M J Bennett

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e35048. 2012
  2. doi request reprint The neuronal ceroid-lipofuscinoses
    Michael J Bennett
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Disabil Res Rev 17:254-9. 2013
  3. doi request reprint Pathophysiology of fatty acid oxidation disorders
    M J Bennett
    Department of Pathology and Laboratory Medicine, University of Pennsylvania and Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Inherit Metab Dis 33:533-7. 2010
  4. ncbi request reprint Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase
    Michael J Bennett
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Mol Genet Metab 89:74-9. 2006
  5. ncbi request reprint Intermediate levels of neuronal palmitoyl-protein Delta-9 desaturase in heterozygotes for murine Batten disease
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Mol Genet Metab 93:89-91. 2008
  6. ncbi request reprint Establishing a reference interval for measurement of flux through the mitochondrial fatty acid oxidation pathway in cultured skin fibroblasts
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Chem 51:644-6. 2005
  7. ncbi request reprint The value of the metabolic autopsy in the pediatric hospital setting
    Linda M Ernst
    Department of Pathology, Metabolic Disease Laboratory, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Pediatr 148:779-83. 2006
  8. ncbi request reprint Hyperinsulinism in infancy and childhood: when an insulin level is not always enough
    Andrew A Palladino
    The Children s Hospital of Philadelphia, Division of Endocrinology, Philadelphia, PA, USA
    Clin Chem 54:256-63. 2008
  9. pmc Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers
    Kristina An Haack
    Department of Pathology and Laboratory Medicine, Division of Metabolic Disease, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1810:186-91. 2011
  10. doi request reprint Very long-chain acyl-CoA dehydrogenase deficiency in a patient with normal newborn screening by tandem mass spectrometry
    Can Ficicioglu
    Department of Pediatrics, Section of Biochemical Genetics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr 156:492-4. 2010

Collaborators

Detail Information

Publications46

  1. pmc Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e35048. 2012
    ..Most of the interactions appear to be independent of SCHAD's role in the penultimate step of fatty acid oxidation suggesting an organizational, structural or non-enzymatic role for the SCHAD protein...
  2. doi request reprint The neuronal ceroid-lipofuscinoses
    Michael J Bennett
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Disabil Res Rev 17:254-9. 2013
    ..The pathogenesis of NCL neuronal loss resulting from loss of function of any of the NCL gene products remains unknown and no treatment options are presently available...
  3. doi request reprint Pathophysiology of fatty acid oxidation disorders
    M J Bennett
    Department of Pathology and Laboratory Medicine, University of Pennsylvania and Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Inherit Metab Dis 33:533-7. 2010
    ..It describes the different tissue involvement with the disease processes and correlates disease phenotype with the nature of the genetic defect for the known disorders of the pathway...
  4. ncbi request reprint Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase
    Michael J Bennett
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Mol Genet Metab 89:74-9. 2006
    ..The spectrum of M/SCHAD phenotype should be broadened to include acute liver disease...
  5. ncbi request reprint Intermediate levels of neuronal palmitoyl-protein Delta-9 desaturase in heterozygotes for murine Batten disease
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Mol Genet Metab 93:89-91. 2008
    ..This is the first report of a heterozygous abnormality in Batten disease and provides important confirmation that this is the function of the CLN3 protein in neuronal tissues...
  6. ncbi request reprint Establishing a reference interval for measurement of flux through the mitochondrial fatty acid oxidation pathway in cultured skin fibroblasts
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Chem 51:644-6. 2005
  7. ncbi request reprint The value of the metabolic autopsy in the pediatric hospital setting
    Linda M Ernst
    Department of Pathology, Metabolic Disease Laboratory, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Pediatr 148:779-83. 2006
    ..To determine the utility of the metabolic autopsy in the hospitalized pediatric patient...
  8. ncbi request reprint Hyperinsulinism in infancy and childhood: when an insulin level is not always enough
    Andrew A Palladino
    The Children s Hospital of Philadelphia, Division of Endocrinology, Philadelphia, PA, USA
    Clin Chem 54:256-63. 2008
    ..HI is characterized by dysregulated insulin secretion, which results in persistent mild to severe hypoglycemia. The various forms of HI represent a group of clinically, genetically, and morphologically heterogeneous disorders...
  9. pmc Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers
    Kristina An Haack
    Department of Pathology and Laboratory Medicine, Division of Metabolic Disease, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1810:186-91. 2011
    ..Prolonged increase of intracellular calcium concentration is considered to be a significant trigger for neuronal apoptosis and cellular loss in JNCL...
  10. doi request reprint Very long-chain acyl-CoA dehydrogenase deficiency in a patient with normal newborn screening by tandem mass spectrometry
    Can Ficicioglu
    Department of Pediatrics, Section of Biochemical Genetics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr 156:492-4. 2010
    ..We report a patient who died as a result of severe brain injury due to hypoglycemia. Newborn screening was normal. Postmortem enzyme analysis and molecular testing confirmed the diagnosis of VLCADD...
  11. pmc Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase
    Changhong Li
    Division of Endocrinology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 285:31806-18. 2010
    ..These studies indicate that SCHAD deficiency causes hyperinsulinism by activation of GDH via loss of inhibitory regulation of GDH by SCHAD...
  12. ncbi request reprint Over-expression of CLN3P, the Batten disease protein, inhibits PANDER-induced apoptosis in neuroblastoma cells: further evidence that CLN3P has anti-apoptotic properties
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Genet Metab 88:178-83. 2006
    ..CLN3P significantly increased the survival rate of the SH-SY5Y cells in this system. This study provides additional evidence that the function of CLN3P is related to preventing neuronal apoptosis...
  13. ncbi request reprint Assays of fatty acid beta-oxidation activity
    Michael J Bennett
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Metabolic Disease Laboratory, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Methods Cell Biol 80:179-97. 2007
  14. ncbi request reprint CLN3P, the Batten's disease protein, is a novel palmitoyl-protein Delta-9 desaturase
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Ann Neurol 60:570-7. 2006
    ..Although the gene for the disorder was cloned more than a decade ago, the function of the encoded protein, CLN3P, has not been defined thus far...
  15. ncbi request reprint Molecular assay for detection of the common carnitine palmitoyltransferase 1A 1436(C>T) mutation
    Jason Y Park
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and the Hospital of the University of Pennsylvania, Philadelphia, 19104, USA
    Clin Chem Lab Med 44:1090-1. 2006
    ..The present study offers a molecular method for assessing CPT1A 1436 (C>T) mutation status...
  16. ncbi request reprint Medium-chain fatty acids undergo elongation before beta-oxidation in fibroblasts
    Patricia M Jones
    Department of Pathology, University of Texas Southwestern Medical Center, Dalls, TX 75235, USA
    Biochem Biophys Res Commun 346:193-7. 2006
    ..This previously undescribed metabolic step may have important implications for the metabolism of medium-chain triglycerides, components in the dietary treatment of a number of disorders...
  17. ncbi request reprint Novel mutations in CPT 1A define molecular heterogeneity of hepatic carnitine palmitoyltransferase I deficiency
    Michael J Bennett
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Mol Genet Metab 82:59-63. 2004
    ..Because there are no easily recognizable disease-specific metabolite markers, diagnostic confirmation of this disorder requires a combination of enzymatic analysis and whole gene sequencing...
  18. ncbi request reprint Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Pediatr Res 56:323-8. 2004
    ....
  19. ncbi request reprint CLN3L, a novel protein related to the Batten disease protein, is overexpressed in Cln3-/- mice and in Batten disease
    Srinivas B Narayan
    Department of Pathology and Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Brain 127:1748-54. 2004
    ..Previous studies of CLN3P tissue distribution and intracellular localization will require extensive reanalysis in order to determine the true expression of CLN3P...
  20. ncbi request reprint Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases
    Prem Shekhawat
    Departments of Pediatric, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 284:E1098-105. 2003
    ..Thus human placenta derives energy from fatty acid oxidation, providing a potential explanation for the association of fetal fatty acid oxidation disorders with maternal liver diseases in pregnancy...
  21. ncbi request reprint Effects of odd-numbered medium-chain fatty acids on the accumulation of long-chain 3-hydroxy-fatty acids in long-chain L-3-hydroxyacyl CoA dehydrogenase and mitochondrial trifunctional protein deficient skin fibroblasts
    Patricia M Jones
    Department of Pathology, University of Texas Southwestern Medical Center, Children s Medical Center of Dallas, Dallas, TX 75235, USA
    Mol Genet Metab 81:96-9. 2004
    ..We found that provision of odd-chain species does decrease the build-up of long-chain FAO intermediates in our in vitro skin fibroblast model, but to a lesser extent than even-numbered MCFAs...
  22. ncbi request reprint Lethal neonatal and severe late infantile forms of carnitine palmitoyltransferase II deficiency associated with compound heterozygosity for different protein truncation mutations
    Georgirene D Vladutiu
    Division of Genetics, Children s Hospital of Buffalo and Department of Pediatrics, School of Medicine and Biomedical Sciences, University at Buffalo, New York 14209, USA
    J Pediatr 141:734-6. 2002
    ..A new phenotype for a severe late infantile form of CPT II deficiency with hypoglycemia is associated with compound heterozygosity for the severe Q413fs mutation and a mild point mutation (P50H)...
  23. ncbi request reprint Early neonatal diagnosis of long-chain 3-hydroxyacyl coenzyme a dehydrogenase and mitochondrial trifunctional protein deficiencies
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Palo Alto, California 94304, USA
    Mol Genet Metab 75:120-7. 2002
    ..However, timely analysis and reporting of results to clinicians are essential, because these disorders can manifest in the first few days of life...
  24. ncbi request reprint Absence of the G1528C (E474Q) mutation in the alpha-subunit of the mitochondrial trifunctional protein in women with acute fatty liver of pregnancy
    Anibran Maitra
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Pediatr Res 51:658-61. 2002
    ..It is likely that AFLP arising in the context of fetal LCHAD deficiency represents only one of the possible etiologies for this uncommon disorder, and the metabolic basis of AFLP is more heterogeneous than previously believed...
  25. ncbi request reprint Accumulation of 3-hydroxy-fatty acids in the culture medium of long-chain L-3-hydroxyacyl CoA dehydrogenase (LCHAD) and mitochondrial trifunctional protein-deficient skin fibroblasts: implications for medium chain triglyceride dietary treatment of LCHAD d
    Patricia M Jones
    Department of Pathology, University of Texas, Southwestern Medical Center, Dallas 75235, USA
    Pediatr Res 53:783-7. 2003
    ..Our results suggest that a medium-chain triglyceride preparation that is higher in decanoate may be more effective in reducing the accumulation of potentially toxic long-chain 3-hydroxy-fatty acids in LCHAD deficiency...
  26. ncbi request reprint Fetal genotypes and pregnancy outcomes in 35 families with mitochondrial trifunctional protein mutations
    Zi Yang
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Obstet Gynecol 187:715-20. 2002
    ..Trifunctional protein has 3 enzymatic activities that include long-chain 3-hydroxyacyl-CoA dehydrogenase, which catalyzes long-chain fatty acid beta-oxidation...
  27. ncbi request reprint Role of short-chain hydroxyacyl CoA dehydrogenases in SCHAD deficiency
    Charlotta Filling
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Biochem Biophys Res Commun 368:6-11. 2008
    ..This association provides a possible link between fatty acid metabolism and the hyperinsulinism/hyperammonia syndrome...
  28. ncbi request reprint The changing face of newborn screening: diagnosis of inborn errors of metabolism by tandem mass spectrometry
    Patricia M Jones
    Department of Pathology, University of Texas Southwestern Medical Center and Children s Medical Center, 1935 Motor Street, Dallas, TX 75235, USA
    Clin Chim Acta 324:121-8. 2002
  29. doi request reprint CPT2 gene mutations resulting in lethal neonatal or severe infantile carnitine palmitoyltransferase II deficiency
    Paul J Isackson
    Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, SUNY at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Mol Genet Metab 94:422-7. 2008
    ..In addition, based on currently available structural, biochemical and clinical data, we have classified all 64 known disease-causing mutations into groups with different predicted phenotypes depending on their CPT2 allelic counterparts...
  30. ncbi request reprint The function of CLN3P, the Batten disease protein
    Dinesh Rakheja
    Department of Pathology, University of Texas Southwestern Medical Center and Children s Medical Center, MC 9073, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Genet Metab 93:269-74. 2008
  31. ncbi request reprint Long-chain L-3-hydroxyacyl-coenzyme a dehydrogenase deficiency: a molecular and biochemical review
    Dinesh Rakheja
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Lab Invest 82:815-24. 2002
    ..In this review we discuss the biochemical and molecular basis, clinical features, diagnosis, and management of long-chain L-3-hydroxyacyl-coenzyme A dehydrogenase deficiency...
  32. ncbi request reprint Fatty acid oxidation disorders
    Piero Rinaldo
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Biochemical Genetics Laboratory, Rochester, Minnesota 55905, USA
    Annu Rev Physiol 64:477-502. 2002
    ..This review addresses the normal process of mitochondrial fatty acid beta-oxidation and discusses the clinical, metabolic, and molecular aspects of more than 20 known inherited diseases of this pathway that have been described to date...
  33. pmc The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    Brian N Finck
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:121-30. 2002
    ....
  34. pmc Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Genet Metab 92:315-24. 2007
    ..Our studies suggest that carnitine supplementation, as a means of boosting fatty acid oxidation, may be therapeutically beneficial in patients with inflammation of the intestinal tract...
  35. ncbi request reprint Diagnostic challenges in a severely delayed infant with hypersomnolence, failure to thrive and arteriopathy: a unique case of gamma-hydroxybutyric aciduria and Williams syndrome
    Ina Knerr
    Children s and Adolescents Hospital, University of Erlangen Nuremberg, Erlangen, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:946-8. 2007
    ....
  36. pmc The mitochondrial inner membrane protein mitofilin controls cristae morphology
    George B John
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mol Biol Cell 16:1543-54. 2005
    ..We propose that mitofilin is a critical organizer of the mitochondrial cristae morphology and thus indispensable for normal mitochondrial function...
  37. ncbi request reprint General mitochondrial trifunctional protein (TFP) deficiency as a result of either alpha- or beta-subunit mutations exhibits similar phenotypes because mutations in either subunit alter TFP complex expression and subunit turnover
    Ute Spiekerkoetter
    Department of Pediatrics and Vanderbilt Children s Hospital, Nashville, TN 37232, USA
    Pediatr Res 55:190-6. 2004
    ..Both alpha- and beta-subunit mutations result in TFP complex instability, demonstrating that the mechanism of disease is the same in alpha- or beta-mutation-derived disease and explaining the biochemical and clinical similarities...
  38. ncbi request reprint Carnitine palmitoyltransferase II deficiency: a clinical, biochemical, and molecular review
    Ellen Sigauke
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Lab Invest 83:1543-54. 2003
    ..We review the clinical features, the diagnostic protocol including expanded neonatal screening, the treatment, and the biochemical and molecular basis of CPT II deficiency...
  39. ncbi request reprint Bile acylcarnitine profiles in pediatric liver disease do not interfere with the diagnosis of long-chain fatty acid oxidation defects
    Franklin Fuda
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, and Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, PA 19104 4399, United States
    Clin Chim Acta 367:185-8. 2006
    ..Disorders of fatty acid oxidation frequently present with deranged liver function and the effect of hepatic disease on biliary acylcarnitine excretion are unknown...
  40. ncbi request reprint Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice
    Marzia Scortegagna
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 8573, USA
    Nat Genet 35:331-40. 2003
    ..We propose a rheostat role for HIF-2alpha that allows for the maintenance of ROS as well as mitochondrial homeostasis...
  41. ncbi request reprint Molecular and phenotypic heterogeneity in mitochondrial trifunctional protein deficiency due to beta-subunit mutations
    Ute Spiekerkoetter
    Department of Pediatrics and Vanderbilt Children s Hospital, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Hum Mutat 21:598-607. 2003
    ..The degree of reduction in thiolase antigen also correlated with the severity of clinical presentation. Although TFP deficiency is highly heterogeneous, there is genotype-phenotype correlation...
  42. ncbi request reprint Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft function
    Dinesh Rakheja
    Department of Pathology, MC 9073, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Med Hypotheses 65:1120-3. 2005
    ..Dietary or therapeutic interventions targeting lipid rafts may thus be an option for cancer treatment...
  43. ncbi request reprint Addition of quantitative 3-hydroxy-octadecanoic acid to the stable isotope gas chromatography-mass spectrometry method for measuring 3-hydroxy fatty acids
    Patricia M Jones
    University of Texas Southwestern Medical Center, Department of Pathology, and Children s Medical Center of Dallas, Dallas, TX 75235, USA
    Clin Chem 48:176-9. 2002
  44. ncbi request reprint Identification of 16 new disease-causing mutations in the CPT2 gene resulting in carnitine palmitoyltransferase II deficiency
    Paul J Isackson
    Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14209, USA
    Mol Genet Metab 89:323-31. 2006
    ..The implications of these mutations are described in light of recent advances in our understanding of the molecular structure of members of the carnitine acyltransferase family...
  45. ncbi request reprint Phenotypic variability among first-degree relatives with carnitine palmitoyltransferase II deficiency
    Georgirene D Vladutiu
    Departments of Pediatrics, Neurology, and Pathology, School of Medicine and Biomedical Sciences, State University of New York, 936 Delaware Avenue, Buffalo, New York 14209, USA
    Muscle Nerve 26:492-8. 2002
    ..Reliance on carbohydrates during stress and hormonal alterations may explain, in part, the variance in ages of onset and serverity of symptoms in myopathic patients...
  46. ncbi request reprint Cloning and characterization of the NAD-dependent 7alpha-Hydroxysteroid dehydrogenase from Bacteroides fragilis
    Michael J Bennett
    Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    Curr Microbiol 47:475-84. 2003
    ..The predicted amino acid sequence of the ORF showed strong sequence similarity to three other bacterial 7-HSDHs, all in the short-chain dehydrogenase family. The regulation of expression of this gene is currently under investigation...