Kathleen Boris-Lawrie

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity
    Amit Sharma
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, United States of America
    PLoS Pathog 8:e1002612. 2012
  2. pmc RNA helicase A modulates translation of HIV-1 and infectivity of progeny virions
    Cheryl Bolinger
    Department of Veterinary Biosciences, Center for Retrovirus Research and Center for RNA Biology, The Ohio State University, Columbus, OH 43210 1093, USA
    Nucleic Acids Res 38:1686-96. 2010
  3. pmc RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1
    Cheryl Bolinger
    Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210 1093, USA
    Nucleic Acids Res 35:2629-42. 2007
  4. pmc Bridging fundamental RNA biology, retroviral replication, and oncogenesis: Karen Beemon wins the 2007 Retrovirology Prize
    Kathleen Boris-Lawrie
    Retrovirology 4:88. 2007
  5. pmc In vivo study of genetically simplified bovine leukemia virus derivatives that lack tax and rex
    K Boris-Lawrie
    Department of Veterinary Biosciences and Center for Retrovirus Research, Ohio State University, Columbus 43210, USA
    J Virol 71:1514-20. 1997
  6. ncbi request reprint Retroviral RNA elements integrate components of post-transcriptional gene expression
    K Boris-Lawrie
    Cente for Retrovirus Research, The Ohio State University, Columbus, OH 43210 1093, USA
    Life Sci 69:2697-709. 2001
  7. pmc HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1
    Shuiming Qian
    Center for Retrovirus Research and Department of Veterinary Biosciences, Molecular, Cellular and Developmental Biology Graduate Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 106:605-10. 2009
  8. pmc Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytes
    Bindhu Michael
    Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Retrovirology 1:39. 2004
  9. ncbi request reprint Analysis of synergy between divergent simple retrovirus posttranscriptional control elements
    Stacey Hull
    Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210 1093, USA
    Virology 317:146-54. 2003
  10. pmc Primary sequence and secondary structure motifs in spleen necrosis virus RU5 confer translational utilization of unspliced human immunodeficiency virus type 1 reporter RNA
    Tiffiney M Roberts
    Center for Retrovirus Research, The Ohio State University, Columbus, Ohio 43210 1093, USA
    J Virol 77:11973-84. 2003

Research Grants

  1. Translational Control of Retroviral Unspliced mRNA
    Kathleen Boris Lawrie; Fiscal Year: 2007
  2. Translational Control of Retroviral Unspliced mRNA
    Kathleen Boris Lawrie; Fiscal Year: 2009
  3. Translational Control of Retroviral Unspliced mRNA
    KATHLEEN A BORIS LAWRIE; Fiscal Year: 2010

Collaborators

Detail Information

Publications24

  1. pmc Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity
    Amit Sharma
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, United States of America
    PLoS Pathog 8:e1002612. 2012
    ..We speculate that a subset of CBP80-bound cellular mRNAs contribute to recovery from significant cellular stress, including human retrovirus infection...
  2. pmc RNA helicase A modulates translation of HIV-1 and infectivity of progeny virions
    Cheryl Bolinger
    Department of Veterinary Biosciences, Center for Retrovirus Research and Center for RNA Biology, The Ohio State University, Columbus, OH 43210 1093, USA
    Nucleic Acids Res 38:1686-96. 2010
    ....
  3. pmc RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1
    Cheryl Bolinger
    Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210 1093, USA
    Nucleic Acids Res 35:2629-42. 2007
    ..We speculate divergent retroviruses have evolved a convergent RNA-protein interaction to modulate translation of their highly structured mRNA...
  4. pmc Bridging fundamental RNA biology, retroviral replication, and oncogenesis: Karen Beemon wins the 2007 Retrovirology Prize
    Kathleen Boris-Lawrie
    Retrovirology 4:88. 2007
    ..The 2007 M. Jeang Retrovirology Prize has been awarded to Dr. Karen L. Beemon...
  5. pmc In vivo study of genetically simplified bovine leukemia virus derivatives that lack tax and rex
    K Boris-Lawrie
    Department of Veterinary Biosciences and Center for Retrovirus Research, Ohio State University, Columbus 43210, USA
    J Virol 71:1514-20. 1997
    ..These viruses will be useful tools in comparative studies with BLV to evaluate the role of tax and rex in maintenance of virus load and in disease outcome...
  6. ncbi request reprint Retroviral RNA elements integrate components of post-transcriptional gene expression
    K Boris-Lawrie
    Cente for Retrovirus Research, The Ohio State University, Columbus, OH 43210 1093, USA
    Life Sci 69:2697-709. 2001
    ..Further characterization of the cellular partners and their regulation will be an important step to full understanding of nuclear-cytoplasmic connections that hardwire post-transcriptional gene expression in eukaryotic cells...
  7. pmc HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1
    Shuiming Qian
    Center for Retrovirus Research and Department of Veterinary Biosciences, Molecular, Cellular and Developmental Biology Graduate Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 106:605-10. 2009
    ..We suggest that RNA silencing-mediated translation repression plays a strategic role in determining the viral set-point in a newly HIV-1-infected patient...
  8. pmc Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytes
    Bindhu Michael
    Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Retrovirology 1:39. 2004
    ..Exogenous expression of p30II differentially modulates CREB and Tax-responsive element-mediated transcription through its interaction with CREB-binding protein/p300 and represses tax/rex RNA nuclear export...
  9. ncbi request reprint Analysis of synergy between divergent simple retrovirus posttranscriptional control elements
    Stacey Hull
    Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210 1093, USA
    Virology 317:146-54. 2003
    ..Our results uncovered a previously unidentified role of CTE in conjunction with Tap and NXT1 in commitment to efficient cytoplasmic RNA utilization...
  10. pmc Primary sequence and secondary structure motifs in spleen necrosis virus RU5 confer translational utilization of unspliced human immunodeficiency virus type 1 reporter RNA
    Tiffiney M Roberts
    Center for Retrovirus Research, The Ohio State University, Columbus, Ohio 43210 1093, USA
    J Virol 77:11973-84. 2003
    ..The results show that the unpaired UUGU loop and U-rich bulges function together and are candidate SNV RU5 binding sites for the host cell protein(s) that directs cytoplasmic utilization of unspliced HIV-1 reporter RNA...
  11. ncbi request reprint RNA helicase A is necessary for translation of selected messenger RNAs
    Tiffiney Roberts Hartman
    Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210 USA
    Nat Struct Mol Biol 13:509-16. 2006
    ..Our results reveal a previously unidentified role for RHA in translation and implicate RHA as an integrative effector in the continuum of gene expression from transcription to translation...
  12. ncbi request reprint Retrovirus translation initiation: Issues and hypotheses derived from study of HIV-1
    Alper Yilmaz
    Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA
    Curr HIV Res 4:131-9. 2006
    ..We discuss key issues that remain to be understood and suggest parameters to validate internal initiation activity in HIV-1 and other retroviruses...
  13. pmc Nuclear interactions are necessary for translational enhancement by spleen necrosis virus RU5
    Andrew W Dangel
    Center for Retrovirus Research, The Ohio State University, Columbus, Ohio 43210 1093, USA
    J Virol 76:3292-300. 2002
    ..Our study is the first to show that a nuclear factor(s) directs SNV RU5-containing RNAs to a distinct export pathway that is not inhibited by LMB and programs the intron-containing transcript for translational enhancement...
  14. pmc Coordinate enhancement of transgene transcription and translation in a lentiviral vector
    Alper Yilmaz
    Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Retrovirology 3:13. 2006
    ....
  15. pmc RU5 of Mason-Pfizer monkey virus 5' long terminal repeat enhances cytoplasmic expression of human immunodeficiency virus type 1 gag-pol and nonviral reporter RNA
    Stacey Hull
    Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Virol 76:10211-8. 2002
    ....
  16. pmc Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome
    Cheryl Bolinger
    Center for Retrovirus Research, Department of Veterinary Biosciences, Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH, USA
    Retrovirology 6:8. 2009
    ..In a broad perspective, each new insight offers a prospective target for antiviral therapy and strategic improvement of gene transfer vectors...
  17. pmc Human T-cell leukemia virus open reading frame II encodes a posttranscriptional repressor that is recruited at the level of transcription
    Ihab Younis
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
    J Virol 80:181-91. 2006
    ....
  18. pmc Tertiary structural and functional analyses of a viroid RNA motif by isostericity matrix and mutagenesis reveal its essential role in replication
    Xuehua Zhong
    Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, 43210, USA
    J Virol 80:8566-81. 2006
    ....
  19. pmc Destiny of unspliced retroviral RNA: ribosome and/or virion?
    Melinda Butsch
    Center for Retrovirus Research, Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210 1093, USA
    J Virol 76:3089-94. 2002
  20. pmc Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1
    Amy M Hayes
    Department of Veterinary Biosciences, Center for Retrovirus Research, Ohio State University, Columbus OH, USA
    Retrovirology 8:36. 2011
    ..The open question stands of what, if any, is the contribution of Tat RNA silencing suppressor activity or Vpr/Vif activity to the perturbation of cellular miRNA by HIV-1...
  21. pmc Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs
    Arnaz Ranji
    Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:5328-37. 2011
    ..The results indicate that the molecular basis for the activation of translation by RHA is recognition of target mRNA by the N-terminal domain that tethers the ATP-dependent helicase for rearrangement of the complex 5'-UTR...
  22. doi request reprint Determination of host RNA helicases activity in viral replication
    Amit Sharma
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, USA
    Methods Enzymol 511:405-35. 2012
    ..The methodology and choice of controls fosters the assessment of the virologic scope of RNA helicases across divergent cell lineages and viral replication cycles...
  23. pmc RNA helicases: emerging roles in viral replication and the host innate response
    Arnaz Ranji
    Department of Veterinary Biosciences, Ohio State University, Columbus, OH, USA
    RNA Biol 7:775-87. 2010
    ..The analysis of RNA helicases in virus model systems continues to provide insights into virology, cell biology and immunology, and has provided fresh perspective to continue unraveling the complexity of virus-host interactions...
  24. pmc Human T lymphotropic virus type 1 accessory protein p12I modulates calcium-mediated cellular gene expression and enhances p300 expression in T lymphocytes
    Amrithraj Nair
    Center for Retrovirus Research and Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    AIDS Res Hum Retroviruses 21:273-84. 2005
    ..Collectively, our data strongly indicate that HTLV-1 p12I modulates cellular gene expression patterns to hasten the activation of T lymphocytes and thereby promote efficient viral infection...

Research Grants5

  1. Translational Control of Retroviral Unspliced mRNA
    Kathleen Boris Lawrie; Fiscal Year: 2007
    ....
  2. Translational Control of Retroviral Unspliced mRNA
    Kathleen Boris Lawrie; Fiscal Year: 2009
    ..abstract_text> ..
  3. Translational Control of Retroviral Unspliced mRNA
    KATHLEEN A BORIS LAWRIE; Fiscal Year: 2010
    ..abstract_text> ..