GEORGE BILLMAN

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Endurance exercise training reduces cardiac sodium/calcium exchanger expression in animals susceptible to ventricular fibrillation
    Monica Kukielka
    Department of Physiology and Cell Biology, The Ohio State University Columbus, OH, USA
    Front Physiol 2:3. 2011
  2. pmc Heart rate variability - a historical perspective
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University Columbus, OH, USA
    Front Physiol 2:86. 2011
  3. pmc Effect of dietary omega-3 polyunsaturated Fatty acids on heart rate and heart rate variability in animals susceptible or resistant to ventricular fibrillation
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University Columbus, OH, USA
    Front Physiol 3:71. 2012
  4. doi request reprint The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: a critical reassessment
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, United States Electronic address
    Pharmacol Ther 140:53-80. 2013
  5. pmc Dietary omega-3 fatty acids and susceptibility to ventricular fibrillation: lack of protection and a proarrhythmic effect
    George E Billman
    Department of Physiology and Cell Biology, College of Pharmacy, The Ohio State University, Columbus, OH 43210 1218, USA
    Circ Arrhythm Electrophysiol 5:553-60. 2012
  6. doi request reprint Effects of a novel amiodarone-like compound SAR114646A on the pig atrium and susceptibility to ventricular fibrillation in dogs and pigs
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    Naunyn Schmiedebergs Arch Pharmacol 385:373-84. 2012
  7. pmc Effect of dietary omega-3 fatty acids on the heart rate and the heart rate variability responses to myocardial ischemia or submaximal exercise
    George E Billman
    Dept of Physiology and Cell Biology, Ohio State Univ, 304 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 300:H2288-99. 2011
  8. ncbi request reprint Vernakalant, a mixed sodium and potassium ion channel antagonist that blocks K(v)1.5 channels, for the potential treatment of atrial fibrillation
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, Columbus OH 43210 1218, USA
    Curr Opin Investig Drugs 11:1048-58. 2010
  9. pmc Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies
    George E Billman
    Dept of Physiology and Cell Biology, The Ohio State Univ, Columbus, 43210 1218, USA
    Am J Physiol Heart Circ Physiol 298:H1219-28. 2010
  10. doi request reprint Cardiac autonomic neural remodeling and susceptibility to sudden cardiac death: effect of endurance exercise training
    George E Billman
    Dept of Physiology and Cell Biology, The Ohio State Univ, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 297:H1171-93. 2009

Collaborators

Detail Information

Publications36

  1. pmc Endurance exercise training reduces cardiac sodium/calcium exchanger expression in animals susceptible to ventricular fibrillation
    Monica Kukielka
    Department of Physiology and Cell Biology, The Ohio State University Columbus, OH, USA
    Front Physiol 2:3. 2011
    ....
  2. pmc Heart rate variability - a historical perspective
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University Columbus, OH, USA
    Front Physiol 2:86. 2011
    ..This essay will conclude with a brief description of time domain, frequency domain, and non-linear dynamic analysis techniques (and their limitations) that are commonly used to measure HRV...
  3. pmc Effect of dietary omega-3 polyunsaturated Fatty acids on heart rate and heart rate variability in animals susceptible or resistant to ventricular fibrillation
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University Columbus, OH, USA
    Front Physiol 3:71. 2012
    ..These data demonstrate that dietary n-3 PUFA decreased HR and increased HRV to a similar extent in animals known to be prone to or resistant to malignant cardiac tachyarrhythmias...
  4. doi request reprint The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: a critical reassessment
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, United States Electronic address
    Pharmacol Ther 140:53-80. 2013
    ....
  5. pmc Dietary omega-3 fatty acids and susceptibility to ventricular fibrillation: lack of protection and a proarrhythmic effect
    George E Billman
    Department of Physiology and Cell Biology, College of Pharmacy, The Ohio State University, Columbus, OH 43210 1218, USA
    Circ Arrhythm Electrophysiol 5:553-60. 2012
    ..Our aim was to clarify this issue using an established and clinical relevant canine model of sudden cardiac death...
  6. doi request reprint Effects of a novel amiodarone-like compound SAR114646A on the pig atrium and susceptibility to ventricular fibrillation in dogs and pigs
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    Naunyn Schmiedebergs Arch Pharmacol 385:373-84. 2012
    ..These data suggest that the amiodarone-like drug SAR114646A may be an effective antiarrhythmic intervention that does not adversely prolong ventricular repolarization...
  7. pmc Effect of dietary omega-3 fatty acids on the heart rate and the heart rate variability responses to myocardial ischemia or submaximal exercise
    George E Billman
    Dept of Physiology and Cell Biology, Ohio State Univ, 304 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 300:H2288-99. 2011
    ..These data demonstrate that dietary n-3 PUFA decreased resting (i.e., preexercise or preocclusion) HR and increased resting HRV but did not alter the cardiac response to physiologic challenges...
  8. ncbi request reprint Vernakalant, a mixed sodium and potassium ion channel antagonist that blocks K(v)1.5 channels, for the potential treatment of atrial fibrillation
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, Columbus OH 43210 1218, USA
    Curr Opin Investig Drugs 11:1048-58. 2010
    ..Phase III clinical trials with intravenous vernakalant are ongoing, and phase II clinical trials are also being conducted with an oral formulation intended for chronic use...
  9. pmc Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies
    George E Billman
    Dept of Physiology and Cell Biology, The Ohio State Univ, Columbus, 43210 1218, USA
    Am J Physiol Heart Circ Physiol 298:H1219-28. 2010
    ..Thus dietary n-3 PUFAs did not adversely alter either in vitro or in vivo ventricular contractile function in dogs with healed infarctions...
  10. doi request reprint Cardiac autonomic neural remodeling and susceptibility to sudden cardiac death: effect of endurance exercise training
    George E Billman
    Dept of Physiology and Cell Biology, The Ohio State Univ, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 297:H1171-93. 2009
    ..Thus exercise training may reverse the autonomic neural remodeling induced by myocardial infarction and thereby enhance the electrical stability of the heart in individuals shown to be at an increased risk for sudden cardiac death...
  11. doi request reprint The cardiac sarcolemmal ATP-sensitive potassium channel as a novel target for anti-arrhythmic therapy
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    Pharmacol Ther 120:54-70. 2008
    ..Thus, selective antagonists of the cardiac cell surface ATP-sensitive potassium channel may represent a new class of ischemia selective anti-arrhythmic medications...
  12. doi request reprint Novel transient outward and ultra-rapid delayed rectifier current antagonist, AVE0118, protects against ventricular fibrillation induced by myocardial ischemia
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio 43210 1218, USA
    J Cardiovasc Pharmacol 51:352-8. 2008
    ..Thus, AVE0118 abolished ischemically induced repolarization abnormalities and prevented malignant arrhythmias induced by ischemia without altering QTc interval...
  13. ncbi request reprint Aerobic exercise conditioning: a nonpharmacological antiarrhythmic intervention
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio 43210, USA
    J Appl Physiol (1985) 92:446-54. 2002
    ....
  14. ncbi request reprint Ambrisentan (Myogen)
    George E Billman
    Department of Physiology and Cell Biology The Ohio State University, Columbus 43210 1218, USA
    Curr Opin Investig Drugs 3:1483-6. 2002
    ..By August 2001, ambrisentan had entered phase II trials for chronic heart failure, hypertension, kidney failure and pulmonary hypertension...
  15. ncbi request reprint RSD-1235. Cardiome
    George E Billman
    Department of Physiology and Cell Biology, Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    Curr Opin Investig Drugs 4:352-4. 2003
    ..RSD-1235 is a novel, mixed ion channel antagonist in development by Cardiome Pharma for the potential treatment of heart arrhythmia. By September 2002, phase II trials had been completed and phase III studies were due to commence in 2003...
  16. ncbi request reprint Effects of a novel cardioselective ATP-sensitive potassium channel antagonist, 1-[[5-[2-(5-chloro-o-anisamido)ethyl]-beta-methoxyethoxyphenyl]sulfonyl]-3-methylthiourea, sodium salt (HMR 1402), on susceptibility to ventricular fibrillation induced by myoc
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    J Pharmacol Exp Ther 309:182-92. 2004
    ..Thus, the ATP-sensitive potassium channel antagonist HMR 1402 can prevent ischemically induced VF without altering coronary blood flow or blood glucose...
  17. ncbi request reprint Effects of endurance exercise training on heart rate variability and susceptibility to sudden cardiac death: protection is not due to enhanced cardiac vagal regulation
    George E Billman
    Dept of Physiology and Cell Biology, The Ohio State Univ, 304 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, USA
    J Appl Physiol (1985) 100:896-906. 2006
    ..Atropine decreased HRV but only induced VF in one of eight trained susceptible dogs. Thus exercise training increased cardiac vagal activity, which was not solely responsible for the training-induced VF protection...
  18. ncbi request reprint Endurance exercise training attenuates cardiac beta2-adrenoceptor responsiveness and prevents ventricular fibrillation in animals susceptible to sudden death
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 290:H2590-9. 2006
    ..Thus exercise training can restore cardiac beta-AR balance (by reducing beta(2)-AR responsiveness) and could, thereby, prevent VF...
  19. ncbi request reprint Heart rate response to onset of exercise: evidence for enhanced cardiac sympathetic activity in animals susceptible to ventricular fibrillation
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 291:H429-35. 2006
    ....
  20. ncbi request reprint Effect of endurance exercise training on heart rate onset and heart rate recovery responses to submaximal exercise in animals susceptible to ventricular fibrillation
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210 1218, USA
    J Appl Physiol (1985) 102:231-40. 2007
    ..8 vs. posttraining 159.4 +/- 7.7 beats/min; HRV pretraining 2.4 +/- 0.3 vs. posttraining 4.0 +/- 0.6 ln ms(2)). Thus endurance exercise training restored a more normal HR regulation in dogs susceptible to VF...
  21. ncbi request reprint Cardiac vagal modulation of heart rate during prolonged submaximal exercise in animals with healed myocardial infarctions: effects of training
    Monica Kukielka
    Dept of Physiology, The Ohio State University, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 290:H1680-5. 2006
    ..Furthermore, exercise training attenuated these exercise-induced reductions in heart rate variability, suggesting maintenance of a higher cardiac vagal activity during exercise in the trained state...
  22. ncbi request reprint Electrotonic remodeling following myocardial infarction in dogs susceptible and resistant to sudden cardiac death
    Carlos L del Rio
    Dept of Physiology and Cell Biology, The Ohio State Univ, 1645 Neil Ave, 305 Hamilton Hall, Columbus, OH 43210, USA
    J Appl Physiol (1985) 104:386-93. 2008
    ..In addition, passive-electrical changes could be a mechanism driving active-electrical remodeling post-MI, thereby facilitating the induction of arrhythmias...
  23. pmc Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death
    Andriy E Belevych
    Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, College of Medicine, Columbus, OH 43210, USA
    Cardiovasc Res 84:387-95. 2009
    ....
  24. doi request reprint Effects of acute vagal nerve stimulation on the early passive electrical changes induced by myocardial ischaemia in dogs: heart rate-mediated attenuation
    Carlos L del Rio
    Department of Physiology and Cell Biology, The Ohio State University, 1645 Neil Avenue, 305 Hamilton Hall, Columbus, OH 43210, USA
    Exp Physiol 93:931-44. 2008
    ..Vagal nerve stimulation during myocardial ischaemia exerts negative chronotropic effects, limiting early ischaemic electrotonic uncoupling and dispersion of repolarization, possibly via a decreased myocardial metabolic demand...
  25. ncbi request reprint Heart rate recovery after exercise: a predictor of ventricular fibrillation susceptibility after myocardial infarction
    Lauren L Smith
    Dept of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 288:H1763-9. 2005
    ..As such, postexercise heart rate recovery may help identify patients with a high risk for VF following myocardial infarction...
  26. pmc Repolarization abnormalities and afterdepolarizations in a canine model of sudden cardiac death
    Arun Sridhar
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1463-72. 2008
    ..These abnormalities may provide a substrate for initiation of postmyocardial infarction ventricular tachyarrhythmias...
  27. ncbi request reprint Exercise training normalizes beta-adrenoceptor expression in dogs susceptible to ventricular fibrillation
    Bethany J Holycross
    Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 293:H2702-9. 2007
    ..These data suggest that beta(1)-AR gene expression was decreased in susceptible dogs compared with resistant dogs and, further, that exercise training improves beta(1)-AR gene expression, thereby restoring a more normal beta-AR balance...
  28. ncbi request reprint Early time course of myocardial electrical impedance during acute coronary artery occlusion in pigs, dogs, and humans
    Carlos L del Rio
    Department of Anesthesiology, The Ohio State University, Columbus, 43210, USA
    J Appl Physiol (1985) 99:1576-81. 2005
    ..Here, the early MEI time course after left anterior descending coronary artery occlusion, represented by the time required to reach ischemic plateau, was proven to reflect such interspecies differences...
  29. pmc Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology
    Gopal J Babu
    Department of Physiology and Cell Biology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    J Mol Cell Cardiol 43:215-22. 2007
    ..In addition we found that in the phospholamban null atria, SLN protein levels are upregulated...
  30. ncbi request reprint A comprehensive review and analysis of 25 years of data from an in vivo canine model of sudden cardiac death: implications for future anti-arrhythmic drug development
    George E Billman
    Department of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210 1218, United States
    Pharmacol Ther 111:808-35. 2006
    ....
  31. ncbi request reprint Effects of exercise training on contractile function in myocardial trabeculae after ischemia-reperfusion
    Hyosook Hwang
    Section of Sport and Exercise Sciences, School of Physical Activity and Educational Services, The Ohio State Univ, Columbus, OH, USA
    J Appl Physiol 99:230-6. 2005
    ..Nevertheless, the trained myocardium appears to have a greater maximum force-generating ability that may, at least partially, compensate for reduced contractile function induced by a brief period of ischemia...

Research Grants8

  1. Effect of Daily Exercise on Cardiac Autonomic Regulation
    GEORGE BILLMAN; Fiscal Year: 2005
    ..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..
  2. Dietary Omega-3 Fatty Acids and Sudden Cardiac Death
    GEORGE EDWARD BILLMAN; Fiscal Year: 2010
    ..This project will also determine the effectiveness of fish oil supplements in reducing sudden death due to a lethal abnormal heart rhythm after a heart attack. ..
  3. Effect of Daily Exercise on Cardiac Autonomic Regulation
    GEORGE BILLMAN; Fiscal Year: 2002
    ..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..
  4. Effect of Daily Exercise on Cardiac Autonomic Regulation
    GEORGE BILLMAN; Fiscal Year: 2003
    ..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..
  5. Dietary Omega-3 Fatty Acids and Sudden Cardiac Death
    GEORGE BILLMAN; Fiscal Year: 2007
    ..This project will also determine the effectiveness of fish oil supplements in reducing sudden death due to a lethal abnormal heart rhythm after a heart attack. ..
  6. Dietary Omega-3 Fatty Acids and Sudden Cardiac Death
    GEORGE BILLMAN; Fiscal Year: 2009
    ..This project will also determine the effectiveness of fish oil supplements in reducing sudden death due to a lethal abnormal heart rhythm after a heart attack. ..
  7. Effect of Daily Exercise on Cardiac Autonomic Regulation
    GEORGE BILLMAN; Fiscal Year: 2004
    ..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..