William Benedict

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Autophagy is induced by adenoviral-mediated interferon alpha treatment in interferon resistant bladder cancer and normal urothelial cells as a cell death protective mechanism but not by the bystander factors produced
    X Q Zhang
    Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Gene Ther 17:579-84. 2010
  2. pmc Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker
    M B Fisher
    Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Gene Ther 16:567-72. 2009
  3. ncbi request reprint Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein
    William F Benedict
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Ther 10:525-32. 2004
  4. ncbi request reprint Role of tumor necrosis factor-related apoptosis-inducing ligand in interferon-induced apoptosis in human bladder cancer cells
    Angela Papageorgiou
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 64:8973-9. 2004
  5. pmc Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis
    Akira Nakamizo
    Department of Neurosurgery, Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 442, Houston, TX 77030 4009, USA
    Neuro Oncol 10:275-91. 2008
  6. ncbi request reprint Adenoviral mediated interferon-alpha 2b gene therapy suppresses the pro-angiogenic effect of vascular endothelial growth factor in superficial bladder cancer
    Liana Adam
    Department of Urology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 177:1900-6. 2007
  7. ncbi request reprint Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells
    Angela Papageorgiou
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Box 173, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:3032-41. 2006
  8. ncbi request reprint Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression
    Anita Sabichi
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 175:1133-7. 2006
  9. ncbi request reprint Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells
    Xinqiao Zhang
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:760-5. 2003
  10. ncbi request reprint Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer
    Motoyuki Yamashita
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Cancer Gene Ther 9:687-91. 2002

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc Autophagy is induced by adenoviral-mediated interferon alpha treatment in interferon resistant bladder cancer and normal urothelial cells as a cell death protective mechanism but not by the bystander factors produced
    X Q Zhang
    Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Gene Ther 17:579-84. 2010
    ....
  2. pmc Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker
    M B Fisher
    Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Gene Ther 16:567-72. 2009
    ....
  3. ncbi request reprint Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein
    William F Benedict
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Ther 10:525-32. 2004
    ..These findings demonstrate that Ad-IFNalpha can overcome resistance to IFN-alpha protein both in vitro and in vivo and support evaluation of intravesical Ad-IFNalpha/Syn3 for the treatment of superficial bladder cancer...
  4. ncbi request reprint Role of tumor necrosis factor-related apoptosis-inducing ligand in interferon-induced apoptosis in human bladder cancer cells
    Angela Papageorgiou
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 64:8973-9. 2004
    ..Combination therapy strategies aimed at overcoming TRAIL resistance may be very effective in restoring IFN sensitivity in a subset of human bladder tumors...
  5. pmc Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis
    Akira Nakamizo
    Department of Neurosurgery, Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 442, Houston, TX 77030 4009, USA
    Neuro Oncol 10:275-91. 2008
    ..These results have implications for p53 gene therapy and inform other strategies that aim to restore p53 function...
  6. ncbi request reprint Adenoviral mediated interferon-alpha 2b gene therapy suppresses the pro-angiogenic effect of vascular endothelial growth factor in superficial bladder cancer
    Liana Adam
    Department of Urology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 177:1900-6. 2007
    ..We determined whether the inhibition of angiogenesis might contribute to the antitumor effect...
  7. ncbi request reprint Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells
    Angela Papageorgiou
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Box 173, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:3032-41. 2006
    ..Together, our results show that combination therapy with IFN-alpha plus bortezomib is effective but can work via different mechanisms (apoptosis versus angiogenesis inhibition) in preclinical models of human bladder cancer...
  8. ncbi request reprint Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression
    Anita Sabichi
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 175:1133-7. 2006
    ..Cell lines have become an essential component for the investigation of cancer. We have developed a panel of cell lines derived from human urothelial cancers and we describe some of their important characteristics...
  9. ncbi request reprint Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells
    Xinqiao Zhang
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:760-5. 2003
    ..The lack of cytotoxicity to normal cells should also provide a high therapeutic index when used in gene therapy protocols for the treatment of bladder and other cancers...
  10. ncbi request reprint Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer
    Motoyuki Yamashita
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Cancer Gene Ther 9:687-91. 2002
    ....
  11. ncbi request reprint Focus on bladder cancer
    Colin P N Dinney
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX USA
    Cancer Cell 6:111-6. 2004
  12. ncbi request reprint Efficient therapeutic gene delivery after systemic administration of a novel polyethylenimine/DNA vector in an orthotopic bladder cancer model
    Paul Sweeney
    Department of Urology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:4017-20. 2003
    ..This novel vector formulation represents a new method to increase i.v. delivery of genes to tumors...
  13. ncbi request reprint Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis
    Jonathan I Izawa
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:1258-70. 2002
    ..These data suggest that the inhibition of tumorigenicity and the metastasis of the 253J B-V(R) cells after infection with Ad-IFN-beta is caused by the inhibition of angiogenesis and the activation of host effector cells...
  14. ncbi request reprint Noninvasive detection of bladder cancer in an orthotopic murine model with green fluorescence protein cytology
    Motoysohi Tanaka
    Department of Urology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Urol 170:975-8. 2003
    ..We investigated whether examining voided urine for GFP expressing cells would indicate the presence of GFP producing tumors in an orthotopic bladder tumor model in nude mice...
  15. ncbi request reprint Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder
    Shanrokh F Shariat
    Scott Department of Urology, Baylor College of Medicine, 6560 Fannin, Houston, TX 77030, USA
    J Urol 170:985-9. 2003
    ....
  16. ncbi request reprint Correlation of metastasis related gene expression and relapse-free survival in patients with locally advanced bladder cancer treated with cystectomy and chemotherapy
    Joel W Slaton
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, 77030USA
    J Urol 171:570-4. 2004
    ....
  17. ncbi request reprint p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer
    Shahrokh F Shariat
    Scott Department of Urology, Baylor College of Medicine, 6560 Fannin, Suite 2100, Houston, TX 77030, USA
    J Clin Oncol 22:1014-24. 2004
    ..To determine whether p53, p21, pRB, and/or p16 expression is associated with bladder cancer stage, progression, and prognosis...
  18. pmc Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy
    Tadeusz Majewski
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Lab Invest 88:694-721. 2008
    ..These analyses provided new insights on the involvement of several non-coding sequences mapping to the region and identified novel target genes, termed forerunner (FR) genes, involved in early phases of cancer development...
  19. ncbi request reprint Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression
    Jain Hua Zhou
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Cancer Gene Ther 9:681-6. 2002
    ....
  20. pmc Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia
    Sangkyou Lee
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:13732-7. 2007
    ..We also show that homozygous inactivation of P2RY5 was antecedent to the loss of RB1 during tumor development, and that nucleotide substitutions in P2RY5 represent a cancer predisposing factor...

Research Grants5

  1. RB4 Intravesical Gene Therapy: Mechanisms of Cell Death
    William Benedict; Fiscal Year: 2003
    ....
  2. RB4 Intravesical Gene Therapy: Mechanisms of Cell Death
    William Benedict; Fiscal Year: 2004
    ....
  3. RB4 Intravesical Gene Therapy: Mechanisms of Cell Death
    William Benedict; Fiscal Year: 2005
    ....
  4. RB4 Intravesical Gene Therapy: Mechanisms of Cell Death
    William Benedict; Fiscal Year: 2006
    ....
  5. RB4 Intravesical Gene Therapy: Mechanisms of Cell Death
    William Benedict; Fiscal Year: 2007
    ....