Roger Brent

Summary

Affiliation: The Molecular Sciences Institute
Country: USA

Publications

  1. ncbi request reprint Building an artificial regulatory system to understand a natural one
    Roger Brent
    The Molecular Sciences Institute, Berkeley, California 94704, USA
    Cell 116:S73-4, 1 p following S76. 2004
  2. ncbi request reprint A partnership between biology and engineering
    Roger Brent
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Biotechnol 22:1211-4. 2004
  3. ncbi request reprint Cell biology. A fishing buddy for hypothesis generators
    Roger Brent
    Molecular Sciences Institute, Berkeley, CA 94704, USA
    Science 308:504-6. 2005
  4. pmc Negative feedback that improves information transmission in yeast signalling
    Richard C Yu
    Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nature 456:755-61. 2008
  5. ncbi request reprint Regulated cell-to-cell variation in a cell-fate decision system
    Alejandro Colman-Lerner
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nature 437:699-706. 2005
  6. ncbi request reprint Using protein-DNA chimeras to detect and count small numbers of molecules
    Ian Burbulis
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Methods 2:31-7. 2005
  7. ncbi request reprint Automatic generation of cellular reaction networks with Moleculizer 1.0
    Larry Lok
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Biotechnol 23:131-6. 2005
  8. ncbi request reprint 2020 computing: can computers help to explain biology?
    Roger Brent
    The Molecular Sciences Institute, Berkeley, California 94704, USA
    Nature 440:416-7. 2006
  9. ncbi request reprint Quantifying small numbers of antibodies with a 'near-universal' protein-DNA chimera
    Ian Burbulis
    Center for Quantitative Genome Function and Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Methods 4:1011-3. 2007
  10. ncbi request reprint Single-cell quantification of molecules and rates using open-source microscope-based cytometry
    Andrew Gordon
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Methods 4:175-81. 2007

Research Grants

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Building an artificial regulatory system to understand a natural one
    Roger Brent
    The Molecular Sciences Institute, Berkeley, California 94704, USA
    Cell 116:S73-4, 1 p following S76. 2004
  2. ncbi request reprint A partnership between biology and engineering
    Roger Brent
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Biotechnol 22:1211-4. 2004
  3. ncbi request reprint Cell biology. A fishing buddy for hypothesis generators
    Roger Brent
    Molecular Sciences Institute, Berkeley, CA 94704, USA
    Science 308:504-6. 2005
  4. pmc Negative feedback that improves information transmission in yeast signalling
    Richard C Yu
    Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nature 456:755-61. 2008
    ..Our work suggests that negative feedback is a general mechanism used in signalling systems to align dose responses and thereby increase the fidelity of information transmission...
  5. ncbi request reprint Regulated cell-to-cell variation in a cell-fate decision system
    Alejandro Colman-Lerner
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nature 437:699-706. 2005
    ..Second, pathway capacity and expression capacity are negatively correlated, suggesting a compensatory mechanism that allows cells to respond more precisely to pheromone in the presence of a large variation in expression capacity...
  6. ncbi request reprint Using protein-DNA chimeras to detect and count small numbers of molecules
    Ian Burbulis
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Methods 2:31-7. 2005
    ..In crudely fractionated human serum, the assays were used to detect as few as 32,000 protective antigen molecules. Tadpoles thus enable sensitive detection and precise quantification of molecules other than DNA and RNA...
  7. ncbi request reprint Automatic generation of cellular reaction networks with Moleculizer 1.0
    Larry Lok
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Biotechnol 23:131-6. 2005
    ..We apply this approach to the automatic generation of reaction systems for the study of signal transduction networks...
  8. ncbi request reprint 2020 computing: can computers help to explain biology?
    Roger Brent
    The Molecular Sciences Institute, Berkeley, California 94704, USA
    Nature 440:416-7. 2006
  9. ncbi request reprint Quantifying small numbers of antibodies with a 'near-universal' protein-DNA chimera
    Ian Burbulis
    Center for Quantitative Genome Function and Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Methods 4:1011-3. 2007
    ..We used this tadpole in affinity capture assays followed by real-time PCR to quantify numerous molecules, including prostate-specific antigen (PSA) in human serum, with great sensitivity and accuracy...
  10. ncbi request reprint Single-cell quantification of molecules and rates using open-source microscope-based cytometry
    Andrew Gordon
    The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, California 94704, USA
    Nat Methods 4:175-81. 2007
    ..Owing to their sensitivity, accuracy and ability to track changes in individual cells over time, these microscope methods may complement flow-cytometric measurements for studies of the quantitative physiology of cellular systems...
  11. pmc Intuition and innumeracy
    Roger Brent
    The Molecular Sciences Institute, Center for Genomic Education and Computation, 2168 Shattuck Avenue, Berkeley, CA 94704, USA
    Cell Biol Educ 3:88-90. 2004
  12. doi request reprint Media preparation and bacteriological tools
    Karen Elbing
    Clark and Elbing LLP, Boston, Massachusetts, USA
    Curr Protoc Mol Biol . 2002
    ..Also included are descriptions and useful information about tools used with growth media such as inoculating loops, sterile toothpicks and spreaders...
  13. doi request reprint Growth in liquid media
    Karen Elbing
    Clark and Elbing LLP, Boston, Massachusetts, USA
    Curr Protoc Mol Biol . 2002
    ..coli from a single colony is described along with considerations for growing larger cultures. Also included are two methods for monitoring cell growth using a spectrophotometer or a hemacytometer...
  14. doi request reprint Growth on solid media
    Karen Elbing
    Clark and Elbing LLP, Boston, Massachusetts, USA
    Curr Protoc Mol Biol . 2002
    ..Support protocols describe replica plating as well as methods for storing strains as agar stabs or frozen glycerol stocks...

Research Grants3

  1. Tadpole Assays for the Molecular Assessment of Cancer
    Roger Brent; Fiscal Year: 2007
    ..During the next 3 years, we seek funding to develop and "harden" these assays to the point that they can be tested in clinical cancer diagnosis. ..