Russell R Broaddus

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas
    Russell R Broaddus
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Tex, USA
    Am J Obstet Gynecol 190:686-92. 2004
  2. ncbi request reprint Neuroendocrine tumors (carcinoid and neuroendocrine carcinoma) presenting at extra-appendiceal sites in childhood and adolescence
    Russell R Broaddus
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Arch Pathol Lab Med 127:1200-3. 2003
  3. pmc Molecular clustering of endometrial carcinoma based on estrogen-induced gene expression
    Shannon N Westin
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer Biol Ther 8:2126-35. 2009
  4. ncbi request reprint Hypomethylation-induced expression of S100A4 in endometrial carcinoma
    Ran Xie
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 20:1045-54. 2007
  5. doi request reprint Phase II trial of imatinib mesylate in patients with recurrent platinum- and taxane-resistant low-grade serous carcinoma of the ovary, peritoneum, or fallopian tube
    Ignacio Romero Noguera
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    Gynecol Oncol 125:640-5. 2012
  6. pmc S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signaling
    Ran Xie
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Lab Invest 89:937-47. 2009
  7. ncbi request reprint Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?
    Pamela T Soliman
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 23:9344-50. 2005
  8. doi request reprint Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
    Karen H Lu
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Clin Cancer Res 14:2543-50. 2008
  9. doi request reprint ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease
    Meenakshi Singh
    Department of Pathology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Mod Pathol 21:912-23. 2008
  10. ncbi request reprint Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer
    Karen H Lu
    Department of Gynecologic Oncology, Division of Surgery, The University of Texas M D Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, TX 77030 4009, USA
    J Clin Oncol 25:5158-64. 2007

Detail Information

Publications71

  1. ncbi request reprint The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas
    Russell R Broaddus
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Tex, USA
    Am J Obstet Gynecol 190:686-92. 2004
    ..This study examined the effects of the chemopreventive agents 4-(N-hydroxyphenyl)retinamide (4-HPR) and alpha-difluoromethylornithine (DFMO) on leiomyoma growth...
  2. ncbi request reprint Neuroendocrine tumors (carcinoid and neuroendocrine carcinoma) presenting at extra-appendiceal sites in childhood and adolescence
    Russell R Broaddus
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Arch Pathol Lab Med 127:1200-3. 2003
    ..We reviewed the clinicopathologic characteristics of 13 carcinoid tumors and neuroendocrine carcinomas presenting at extra-appendiceal sites to better characterize this rare set of neoplasms in childhood...
  3. pmc Molecular clustering of endometrial carcinoma based on estrogen-induced gene expression
    Shannon N Westin
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer Biol Ther 8:2126-35. 2009
    ..This proof-of-concept study demonstrates that biomarker analysis may play a role in clinical decision making for the therapy of women with endometrial cancer...
  4. ncbi request reprint Hypomethylation-induced expression of S100A4 in endometrial carcinoma
    Ran Xie
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 20:1045-54. 2007
    ..These results support the emerging concept that hypomethylation may play a role in the upregulation of genes during later stages of tumorigenesis...
  5. doi request reprint Phase II trial of imatinib mesylate in patients with recurrent platinum- and taxane-resistant low-grade serous carcinoma of the ovary, peritoneum, or fallopian tube
    Ignacio Romero Noguera
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    Gynecol Oncol 125:640-5. 2012
    ..To evaluate the efficacy and tolerability of imatinib mesylate in patients with recurrent low-grade serous carcinoma (LGSC) of the ovary, peritoneum, or fallopian tube...
  6. pmc S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signaling
    Ran Xie
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Lab Invest 89:937-47. 2009
    ..These results also suggest that endometrial cancer cell invasion and fibrosis share common molecular mechanisms...
  7. ncbi request reprint Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?
    Pamela T Soliman
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 23:9344-50. 2005
    ..The purpose of our study was to determine the likelihood of MMR defects (MSH2, MSH6, MLH1) in women with synchronous endometrial and ovarian cancer...
  8. doi request reprint Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
    Karen H Lu
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Clin Cancer Res 14:2543-50. 2008
    ....
  9. doi request reprint ZEB1 expression in type I vs type II endometrial cancers: a marker of aggressive disease
    Meenakshi Singh
    Department of Pathology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Mod Pathol 21:912-23. 2008
    ..It may help identify women who would most benefit from chemotherapy. Furthermore, if expression of ZEB1 in type II endometrial cancers could be reversed, it might be exploited as therapy for these highly aggressive tumors...
  10. ncbi request reprint Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer
    Karen H Lu
    Department of Gynecologic Oncology, Division of Surgery, The University of Texas M D Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, TX 77030 4009, USA
    J Clin Oncol 25:5158-64. 2007
    ..The purpose of this study was to determine the prevalence of MLH1, MSH2, and MSH6 mutations in an unselected cohort of women diagnosed with endometrial cancer at age younger than 50 years...
  11. pmc Enhanced estrogen-induced proliferation in obese rat endometrium
    Qian Zhang
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Obstet Gynecol 200:186.e1-8. 2009
    ..We tested the hypothesis that the proliferative estrogen effect on the endometrium is enhanced in obese vs lean animals...
  12. pmc Molecular clustering based on ERα and EIG121 predicts survival in high-grade serous carcinoma of the ovary/peritoneum
    Matthew P Schlumbrecht
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 24:453-62. 2011
    ..Such a biomarker panel may potentially be used to guide management with estrogen antagonists in this patient population...
  13. pmc Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse
    Heather L Franco
    Department of Molecular and Cellular Biology, Department of Molecular and Human Genetics, The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 82:991-9. 2010
    ..Thus, constitutive activation of Smo in the mouse uterus alters postnatal uterine differentiation which interferes with early pregnancy. These results provide new insight into the role of Hedgehog signaling during embryo implantation...
  14. doi request reprint Primary peritoneal cancer after bilateral salpingo-oophorectomy in two patients with Lynch syndrome
    Kathleen M Schmeler
    Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230 1439, USA
    Obstet Gynecol 115:432-4. 2010
    ..We describe two cases of primary peritoneal cancer after BSO in women with Lynch syndrome or HNPCC...
  15. doi request reprint Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma
    Adrienne S McCampbell
    Department of Pathology, Science Park Research Division, The University of Texas M D Anderson Cancer Center, 1808 Park Road 1C, Smithville, TX 78957, USA
    Cancer Prev Res (Phila) 3:290-300. 2010
    ....
  16. ncbi request reprint Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas
    Jimmy J Caudell
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Appl Immunohistochem Mol Morphol 13:167-70. 2005
    ..These results indicate that many uterine sarcomas express 1 or more of the kinases targeted by imatinib mesylate and that further investigation of imatinib as a therapy for uterine sarcomas is warranted...
  17. pmc Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease
    Jae Wook Jeong
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:8677-82. 2009
    ..Since Mig-6 is regulated by both PR and SRC-1, this identifies a PR, SRC-1, Mig-6 regulatory pathway that is critical in the suppression of endometrial cancer...
  18. ncbi request reprint Expression of imatinib mesylate-targeted kinases in endometrial carcinoma
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Gynecol Oncol 95:32-6. 2004
    ..To determine whether imatinib mesylate could be a potentially useful agent in the treatment of endometrial cancer, we assessed the expressions of Abl, c-Kit, and PDGFR in both primary and recurrent endometrial carcinoma...
  19. ncbi request reprint Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma
    Russell R Broaddus
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:87-94. 2006
    ..It was the purpose of this study to pathologically characterize a series of HNPCC associated endometrial carcinomas...
  20. pmc Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice
    Xiangsheng Zuo
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 104:709-16. 2012
    ....
  21. doi request reprint A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 116:5415-9. 2010
    ..Loss of PTEN or activation of PIK3CA results in constitutive activation of AKT, which leads to up-regulation of mammalian target of rapamycin (mTOR). Everolimus is an oral rapamycin analog that acts by selectively inhibiting mTOR...
  22. pmc Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome
    Shannon N Westin
    Department of Gynecologic Oncology and Division of Quantitative Sciences, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 26:5965-71. 2008
    ..We performed a case-comparison study to document the clinicopathologic characteristics of LUS tumors and their association with risk factors for endometrial cancer...
  23. pmc Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling
    Heather L Franco
    Departments of Molecular and Cellular Biology and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Biol Reprod 82:783-90. 2010
    ..Thus, Ihh regulates embryo implantation by having an impact on the cell cycle, EGF signaling, and E2 signaling...
  24. ncbi request reprint The BRK tyrosine kinase is expressed in high-grade serous carcinoma of the ovary
    Rosemarie E Schmandt
    Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230 1439, USA
    Cancer Biol Ther 5:1136-41. 2006
    ..Its expression in normal ovary and ovarian tumors has not previously been described, and is the focus of this study...
  25. ncbi request reprint Lymphatic mapping and sentinel node biopsy in women with high-risk endometrial cancer
    Michael Frumovitz
    Department of Gynecologic Oncology, CPB6 3244, Unit 1362, The University of Texas M D Anderson Cancer Center, 1155 Herman Pressler, TX 77030, USA
    Gynecol Oncol 104:100-3. 2007
    ..To evaluate fundal injection of blue dye and radiocolloid for lymphatic mapping and sentinel node identification in women with high-risk endometrial cancer...
  26. pmc AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27
    John D Short
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 68:6496-506. 2008
    ....
  27. pmc Differential roles of telomere attrition in type I and II endometrial carcinogenesis
    Esra A Akbay
    Department of Pathology, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Am J Pathol 173:536-44. 2008
    ..Based on this and previous studies, we propose a model in which telomere attrition contributes to the initiation of TII and progression of TI endometrial cancers...
  28. ncbi request reprint Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases
    Pamela T Soliman
    Department of Gynecologic Oncology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Gynecol Oncol 94:456-62. 2004
    ..The purpose of this study was to characterize patients diagnosed with synchronous primary cancers of the endometrium and ovary with an emphasis on risk factors...
  29. doi request reprint Sex hormone regulation of survivin gene expression
    Nancy H Nabilsi
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5 132A, Houston, Texas 77030, USA
    J Endocrinol 207:237-43. 2010
    ..The data also suggest that survivin transcript may be used as a biomarker of estrogen and progestin treatment efficacy, but validation studies must be conducted to support this conclusion...
  30. ncbi request reprint Phase II trial of imatinib mesylate in patients with recurrent platinum- and taxane-resistant epithelial ovarian and primary peritoneal cancers
    Robert L Coleman
    Department of Gynecologic Oncology, Pathology, and Gynecologic Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 101:126-31. 2006
    ..To evaluate the efficacy and tolerability of imatinib mesylate (Gleevec; Novartis Pharmaceuticals, Basel, Switzerland) in patients with recurrent ovarian and primary peritoneal cancer...
  31. ncbi request reprint Her-2/neu overexpression and amplification in uterine papillary serous carcinoma
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 440, Houston, TX 77030 4009, USA
    J Clin Oncol 22:3126-32. 2004
    ..The purpose of this study was to evaluate the protein expression and gene amplification of Her-2/neu in UPSC and to determine its prognostic value...
  32. ncbi request reprint Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model
    Michael R Milam
    Department of Gynecologic Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Obstet Gynecol 196:247.e1-5. 2007
    ..The objective of this study was to evaluate an oral mTOR inhibitor (mTOR-I) on the reduction of endometrial hyperplasia in an animal model...
  33. pmc Clinical and biological impact of EphA2 overexpression and angiogenesis in endometrial cancer
    William M Merritt
    Department of Gynecologic Oncology, Anderson Cancer Center, Houston, TX, USA
    Cancer Biol Ther 10:1306-14. 2010
    ....
  34. pmc Endometrial cancer and Lynch syndrome: clinical and pathologic considerations
    Larissa A Meyer
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Cancer Control 16:14-22. 2009
    ..Lynch syndrome is associated with early onset of cancer and the development of multiple cancer types, particularly colon and endometrial cancer...
  35. doi request reprint Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat
    Adrienne S McCampbell
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Lab Invest 88:615-26. 2008
    ....
  36. doi request reprint Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
    Cristina M Contreras
    Department of Pathology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    Cancer Res 68:759-66. 2008
    ..This study shows that Lkb1 plays an important role in the malignant transformation of endometrium and that Lkb1 loss promotes a highly invasive phenotype...
  37. ncbi request reprint Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas
    Seetharaman Balasenthil
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 37:656-61. 2006
    ..7%) tumors. In grade 1 and grade 2 tumors, MTA1 was present in both nucleus and cytoplasm. Interestingly, in grade 3 tumors, MTA1 was localized in the cytoplasm only. Our results suggest a potential role of MTA1 in endometrial carcinomas...
  38. ncbi request reprint Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium
    Adrienne S McCampbell
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:6373-8. 2006
    ..Although there is considerable information on the molecular aberrations associated with endometrial cancer, very little is known of the changes in gene expression associated with endometrial hyperplasia...
  39. ncbi request reprint Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer
    Michael R Milam
    Department of Gynecologic Oncology, The University of Texas, Unit 1362, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Gynecol Oncol 106:12-5. 2007
    ..To determine the association between findings on review of preoperative biopsy specimens and the risk of lymph node involvement (LNI) at radical hysterectomy in patients with early-stage cervical cancer...
  40. ncbi request reprint Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis
    Lixia Liu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:1632-40. 2005
    ..044). Our study shows that in neuroendocrine tumors epigenetic alterations vary by tumor subsite and clinicopathologic features, including age of onset, histopathologic type and metastasis status...
  41. pmc Identification of cancer patients with Lynch syndrome: clinically significant discordances and problems in tissue-based mismatch repair testing
    Angela N Bartley
    Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Prev Res (Phila) 5:320-7. 2012
    ..Thus, a major consequence of the use of immunohistochemistry by itself as a screen is the failure to identify colorectal and endometrial cancer patients who likely have Lynch syndrome...
  42. doi request reprint Clinicodemographic factors influencing outcomes in patients with low-grade serous ovarian carcinoma
    Matthew P Schlumbrecht
    Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 117:3741-9. 2011
    ..The objective of this study was to determine whether patient demographic factors and clinical treatment histories affected survival in a population of women with LGSC...
  43. pmc Functional regulation of oestrogen receptor pathway by the dynein light chain 1
    Suresh K Rayala
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    EMBO Rep 6:538-44. 2005
    ..Together, these data define an unexpected upregulation of DLC1 by oestrogen and a previously unrecognized DLC1-ER interaction in supporting and amplifying ER-initiated cellular responses in breast cancer cells...
  44. pmc The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action
    Tae Hoon Kim
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Oncol 2010:139087. 2010
    ..Therefore, these results suggest a synergistic effect of dysregulation of the Pten and K-ras signaling pathways during endometrial tumorigenesis...
  45. pmc Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis
    Xiangsheng Zuo
    Department of Clinical Cancer Prevention, Unit 1360, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Natl Cancer Inst 101:762-7. 2009
    ..Increased expression of vascular endothelial growth factor in colon tumors vs normal colon was suppressed by loss of PPAR-delta expression. These findings indicate that PPAR-delta has a crucial role in promoting colonic tumorigenesis...
  46. pmc Critical Tumor Suppressor Function Mediated by Epithelial Mig-6 in Endometrial Cancer
    Tae Hoon Kim
    Authors Affiliations Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, Grand Rapids, Michigan Department of Molecular and Cellular Biology, Baylor College of Medicine Departments of Genetics and Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea and WCU Biomodulation Program, Seoul National University, Seoul, Republic of Korea
    Cancer Res 73:5090-5099. 2013
    ..In summary, our results establish that epithelial Mig-6 functions as a critical tumor suppressor that mediates the ability of progesterone to prevent the development of endometrial cancer. Cancer Res; 73(16); 5090-9. ©2013 AACR...
  47. pmc Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer
    Bryan T J Hennessy
    Department of Gynecology Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 28:3570-6. 2010
    ..3%. It is important to determine the frequency of somatic BRCA(1/2) changes, given the sensitivity of BRCA-mutated cancers to poly (ADP ribose) polymerase-1 (PARP1) inhibitors and platinum analogs...
  48. ncbi request reprint Frozen section analyses as predictors of lymphatic spread in patients with early-stage uterine cancer
    Michael Frumovitz
    Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 199:388-93. 2004
    ..This clinical decision method has never been critically examined...
  49. ncbi request reprint Gynecologic Cancers in Lynch Syndrome/HNPCC
    Karen H Lu
    Department of Gynecologic Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA
    Fam Cancer 4:249-54. 2005
    ..With increasing evidence that women with Lynch/HNPCC have significant risks for both colon and endometrial cancers, we believe a multi-disciplinary approach to the management of these individuals is crucial...
  50. ncbi request reprint Women with HNPCC: a target population for the chemoprevention of gynecologic cancers
    Russell R Broaddus
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Front Biosci 11:2077-80. 2006
    ..The purpose of this review is to provide an analytical background about the current knowledge regarding gynecological cancers in patients with HNPCC...
  51. pmc Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing
    Bojana Djordjevic
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 25:699-708. 2012
    ..Therefore, for clinical purposes, immunohistochemistry appears to be a preferable technique for identifying endometrial tumors with loss of PTEN function...
  52. ncbi request reprint Gynecologic cancer as a "sentinel cancer" for women with hereditary nonpolyposis colorectal cancer syndrome
    Karen H Lu
    Department of Gynecologic Oncology, Division of Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Obstet Gynecol 105:569-74. 2005
    ..The purpose of this study was to estimate whether women with hereditary nonpolyposis colorectal cancer syndrome who develop 2 primary cancers present with gynecologic or colon cancer as their "sentinel cancer."..
  53. ncbi request reprint Identification of a novel estrogen-regulated gene, EIG121, induced by hormone replacement therapy and differentially expressed in type I and type II endometrial cancer
    Lei Deng
    Department of Pathology, University of Texas M D Anderson Cancer Center, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Clin Cancer Res 11:8258-64. 2005
    ..Here, we describe the expression pattern of a novel estrogen-induced gene, EIG121, in distinct types of endometrial cancer...
  54. pmc Prospective Multicenter Randomized Intermediate Biomarker Study of Oral Contraceptive versus Depo-Provera for Prevention of Endometrial Cancer in Women with Lynch Syndrome
    Karen H Lu
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1155 Hermann Pressler Dr, Unit 1362, Houston, TX 77030
    Cancer Prev Res (Phila) 6:774-81. 2013
    ..Cancer Prev Res; 6(8); 774-81. ©2013 AACR. ..
  55. doi request reprint Somatic deletions of the polyA tract in the 3' untranslated region of epidermal growth factor receptor are common in microsatellite instability-high endometrial and colorectal carcinomas
    Ma Deqin
    Division of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, 8515 Fannin Street, Houston, TX 77054, USA
    Arch Pathol Lab Med 136:510-6. 2012
    ..This phenomenon has not been reported in other MSI-H tumors...
  56. pmc Personalized therapy in endometrial cancer: challenges and opportunities
    Shannon N Westin
    Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cancer Biol Ther 13:1-13. 2012
    ..traditional chemotherapy or radiation treatment. This review will discuss relevant pathways to target in endometrial cancer as well as the challenges that arise during development of a personalized oncology approach...
  57. ncbi request reprint Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma
    Kevin D Houston
    University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Cancer Res 63:1221-7. 2003
    ..These results suggest that in uterine leiomyomas PPARgamma activation is growth inhibitory and that this inhibition is mediated at least in part by negative cross-talk between ER and PPAR signaling pathways...
  58. pmc Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors
    Ratna K Vadlamudi
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    J Clin Endocrinol Metab 89:6130-8. 2004
    ..In addition, PELP1 and ERbeta were localized predominantly in the cytoplasm of high-grade endometrial tumors. Our results suggest that PELP1 plays an essential role in the proliferation of cancerous endometrial cells...
  59. pmc CpG island methylation in aberrant crypt foci of the colorectum
    Annie On On Chan
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 160:1823-30. 2002
    ....
  60. pmc Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer
    Han Liang
    Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Genome Res 22:2120-9. 2012
    ..Our study presents the first unbiased view of somatic coding mutations in endometrial cancer and provides functional evidence for diverse driver genes and mutations in this disease...
  61. doi request reprint Primary liver sarcoma in an immunocompetent patient with hepatitis C virus infection
    Amer A Alkhatib
    Department of Internal Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
    Am J Clin Oncol 31:207-8. 2008
  62. pmc Regulation of inflammatory responses by IL-17F
    Xuexian O Yang
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 205:1063-75. 2008
    ..Our results thus demonstrate that IL-17F is an important regulator of inflammatory responses that seems to function differently than IL-17 in immune responses and diseases...
  63. ncbi request reprint Uterine papillary serous carcinoma (UPSC): a single institution review of 129 cases
    Brian M Slomovitz
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gynecol Oncol 91:463-9. 2003
    ..The identified characteristics were then correlated with overall survival (OS)...
  64. ncbi request reprint Unusual tumors associated with the hereditary nonpolyposis colorectal cancer syndrome
    Russell R Broaddus
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 17:981-9. 2004
    ..Therefore, when analyzing unusual tumors in patients with known or suspected HNPCC syndrome, we advocate the performance of immunohistochemistry for mismatch repair gene products in addition to microsatellite instability analysis...
  65. ncbi request reprint Florid cystic endosalpingiosis presenting as an obstructive colon mass mimicking malignancy: case report and literature review
    John J Liang
    Department of Pathology, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Gastrointest Cancer 38:83-6. 2007
    ..To our knowledge, this is only the second reported case in the English literature of this entity presenting as an obstructive colon mass...
  66. ncbi request reprint Generation of a Mig-6 conditional null allele
    Nili Jin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 45:716-21. 2007
    ..In addition, these mice also had enlarged uteri with endometrial hyperplasia. In summary, this Mig-6(f/f) mouse is a useful tool for the functional study of the Mig-6 gene in a tissue-specific fashion...
  67. doi request reprint Pathologic scoring of PTEN immunohistochemistry in endometrial carcinoma is highly reproducible
    Karuna Garg
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Gynecol Pathol 31:48-56. 2012
    ..Our study shows that evaluation of PTEN loss by immunohistochemistry is highly reproducible with the application of standard immunohistochemical techniques and simple scoring criteria...
  68. doi request reprint Role of PELP1/MNAR signaling in ovarian tumorigenesis
    Chakravarty Dimple
    Department of Obstetrics and Gynecology and Cancer Research and Therapy Center at The University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Res 68:4902-9. 2008
    ..Collectively, these results suggest that PELP1/MNAR signaling plays a role in ovarian cancer cell proliferation and survival, and that its expression is deregulated in ovarian carcinomas...
  69. ncbi request reprint Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia
    Jennifer M Rubatt
    Department of Obstetrics and Gynecology, VCUMC Medical College of Virginia, VA 23287, USA
    Gynecol Oncol 99:472-6. 2005
    ..The risk of progression to a high-stage endometrial cancer is quite low, with only two previously reported cases in the English literature...
  70. ncbi request reprint PTEN expression in tamoxifen-associated endometrial cancers
    David Holtz
    Thomas Jefferson University, 111S 11th Street, 620 Gibbon Building, Department of Obstetrics and Gynecology, Philadelphia, PA 19107, USA
    Anticancer Res 22:2945-8. 2002
    ..PTEN, a tumor suppressor gene, is altered in low-grade endometrial carcinoma. This study evaluates PTEN immunohistochemical (IHC) expression in tamoxifen-associated endometrial cancers...
  71. ncbi request reprint The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers
    Nicole S Spoelstra
    Department of Medicine, Division of Endocrinology, University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO 80045, USA
    Cancer Res 66:3893-902. 2006
    ....