P Blume-Jensen

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
    P Blume-Jensen
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037, USA
    Curr Biol 8:779-82. 1998
  2. ncbi Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility
    P Blume-Jensen
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California, USA
    Nat Genet 24:157-62. 2000
  3. ncbi Oncogenic kinase signalling
    P Blume-Jensen
    The Salk Institute, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 411:355-65. 2001
  4. ncbi Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase
    Z Lu
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 21:4016-31. 2001
  5. ncbi Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C
    P Blume-Jensen
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:21793-802. 1994
  6. ncbi Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells
    P Blume-Jensen
    Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, Sweden
    J Biol Chem 270:14192-200. 1995
  7. ncbi Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C
    P Blume-Jensen
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    EMBO J 12:4199-209. 1993
  8. ncbi Kit/stem cell factor receptor-induced phosphatidylinositol 3'-kinase signalling is not required for normal development and function of interstitial cells of Cajal in mouse gastrointestinal tract
    S J Gibbons
    Enteric Neurosciences Program, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Neurogastroenterol Motil 15:643-53. 2003
  9. ncbi Fibroblast growth factor receptor-1 regulation of Src family kinases
    E Landgren
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    Oncogene 10:2027-35. 1995

Detail Information

Publications9

  1. ncbi The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
    P Blume-Jensen
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037, USA
    Curr Biol 8:779-82. 1998
    ..Such a mechanism may account for how deregulated PI 3-kinase activity and naturally occurring gain-of-function point mutants of Kit/SCF-R lead to cellular transformation and fatal malignancies in man...
  2. ncbi Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility
    P Blume-Jensen
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California, USA
    Nat Genet 24:157-62. 2000
    ..It provides the first in vivo model for male sterility caused by a discrete signalling pathway defect affecting early germ cells...
  3. ncbi Oncogenic kinase signalling
    P Blume-Jensen
    The Salk Institute, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 411:355-65. 2001
    ....
  4. ncbi Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase
    Z Lu
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 21:4016-31. 2001
    ....
  5. ncbi Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C
    P Blume-Jensen
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:21793-802. 1994
    ..In conclusion, SCF-induced PI-3'-kinase activation paralleled the increased SCF-induced mitogenicity after inhibition of PKC...
  6. ncbi Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells
    P Blume-Jensen
    Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, Sweden
    J Biol Chem 270:14192-200. 1995
    ....
  7. ncbi Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C
    P Blume-Jensen
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    EMBO J 12:4199-209. 1993
    ..Our data suggest that PKC is involved in a negative feedback loop which regulates the Kit/SCF-R and that the activity of PKC determines whether the effect of SCF will be preferentially mitogenic or motogenic...
  8. ncbi Kit/stem cell factor receptor-induced phosphatidylinositol 3'-kinase signalling is not required for normal development and function of interstitial cells of Cajal in mouse gastrointestinal tract
    S J Gibbons
    Enteric Neurosciences Program, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Neurogastroenterol Motil 15:643-53. 2003
    ..This is an important and counterintuitive result, given the role of PI3'-kinase signalling downstream of c-Kit and the role of both c-Kit and PI3'-kinase individually in ICC development...
  9. ncbi Fibroblast growth factor receptor-1 regulation of Src family kinases
    E Landgren
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    Oncogene 10:2027-35. 1995
    ..Moreover, inhibition of PKC attenuated the bFGF induced decrease in autophosphorylation of Src family members. These data indicate a negative regulatory role for PKC on Src kinase activity in certain cell types...