Research Topics
Genomes and Genes
| Ella Bossy-WetzelSummaryAffiliation: The Burnham Institute Country: USA Publications
| Collaborators
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Detail Information
Publications
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosisShu ichi Okamoto
Center for Neuroscience and Aging, Apoptosis and Cell Death Research Program, The Burnham Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:3974-9. 2002..Additionally, we show that similar MEF2 cleavage fragments are generated in vivo during focal stroke damage. Hence, this pathway appears to have pathophysiological relevance in vivo...
GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2Chunmei Zhao
Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 278:34641-53. 2003....- Mitochondrial fission in apoptosis, neurodegeneration and agingElla Bossy-Wetzel
Del E Webb Center for Neuroscience and Aging The Burnham Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
Curr Opin Cell Biol 15:706-16. 2003..A shift in the rate of mitochondrial fission or fusion may provide a new mechanistic explanation for the mitochondrial dysfunction in neurodegenerative diseases and normal aging, and may offer a new target for therapeutic intervention... - Molecular pathways to neurodegenerationElla Bossy-Wetzel
Center for Neuroscience and Aging, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Med 10:S2-9. 2004.... - Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neuronsMark J Barsoum
Apoptosis and Cell Death Program, Burnham Institute for Medical Research, La Jolla, CA, USA
EMBO J 25:3900-11. 2006..Importantly, NO-induced neuronal cell death was mitigated by Mfn1 and Drp1(K38A). Thus, persistent mitochondrial fission may play a causal role in NO-mediated neurotoxicity... - Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channelsElla Bossy-Wetzel
Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
Neuron 41:351-65. 2004..Thus, these data establish a new form of crosstalk between NO and Zn2+ apoptotic signal transduction pathways that may contribute to neurodegeneration... - A Golgi fragmentation pathway in neurodegenerationSaya Nakagomi
Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Neurobiol Dis 29:221-31. 2008..Taken together, these findings implicate the Golgi as a sensor of stress signals in cell death pathways... - Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cellsChangjun Zhu
Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Biochem J 389:373-81. 2005..Three-dimensional reconstruction imaging analysis suggests that recruitment of MKLP1 to the midzone/midbody by INCENP is a crucial step for the midbody formation and completion of cytokinesis in mammalian cells... - Spatiotemporal control of spindle midzone formation by PRC1 in human cellsChangjun Zhu
The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:6196-201. 2006..Our results thus indicate that PRC1 is an essential factor in controlling the spatiotemporal formation of the midzone in human cells... - Dueling activities of AIF in cell death versus survival: DNA binding and redox activityStuart A Lipton
Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
Cell 111:147-50. 2002..New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic... - New insights into mitochondrial structure during cell deathGuy Perkins
National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, 92093 0608, USA
Exp Neurol 218:183-92. 2009.... - OPA1 expression in the normal rat retina and optic nerveWon Kyu Ju
Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
J Comp Neurol 488:1-10. 2005..Thus, OPA1 is predominantly expressed in retinal ganglion cells of the normal rat retina and axons of the optic nerve. These findings may explain the selective vulnerability of retinal ganglion cells to OPA1 loss of function... - Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosisRobert Schwarzenbacher
The Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 279:29320-4. 2004..We conclude that CADD is a novel redox protein toxin unique to Chlamydia species and propose that both its redox activity and death domain binding ability are required for its biological activity... - Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interferenceChangjun Zhu
The Burnham Institute, La Jolla, CA 92037, USA
Mol Biol Cell 16:3187-99. 2005..Using immunofluorescence analysis, time-lapse microscopy, and rescue experiments, we investigate the roles of these 12 kinesins in detail... - Mitochondrial fragmentation in neurodegenerationAndrew B Knott
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Boulevard, Orlando, Florida 32816, USA
Nat Rev Neurosci 9:505-18. 2008..This results in impaired bioenergetics and mitochondrial migration, and can trigger neurodegeneration. These findings suggest potential new treatment avenues for neurodegenerative diseases... - Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neuronsHongmei Li
Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 105:2169-74. 2008..These findings suggest that Bcl-xL positively regulates Drp1 to alter mitochondrial function in a manner that stimulates synapse formation... - Mitochondrial swelling measurement in situ by optimized spatial filtering: astrocyte-neuron differencesAkos A Gerencser
Department of Medical Biochemistry, Semmelweis University, Neurobiochemical Group, Hungarian Academy of Sciences, Szentagothai Knowledge Center, Budapest, Hungary
Biophys J 95:2583-98. 2008..We found that in situ astrocytic mitochondria swell upon short-term uncoupling or inhibition of oxidative phosphorylation, whereas such responses are absent in cultured cortical neurons...