J M Bethony

Summary

Affiliation: The George Washington University
Country: USA

Publications

  1. ncbi request reprint Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
    Int J Parasitol 33:1245-58. 2003
  2. ncbi request reprint Hookworm infection
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 351:799-807. 2004
  3. doi request reprint Hookworm vaccines
    David J Diemert
    Sabin Vaccine Institute, George Washington University, Washington, DC 20037, USA
    Clin Infect Dis 46:282-8. 2008
  4. doi request reprint New drugs for an ancient parasite
    Alex Loukas
    Nat Med 14:365-7. 2008
  5. ncbi request reprint Can schistosomiasis really be consigned to history without a vaccine?
    Jeffrey M Bethony
    Vaccine 26:3373-6. 2008
  6. pmc Vaccines to combat the neglected tropical diseases
    Jeffrey M Bethony
    Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Immunol Rev 239:237-70. 2011
  7. ncbi request reprint Exposure to Schistosoma mansoni infection in a rural area in Brazil. Part III: household aggregation of water-contact behaviour
    Jeffrey Bethony
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Trop Med Int Health 9:381-9. 2004
  8. doi request reprint Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adults
    Jeffrey M Bethony
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Health Center, Washington, DC 20037, United States
    Vaccine 26:2408-17. 2008
  9. ncbi request reprint Vaccines against blood-feeding nematodes of humans and livestock
    J M Bethony
    Centro de Pesquisas René Rachou CPqRR, A FIOCRUZ em Minas Gerais Rene Rachou Research Center CPqRR, The Oswaldo Cruz Foundation, Minas Gerais, Brazil
    Parasitology 133:S63-79. 2006
  10. pmc Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16
    Ricardo T Fujiwara
    Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Ross Hall Room 727, 2300 Eye St NW, Washington, DC 20037, USA
    Clin Vaccine Immunol 14:281-7. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
    Int J Parasitol 33:1245-58. 2003
    ..Another challenge will be to produce anti-hookworm vaccine antigens at high yield low cost suitable for immunising large impoverished populations living in the developing nations of the tropics...
  2. ncbi request reprint Hookworm infection
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 351:799-807. 2004
  3. doi request reprint Hookworm vaccines
    David J Diemert
    Sabin Vaccine Institute, George Washington University, Washington, DC 20037, USA
    Clin Infect Dis 46:282-8. 2008
    ..Plans call for eventual development of a vaccine that will combine at least 2 hookworm antigens--one targeting the larval stage of the life cycle and another targeting the adult worm living in the gastrointestinal tract...
  4. doi request reprint New drugs for an ancient parasite
    Alex Loukas
    Nat Med 14:365-7. 2008
  5. ncbi request reprint Can schistosomiasis really be consigned to history without a vaccine?
    Jeffrey M Bethony
    Vaccine 26:3373-6. 2008
    ..Funding bodies supporting research into the control of schistosomiasis should invest not only in mass drug administration but also in the development of new control strategies, including the development of vaccines...
  6. pmc Vaccines to combat the neglected tropical diseases
    Jeffrey M Bethony
    Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Immunol Rev 239:237-70. 2011
    ..Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access...
  7. ncbi request reprint Exposure to Schistosoma mansoni infection in a rural area in Brazil. Part III: household aggregation of water-contact behaviour
    Jeffrey Bethony
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Trop Med Int Health 9:381-9. 2004
    ..Our results also support a focus on the household in the implementation of schistosomiasis prevention and control efforts...
  8. doi request reprint Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 hookworm vaccine in unexposed adults
    Jeffrey M Bethony
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Health Center, Washington, DC 20037, United States
    Vaccine 26:2408-17. 2008
    ....
  9. ncbi request reprint Vaccines against blood-feeding nematodes of humans and livestock
    J M Bethony
    Centro de Pesquisas René Rachou CPqRR, A FIOCRUZ em Minas Gerais Rene Rachou Research Center CPqRR, The Oswaldo Cruz Foundation, Minas Gerais, Brazil
    Parasitology 133:S63-79. 2006
    ....
  10. pmc Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16
    Ricardo T Fujiwara
    Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Ross Hall Room 727, 2300 Eye St NW, Washington, DC 20037, USA
    Clin Vaccine Immunol 14:281-7. 2007
    ..Our data support the use of Ac-16 as a potential candidate for vaccination against hookworm infection...
  11. ncbi request reprint Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms
    Alex Loukas
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
    J Infect Dis 189:1952-61. 2004
    ..These results indicate that cysteine proteases involved in parasite nutrition are promising candidates as vaccines against hookworm disease...
  12. doi request reprint Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasis
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
    Expert Rev Vaccines 7:745-52. 2008
    ..A multivalent anthelminthic vaccine for hookworm infection and schistosomiasis would represent an important new tool for combating disease and poverty...
  13. ncbi request reprint Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials
    Gaddam Narsa Goud
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall 736, 2300 Eye Street NW, Washington, DC 20037, USA
    Vaccine 23:4754-64. 2005
    ..The processes developed and tested for the high yield production of recombinant Na-ASP-2 provide a foundation for clinical vaccine development...
  14. ncbi request reprint Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs
    Ricardo T Fujiwara
    Department of Microbiology and Tropical Medicine, The George Washington University, 2300 Eye Street, Ross Hall Room 727, Medical Center, Washington, DC 20037, USA
    Vaccine 24:501-9. 2006
    ....
  15. pmc Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum
    Bin Zhan
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
    Infect Immun 73:6903-11. 2005
    ..7%) following challenge with heterologous Necator americanus larvae. These studies suggest that Ac-GST-1 is a possible drug and vaccine target for hookworm infection...
  16. doi request reprint Developing vaccines to combat hookworm infection and intestinal schistosomiasis
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    Nat Rev Microbiol 8:814-26. 2010
    ..New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development...
  17. pmc Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil
    Andréa Teixeira-Carvalho
    Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Minas Gerais, Brazil
    Infect Immun 76:5810-6. 2008
    ..Binding of ES products causes the NK cells to become activated and secrete IFN-gamma locally, thereby contributing to the adult hookworm's ability to evade host immune responses...
  18. pmc Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil
    Maria Flavia Gazzinelli
    School of Nursing, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 4:e749. 2010
    ....
  19. doi request reprint Genetic epidemiology of human schistosomiasis in Brazil
    Jeffrey M Bethony
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, United States
    Acta Trop 108:166-74. 2008
    ..Results from Brazilian studies are compared with studies of S. mansoni and other schistosome species elsewhere in the world...
  20. ncbi request reprint Synergistic associations between hookworm and other helminth species in a rural community in Brazil
    Fiona M Fleming
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Trop Med Int Health 11:56-64. 2006
    ..To identify possible synergistic associations of hookworm and other helminths...
  21. ncbi request reprint Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil
    Simon Brooker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trans R Soc Trop Med Hyg 101:146-54. 2007
    ..Our results indicate that, even in areas where there is a low overall prevalence of anaemia, hookworm can still have an important impact on host iron status, especially in school-aged children and the elderly...
  22. ncbi request reprint Immunobiology of hookworm infection
    Alex Loukas
    Helminth Biology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, 300 Herston Road, Herston, QLD 4006, Australia
    FEMS Immunol Med Microbiol 43:115-24. 2005
    ..Significant progress has been made in the development of anti-hookworm recombinant vaccines, and clinical trials are expected to begin in the near future...
  23. pmc Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs
    Alex Loukas
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Med 2:e295. 2005
    ..The parasites subsequently digest hemoglobin in their intestines using a cascade of proteolysis that begins with the Ancylostoma caninum aspartic protease 1, APR-1...
  24. ncbi request reprint Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis
    Mai H Tran
    Helminth Biology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia
    Nat Med 12:835-40. 2006
    ..When coupled with its selective recognition by naturally resistant people, TSP-2 seems to be an effective vaccine antigen against S. mansoni...