/or juxtacrine activation by ephrin-B ligands that are expressed in the same or neighboring cells...
  33. ncbi request reprint Outcomes of children with intermediate-risk neuroblastoma after treatment stratified by MYCN status and tumor cell ploidy
    Rochelle Bagatell
    University of Arizona, Department of Pediatrics and Steele Children s Research Center, Tuscon, AZ, USA
    J Clin Oncol 23:8819-27. 2005
    ..The goal of Pediatric Oncology Group 9243 was to improve outcomes for children with intermediate-risk neuroblastoma (NB)...
  34. ncbi request reprint Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number
    Qun Wang
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104 4399, USA
    Cancer Res 66:6050-62. 2006
    ..Lead positional candidates for neuroblastoma suppressor genes can be inferred from these data, but the potential multiplicity of transcripts involved has significant implications for ongoing gene discovery strategies...
  35. doi request reprint Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group
    Jennifer Schneiderman
    Children s Memorial Hospital, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    J Clin Oncol 26:913-8. 2008
    ..To determine the clinical significance of MYCN amplification in children with favorable-stage NB, we performed a retrospective review of data from the Pediatric Oncology Group (POG) biology study 9047...
  36. pmc A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene
    Kristina A Cole
    Division of Oncology, Children s Hospital of Philadelphia, Abramson Pediatric Research Center 902A, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    Mol Cancer Res 6:735-42. 2008
    ..BCL2 and MYCN were identified as miR-34a targets and likely mediators of the tumor suppressor phenotypic effect. These data support miR-34a as a tumor suppressor gene in human neuroblastoma...
  37. pmc CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas
    Tomoyuki Fujita
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Natl Cancer Inst 100:940-9. 2008
    ..31 that encodes 23 genes. Based on mutation analysis, expression pattern, and putative function, we identified CHD5 as the best tumor suppressor gene candidate...
  38. pmc Identification of ALK as a major familial neuroblastoma predisposition gene
    Yael P Mosse
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 455:930-5. 2008
    ....
  39. ncbi request reprint Chromosome 1p and 11q deletions and outcome in neuroblastoma
    Edward F Attiyeh
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA 19104 4318, USA
    N Engl J Med 353:2243-53. 2005
    ..Neuroblastoma is a childhood cancer with considerable morbidity and mortality. Tumor-derived biomarkers may improve risk stratification...
  40. ncbi request reprint Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study
    Rani E George
    Department of Pediatric Hematology and Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 23:6466-73. 2005
    ..To determine predictive strength of tumor cell ploidy and MYCN gene amplification on survival of children older than 12 months with disseminated neuroblastoma (NB)...
  41. ncbi request reprint Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13
    John M Maris
    Department of Pediatrics, University of Pennsylvania School of Medicine and Children s Hospital of Philadelphia, Abramson Pediatric Research Center, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 62:6651-8. 2002
    ..Taken together, these data suggest that a hereditary neuroblastoma predisposition gene (HNB1) is located at 16p12-13 and that disruption of this gene may contribute to the pathogenesis of nonfamilial neuroblastomas...
  42. ncbi request reprint Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma
    Peter S White
    Division of Oncology, The Children s Hospital of Philadelphia, 3516 Civic Center Blvd, Philadelphia, PA 19104, USA
    Oncogene 24:2684-94. 2005
    ..Together, these results suggest that one or more genes involved in neuroblastoma tumorigenesis or tumor progression are likely contained within this region...
  43. ncbi request reprint Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas
    Johannes H Schulte
    University Children s Hospital of Essen, Germany
    Oncogene 24:165-77. 2005
    ..Fine-tuning of the malignant phenotype may be achieved by additional ligand stimulation with subsequent activation of a few specific genes...
  44. ncbi request reprint CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system
    Patricia M Thompson
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Oncogene 22:1002-11. 2003
    ..These findings suggest that this gene may play a role in the development of the nervous system, and it may also play a role in the pathogenesis of neural tumors...
  45. ncbi request reprint Commentary on Kaneko et al.: Intensified chemotherapy increases the survival rates in patients with stage 4 neuroblastoma with MYCN amplification
    Garrett M Brodeur
    J Pediatr Hematol Oncol 24:608-9. 2002
  46. ncbi request reprint Expression of the neurotrophin receptor TrkA down-regulates expression and function of angiogenic stimulators in SH-SY5Y neuroblastoma cells
    Angelika Eggert
    Division of Oncology, The Children s Hospital of Philadelphia and Department of Pediatrics, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 62:1802-8. 2002
    ..The biologically different behavior of TrkA- and TrkB-expressing NBs may be explained in part by their effects on angiogenesis...
  47. ncbi request reprint No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3
    Michael D Hogarty
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 62:6481-4. 2002
    ..58). These data strongly refute a parent-of-origin effect for 1p deletions in NB and exclude the existence of an imprinted NB suppressor locus in this region...
  48. ncbi request reprint Resistance to chemotherapy mediated by TrkB in neuroblastomas
    Ruth Ho
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 62:6462-6. 2002
    ..Activation of PI3K/AKT survival pathway may contribute to the increased drug resistance in TrkB-expressing neuroblastomas...
  49. ncbi request reprint Proliferation of human neuroblastomas mediated by the epidermal growth factor receptor
    Ruth Ho
    Division of Oncology, Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 65:9868-75. 2005
    ..Our results also indicate that ZD1839 is a potent inhibitor of neuroblastoma cell proliferation; therefore, it may be a useful, biologically based therapeutic agent for these tumors...
  50. ncbi request reprint Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34
    Erik P Sulman
    The Fels Institute for Molecular Biology and Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Oncogene 23:1014-20. 2004
    ..This annotation of a putative tumor suppressor locus provides a resource for further analysis of meningioma candidate genes...

Research Grants24

  1. Effect of Trk Expression and Inhibition in Neuroblastoma
    GARRETT BRODEUR; Fiscal Year: 2005
    ..Given the increasing evidence for a role of Trk receptors in a variety of pediatric and adult tumors, these data would argue strongly for the utility of Trk receptor inhibition in therapy, alone or in combination. ..
  2. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2005
    ..Finally, deletions of 1p36 are found in many other cancers, so the identification of this TSG could have broad implications for many forms of neoplasia. ..
  3. Effect of Trk Expression and Inhibition in Neuroblastoma
    GARRETT BRODEUR; Fiscal Year: 2006
    ..Given the increasing evidence for a role of Trk receptors in a variety of pediatric and adult tumors, these data would argue strongly for the utility of Trk receptor inhibition in therapy, alone or in combination. ..
  4. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2006
    ..Finally, deletions of 1p36 are found in many other cancers, so the identification of this TSG could have broad implications for many forms of neoplasia. ..
  5. Cancer center research training program
    GARRETT BRODEUR; Fiscal Year: 2007
    ....
  6. Neuroblastoma Biology and Therapy
    GARRETT BRODEUR; Fiscal Year: 2007
    ..P75 and Trk in Neuroblastoma Differentiation and Death (Garrett Brodeur, Leader). Project 2. Antiangiogenic Strategies for Neuroblastoma Therapy (John Maris, Leader) Project 3...
  7. Trk Expression and Inhibition in Human Neuroblastomas
    GARRETT BRODEUR; Fiscal Year: 2009
    ..We will also determine the optimum Trk inhibitor (agent, dose, schedule) to incorporate into future clinical trials, and we will determine which tumors express Trk receptors to identify who would benefit from Trk inhibitor therapy. ..
  8. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2009
    ....
  9. Trk Expression and Inhibition in Human Neuroblastomas
    Garrett M Brodeur; Fiscal Year: 2010
    ..We will also determine the optimum Trk inhibitor (agent, dose, schedule) to incorporate into future clinical trials, and we will determine which tumors express Trk receptors to identify who would benefit from Trk inhibitor therapy. ..
  10. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2004
    ..Finally, deletions of 1p36 are found in many other cancers, so the identification of this TSG could have broad implications for many forms of neoplasia. ..
  11. Effect of Trk Expression and Inhibition in Neuroblastoma
    GARRETT BRODEUR; Fiscal Year: 2004
    ..Given the increasing evidence for a role of Trk receptors in a variety of pediatric and adult tumors, these data would argue strongly for the utility of Trk receptor inhibition in therapy, alone or in combination. ..
  12. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 1999
    ..The final specific aim is to clone and characterize the neuroblastoma TSG and use transgenic mice experiments to determine gene function. ..
  13. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 1993
    ..They will be extended to all samples studied, and they should allow us to address issues of tumor heterogeneity and progression within and between primary and metastatic lesions...
  14. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2000
    ..The final specific aim is to clone and characterize the neuroblastoma TSG and use transgenic mice experiments to determine gene function. ..
  15. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2001
    ..The final specific aim is to clone and characterize the neuroblastoma TSG and use transgenic mice experiments to determine gene function. ..
  16. Effect of Trk Expression and Inhibition in Neuroblastoma
    GARRETT BRODEUR; Fiscal Year: 2002
    ..Given the increasing evidence for a role of Trk receptors in a variety of pediatric and adult tumors, these data would argue strongly for the utility of Trk receptor inhibition in therapy, alone or in combination. ..
  17. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    GARRETT BRODEUR; Fiscal Year: 2003
    ..Finally, deletions of 1p36 are found in many other cancers, so the identification of this TSG could have broad implications for many forms of neoplasia. ..
  18. Effect of Trk Expression and Inhibition in Neuroblastoma
    GARRETT BRODEUR; Fiscal Year: 2003
    ..Given the increasing evidence for a role of Trk receptors in a variety of pediatric and adult tumors, these data would argue strongly for the utility of Trk receptor inhibition in therapy, alone or in combination. ..
  19. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    Garrett M Brodeur; Fiscal Year: 2010
    ....