Laurence M Brill

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Comprehensive proteomic analysis of Schizosaccharomyces pombe by two-dimensional HPLC-tandem mass spectrometry
    Laurence M Brill
    NCI Cancer Center Proteomics Facility, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Methods 48:311-9. 2009
  2. pmc Phosphoproteomic analysis of human embryonic stem cells
    Laurence M Brill
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92109, USA
    Cell Stem Cell 5:204-13. 2009
  3. ncbi request reprint Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites
    Scott B Ficarro
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Rapid Commun Mass Spectrom 19:57-71. 2005
  4. doi request reprint Combined total proteomic and phosphoproteomic analysis of human pluripotent stem cells
    Junjie Hou
    Advanced Proteomics, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Methods Mol Biol 1029:163-89. 2013
  5. ncbi request reprint A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways
    Mridul Mukherji
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:15529-40. 2006
  6. ncbi request reprint Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry
    Laurence M Brill
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Anal Chem 76:2763-72. 2004
  7. ncbi request reprint An automated noncontact deposition interface for liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry
    Christer Ericson
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Anal Chem 75:2309-15. 2003
  8. pmc Phosphoproteomic analysis: an emerging role in deciphering cellular signaling in human embryonic stem cells and their differentiated derivatives
    Brian T D Tobe
    The Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Stem Cell Rev 8:16-31. 2012
  9. pmc c-Myc phosphorylation by PKCζ represses prostate tumorigenesis
    Ji Young Kim
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:6418-23. 2013
  10. pmc Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry
    Arthur R Salomon
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:443-8. 2003

Collaborators

Detail Information

Publications12

  1. pmc Comprehensive proteomic analysis of Schizosaccharomyces pombe by two-dimensional HPLC-tandem mass spectrometry
    Laurence M Brill
    NCI Cancer Center Proteomics Facility, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Methods 48:311-9. 2009
    ..pombe proteome. In addition, these methods are widely applicable, having been used for proteomic profiling of several other organisms...
  2. pmc Phosphoproteomic analysis of human embryonic stem cells
    Laurence M Brill
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92109, USA
    Cell Stem Cell 5:204-13. 2009
    ..These results support the utility of phosphoproteomic data, provide guidance for investigating protein function in hESCs, and complement transcriptomics/epigenetics for broadening our understanding of hESC fate determination...
  3. ncbi request reprint Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites
    Scott B Ficarro
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Rapid Commun Mass Spectrom 19:57-71. 2005
    ....
  4. doi request reprint Combined total proteomic and phosphoproteomic analysis of human pluripotent stem cells
    Junjie Hou
    Advanced Proteomics, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Methods Mol Biol 1029:163-89. 2013
    ..We summarize additional data analysis procedures, the subject of ongoing efforts...
  5. ncbi request reprint A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways
    Mridul Mukherji
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:15529-40. 2006
    ..Selective depletion of some of these proteins, including RNA binding proteins SRRM2, SFRS1, SFRS9, and SFRS10, by siRNAs reduced the rate of migration of ErbB2-overexpressing ovarian cancer cells...
  6. ncbi request reprint Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry
    Laurence M Brill
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Anal Chem 76:2763-72. 2004
    ..These proteins had unknown functions or were associated with a plethora of fundamental cellular processes. This robust technology platform should be broadly applicable to profiling the dynamics of tyrosine phosphorylation...
  7. ncbi request reprint An automated noncontact deposition interface for liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry
    Christer Ericson
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    Anal Chem 75:2309-15. 2003
    ..To assess the behavior of the apparatus for complex mixtures, 5 microg of a tryptic digest of the cytosolic proteins of yeast was analyzed by LC/MALDI-MS and more than 13,500 unique analytes were detected in a single LC/MS analysis...
  8. pmc Phosphoproteomic analysis: an emerging role in deciphering cellular signaling in human embryonic stem cells and their differentiated derivatives
    Brian T D Tobe
    The Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Stem Cell Rev 8:16-31. 2012
    ..However, such studies have already begun to contribute to an improved and accelerated understanding of basic pluripotent stem cell signaling and fate control, especially at the systems-biology level...
  9. pmc c-Myc phosphorylation by PKCζ represses prostate tumorigenesis
    Ji Young Kim
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:6418-23. 2013
    ..Collectively, these results establish PKCζ as an important tumor suppressor and regulator of c-Myc function in prostate cancer...
  10. pmc Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry
    Arthur R Salomon
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:443-8. 2003
    ..This methodology should enable the rapid generation of new insights into signaling pathways as they occur in states of health and disease...
  11. pmc Dimerization of recombinant tobacco mosaic virus movement protein
    Laurence M Brill
    Department of Cell Biology, The Scripps Research Institute, Scripps Clinic, La Jolla, California 92037, USA
    J Virol 78:3372-7. 2004
    ..We propose that MP dimers are stabilized by electrostatic interactions in the C terminus as well as hydrophobic interactions between putative transmembrane alpha-helical coiled coils...
  12. ncbi request reprint Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis
    Flavio Cimadamore
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 8:538-51. 2011
    ..We found that SOX2 binds directly to NGN1 and MASH1 promoters and is required for their expression. Our data suggest that SOX2 plays a key role for NGN1-dependent acquisition of neuronal fates in sensory ganglia...