Shelley L Berger

Summary

Affiliation: The Wistar Institute
Country: USA

Publications

  1. pmc The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression
    Efrat Shema
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 22:2664-76. 2008
  2. ncbi request reprint The complex language of chromatin regulation during transcription
    Shelley L Berger
    The Wistar Institute, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA
    Nature 447:407-12. 2007
  3. doi request reprint Out of the jaws of death: PRMT5 steers p53
    Shelley L Berger
    The Wistar Institute, Gene Expression and Regulation Program, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA
    Nat Cell Biol 10:1389-90. 2008
  4. pmc Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae
    Kristin Ingvarsdottir
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 27:7856-64. 2007
  5. ncbi request reprint Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing
    N C Tolga Emre
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19024, USA
    Mol Cell 17:585-94. 2005
  6. ncbi request reprint H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex
    Anastasia Wyce
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cell 27:275-88. 2007
  7. pmc Histone H4 lysine 16 acetylation regulates cellular lifespan
    Weiwei Dang
    Gene Expression and Regulation Program, The Wistar Institute Philadelphia, Pennsylvania 19104, USA
    Nature 459:802-7. 2009
  8. pmc Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8
    Karl W Henry
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 17:2648-63. 2003
  9. pmc Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae
    Jerome Govin
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucleic Acids Res 38:4599-606. 2010
  10. pmc Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction
    Marina L Kozak
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6100, USA
    EMBO J 29:158-70. 2010

Research Grants

  1. The Enzymology of Chromatin and Transcription
    Shelley Berger; Fiscal Year: 2003

Detail Information

Publications56

  1. pmc The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression
    Efrat Shema
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 22:2664-76. 2008
    ..Furthermore, frequent RNF20 promoter hypermethylation was observed in tumors. RNF20 may thus be a putative tumor suppressor, acting through selective regulation of a distinct subset of genes...
  2. ncbi request reprint The complex language of chromatin regulation during transcription
    Shelley L Berger
    The Wistar Institute, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA
    Nature 447:407-12. 2007
    ..Although such modifications were initially thought to be a simple code, a more likely model is of a sophisticated, nuanced chromatin 'language' in which different combinations of basic building blocks yield dynamic functional outcomes...
  3. doi request reprint Out of the jaws of death: PRMT5 steers p53
    Shelley L Berger
    The Wistar Institute, Gene Expression and Regulation Program, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA
    Nat Cell Biol 10:1389-90. 2008
    ..Now, arginine methylation joins a panoply of other post-translational modifications that regulate p53. PRMT5 mediates p53 methylation, which disposes the cell to arrest rather than death...
  4. pmc Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae
    Kristin Ingvarsdottir
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 27:7856-64. 2007
    ..Thus, analysis of lysine demethylation in yeast provides new insight into the physiological roles of jumonji demethylase enzymes...
  5. ncbi request reprint Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing
    N C Tolga Emre
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19024, USA
    Mol Cell 17:585-94. 2005
    ..Our results suggest that these H2B-deubiquitylating enzymes have distinct genomic functions...
  6. ncbi request reprint H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex
    Anastasia Wyce
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cell 27:275-88. 2007
    ..These findings reveal a mechanism by which H2B ubiquitylation acts as a barrier to Ctk1 association with active genes, while subsequent deubiquitylation by Ubp8 triggers Ctk1 recruitment at the appropriate point in activation...
  7. pmc Histone H4 lysine 16 acetylation regulates cellular lifespan
    Weiwei Dang
    Gene Expression and Regulation Program, The Wistar Institute Philadelphia, Pennsylvania 19104, USA
    Nature 459:802-7. 2009
    ..This pathway, distinct from existing ageing models for yeast, may represent an evolutionarily conserved function of sirtuins in regulation of replicative ageing by maintenance of intact telomeric chromatin...
  8. pmc Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8
    Karl W Henry
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 17:2648-63. 2003
    ..These results suggest that the histone H2B ubiquitylation state is dynamic during transcription, and that the sequence of histone modifications helps to control transcription...
  9. pmc Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae
    Jerome Govin
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucleic Acids Res 38:4599-606. 2010
    ..These studies indicate distinctive features of a histone H4 modification marking system during sporulation compared with DSB repair...
  10. pmc Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction
    Marina L Kozak
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6100, USA
    EMBO J 29:158-70. 2010
    ..In contrast, sir4 deletion sped senescence and blocked the delay conferred by sas2 or sir3 deletion. We thus show that manipulation of telomere chromatin modulates senescence caused by telomere shortening...
  11. ncbi request reprint Histone modification patterns during gene activation
    Wan Sheng Lo
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Methods Enzymol 377:130-53. 2004
  12. pmc SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription
    David E Sterner
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:11622-7. 2002
    ..These data clarify a mechanism by which a transcriptional regulatory complex can switch between positive and negative modulation...
  13. pmc The histone variant H3.3 regulates gene expression during lytic infection with herpes simplex virus type 1
    Brandon J Placek
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennysylvania 19104, USA
    J Virol 83:1416-21. 2009
    ..These findings show that incorporation of H3.3 facilitates transcription, and they provide new evidence for a regulatory role of chromatin composition during HSV-1 acute infection...
  14. pmc Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
    Dafna Nathan
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 20:966-76. 2006
    ..These results indicate that sumoylation is the first negative histone modification to be identified in S. cerevisiae and further suggest that sumoylation may serve as a general dynamic mark to oppose transcription...
  15. doi request reprint Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation
    David Bungard
    Department of Cellular and Developmental Biology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Science 329:1201-5. 2010
    ..Our results place AMPK-dependent H2B Ser36 phosphorylation in a direct transcriptional and chromatin regulatory pathway leading to cellular adaptation to stress...
  16. ncbi request reprint Good fences make good neighbors: barrier elements and genomic regulation
    Jumin Zhou
    The Wistar Institute, Philadelphia, Pennsylvania 19014, USA
    Mol Cell 16:500-2. 2004
    ..In a recent issue of Molecular Cell, West et al. (2004) shed light on mechanisms underlying these molecular "fences."..
  17. pmc H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex
    Kristin Ingvarsdottir
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:1162-72. 2005
    ..These data indicate that Ubp8 and Sgf11 likely represent a new functional module within SAGA that is involved in gene regulation through H2B deubiquitylation...
  18. pmc CTCF-dependent chromatin boundary element between the latency-associated transcript and ICP0 promoters in the herpes simplex virus type 1 genome
    Qi Chen
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    J Virol 81:5192-201. 2007
    ....
  19. pmc Systematic screen reveals new functional dynamics of histones H3 and H4 during gametogenesis
    Jerome Govin
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genes Dev 24:1772-86. 2010
    ..Thus, our results show that investigation of gametogenesis in yeast provides novel insights into chromatin dynamics, which are potentially relevant to epigenetic modulation of the mammalian process...
  20. pmc Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality
    Daniel F Simola
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 23:1235-47. 2013
    ..We propose that changes in gene regulation played a key role in the origins of insect eusociality, whereas changes in gene composition were more relevant for lineage-specific eusocial adaptations. ..
  21. pmc Histone H4 lysine 20 of Saccharomyces cerevisiae is monomethylated and functions in subtelomeric silencing
    Christopher R Edwards
    Department of Cellular and Developmental Biology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Biochemistry 50:10473-83. 2011
    ..Our findings reveal the first negative regulatory histone methylation in budding yeast and indicate that H4 K20me1 is evolutionarily conserved from simple to complex eukaryotes...
  22. pmc The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression
    Xiao Yong Zhang
    The Department of Cancer Biology, The Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, PA 19107, USA
    Mol Cell 29:102-11. 2008
    ..In support of a functional role within the Polycomb/cancer stem cell signature, USP22 is required for appropriate progression through the cell cycle...
  23. ncbi request reprint p53 is regulated by the lysine demethylase LSD1
    Jing Huang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 449:105-8. 2007
    ..Lysine methylation therefore provides similar regulatory complexity for non-histone proteins and for histones...
  24. ncbi request reprint Structure and dimerization of the kinase domain from yeast Snf1, a member of the Snf1/AMPK protein family
    Vinod Nayak
    The Wistar Institute, University of Pennsylvania, Philadelphia 19104, USA
    Structure 14:477-85. 2006
    ..Taken together, these studies suggest another layer of kinase regulation within the Snf1/AMPK family, and an avenue for development of AMPK-specific activating compounds...
  25. pmc The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae
    Jessica M Bryant
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:2771-83. 2012
    ....
  26. doi request reprint Chromatin dynamics during herpes simplex virus-1 lytic infection
    Brandon J Placek
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1799:223-7. 2010
    ..Here we discuss recent studies that underscore the importance of chromatin regulation during the lytic phase of the HSV-1 life-cycle...
  27. ncbi request reprint Histone modifications in transcriptional regulation
    Shelley L Berger
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Genet Dev 12:142-8. 2002
    ..This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues persuasively for the existence of a histone code...
  28. ncbi request reprint Repression of p53 activity by Smyd2-mediated methylation
    Jing Huang
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nature 444:629-32. 2006
    ..Thus, similar to histones, p53 is subject to both activating and repressing lysine methylation. Our results also predict that Smyd2 may function as a putative oncogene by methylating p53 and repressing its tumour suppressive function...
  29. ncbi request reprint Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase
    Adrienne Clements
    The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cell 12:461-73. 2003
    ..Together, these studies reveal how one histone modification can modulate another to affect distinct transcriptional signals...
  30. ncbi request reprint Sumoylation of the yeast Gcn5 protein
    David E Sterner
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Biochemistry 45:1035-42. 2006
    ..Taken together with recent identification of multiple additional subunits of SAGA as sumoylated proteins in vivo, these data suggest that Gcn5 sumoylation may have an inhibitory role in transcriptional regulation...
  31. pmc Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1
    Jing Huang
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Virol 80:5740-6. 2006
    ....
  32. doi request reprint Hit and run: transient deubiquitylase activity in a chromatin-remodeling complex
    Valerie P Zediak
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cell 31:773-4. 2008
    ..2008) provide a glimpse into an interesting mechanism to control a deubiquitylating enzyme via interaction of two complexes-the 19S proteasome regulatory particle and an ATP-dependent nucleosome remodeling complex...
  33. pmc Identification and characterization of novel sirtuin inhibitor scaffolds
    Brandi D Sanders
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Bioorg Med Chem 17:7031-41. 2009
    ....
  34. pmc Histone modifications: Now summoning sumoylation
    Dafna Nathan
    Gene Expression and Regulation Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 100:13118-20. 2003
  35. ncbi request reprint H2B ubiquitylation and de-ubiquitylation in gene activation
    Anastasia Wyce
    The Wistar Institute, Gene Expression and Regulation Program, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Novartis Found Symp 259:63-73; discussion 73-7, 163-9. 2004
    ..These results suggest that ubiquitylation of histones has a unique role among histone modifications, possibly to orchestrate an ordered pathway of chromatin alterations...
  36. doi request reprint Genome reprogramming during sporulation
    Jerome Govin
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA19104, USA
    Int J Dev Biol 53:425-32. 2009
    ..Here, we review how chromatin structure and genome reprogramming regulate the sporulation transcription program, and how post-meiotic events reorganize spore chromatin...
  37. pmc Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
    Parisha P Shah
    Epigenetics Program, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 27:1787-99. 2013
    ..Our data illustrate profound chromatin reorganization during senescence and suggest that lamin B1 down-regulation in senescence is a key trigger of global and local chromatin changes that impact gene expression, aging, and cancer. ..
  38. pmc MYST protein acetyltransferase activity requires active site lysine autoacetylation
    Hua Yuan
    Gene Expression and Regulation Program, The Wistar Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    EMBO J 31:58-70. 2012
    ..These findings provide an avenue for the autoposttranslational regulation of MYST proteins that is distinct from other acetyltransferases but draws similarities to the phosphoregulation of protein kinases...
  39. pmc A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription
    Nickolai A Barlev
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 23:6944-57. 2003
    ....
  40. pmc A chromatin link to caste identity in the carpenter ant Camponotus floridanus
    Daniel F Simola
    Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Genome Res 23:486-96. 2013
    ..We propose that epigenetic mechanisms that modify chromatin structure may help orchestrate the generation and maintenance of polyphenic caste morphology and social behavior in ants...
  41. pmc Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis
    Thanuja Krishnamoorthy
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 20:2580-92. 2006
    ..Thus, H4 S1ph may be an evolutionarily ancient histone modification to mark the genome for gamete-associated packaging...
  42. doi request reprint The emerging field of dynamic lysine methylation of non-histone proteins
    Jing Huang
    Gene Expression and Regulation Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19087, United States
    Curr Opin Genet Dev 18:152-8. 2008
    ..Taking into account combinatorial activity with numerous other PTMs, lysine methylation provides enormous functional diversity and regulatory complexity...
  43. ncbi request reprint In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation
    Ping Yao Zeng
    The Wistar Institute, Philadelphia, PA 19104, USA
    Biotechniques 41:694, 696, 698. 2006
  44. doi request reprint An operational definition of epigenetics
    Shelley L Berger
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 23:781-3. 2009
    ..It was evident that multiple mechanistic steps lead to the stable heritance of the epigenetic phenotype. Below we provide our view and interpretation of the proceedings at the meeting...
  45. ncbi request reprint Temporal and spatial changes in transcription factor binding and histone modifications at the steroidogenic acute regulatory protein (stAR) locus associated with stAR transcription
    Hisahiko Hiroi
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, 1354 Biomedical Research Building, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Endocrinol 18:791-806. 2004
    ..Our findings demonstrate that increased StAR transcription can occur in the context of different patterns of transcription factor binding and histone modification...
  46. ncbi request reprint LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation
    Ping Yao Zeng
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania and Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, P R China
    Cancer Res 66:10701-8. 2006
    ..Finally, a genetic fusion of LKB1 to defective p53, deleted for its activation domains, promotes activation of p21/WAF1. These results indicate that LKB1 has a direct role in activation of p21/WAF1 gene...
  47. pmc Cutting edge: persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status
    Valerie P Zediak
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 186:2705-9. 2011
    ..We propose that these chromatin changes poise effector genes for rapid upregulation, but are insufficient for PolII recruitment and transcription...
  48. ncbi request reprint The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex
    David E Sterner
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:8178-86. 2002
    ..These results suggest that histone and nucleosomal substrate recognition by SAGA involves multiple conserved domains and proteins, beyond those that have been previously identified...
  49. pmc A feed-forward repression mechanism anchors the Sin3/histone deacetylase and N-CoR/SMRT corepressors on chromatin
    Michiel Vermeulen
    NCMLS, Radboud University Nijmegen, Department of Molecular Biology, Geert Grooteplein Zuid 30, Nijmegen, The Netherlands
    Mol Cell Biol 26:5226-36. 2006
    ....
  50. ncbi request reprint Trans-tail histone modifications: wedge or bridge?
    Karl W Henry
    Nat Struct Biol 9:565-6. 2002
  51. ncbi request reprint Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
    Sean R Collins
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA
    Nature 446:806-10. 2007
    ..This modification, in turn, enables a ubiquitin ligase complex containing the cullin Rtt101 to ensure genomic integrity during DNA replication...
  52. ncbi request reprint New nomenclature for chromatin-modifying enzymes
    C David Allis
    Cell 131:633-6. 2007
  53. pmc 14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylation
    Wendy Walter
    Division of Molecular Genetics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3 QU, United Kingdom
    Mol Cell Biol 28:2840-9. 2008
    ..The importance of acetylation in this interaction is also seen in vivo, where K14 acetylation is required for optimal Bmh1 recruitment to the GAL1 promoter during transcriptional activation...
  54. ncbi request reprint Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae
    Wang L Cheung
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21210, USA
    Curr Biol 15:656-60. 2005
    ..CK2 has been implicated in regulating a DNA-damage response; our data suggest that histone H4 S1 is one of its physiological substrates. These data suggest that this modification is a part of the DNA-repair histone code...
  55. pmc Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms
    Wan Sheng Lo
    Division of Biological Sciences and UCSD Cancer Center, University of California, San Diego, CA, USA
    EMBO J 24:997-1008. 2005
    ..Our results emphasize that histone modifications share general functions between promoters, but also acquire distinct roles tailored for promoter-specific requirements...
  56. pmc Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins
    Young Hwa Goo
    Department of Life Science, Pohang University of Science and Technology, Korea
    Mol Cell Biol 23:140-9. 2003
    ..Further characterization of ASCOM will lead to a better understanding of how nuclear receptors and other transcription factors mediate transcriptional activation...

Research Grants2

  1. The Enzymology of Chromatin and Transcription
    Shelley Berger; Fiscal Year: 2003
    ..The proposed program will bring together experts in chromatin and transcriptional regulation to focus on the intersection between these two areas. ..