Robert I Berkowitz

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc Maintenance of weight loss in adolescents: current status and future directions
    Meghan L Butryn
    Department of Psychology, Drexel University, Philadelphia, PA 19104, USA
    J Obes 2010:789280. 2010
  2. pmc Treatment of adolescent obesity comparing self-guided and group lifestyle modification programs: a potential model for primary care
    Robert I Berkowitz
    MD, The Department of Child and Adolescent Psychiatry and Behavioral Sciences, The Children s Hospital of Philadelphia, 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA
    J Pediatr Psychol 38:978-86. 2013
  3. pmc Meal replacements in the treatment of adolescent obesity: a randomized controlled trial
    Robert I Berkowitz
    Department of Child and Adolescent Psychiatry, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1193-9. 2011
  4. pmc Identification of an obese eating style in 4-year-old children born at high and low risk for obesity
    Robert I Berkowitz
    Department of Child and Adolescent Psychiatry, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 18:505-12. 2010
  5. ncbi request reprint Effects of sibutramine treatment in obese adolescents: a randomized trial
    Robert I Berkowitz
    The Behavioral Health Center, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 145:81-90. 2006
  6. pmc Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:751-5. 2010
  7. pmc The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry
    Sandra Deliard
    Division of Human Genetics, Research Institute, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:159-63. 2013
  8. pmc The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    BMC Med Genet 11:96. 2010
  9. pmc The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:2254-7. 2009
  10. doi request reprint Role of BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:2436-9. 2011

Detail Information

Publications46

  1. pmc Maintenance of weight loss in adolescents: current status and future directions
    Meghan L Butryn
    Department of Psychology, Drexel University, Philadelphia, PA 19104, USA
    J Obes 2010:789280. 2010
    ..More research is needed on the management of adolescent obesity, which has been overlooked when compared with research on the treatment of obesity in children and adults...
  2. pmc Treatment of adolescent obesity comparing self-guided and group lifestyle modification programs: a potential model for primary care
    Robert I Berkowitz
    MD, The Department of Child and Adolescent Psychiatry and Behavioral Sciences, The Children s Hospital of Philadelphia, 3440 Market Street, Suite 200, Philadelphia, PA 19104, USA
    J Pediatr Psychol 38:978-86. 2013
    ..17% (0.99%) decrease in the Self-Guided LMP (p = 0.92). Both treatments were significantly effective in reducing body mass index. Given its brevity, the Self-Guided LMP offers an innovative approach for primary care. ..
  3. pmc Meal replacements in the treatment of adolescent obesity: a randomized controlled trial
    Robert I Berkowitz
    Department of Child and Adolescent Psychiatry, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1193-9. 2011
    ..Across groups, mean reduction in BMI from baseline to month 12 was 3.4 ± 0.7% (P < 0.01). Use of MR significantly improved short-term weight loss, compared with CD, but its continued use did not improve maintenance of lost weight...
  4. pmc Identification of an obese eating style in 4-year-old children born at high and low risk for obesity
    Robert I Berkowitz
    Department of Child and Adolescent Psychiatry, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 18:505-12. 2010
    ..Thus, a rapid eating style, characterized by increased mouthfuls of food/min, may be a behavioral marker for the development of childhood obesity...
  5. ncbi request reprint Effects of sibutramine treatment in obese adolescents: a randomized trial
    Robert I Berkowitz
    The Behavioral Health Center, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 145:81-90. 2006
    ..Increased prevalence of adolescent obesity requires effective treatment options beyond behavior therapy...
  6. pmc Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:751-5. 2010
    ..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood...
  7. pmc The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry
    Sandra Deliard
    Division of Human Genetics, Research Institute, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:159-63. 2013
    ..Investigations if these loci also harbor rarer missense variants that confer substantially higher risk of common childhood obesity in African American (AA) children were conducted...
  8. pmc The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    BMC Med Genet 11:96. 2010
    ..Despite environmental influences, genetic factors are known to play an important role in stature determination. A number of genetic determinants of adult height have already been established through genome wide association studies...
  9. pmc The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:2254-7. 2009
    ..We conclude that among 13 loci that have been reported to associate with adult BMI, at least nine also contribute to the determination of BMI in childhood as demonstrated by their associations in our pediatric cohort...
  10. doi request reprint Role of BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:2436-9. 2011
    ....
  11. pmc Changes in symptoms of depression with weight loss: results of a randomized trial
    Lucy F Faulconbridge
    Department of Psychiatry, Center for Weight and Eating Disorders, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:1009-16. 2009
    ..Further research is needed to identify characteristics of obese patients at risk of negative mood changes (and suicidal ideation) in response to behavioral and pharmacologic therapies...
  12. pmc Adolescent eating in the absence of hunger and relation to discretionary calorie allowance
    Tanja V E Kral
    Division of Biostatistics, Center for Clinical Epidemiology and Biostatistics, Department of Psychiatry, Philadelphia, PA, USA
    J Am Diet Assoc 110:1896-900. 2010
    ..The association between eating in the absence of hunger and weight and obesity risk status depended on adolescents' sex and could reflect emerging developmental differences, such as dieting or social desirability...
  13. doi request reprint BMD-associated variation at the Osterix locus is correlated with childhood obesity in females
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1311-4. 2011
    ..In conclusion, these findings indicate that a well established variant at the Osterix locus associated with increased BMD is also associated with childhood obesity primarily in females...
  14. pmc Threshold for improvement in insulin sensitivity with adolescent weight loss
    Pamela Abrams
    Division of Endocrinology and Diabetes, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr 163:785-90. 2013
    ....
  15. ncbi request reprint Maternal obesity associated with inflammation in their children
    Karen L Leibowitz
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    World J Pediatr 8:76-9. 2012
    ....
  16. pmc A two-year randomized trial of obesity treatment in primary care practice
    Thomas A Wadden
    Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    N Engl J Med 365:1969-79. 2011
    ..This randomized trial compared weight loss during a 2-year period in response to three lifestyle interventions, all delivered by PCPs in collaboration with auxiliary health professionals (lifestyle coaches) in their practices...
  17. pmc Weight reduction in obese adolescents with and without binge eating
    Chanelle T Bishop-Gilyard
    Department of Child and Adolescent Psychiatry and Behavioral Science, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:982-7. 2011
    ..0001). Findings suggest a combination of behavioral and pharmacologic therapy may produce both weight loss and improvement in BE...
  18. ncbi request reprint Randomized trial of lifestyle modification and pharmacotherapy for obesity
    Thomas A Wadden
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    N Engl J Med 353:2111-20. 2005
    ..This practice is likely to limit therapeutic benefits...
  19. pmc Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2414-8. 2009
    ..In order to investigate whether type 2 diabetes risk-conferring alleles associate with low birth weight in our Caucasian childhood cohort, we examined the effects of 20 such loci on this trait...
  20. pmc Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:1461-5. 2009
    ..As such, variants 3' to the MC4R locus present on the genotyping platform utilized confer a similar magnitude of risk of obesity in white children as to their adult white counterparts but this observation did not extend to AAs...
  21. pmc Four-year weight losses in the Look AHEAD study: factors associated with long-term success
    Thomas A Wadden
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1987-98. 2011
    ..e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years...
  22. ncbi request reprint Metabolic syndrome and health-related quality of life in obese individuals seeking weight reduction
    Adam Gilden Tsai
    Center for Weight and Eating Disorders, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 16:59-63. 2008
    ..We hypothesized that MetSyn would be associated with lower HRQoL on measures of physical and mental health...
  23. ncbi request reprint Eating in the absence of hunger: a genetic marker for childhood obesity in prepubertal boys?
    Myles S Faith
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Obesity (Silver Spring) 14:131-8. 2006
    ..The primary aim of this study was to compare children born at high vs. low risk for obesity with respect to EAH at 5 years of age...
  24. pmc The association between weight loss in caregivers and adolescents in a treatment trial of adolescents with obesity
    Melissa S Xanthopoulos
    Department of Child and Adolescent Psychiatry and Behavioral Sciences, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Psychol 38:766-74. 2013
    ..The relationship between weight change in caregivers and their adolescents was evaluated following a randomized trial of lifestyle modification for adolescents, which included either a conventional diet or meal replacements...
  25. doi request reprint Obesity, psychiatric status, and psychiatric medications
    Robert I Berkowitz
    Children s Hospital of Philadelphia, and Center for Weight and Eating Disorders, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, 3535 Market Street, Suite 3029, Philadelphia, PA 19104, USA
    Psychiatr Clin North Am 34:747-64. 2011
    ..Persons who require antipsychotic medications are at risk for weight gain and metabolic abnormalities, and their management should be informed by consensus guidelines...
  26. pmc A genome-wide study reveals copy number variants exclusive to childhood obesity cases
    Joseph T Glessner
    Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, 19104, USA
    Am J Hum Genet 87:661-6. 2010
    ..Although these variants may be individually rare, our results indicate that CNVs contribute to the genetic susceptibility of common childhood obesity in subjects of both European and African ancestry...
  27. ncbi request reprint Changes in obesity-related attitudes in women seeking weight reduction
    Canice E Crerand
    Department of Psychiatry, Center for Weight and Eating Disorders, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Obesity (Silver Spring) 15:740-7. 2007
    ..To examine changes in obesity-related attitudes in a sample of obese women who participated in either dieting or non-dieting interventions...
  28. pmc Beverage consumption patterns of children born at different risk of obesity
    Tanja V E Kral
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 16:1802-8. 2008
    ..Increased intake of sugar-sweetened beverages and fruit juice has been associated with overweight in children...
  29. ncbi request reprint Weight loss in obese African American and Caucasian adolescents: secondary analysis of a randomized clinical trial of behavioral therapy plus sibutramine
    Geraldine M Budd
    Doctoral Program, College of Nursing and Health Professions, Drexel University, Philadelphia, PA 19102, USA
    J Cardiovasc Nurs 22:288-96. 2007
    ....
  30. ncbi request reprint Parental feeding attitudes and styles and child body mass index: prospective analysis of a gene-environment interaction
    Myles S Faith
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 114:e429-36. 2004
    ..Parental feeding styles were linked to child weight in cross-sectional studies, which were unable to test the direction of effect. Prospective studies can best establish causal relationships among such variables...
  31. ncbi request reprint Growth of children at high risk of obesity during the first 6 y of life: implications for prevention
    Robert I Berkowitz
    Departments of Psychiatry and the Division of GI and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Clin Nutr 81:140-6. 2005
    ..The contribution of familial factors to adiposity in children is poorly understood...
  32. ncbi request reprint Daily food intake in relation to dietary energy density in the free-living environment: a prospective analysis of children born at different risk of obesity
    Tanja V E Kral
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Clin Nutr 86:41-7. 2007
    ..Young children adjust their short-term intake in response to variations in energy density (ED; kcal/g) from preloads in laboratory studies. It remains unknown whether this compensation also occurs under free-living conditions...
  33. doi request reprint Cardiovascular disease risk factor (CVDRF) associated waist circumference patterns in obese-prone children
    Karen L Leibowitz
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Int J Pediatr Obes 4:150-9. 2009
    ....
  34. pmc The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it
    Thomas A Wadden
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA corrected
    Obesity (Silver Spring) 14:737-52. 2006
    ..After Year 4, participants are offered monthly individual visits. The intervention is delivered by a multidisciplinary team that includes medical staff who monitor participants at risk of hypoglycemic episodes...
  35. pmc One-year weight losses in the Look AHEAD study: factors associated with success
    Thomas A Wadden
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:713-22. 2009
    ..The lifestyle intervention was clinically effective in all subsets of an ethnically and demographically diverse population...
  36. ncbi request reprint An open-label efficacy trial of escitalopram for night eating syndrome
    Kelly C Allison
    Center for Weight and Eating Disorders, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Eat Behav 14:199-203. 2013
    ..Selective serotonin reuptake inhibitors have shown efficacy in previous trials, so we sought to expand our understanding of the efficacy of escitalopram in the current trial...
  37. pmc Sleep architecture and glucose and insulin homeostasis in obese adolescents
    Dorit Koren
    Division of Pediatric Endocrinology and Diabetes, The Children s Hospital of Philadelphia, PA, USA
    Diabetes Care 34:2442-7. 2011
    ..We hypothesized that in obese adolescents, sleep disturbances would associate with altered glucose and insulin homeostasis...
  38. pmc A genome-wide association meta-analysis identifies new childhood obesity loci
    Jonathan P Bradfield
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Nat Genet 44:526-31. 2012
    ..These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI(1)...
  39. ncbi request reprint Dieting and the development of eating disorders in obese women: results of a randomized controlled trial
    Thomas A Wadden
    Department of Psychiatry, Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA 19104, USA
    Am J Clin Nutr 80:560-8. 2004
    ..Some investigators fear that dieting may precipitate binge eating and other adverse behavioral consequences...
  40. ncbi request reprint Obesity, psychiatric status, and psychiatric medications
    Robert I Berkowitz
    Weight and Eating Disorders Program, Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA 19104, USA
    Psychiatr Clin North Am 28:39-54, vii-viii. 2005
  41. pmc Treatment of Comorbid Obesity and Major Depressive Disorder: A Prospective Pilot Study for their Combined Treatment
    Lucy F Faulconbridge
    Center for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Obes 2011:870385. 2011
    ..A larger randomized controlled trial is needed to establish the efficacy of this treatment...
  42. pmc Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e1746. 2008
    ..As such, variants in the FTO gene confer a similar magnitude of risk of obesity to children as to their adult counterparts and appear to have a global impact...
  43. ncbi request reprint Efficacy of sibutramine for the treatment of binge eating disorder: a randomized multicenter placebo-controlled double-blind study
    Denise E Wilfley
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 165:51-8. 2008
    ..This study is the first large-scale, multisite, placebo-controlled trial to test the efficacy of sibutramine in binge eating disorder...
  44. ncbi request reprint Behavior therapy and sibutramine for the treatment of adolescent obesity: a randomized controlled trial
    Robert I Berkowitz
    Department of Psychiatry, Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, Philadelphia 19104 3309, USA
    JAMA 289:1805-12. 2003
    ..Adolescent obesity is becoming a national public health problem. Weight-loss medications including sibutramine facilitate weight control in adults and could be used with obese adolescents in combination with behavior therapy (BT)...
  45. ncbi request reprint Great expectations: "I'm losing 25% of my weight no matter what you say"
    Thomas A Wadden
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Consult Clin Psychol 71:1084-9. 2003
    ..Results are discussed in terms of the origins, clinical significance, and potential malleability of obese individuals' weight loss expectations...
  46. pmc Placebo response in binge eating disorder
    M Joy Jacobs-Pilipski
    UCSD Eating Disorders Treatment Center, San Diego, California, USA
    Int J Eat Disord 40:204-11. 2007
    ..The aims of this study were (1) to compare placebo responders (PRs) with nonresponders (NRs); (2) to investigate the course of BED following placebo response; and (3) to examine attributions regarding placebo response...