Research Topics
Genomes and Genes | Kathleen Boris-LawrieSummaryAffiliation: The Ohio State University Country: USA Publications
Research Grants
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Publications
Bridging fundamental RNA biology, retroviral replication, and oncogenesis: Karen Beemon wins the 2007 Retrovirology PrizeKathleen Boris-Lawrie
Retrovirology 4:88. 2007..The 2007 M. Jeang Retrovirology Prize has been awarded to Dr. Karen L. Beemon...- In vivo study of genetically simplified bovine leukemia virus derivatives that lack tax and rexK Boris-Lawrie
Department of Veterinary Biosciences and Center for Retrovirus Research, Ohio State University, Columbus 43210, USA
J Virol 71:1514-20. 1997..These viruses will be useful tools in comparative studies with BLV to evaluate the role of tax and rex in maintenance of virus load and in disease outcome... 
Retroviral RNA elements integrate components of post-transcriptional gene expressionK Boris-Lawrie
Cente for Retrovirus Research, The Ohio State University, Columbus, OH 43210 1093, USA
Life Sci 69:2697-709. 2001..Further characterization of the cellular partners and their regulation will be an important step to full understanding of nuclear-cytoplasmic connections that hardwire post-transcriptional gene expression in eukaryotic cells...- RNA helicase A modulates translation of HIV-1 and infectivity of progeny virionsCheryl Bolinger
Department of Veterinary Biosciences, Center for Retrovirus Research and Center for RNA Biology, The Ohio State University, Columbus, OH 43210 1093, USA
Nucleic Acids Res 38:1686-96. 2010.... - RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1Cheryl Bolinger
Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210 1093, USA
Nucleic Acids Res 35:2629-42. 2007..We speculate divergent retroviruses have evolved a convergent RNA-protein interaction to modulate translation of their highly structured mRNA... - HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1Shuiming Qian
Center for Retrovirus Research and Department of Veterinary Biosciences, Molecular, Cellular and Developmental Biology Graduate Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 106:605-10. 2009..We suggest that RNA silencing-mediated translation repression plays a strategic role in determining the viral set-point in a newly HIV-1-infected patient... - Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytesBindhu Michael
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
Retrovirology 1:39. 2004..Exogenous expression of p30II differentially modulates CREB and Tax-responsive element-mediated transcription through its interaction with CREB-binding protein/p300 and represses tax/rex RNA nuclear export... - Analysis of synergy between divergent simple retrovirus posttranscriptional control elementsStacey Hull
Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210-1093, USA
Virology 317:146-54. 2003..Our results uncovered a previously unidentified role of CTE in conjunction with Tap and NXT1 in commitment to efficient cytoplasmic RNA utilization... - Primary sequence and secondary structure motifs in spleen necrosis virus RU5 confer translational utilization of unspliced human immunodeficiency virus type 1 reporter RNATiffiney M Roberts
Center for Retrovirus Research, The Ohio State University, Columbus, Ohio 43210-1093, USA
J Virol 77:11973-84. 2003..The results show that the unpaired UUGU loop and U-rich bulges function together and are candidate SNV RU5 binding sites for the host cell protein(s) that directs cytoplasmic utilization of unspliced HIV-1 reporter RNA... - Coordinate enhancement of transgene transcription and translation in a lentiviral vectorAlper Yilmaz
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Retrovirology 3:13. 2006.... - Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteomeCheryl Bolinger
Center for Retrovirus Research, Department of Veterinary Biosciences, Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH, USA
Retrovirology 6:8. 2009..In a broad perspective, each new insight offers a prospective target for antiviral therapy and strategic improvement of gene transfer vectors... - Nuclear interactions are necessary for translational enhancement by spleen necrosis virus RU5Andrew W Dangel
Center for Retrovirus Research, The Ohio State University, Columbus, Ohio 43210-1093, USA
J Virol 76:3292-300. 2002..Our study is the first to show that a nuclear factor(s) directs SNV RU5-containing RNAs to a distinct export pathway that is not inhibited by LMB and programs the intron-containing transcript for translational enhancement... - Tertiary structural and functional analyses of a viroid RNA motif by isostericity matrix and mutagenesis reveal its essential role in replicationXuehua Zhong
Department of Plant Cellular and Molecular Biology, Ohio State University, Columbus, 43210, USA
J Virol 80:8566-81. 2006.... - Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAsArnaz Ranji
Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 286:5328-37. 2011..The results indicate that the molecular basis for the activation of translation by RHA is recognition of target mRNA by the N-terminal domain that tethers the ATP-dependent helicase for rearrangement of the complex 5'-UTR... - Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activityAmit Sharma
Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, United States of America
PLoS Pathog 8:e1002612. 2012..We speculate that a subset of CBP80-bound cellular mRNAs contribute to recovery from significant cellular stress, including human retrovirus infection... - Retrovirus translation initiation: Issues and hypotheses derived from study of HIV-1Alper Yilmaz
Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA
Curr HIV Res 4:131-9. 2006..We discuss key issues that remain to be understood and suggest parameters to validate internal initiation activity in HIV-1 and other retroviruses... - RU5 of Mason-Pfizer monkey virus 5' long terminal repeat enhances cytoplasmic expression of human immunodeficiency virus type 1 gag-pol and nonviral reporter RNAStacey Hull
Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210-1093, USA
J Virol 76:10211-8. 2002.... - Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1Amy M Hayes
Department of Veterinary Biosciences, Center for Retrovirus Research, Ohio State University, Columbus OH, USA
Retrovirology 8:36. 2011..The open question stands of what, if any, is the contribution of Tat RNA silencing suppressor activity or Vpr/Vif activity to the perturbation of cellular miRNA by HIV-1... - RNA helicase A is necessary for translation of selected messenger RNAsTiffiney Roberts Hartman
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210 USA
Nat Struct Mol Biol 13:509-16. 2006..Our results reveal a previously unidentified role for RHA in translation and implicate RHA as an integrative effector in the continuum of gene expression from transcription to translation... 
Determination of host RNA helicases activity in viral replicationAmit Sharma
Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, USA
Methods Enzymol 511:405-35. 2012..The methodology and choice of controls fosters the assessment of the virologic scope of RNA helicases across divergent cell lineages and viral replication cycles...- Human T-cell leukemia virus open reading frame II encodes a posttranscriptional repressor that is recruited at the level of transcriptionIhab Younis
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
J Virol 80:181-91. 2006.... - RNA helicases: emerging roles in viral replication and the host innate responseArnaz Ranji
Department of Veterinary Biosciences, Ohio State University, Columbus, OH, USA
RNA Biol 7:775-87. 2010..The analysis of RNA helicases in virus model systems continues to provide insights into virology, cell biology and immunology, and has provided fresh perspective to continue unraveling the complexity of virus-host interactions... - Human T lymphotropic virus type 1 accessory protein p12I modulates calcium-mediated cellular gene expression and enhances p300 expression in T lymphocytesAmrithraj Nair
Center for Retrovirus Research and Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
AIDS Res Hum Retroviruses 21:273-84. 2005..Collectively, our data strongly indicate that HTLV-1 p12I modulates cellular gene expression patterns to hasten the activation of T lymphocytes and thereby promote efficient viral infection... - Destiny of unspliced retroviral RNA: ribosome and/or virion?Melinda Butsch
Center for Retrovirus Research, Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210 1093, USA
J Virol 76:3089-94. 2002
Research Grants
- Translational Control of Retroviral Unspliced mRNAKathleen Boris Lawrie; Fiscal Year: 2007....
- Translational Control of Retroviral Unspliced mRNAKathleen Boris Lawrie; Fiscal Year: 2009..abstract_text> ..
- Translational Control of Retroviral Unspliced mRNAKATHLEEN A BORIS LAWRIE; Fiscal Year: 2010..abstract_text> ..