Research Topics
| J M BethonySummaryAffiliation: The George Washington University Country: USA Publications
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Detail Information
Publications
Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine InitiativePeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
Int J Parasitol 33:1245-58. 2003..Another challenge will be to produce anti-hookworm vaccine antigens at high yield low cost suitable for immunising large impoverished populations living in the developing nations of the tropics...- Hookworm infectionPeter J Hotez
Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20037, USA
N Engl J Med 351:799-807. 2004 
Hookworm vaccinesDavid J Diemert
Sabin Vaccine Institute, George Washington University, Washington, DC 20037, USA
Clin Infect Dis 46:282-8. 2008..Plans call for eventual development of a vaccine that will combine at least 2 hookworm antigens--one targeting the larval stage of the life cycle and another targeting the adult worm living in the gastrointestinal tract...- New drugs for an ancient parasiteAlex Loukas
Nat Med 14:365-7. 2008 - Can schistosomiasis really be consigned to history without a vaccine?Jeffrey M Bethony
Vaccine 26:3373-6. 2008..Funding bodies supporting research into the control of schistosomiasis should invest not only in mass drug administration but also in the development of new control strategies, including the development of vaccines... 
Vaccines to combat the neglected tropical diseasesJeffrey M Bethony
Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
Immunol Rev 239:237-70. 2011..Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access...- Exposure to Schistosoma mansoni infection in a rural area in Brazil. Part III: household aggregation of water-contact behaviourJeffrey Bethony
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Trop Med Int Health 9:381-9. 2004..Our results also support a focus on the household in the implementation of schistosomiasis prevention and control efforts... - Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adultsJeffrey M Bethony
Department of Microbiology, Immunology and Tropical Medicine, George Washington University Health Center, Washington, DC 20037, United States
Vaccine 26:2408-17. 2008.... - Vaccines against blood-feeding nematodes of humans and livestockJ M Bethony
Centro de Pesquisas René Rachou CPqRR, A FIOCRUZ em Minas Gerais Rene Rachou Research Center CPqRR, The Oswaldo Cruz Foundation, Minas Gerais, Brazil
Parasitology 133:S63-79. 2006.... - Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16Ricardo T Fujiwara
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Ross Hall Room 727, 2300 Eye St NW, Washington, DC 20037, USA
Clin Vaccine Immunol 14:281-7. 2007..Our data support the use of Ac-16 as a potential candidate for vaccination against hookworm infection... - Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of wormsAlex Loukas
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
J Infect Dis 189:1952-61. 2004..These results indicate that cysteine proteases involved in parasite nutrition are promising candidates as vaccines against hookworm disease... - Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasisPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
Expert Rev Vaccines 7:745-52. 2008..A multivalent anthelminthic vaccine for hookworm infection and schistosomiasis would represent an important new tool for combating disease and poverty... - Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trialsGaddam Narsa Goud
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall 736, 2300 Eye Street NW, Washington, DC 20037, USA
Vaccine 23:4754-64. 2005..The processes developed and tested for the high yield production of recombinant Na-ASP-2 provide a foundation for clinical vaccine development... - Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogsRicardo T Fujiwara
Department of Microbiology and Tropical Medicine, The George Washington University, 2300 Eye Street, Ross Hall Room 727, Medical Center, Washington, DC 20037, USA
Vaccine 24:501-9. 2006.... - Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninumBin Zhan
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
Infect Immun 73:6903-11. 2005..7%) following challenge with heterologous Necator americanus larvae. These studies suggest that Ac-GST-1 is a possible drug and vaccine target for hookworm infection... - Developing vaccines to combat hookworm infection and intestinal schistosomiasisPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
Nat Rev Microbiol 8:814-26. 2010..New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development... - Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from BrazilAndréa Teixeira-Carvalho
Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Minas Gerais, Brazil
Infect Immun 76:5810-6. 2008..Binding of ES products causes the NK cells to become activated and secrete IFN-gamma locally, thereby contributing to the adult hookworm's ability to evade host immune responses... - Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of BrazilMaria Flavia Gazzinelli
School of Nursing, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
PLoS Negl Trop Dis 4:e749. 2010.... - Genetic epidemiology of human schistosomiasis in BrazilJeffrey M Bethony
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, United States
Acta Trop 108:166-74. 2008..Results from Brazilian studies are compared with studies of S. mansoni and other schistosome species elsewhere in the world... - Synergistic associations between hookworm and other helminth species in a rural community in BrazilFiona M Fleming
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
Trop Med Int Health 11:56-64. 2006..More research is needed to examine the rates of re-infection and immune responses after chemotherapy, and to what extent the effects of polyparasitism are altered by chemotherapy... - Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern BrazilSimon Brooker
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Trans R Soc Trop Med Hyg 101:146-54. 2007..Our results indicate that, even in areas where there is a low overall prevalence of anaemia, hookworm can still have an important impact on host iron status, especially in school-aged children and the elderly... - Immunobiology of hookworm infectionAlex Loukas
Helminth Biology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, 300 Herston Road, Herston, QLD 4006, Australia
FEMS Immunol Med Microbiol 43:115-24. 2005..Significant progress has been made in the development of anti-hookworm recombinant vaccines, and clinical trials are expected to begin in the near future... - Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogsAlex Loukas
Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
PLoS Med 2:e295. 2005..The parasites subsequently digest hemoglobin in their intestines using a cascade of proteolysis that begins with the Ancylostoma caninum aspartic protease 1, APR-1... - Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasisMai H Tran
Helminth Biology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia
Nat Med 12:835-40. 2006..When coupled with its selective recognition by naturally resistant people, TSP-2 seems to be an effective vaccine antigen against S. mansoni...