Krishna P Bhat

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. doi request reprint Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2
    Krishna P Bhat
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    FEBS Lett 582:3193-200. 2008
  2. pmc Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma
    Krishna P L Bhat
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA Electronic address
    Cancer Cell 24:331-46. 2013
  3. pmc The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma
    Krishna P L Bhat
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 25:2594-609. 2011
  4. pmc Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors
    Melissa M Singh
    Department of Pediatrics Research, The Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Neuro Oncol 13:894-903. 2011
  5. ncbi request reprint PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway
    Dimpy Koul
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell Biochem 300:77-87. 2007
  6. pmc Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma
    Tiffany A Doucette
    Department of Neurosurgery, The Brain Tumor Center, Houston, TX, USA
    Neuro Oncol 14:1136-45. 2012
  7. pmc Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT
    Dongmin Gu
    Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA
    J Biol Chem 286:23178-88. 2011
  8. pmc Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation
    Krishna P Bhat
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    EMBO J 23:2402-12. 2004
  9. ncbi request reprint Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation
    Koji Itahana
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 12:1151-64. 2003
  10. ncbi request reprint Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
    Koji Itahana
    Department of Radiation Oncology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 12:355-66. 2007

Collaborators

Detail Information

Publications10

  1. doi request reprint Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2
    Krishna P Bhat
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    FEBS Lett 582:3193-200. 2008
    ..This study presents a paradigm for NF-kappaB regulation of one of its targets in a strict cell type specific manner...
  2. pmc Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma
    Krishna P L Bhat
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA Electronic address
    Cancer Cell 24:331-46. 2013
    ..We further show that the MES signature, CD44 expression, and NF-κB activation correlate with poor radiation response and shorter survival in patients with GBM. ..
  3. pmc The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma
    Krishna P L Bhat
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 25:2594-609. 2011
    ..Our studies uncover a direct role for TAZ and TEAD in driving the MES differentiation of malignant glioma...
  4. pmc Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors
    Melissa M Singh
    Department of Pediatrics Research, The Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Neuro Oncol 13:894-903. 2011
    ....
  5. ncbi request reprint PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway
    Dimpy Koul
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell Biochem 300:77-87. 2007
    ....
  6. pmc Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma
    Tiffany A Doucette
    Department of Neurosurgery, The Brain Tumor Center, Houston, TX, USA
    Neuro Oncol 14:1136-45. 2012
    ..These results demonstrate that STAT3 promotes the malignant progression of glioma. Inhibiting STAT3 expression mitigates tumor progression and improves survival, validating it as a therapeutic target...
  7. pmc Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT
    Dongmin Gu
    Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA
    J Biol Chem 286:23178-88. 2011
    ..Our findings potentially reveal a simple yet novel signaling pathway based upon caspase-3 cleavage of p120-catenin subfamily members, facilitating the coordinate modulation of cadherins, small GTPases, and nuclear functions...
  8. pmc Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation
    Krishna P Bhat
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    EMBO J 23:2402-12. 2004
    ..Growth inhibition, presumably through suppression of rRNA production in the nucleolus, facilitates translocation of L11 to the nucleoplasm, thus activating p53 through inhibiting HDM2...
  9. ncbi request reprint Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation
    Koji Itahana
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 12:1151-64. 2003
    ..Together, our results reveal a molecular mechanism of ARF in regulating ribosome biogenesis and cell proliferation via inhibiting B23, and suggest a nucleolar role of ARF in surveillance of oncogenic insults...
  10. ncbi request reprint Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
    Koji Itahana
    Department of Radiation Oncology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 12:355-66. 2007
    ....