Isabelle Bedrosian

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. doi request reprint Population-based study of contralateral prophylactic mastectomy and survival outcomes of breast cancer patients
    Isabelle Bedrosian
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 102:401-9. 2010
  2. pmc Impact of internal mammary lymph node drainage identified by preoperative lymphoscintigraphy on outcomes in patients with stage I to III breast cancer
    Amanda L Kong
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 118:6287-96. 2012
  3. doi request reprint Impact of the american college of surgeons oncology group Z0011 criteria applied to a contemporary patient population
    Min Yi
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 216:105-13. 2013
  4. ncbi request reprint The role for sentinel lymph node dissection after neoadjuvant chemotherapy in patients who present with node-positive breast cancer
    Rosalinda Alvarado
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 19:3177-84. 2012
  5. doi request reprint Trends in and outcomes from sentinel lymph node biopsy (SLNB) alone vs. SLNB with axillary lymph node dissection for node-positive breast cancer patients: experience from the SEER database
    Min Yi
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 17:343-51. 2010
  6. doi request reprint Neoadjuvant chemotherapy in invasive lobular carcinoma may not improve rates of breast conservation
    Judy C Boughey
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Ann Surg Oncol 16:1606-11. 2009
  7. doi request reprint Sentinel lymph node surgery after neoadjuvant chemotherapy is accurate and reduces the need for axillary dissection in breast cancer patients
    Kelly K Hunt
    Department of Surgical Oncology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    Ann Surg 250:558-66. 2009
  8. doi request reprint Primary tumor extirpation in breast cancer patients who present with stage IV disease is associated with improved survival
    Julie E Lang
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 20:1893-9. 2013
  9. ncbi request reprint Incidence and consequence of close margins in patients with ductal carcinoma-in situ treated with mastectomy: is further therapy warranted?
    Elizabeth FitzSullivan
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 20:4103-12. 2013
  10. ncbi request reprint Role of primary tumor characteristics in predicting positive sentinel lymph nodes in patients with ductal carcinoma in situ or microinvasive breast cancer
    Min Yi
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg 196:81-7. 2008

Detail Information

Publications63

  1. doi request reprint Population-based study of contralateral prophylactic mastectomy and survival outcomes of breast cancer patients
    Isabelle Bedrosian
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 102:401-9. 2010
    ..Despite increased demand for contralateral prophylactic mastectomy (CPM), the survival benefit of this procedure remains uncertain...
  2. pmc Impact of internal mammary lymph node drainage identified by preoperative lymphoscintigraphy on outcomes in patients with stage I to III breast cancer
    Amanda L Kong
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 118:6287-96. 2012
    ..Involvement of internal mammary (IM) lymph nodes is associated with a poor prognosis for patients with breast cancer. This study examined the effect of drainage to IM nodes identified by lymphoscintigraphy on oncologic outcomes...
  3. doi request reprint Impact of the american college of surgeons oncology group Z0011 criteria applied to a contemporary patient population
    Min Yi
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 216:105-13. 2013
    ..The aim of this study was to assess applicability of Z0011 results to our patient population and determine what percentage may be affected by these results...
  4. ncbi request reprint The role for sentinel lymph node dissection after neoadjuvant chemotherapy in patients who present with node-positive breast cancer
    Rosalinda Alvarado
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 19:3177-84. 2012
    ..Our objective was to evaluate SLN dissection in node-positive patients and to determine whether postchemotherapy ultrasound could select patients for this technique...
  5. doi request reprint Trends in and outcomes from sentinel lymph node biopsy (SLNB) alone vs. SLNB with axillary lymph node dissection for node-positive breast cancer patients: experience from the SEER database
    Min Yi
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 17:343-51. 2010
    ..The purpose of this study was to examine differences in survival for patients undergoing SLNB alone versus SLNB with complete ALND...
  6. doi request reprint Neoadjuvant chemotherapy in invasive lobular carcinoma may not improve rates of breast conservation
    Judy C Boughey
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Ann Surg Oncol 16:1606-11. 2009
    ..This study was intended to evaluate the impact of neoadjuvant chemotherapy in ILC on breast-conserving surgery (BCS) rates...
  7. doi request reprint Sentinel lymph node surgery after neoadjuvant chemotherapy is accurate and reduces the need for axillary dissection in breast cancer patients
    Kelly K Hunt
    Department of Surgical Oncology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    Ann Surg 250:558-66. 2009
    ..This study was performed to evaluate the accuracy of SLN surgery for patients undergoing neoadjuvant chemotherapy versus patients undergoing surgery first...
  8. doi request reprint Primary tumor extirpation in breast cancer patients who present with stage IV disease is associated with improved survival
    Julie E Lang
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 20:1893-9. 2013
    ..1 months median follow-up. We assessed the impact of surgery after 74.2 months median follow-up, and the effect of systemic therapy and local radiotherapy (RT)...
  9. ncbi request reprint Incidence and consequence of close margins in patients with ductal carcinoma-in situ treated with mastectomy: is further therapy warranted?
    Elizabeth FitzSullivan
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 20:4103-12. 2013
    ..We sought to determine the incidence and consequences of close margins in patients with DCIS treated with mastectomy...
  10. ncbi request reprint Role of primary tumor characteristics in predicting positive sentinel lymph nodes in patients with ductal carcinoma in situ or microinvasive breast cancer
    Min Yi
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg 196:81-7. 2008
    ..We determined the incidence of positive sentinel lymph nodes (SLNs) in patients with ductal carcinoma in situ (DCIS) or microinvasive breast cancer (MIC) and the predictive factors of SLN metastasis in these patients...
  11. doi request reprint Impact of chemotherapy sequencing on local-regional failure risk in breast cancer patients undergoing breast-conserving therapy
    Elizabeth A Mittendorf
    Department of Surgical Oncology, Unit 1484, The University of TexasMDAnderson Cancer Center, 1400 Pressler St, Houston, TX 77030, USA
    Ann Surg 257:173-9. 2013
    ..This study was performed to evaluate long-term local-regional control rates after breast-conserving therapy (BCT) for patients undergoing surgery before or after neoadjuvant chemotherapy...
  12. pmc Biology, treatment, and outcome in very young and older women with DCIS
    Rosalinda Alvarado
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 19:3777-84. 2012
    ..This study examines a modern cohort of women with ductal carcinoma-in-situ (DCIS) in order to identify potential differences in clinical presentation, treatments, and outcome based on age...
  13. ncbi request reprint Decision analysis to assess the efficacy of routine sentinel lymphadenectomy in patients undergoing prophylactic mastectomy
    Judy C Boughey
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Cancer 110:2542-50. 2007
    ..The objective of this study was to compare the efficacy of 2 surgical strategies, routine SLND versus directed ALND, in PM patients...
  14. doi request reprint Margin assessment after neoadjuvant chemotherapy in invasive lobular cancer
    Jamie Wagner
    Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg 198:387-91. 2009
    ..Optimal surgical management of patients with invasive lobular carcinoma (ILC) who undergo neoadjuvant chemotherapy (NAC) is unknown. We evaluated optimal margin distance and local recurrence (LR) rates for these patients...
  15. doi request reprint Does blue dye contribute to success of sentinel node mapping for breast cancer?
    Taewoo Kang
    Department of Surgical Oncology, M D Anderson Cancer Center, The University of Texas, Houston, TX, USA
    Ann Surg Oncol 17:280-5. 2010
    ..We sought to evaluate the utilization of blue dye in addition to radioisotope and its relative contribution to sentinel lymph node (SLN) mapping at a high-volume institution...
  16. doi request reprint Sentinel lymph node dissection is technically feasible in older breast cancer patients
    Vicente Valero
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Breast Cancer 10:477-82. 2010
    ..This study was undertaken to compare identification rates in patients 70 years of age and older versus those younger than 70 years in a large cohort undergoing sentinel lymph node dissection (SLND)...
  17. doi request reprint A prospective study comparing touch imprint cytology, frozen section analysis, and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer
    Savitri Krishnamurthy
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:1555-62. 2009
    ....
  18. ncbi request reprint Comparative analysis of sentinel lymph node operation in male and female breast cancer patients
    Judy C Boughey
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Am Coll Surg 203:475-80. 2006
    ..The purpose of this study was to determine whether SLN operation is as feasible and accurate in male patients compared with female patients...
  19. pmc Local-regional control according to surrogate markers of breast cancer subtypes and response to neoadjuvant chemotherapy in breast cancer patients undergoing breast conserving therapy
    Abigail S Caudle
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Hermann Pressler Drive, Unit 1484, Houston, TX 77030, USA
    Breast Cancer Res 14:R83. 2012
    ....
  20. ncbi request reprint Outcomes of breast-conservation therapy for invasive lobular carcinoma are equivalent to those for invasive ductal carcinoma
    Thao N Vo
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg 192:552-5. 2006
    ..We evaluated our institutional experience with BCT and compared treatment outcomes for ILC with those for IDC...
  21. doi request reprint Present-day locoregional control in patients with t1 or t2 breast cancer with 0 and 1 to 3 positive lymph nodes after mastectomy without radiotherapy
    Ranjna Sharma
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 17:2899-908. 2010
    ..We sought to determine present-day locoregional recurrence (LRR) rates to better understand the role of postmastectomy radiotherapy (PMRT) in women with 0 to 3 positive lymph nodes...
  22. doi request reprint Disseminated tumor cells in biologic subtypes of stage I-III breast cancer patients
    Carolyn Hall
    Department of Surgical Oncology, Unit 444, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 17:3252-8. 2010
    ..Conversely, late recurrences are seen in estrogen receptor (ER)-positive (luminal) cancers. Disseminated tumor cells (DTCs) may be responsible for late recurrences. We compared rates of DTCs in basal and luminal subtypes...
  23. ncbi request reprint A phase I study to assess the feasibility and oncologic safety of axillary reverse mapping in breast cancer patients
    Isabelle Bedrosian
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston Texas, USA
    Cancer 116:2543-8. 2010
    ..This study reported a phase 1 trial conducted in patients with cytologically documented axillary metastasis undergoing axillary lymph node dissection to determine the feasibility and oncologic safety of ARM...
  24. ncbi request reprint Selective use of sentinel lymph node surgery during prophylactic mastectomy
    Judy C Boughey
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 107:1440-7. 2006
    ..The current study investigates the invasive cancer rate in PM and evaluates factors associated with invasive cancer to guide SLN surgery use...
  25. pmc Automatic segmentation of whole breast using atlas approach and deformable image registration
    Valerie K Reed
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 73:1493-500. 2009
    ..To compare interobserver variations in delineating the whole breast for treatment planning using two contouring methods...
  26. pmc Evaluation of a breast cancer nomogram for predicting risk of ipsilateral breast tumor recurrences in patients with ductal carcinoma in situ after local excision
    Min Yi
    Department of Surgical Oncology, Unit 1484, The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030, USA
    J Clin Oncol 30:600-7. 2012
    ..The aim of our study was to evaluate a published nomogram from Memorial Sloan-Kettering Cancer Center to predict for risk of IBTR in patients with DCIS from our institution...
  27. ncbi request reprint Predictors of contralateral breast cancer in patients with unilateral breast cancer undergoing contralateral prophylactic mastectomy
    Min Yi
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer 115:962-71. 2009
    ..The objective of this study was to identify the clinicopathologic factors that predict contralateral breast cancer and thereby inform decisions regarding performing CPM in unilateral breast cancer patients...
  28. doi request reprint Factors affecting the decision of breast cancer patients to undergo contralateral prophylactic mastectomy
    Min Yi
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Prev Res (Phila) 3:1026-34. 2010
    ..Evidence-driven models are needed to better inform women of their absolute risk of contralateral breast cancer as well as their competing risk of recurrence from the primary breast cancer to empower them in their active decision making...
  29. pmc Implications of constructed biologic subtype and its relationship to locoregional recurrence following mastectomy
    Laura S Dominici
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res 14:R82. 2012
    ..We examined the prognostic value of biologic subtype on locoregional recurrence (LRR) after mastectomy in a cohort of low risk women who did not receive adjuvant radiation therapy...
  30. ncbi request reprint Utility of ultrasound and fine-needle aspiration biopsy of the axilla in the assessment of invasive lobular carcinoma of the breast
    Judy C Boughey
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Blvd, Houston, TX 77030, USA
    Am J Surg 194:450-5. 2007
    ..Whether it similarly limits lymph node staging by ultrasound (US) and fine-needle aspiration (FNA) biopsy was the subject of the current study...
  31. doi request reprint Evaluation of the MD Anderson Prognostic Index for local-regional recurrence after breast conserving therapy in patients receiving neoadjuvant chemotherapy
    Catherine L Akay
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 19:901-7. 2012
    ..The current study was undertaken to evaluate this prognostic index in an independent cohort...
  32. doi request reprint Disseminated tumor cells predict survival after neoadjuvant therapy in primary breast cancer
    Carolyn Hall
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 118:342-8. 2012
    ..Neoadjuvant chemotherapy (NACT) is effective in reducing the size of primary tumors or eradicating lymph node metastases before surgery, but little is known regarding the presence or significance of DTCs after NACT...
  33. doi request reprint Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning
    Min Yi
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, TX, USA
    Ann Surg 253:572-9. 2011
    ..We utilized 2 different methods and compared sensitivities and specificities between them. Our goal was to determine whether distinguishing NP from TR had prognostic value...
  34. ncbi request reprint Primary tumor resection as a component of multimodality treatment may improve local control and survival in patients with stage IV inflammatory breast cancer
    Catherine L Akay
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer 120:1319-28. 2014
    ..To the authors' knowledge, the benefit of primary tumor resection among patients with metastatic inflammatory breast cancer (IBC) is unknown...
  35. doi request reprint Cyclin E deregulation is an early event in the development of breast cancer
    Alexandra Shaye
    Department of Pathology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Breast Cancer Res Treat 115:651-9. 2009
    ..Our findings suggest that cyclin E deregulation is an early event in the progression from histologically benign mammary epithelial cells to invasive carcinoma and occurs through both overexpression and altered cellular localization...
  36. doi request reprint HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer
    Julie E Lang
    Department of Surgical Oncology, MD Anderson Cancer Center, Advanced Research Center for Microscopic Disease, The University of Texas, Houston, TX 77030, USA
    Breast Cancer Res Treat 113:501-7. 2009
    ..We hypothesized that primary tumor characteristics would predict the likelihood of identifying CTCs in patients with operable breast cancer...
  37. pmc Biologic features and prognosis of ductal carcinoma in situ are not adversely impacted by initial large body mass
    Henry M Kuerer
    Department of Surgical Oncology, DCIS Discovery Enterprise, Unit 1484, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77230 1402, USA
    Breast Cancer Res Treat 133:1131-41. 2012
    ..Furthermore, there was no significant difference in risk of recurrence between diabetic patients receiving metformin or not. In conclusion, higher BMI is not associated with adverse biologic features or prognosis in patients with DCIS...
  38. pmc Prospective evaluation of the nipple-areola complex sparing mastectomy for risk reduction and for early-stage breast cancer
    Jamie L Wagner
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 19:1137-44. 2012
    ..We prospectively evaluated NSM for patients undergoing mastectomy for early-stage breast cancer or risk reduction...
  39. pmc Risk of subclinical micrometastatic disease in the supraclavicular nodal bed according to the anatomic distribution in patients with advanced breast cancer
    Valerie K Reed
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 71:435-40. 2008
    ....
  40. ncbi request reprint Implementation of the american college of surgeons oncology group z1071 trial data in clinical practice: is there a way forward for sentinel lymph node dissection in clinically node-positive breast cancer patients treated with neoadjuvant chemotherapy?
    Elizabeth A Mittendorf
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 21:2468-73. 2014
    ..We are currently evaluating the efficacy of TAD in axillary staging after neoadjuvant chemotherapy. ..
  41. ncbi request reprint Long-term outcomes in patients with mucinous, medullary, tubular, and invasive ductal carcinomas after lumpectomy
    Thao Vo
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Surg 194:527-31. 2007
    ..In this study, we evaluated the long-term outcomes of breast-conserving therapy (BCT) for these subtypes of breast cancer and compared them with those for invasive ductal carcinoma...
  42. doi request reprint Mammography before diagnosis among women age 80 years and older with breast cancer
    Brian D Badgwell
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Blvd, PO Box 301402, Houston, TX 77030 1402, USA
    J Clin Oncol 26:2482-8. 2008
    ..Screening mammography guidelines for patients age 80 years and older are variable. We determined the effect of mammography use on stage at breast cancer diagnosis and survival among women of this age range...
  43. doi request reprint Delays in primary surgical treatment are not associated with significant tumor size progression in breast cancer patients
    Jamie L Wagner
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Ann Surg 254:119-24. 2011
    ..We evaluated the effect of time to surgery on tumor growth by comparing initial imaging and pathologic tumor size estimates. We also determined predictors of delay to surgery...
  44. doi request reprint Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow
    Anthony Lucci
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Breast Cancer Res Treat 117:61-8. 2009
    ....
  45. ncbi request reprint Breast cancer in the very elderly: treatment patterns and complications in a tertiary cancer center
    Kari M Rosenkranz
    MD Anderson Cancer Center, Department of Surgical Oncology, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Surg 192:541-4. 2006
    ..We performed a retrospective review of the very elderly population treated at our institution in order to assess treatment patterns and the safety of therapy in an older population...
  46. doi request reprint Circulating tumour cells in non-metastatic breast cancer: a prospective study
    Anthony Lucci
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Lancet Oncol 13:688-95. 2012
    ..Our aim was to establish if circulating tumour cells predicted worse outcome in patients with non-metastatic breast cancer...
  47. doi request reprint False negative rate of sentinel lymph node biopsy in multicentric and multifocal breast cancers may be higher in cases with large additive tumor burden
    Regina M Fearmonti
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Breast J 15:645-8. 2009
    ..SLNB using sub-areolar injection is feasible for patients with multicentric/multifocal breast cancer yet may be associated with a higher FN rate in patients with large additive tumor burden...
  48. pmc Impact of preoperative versus postoperative chemotherapy on the extent and number of surgical procedures in patients treated in randomized clinical trials for breast cancer
    Judy C Boughey
    Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Surg 244:464-70. 2006
    ..To determine the effect of preoperative chemotherapy on the volume of tissue excised and the number of breast operations in patients undergoing breast-conserving therapy (BCT)...
  49. doi request reprint Invasive paget disease of the breast: clinicopathologic study of an underrecognized entity in the breast
    Xiuzhen Duan
    Department of Pathology, The University of Texas Health Science Center Department of Pathology, Houston, TX 77030, USA
    Am J Surg Pathol 36:1353-8. 2012
    ..Further studies are required to determine whether invasion in MPD has clinical significance...
  50. doi request reprint Prospective randomized trial of paravertebral block for patients undergoing breast cancer surgery
    Judy C Boughey
    Department of Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    Am J Surg 198:720-5. 2009
    ..The goal of the current study was to evaluate the effect of regional anesthesia using paravertebral block (PVB) on postoperative pain after breast surgery...
  51. ncbi request reprint Timing of infectious complications following breast-conserving therapy with catheter-based accelerated partial breast irradiation
    Alex B Haynes
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 21:2512-6. 2014
    ..Previous publications have focused on early postoperative infections and reported low rates of delayed infection. We investigated the pattern of infection after catheter-based APBI at our institution...
  52. ncbi request reprint Outcome after curative resection for locally recurrent rectal cancer
    Isabelle Bedrosian
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 444, Houston, Texas 77030, USA
    Dis Colon Rectum 49:175-82. 2006
    ..We sought to determine the influence of clinical, pathologic, and biologic (p53, bcl-2, and ki-67) variables on survival after curative resection of locally recurrent rectal cancer...
  53. ncbi request reprint Locoregional treatment outcomes for breast cancer patients with ipsilateral supraclavicular metastases at diagnosis
    Eugene H Huang
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 67:490-6. 2007
    ..To evaluate the locoregional efficacy of multimodality treatment for breast cancer patients who present with ipsilateral supraclavicular (SCV) disease without systemic metastases...
  54. pmc Underuse of trimodality treatment affects survival for patients with inflammatory breast cancer: an analysis of treatment and survival trends from the national cancer database
    Natasha M Rueth
    All authors The University of Texas MD Anderson Cancer Center, Houston, TX
    J Clin Oncol 32:2018-24. 2014
    ..To analyze factors that predict the use of trimodality treatment (chemotherapy, surgery, and radiation therapy [RT]) and evaluate the impact that trimodality treatment use has on survival for patients with inflammatory breast cancer (IBC)...
  55. ncbi request reprint Impact of clinicopathological factors on sensitivity of axillary ultrasonography in the detection of axillary nodal metastases in patients with breast cancer
    Isabelle Bedrosian
    Departments of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Surg Oncol 10:1025-30. 2003
    ..Ultrasonography and fine-needle aspiration (FNA) are used to evaluate the breast and regional nodes in breast cancer patients. We sought to identify factors influencing the sensitivity of ultrasonography for detection of nodal metastasis...
  56. pmc Association between contralateral prophylactic mastectomy and breast cancer outcomes by hormone receptor status
    Abenaa M Brewster
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230 1439, USA
    Cancer 118:5637-43. 2012
    ..The objective of this study was to evaluate the benefits of CPM using a propensity scoring approach that reduces selection bias from the nonrandom assignment of patients in observational studies...
  57. pmc Suppression of Akt-mTOR pathway-a novel component of oncogene induced DNA damage response barrier in breast tumorigenesis
    Anjana Bhardwaj
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 9:e97076. 2014
    ..These data suggest that AKT-mTOR pathway is a novel component of oncogene induced DNA damage response in immortalized 'normal-like' breast cells and its suppression may contribute to growth arrest and arrest of the breast tumorigenesis. ..
  58. ncbi request reprint Cyclin E-associated kinase activity predicts response to platinum-based chemotherapy
    Isabelle Bedrosian
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:4800-6. 2007
    ..We hypothesized that cyclin E deregulation would predict for responsiveness to platinum-based regimens in ovarian cancer patients...
  59. ncbi request reprint Predicting the node-negative mesorectum after preoperative chemoradiation for locally advanced rectal carcinoma
    Isabelle Bedrosian
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Gastrointest Surg 8:56-62; discussion 62-3. 2004
    ..Despite a substantial reduction in tumor volume with neoadjuvant CRT, local excision should be recommended with caution in patients with locally advanced rectal cancer...
  60. ncbi request reprint Predictors of systemic recurrence and disease-specific survival after ipsilateral breast tumor recurrence
    Jeannie Shen
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer 104:479-90. 2005
    ..Therefore, the management of isolated IBTR remains controversial. The objective of the current study was to identify determinants of systemic recurrence and DSS after IBTR...
  61. ncbi request reprint Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway
    Xiao Feng Le
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cell Cycle 5:1654-61. 2006
    ....
  62. ncbi request reprint The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27
    Hannah Wingate
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    J Biol Chem 280:15148-57. 2005
    ..Thus, the LMW forms of cyclin E may contribute to tumorigenesis through their resistance to the inhibitory activities of p21 and p27 while sequestering these CKIs from the full-length cyclin E...
  63. pmc Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection
    Guang Peng
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Cancer Res 72:2802-13. 2012
    ..Our findings therefore indicate that enhanced activity of DSB resection likely constitutes one mechanism whereby precancerous and cancerous cells might alleviate replication stress...