Affiliation: The Scripps Research Institute
Country: USA


  1. Beutler B, Georgel P, Rutschmann S, Jiang Z, Croker B, Crozat K. Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief Funct Genomic Proteomic. 2005;4:203-13 pubmed
    ..The forward genetics approach offers an excellent opportunity to identify many of the key components of the innate immune system. ..
  2. Beutler B. Toll-like receptors and their place in immunology. Where does the immune response to infection begin?. Nat Rev Immunol. 2004;4:498 pubmed publisher
  3. Beutler B. The Toll-like receptors: analysis by forward genetic methods. Immunogenetics. 2005;57:385-92 pubmed
    ..These include the development of fever, shock, and tissue injury, but also the activation of innate and adaptive effector mechanisms that lead to the elimination of microbes. ..
  4. Crozat K, Georgel P, Rutschmann S, Mann N, Du X, Hoebe K, et al. Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome. 2006;17:398-406 pubmed
  5. Beutler B. Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Immunol Rev. 2009;227:248-63 pubmed publisher
    ..We have also developed some insight into critical points at which feedback loops can be interrupted. ..