Gunter Blobel


Affiliation: The Rockefeller University
Country: USA


  1. Quan B, Seo H, Blobel G, Ren Y. Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 • Nup98). Proc Natl Acad Sci U S A. 2014;111:9127-32 pubmed publisher
    ..We suggest that such repetitive cycles provide cytoplasmic stopover sites required for ratcheting mRNA across the nuclear pore. ..
  2. Li X, Wang J, Coutavas E, Shi H, Hao Q, Blobel G. Structure of human Niemann-Pick C1 protein. Proc Natl Acad Sci U S A. 2016;113:8212-7 pubmed publisher
    ..We propose a model for NPC1 function in cholesterol sensing and transport. ..
  3. Blobel G. Three-dimensional organization of chromatids by nuclear envelope-associated structures. Cold Spring Harb Symp Quant Biol. 2010;75:545-54 pubmed publisher
  4. Sharma A, Solmaz S, Blobel G, Melčák I. Ordered Regions of Channel Nucleoporins Nup62, Nup54, and Nup58 Form Dynamic Complexes in Solution. J Biol Chem. 2015;290:18370-8 pubmed publisher
    ..These data are consistent both with our crystal structure-deduced copy numbers and stoichiometries and also with our ring cycle model for structure and dynamics of the nuclear pore channel. ..
  5. Koh J, Blobel G. Allosteric Regulation in Gating the Central Channel of the Nuclear Pore Complex. Cell. 2015;161:1361-73 pubmed publisher
    ..Based on these and previous crystallographic results, a quantitative framework was established to describe constriction and dilation of the central channel as a function of transport factor occupancy. ..