Ella Bossy-Wetzel

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis
    Shu ichi Okamoto
    Center for Neuroscience and Aging, Apoptosis and Cell Death Research Program, The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:3974-9. 2002
  2. ncbi request reprint GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2
    Chunmei Zhao
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 278:34641-53. 2003
  3. ncbi request reprint Mitochondrial fission in apoptosis, neurodegeneration and aging
    Ella Bossy-Wetzel
    Del E Webb Center for Neuroscience and Aging The Burnham Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 15:706-16. 2003
  4. ncbi request reprint Molecular pathways to neurodegeneration
    Ella Bossy-Wetzel
    Center for Neuroscience and Aging, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 10:S2-9. 2004
  5. pmc Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
    Mark J Barsoum
    Apoptosis and Cell Death Program, Burnham Institute for Medical Research, La Jolla, CA, USA
    EMBO J 25:3900-11. 2006
  6. ncbi request reprint Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels
    Ella Bossy-Wetzel
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    Neuron 41:351-65. 2004
  7. pmc A Golgi fragmentation pathway in neurodegeneration
    Saya Nakagomi
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurobiol Dis 29:221-31. 2008
  8. pmc Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells
    Changjun Zhu
    Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 389:373-81. 2005
  9. pmc Spatiotemporal control of spindle midzone formation by PRC1 in human cells
    Changjun Zhu
    The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:6196-201. 2006
  10. ncbi request reprint Dueling activities of AIF in cell death versus survival: DNA binding and redox activity
    Stuart A Lipton
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    Cell 111:147-50. 2002

Collaborators

Detail Information

Publications17

  1. pmc Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis
    Shu ichi Okamoto
    Center for Neuroscience and Aging, Apoptosis and Cell Death Research Program, The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:3974-9. 2002
    ..Additionally, we show that similar MEF2 cleavage fragments are generated in vivo during focal stroke damage. Hence, this pathway appears to have pathophysiological relevance in vivo...
  2. ncbi request reprint GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2
    Chunmei Zhao
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 278:34641-53. 2003
    ....
  3. ncbi request reprint Mitochondrial fission in apoptosis, neurodegeneration and aging
    Ella Bossy-Wetzel
    Del E Webb Center for Neuroscience and Aging The Burnham Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 15:706-16. 2003
    ..A shift in the rate of mitochondrial fission or fusion may provide a new mechanistic explanation for the mitochondrial dysfunction in neurodegenerative diseases and normal aging, and may offer a new target for therapeutic intervention...
  4. ncbi request reprint Molecular pathways to neurodegeneration
    Ella Bossy-Wetzel
    Center for Neuroscience and Aging, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 10:S2-9. 2004
    ....
  5. pmc Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
    Mark J Barsoum
    Apoptosis and Cell Death Program, Burnham Institute for Medical Research, La Jolla, CA, USA
    EMBO J 25:3900-11. 2006
    ..Importantly, NO-induced neuronal cell death was mitigated by Mfn1 and Drp1(K38A). Thus, persistent mitochondrial fission may play a causal role in NO-mediated neurotoxicity...
  6. ncbi request reprint Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels
    Ella Bossy-Wetzel
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    Neuron 41:351-65. 2004
    ..Thus, these data establish a new form of crosstalk between NO and Zn2+ apoptotic signal transduction pathways that may contribute to neurodegeneration...
  7. pmc A Golgi fragmentation pathway in neurodegeneration
    Saya Nakagomi
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurobiol Dis 29:221-31. 2008
    ..Taken together, these findings implicate the Golgi as a sensor of stress signals in cell death pathways...
  8. pmc Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells
    Changjun Zhu
    Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 389:373-81. 2005
    ..Three-dimensional reconstruction imaging analysis suggests that recruitment of MKLP1 to the midzone/midbody by INCENP is a crucial step for the midbody formation and completion of cytokinesis in mammalian cells...
  9. pmc Spatiotemporal control of spindle midzone formation by PRC1 in human cells
    Changjun Zhu
    The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:6196-201. 2006
    ..Our results thus indicate that PRC1 is an essential factor in controlling the spatiotemporal formation of the midzone in human cells...
  10. ncbi request reprint Dueling activities of AIF in cell death versus survival: DNA binding and redox activity
    Stuart A Lipton
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    Cell 111:147-50. 2002
    ..New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic...
  11. pmc New insights into mitochondrial structure during cell death
    Guy Perkins
    National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, 92093 0608, USA
    Exp Neurol 218:183-92. 2009
    ....
  12. pmc OPA1 expression in the normal rat retina and optic nerve
    Won Kyu Ju
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Comp Neurol 488:1-10. 2005
    ..Thus, OPA1 is predominantly expressed in retinal ganglion cells of the normal rat retina and axons of the optic nerve. These findings may explain the selective vulnerability of retinal ganglion cells to OPA1 loss of function...
  13. ncbi request reprint Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis
    Robert Schwarzenbacher
    The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:29320-4. 2004
    ..We conclude that CADD is a novel redox protein toxin unique to Chlamydia species and propose that both its redox activity and death domain binding ability are required for its biological activity...
  14. pmc Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference
    Changjun Zhu
    The Burnham Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 16:3187-99. 2005
    ..Using immunofluorescence analysis, time-lapse microscopy, and rescue experiments, we investigate the roles of these 12 kinesins in detail...
  15. pmc Mitochondrial fragmentation in neurodegeneration
    Andrew B Knott
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Boulevard, Orlando, Florida 32816, USA
    Nat Rev Neurosci 9:505-18. 2008
    ..This results in impaired bioenergetics and mitochondrial migration, and can trigger neurodegeneration. These findings suggest potential new treatment avenues for neurodegenerative diseases...
  16. pmc Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons
    Hongmei Li
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 105:2169-74. 2008
    ..These findings suggest that Bcl-xL positively regulates Drp1 to alter mitochondrial function in a manner that stimulates synapse formation...
  17. pmc Mitochondrial swelling measurement in situ by optimized spatial filtering: astrocyte-neuron differences
    Akos A Gerencser
    Department of Medical Biochemistry, Semmelweis University, Neurobiochemical Group, Hungarian Academy of Sciences, Szentagothai Knowledge Center, Budapest, Hungary
    Biophys J 95:2583-98. 2008
    ..We found that in situ astrocytic mitochondria swell upon short-term uncoupling or inhibition of oxidative phosphorylation, whereas such responses are absent in cultured cortical neurons...