Darrell R Boverhof

Summary

Affiliation: The Dow Chemical Company
Country: USA

Publications

  1. ncbi request reprint Respiratory sensitization and allergy: current research approaches and needs
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland MI 48674, USA
    Toxicol Appl Pharmacol 226:1-13. 2008
  2. doi request reprint Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: A workshop summary
    Darrell R Boverhof
    The Dow Chemical Company, Midland, MI, United States Electronic address
    Regul Toxicol Pharmacol 68:96-107. 2014
  3. doi request reprint Assessment of the immunotoxic potential of trichloroethylene and perchloroethylene in rats following inhalation exposure
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, Dow Chemical Company, Midland, MI 48674, USA
    J Immunotoxicol 10:311-20. 2013
  4. doi request reprint Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA)
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 107:427-39. 2009
  5. doi request reprint A draining lymph node assay (DLNA) for assessing the sensitizing potential of proteins
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Toxicol Lett 193:144-51. 2010
  6. doi request reprint Transgenic animal models in toxicology: historical perspectives and future outlook
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 121:207-33. 2011
  7. doi request reprint Differential gene expression responses distinguish contact and respiratory sensitizers and nonsensitizing irritants in the local lymph node assay
    David Adenuga
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 126:413-25. 2012
  8. pmc An F1-Extended One-Generation Reproductive Toxicity Study in Crl:CD(SD) Rats With 2,4-Dichlorophenoxyacetic Acid
    Mary Sue Marty
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan
    Toxicol Sci 136:527-47. 2013
  9. doi request reprint Interlaboratory validation of 1% pluronic l92 surfactant as a suitable, aqueous vehicle for testing pesticide formulations using the murine local lymph node assay
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 105:79-85. 2008

Detail Information

Publications9

  1. ncbi request reprint Respiratory sensitization and allergy: current research approaches and needs
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, 1803 Building, Midland MI 48674, USA
    Toxicol Appl Pharmacol 226:1-13. 2008
    ..Ultimately, the development of a consistent, accurate and cost-effective model will likely incorporate a number of these approaches and will require effective communication, collaboration and consensus among all stakeholders...
  2. doi request reprint Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: A workshop summary
    Darrell R Boverhof
    The Dow Chemical Company, Midland, MI, United States Electronic address
    Regul Toxicol Pharmacol 68:96-107. 2014
    ..These workshop discussions should contribute to developing an effective but more resource and animal efficient approach for evaluating chemical immunotoxicity. ..
  3. doi request reprint Assessment of the immunotoxic potential of trichloroethylene and perchloroethylene in rats following inhalation exposure
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, Dow Chemical Company, Midland, MI 48674, USA
    J Immunotoxicol 10:311-20. 2013
    ..The results of these studies indicate that TCE had immunotoxic potential only at high exposure concentrations (1000 ppm), while PERC, at similar exposure concentrations, did not display any evidence of immunotoxicity. ..
  4. doi request reprint Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA)
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 107:427-39. 2009
    ..Overall, these experiments have systematically illustrated the potential utility of genomic endpoints to enhance the LLNA and support further exploration of this approach through examination of a more diverse array of chemicals...
  5. doi request reprint A draining lymph node assay (DLNA) for assessing the sensitizing potential of proteins
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Toxicol Lett 193:144-51. 2010
    ..These data illustrate both the opportunities and challenges associated with the examination of the draining lymph node proliferative response to assess the allergenic potential of proteins...
  6. doi request reprint Transgenic animal models in toxicology: historical perspectives and future outlook
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 121:207-33. 2011
    ..Perspectives are also shared on the future outlook for these models in toxicology and risk assessment and how transgenic technologies are likely to be an integral tool for toxicity testing in the 21st century...
  7. doi request reprint Differential gene expression responses distinguish contact and respiratory sensitizers and nonsensitizing irritants in the local lymph node assay
    David Adenuga
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 126:413-25. 2012
    ..Collectively, these data suggest that gene expression responses may serve as useful biomarkers to distinguish between respiratory and contact sensitizers and nonsensitizing irritants in the LLNA...
  8. pmc An F1-Extended One-Generation Reproductive Toxicity Study in Crl:CD(SD) Rats With 2,4-Dichlorophenoxyacetic Acid
    Mary Sue Marty
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan
    Toxicol Sci 136:527-47. 2013
    ..6mg/kg/day) and females (20.6mg/kg/day), which is approximately 6700- to 93 000-fold higher than that reported for 2,4-D exposures in human biomonitoring studies. ..
  9. doi request reprint Interlaboratory validation of 1% pluronic l92 surfactant as a suitable, aqueous vehicle for testing pesticide formulations using the murine local lymph node assay
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 105:79-85. 2008
    ..These data support testing aqueous compatible chemicals or pesticide formulations using the mouse LLNA, and provide additional support for the use of 1% aqueous L92 as a suitable, aqueous-based vehicle...