Melissa Bondy

..In this analysis we examined the relationship between susceptibility to smoking and well-known risk factors associated with smoking initiation among a cohort of 11 to 13 year old Mexican origin youth residing in Houston, Texas...

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..In this report, BTEC epidemiologists reviewed the group's consensus on the current state of scientific findings, and they present a consensus on research priorities to identify which important areas the science should move to address...

..Our results lend additional support for an important but unknown link between malignant brain tumors and immune mediators...

..Therefore, identifying the genetic variants that influence this small number of unusually long-term survivors may provide important insight into tumor biology and treatment...

..The current study was performed to investigate the role of GST enzyme polymorphisms in predicting the survival of patients with AG...

..These data suggest the existence of gender-specific susceptibility to tobacco carcinogen and dietary mutagen exposure in PC...

..This model predicts that BCs with low or no TRPS-1 expression may inherently be much less differentiated and more aggressive tumors with less favorable prognosis...

..Further large-scale studies are required to determine the exact role of these polymorphisms and types of DNA damage in breast cancer susceptibility...

..To understand the mechanism through which obesity in breast cancer patients is associated with poorer outcome, we evaluated body mass index (BMI) and response to neoadjuvant chemotherapy (NC) in women with operable breast cancer...

..In conclusion, the PIN1 polymorphisms may contribute to the etiology of sporadic breast cancer in non-Hispanic white women 55 years and younger. Further validation in large population-based studies is needed...

..This review examines IBC's unique clinical presentation, pathology, epidemiology, imaging, and biology and details current multidisciplinary management of the disease, which comprises systemic therapy, surgery, and radiation therapy...

..Smoking and XRT combined enhanced the effect of either alone, with marked increased risks of lung carcinoma after XRT for breast carcinoma...

..Our results suggest that tailoring primary prevention programs by a youth's susceptibility status may increase the efficacy of prevention efforts among Mexican origin youth...

..Here, we review the rationale for studying familial glioma and our proposed strategy for the GLIOGENE study...

..Our data provide not only networks for understanding the biological properties of gliomagenesis but also useful pathway maps for future understanding of disease...

..95; 95% confidence intervals, 2.21-16.65). Taken together, these results suggest that polymorphisms in DNA repair genes may act individually or together to contribute to glioma risk...

..The authors hypothesized that genetic variants of glutathione S-transferase (GST) affect detoxification of carcinogens and anticancer agents in the human pancreas and, thus, the risk and survival of pancreatic cancer...

..24-0.88) (P for interaction=0.03). The (312)Asp-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer...

..3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor...

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..These data strongly support the hypothesis that HCA exposure contributes to human breast cancer among genetically susceptible individuals...

..These findings suggest that women with reduced DRC may be at an increased risk of developing breast cancer. Large studies are warranted to confirm these preliminary findings...

..The NAT2*6A/any slow acetylation genotype may be a predisposing factor for pancreatic cancer among diabetics with smoking exposure. Our observations must be confirmed in larger independent studies...

..0001). Our study indicates that polymorphisms in inflammation genes are associated with glioma susceptibility, especially when a history of asthma/allergies is absent...

..006). These findings suggest that NBS1 polymorphisms and haplotypes may contribute to the etiology of sporadic breast cancer in young non-Hispanic white women. Large studies are warranted to confirm these findings...

..The purpose of this study was to evaluate if birth weight (BW) corrected-for-gestational age is a better predictor than BW alone for occurrence of ALL and other malignancies in children...

..The purpose of this research was to investigate the relationship between glutathione S-transferase (GST) polymorphisms and survival, and chemotherapy-related toxicity in 278 glioma patients...

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..Malignant gliomas are the most common type of primary brain tumor in adults, however, few prognostic factors have been identified...

..However, larger studies are needed to verify these findings...

..We evaluated the effect of epidemiologic breast cancer risk factors on recurrence in women with early-stage disease...

..An additional 3700 lives could be saved if 90% of women aged ≥40 years were recently screened for breast cancer...

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..However, there will always be the need for impeccably designed and well-powered epidemiologic studies with rigorous quality control of data, specimen acquisition and statistical analysis...

..Previous studies have been inconclusive in estimating the risk of different cancer sites among close relatives of glioma patients; however, malignant melanoma has consistently been described...

..We evaluated the independent effects of multiple risk factors for pancreatic cancer and determined whether the magnitude of cigarette smoking was modified by other risk factors in men and women...

..Among Mexican-born youth, exposure to smoking imagery in the movies may be an important part of the acculturation process associated with smoking initiation...

..More biological and epidemiological research is warranted to clarify the exact mechanisms through which the timing of common childhood infections and the course of early life immune development affect gliomagenesis...

..Obesity has been implicated as a risk factor for pancreatic cancer...

..The goal of this study was to test the hypothesis that SSS moderates the relationship between POE and experimentation with cigarettes...

..However, little is known about the role of HBV and HCV infection in other malignancies. This study aimed to determine whether HBV and HCV infections increase the risk for pancreatic cancer development...

..Interventions targeting these factors could potentially lower the stage at diagnosis for African-American breast cancer patients and, in doing so, improve their survival and other outcomes...

..These observations suggest that genetic susceptibility to carcinogen exposure may play an important role in breast carcinogenesis...

..9, 95% CI: 1.2-6.9) and among females (AOR: 2.5, 95% CI: 1.1-5.7). These data suggest that polymorphisms of the CYP1A2 and NAT1 genes modify the risk of pancreatic cancer...

..23 (0.88-20.3) for heavy drinkers with the TT genotype compared with nondrinkers with the CC/CT genotypes. These observations support a role for folate metabolism in pancreatic cancer, especially among smokers and heavy drinkers...

..We investigated differences in smoking behaviors between US-and Mexican-born ever smokers and examined the influence of US culture on smoking initiation...

..Such findings suggest new directions for mechanistic research on dietary factors in breast carcinogenesis that may have relevance for prevention and clinical treatment...

..To determine patterns and predictors of concordance with institutional treatment guidelines among older women with breast cancer...

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..Organochlorine serum level was not a risk factor of breast cancer in this population...

..In Egypt, the disease has traditionally been considered rare, and there has not been a previous publication on its population-based incidence or age distribution...

..This review highlights current insights into the molecular epidemiology of GBM...

..A more complete understanding of adult glioma incidence trends might provide indications of risk factors for gliomas and contribute to the search for improved therapies...

..09 and 0.099, respectively. These data support the hypothesis that dietary mutagen exposure alone and in interaction with other factors contribute to the development of pancreatic cancer...

..However, it is not known if existing breast cancer prediction models are accurate predictors of the disease among African-American women...

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..Breast cancer patients have a substantial residual risk of recurrence, and selected tumor characteristics are associated with late recurrences...

..We evaluated the relationship between folate pathway polymorphisms and neurocognitive impairment after childhood ALL chemotherapy...

..Larger association studies and related functional studies are warranted to confirm these findings...

..e., linoleic acid), suggesting dietary influence of this factor on ER status in premenopausal breast cancer patients. However, larger studies are needed to clarify the role of micronutrients in ER status in breast cancer...

..Our findings present opportunities and challenges for addressing obesity as a pubertal risk factor in MA girls; however, more studies are needed to understand family beliefs and sociocultural dynamics surrounding puberty in MAs...

..13-2.93). These results suggest that the T allele may be a risk allele, and this XRCC7 polymorphism may be a marker for the susceptibility to glioma. Larger studies are needed to confirm our findings and unravel the underlying mechanisms...

..However, misclassification due to unvalidated cancers among family members could account for the differences seen by study site...

..We investigated whether hTERT MNS16A variant genotype predicted survival in GBM patients...

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..This study showed that although imputation of missing data for a key predictor variable can improve a risk health-outcome prediction model, further work is needed to illuminate the risk factors associated with SRH...

..Our study identifies that there are differences in the types of mutations found in tumors from pancreatic carcinoma patients in Egypt and the US, and suggests that environmental factors may explain these differences...

..Literature searches were done on PubMed in March 2009 with the terms glioma, glioblastoma, brain tumor, association, and polymorphism, and we only reviewed English language publications...

..The associations between passive smoking and the use of noncigarette tobacco products with pancreatic cancer are not clear...

..These molecular differences could affect prevention strategies, therapeutic efficacy, and transferability of clinical trial results...

..High levels of chromatid breaks induced by gamma-radiation may constitute an independent risk factor for PTC, but further study is needed...

..Accurate assessment of N-nitroso intake is fundamental to advancing research regarding its role with cancer. Previous studies have not used a quantitative database to estimate the intake of these compounds in a US population...

..Most breast cancers develop from mammary epithelial cells; therefore, NO may play a role in their development. It was hypothesized that eNOS polymorphisms are associated with risk of breast cancer...

..We hypothesized that the altered HR repair capacity conferred by single nucleotide polymorphisms (SNPs) would modify individual susceptibility to sporadic pancreatic cancer...

..However, polymorphisms in DNA strand break repair genes that may determine mutagen sensitivity are not well studied in cancer risk, especially in gliomas...

..4, 95% confidence interval: 1.4, 8.4). This preliminary finding may be due to bias, confounding, or chance, and additional studies are needed for confirmation...

..Finally, we hope that a greater understanding of the biological basis of the disease will lead to the development of novel therapeutic interventions...

..This will allow for detection of low-level latent infections that may play an important role in the initiation and/or promotion of malignant gliomas...

..The purpose of our study was to use this exploratory design to identify potential pair wise SNP-SNP interactions from genes involved in several different immune-related pathways for investigation in future studies...

..To evaluate the association between birthplace (Mexico or U.S.) and obesity in men and women and to analyze the relationship between duration of U.S. residency and prevalence of obesity in Mexican immigrants...

..This suggests a possible role of infectious agents in neuroblastoma etiology. Future epidemiologic studies should incorporate more direct data on infection...

..It is essential that epidemiologists and neuropathologists collaborate to develop appropriate study designs and protocols for specific hypothesis and populations...

..Using data from a large North American study, we conducted an analysis to investigate maternal vitamin use and neuroblastoma in offspring...

..This review highlights current knowledge of meningioma epidemiology and new directions for research efforts in this field...

..The purpose of this research was to compare methylation status and mRNA expression of p15INK4b and p16INK4a in serous epithelial ovarian cancer tissues and normal ovarian tissues...

..Several risk factors for CNS metastases have been reported. The objective of the current study was to describe clinicopathologic characteristics and prognostic factors in breast cancer patients with CNS metastases...

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..abstract_text> ..

..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningiomas. ..

..This information has translational significance for brain tumor patients and their families, and will enable us to develop appropriate genetic screening and counseling approaches to reduce the incidence and mortality of this disease. ..

..It will identify common genetic variants contributing to the risk of glioma from a genome wide association study. ..

..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningiomas. ..

..Thus, patients who can tolerate higher doses of chemotherapy can be treated more efficiently, suffering from less side effects and potentially may have a better outcome. ..

..In addition, they are collecting blood from each new patient and their specimen repository will be available to study future candidate genes to integrate with the family data. ..

..no abstract available ..

..This information has translational significance for brain tumor patients and their families, and will enable us to develop appropriate genetic screening and counseling approaches to reduce the incidence and mortality of this disease. ..