CHRISTINE BEATTIE

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding
    Michelle L McWhorter
    Center for Molecular Neurobiology, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 162:919-31. 2003
  2. ncbi Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2 gene
    Le T Hao
    Dept of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Rd, Columbus OH 43210, USA
    Mol Neurodegener 6:24. 2011
  3. ncbi Mutations in the stumpy gene reveal intermediate targets for zebrafish motor axons
    C E Beattie
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 127:2653-62. 2000
  4. ncbi Control of motor axon guidance in the zebrafish embryo
    C E Beattie
    Neurobiotechnology Center and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Brain Res Bull 53:489-500. 2000
  5. ncbi Fishing for a mechanism: using zebrafish to understand spinal muscular atrophy
    Christine E Beattie
    Ohio State University Center for Molecular Neurobiology, Department of Neuroscience, Columbus, OH, USA
    J Child Neurol 22:995-1003. 2007
  6. ncbi Attraction versus repulsion: modular receptors make the difference in axon guidance
    M A Seeger
    Department of Molecular Genetics, Ohio State University, Columbus 43210, USA
    Cell 97:821-4. 1999
  7. ncbi Notochord alters the permissiveness of myotome for pathfinding by an identified motoneuron in embryonic zebrafish
    C E Beattie
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Development 124:713-20. 1997
  8. ncbi Zebrafish deadly seven functions in neurogenesis
    M Gray
    Neurobiotechnology Center, Ohio State University, Columbus, Ohio 43210, USA
    Dev Biol 237:306-23. 2001
  9. ncbi Identification and characterization of roundabout orthologs in zebrafish
    A K Challa
    Neurobiotechnology Center, The Ohio State University, Columbus, OH 43210, USA
    Mech Dev 101:249-53. 2001
  10. ncbi Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis
    Tessa L Carrel
    Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 26:11014-22. 2006

Research Grants

  1. Spinal Muscular Atrophy: Is it a motor axon disease?
    CHRISTINE BEATTIE; Fiscal Year: 2009
  2. Spinal Muscular Atrophy: Is it a motor axon disease?
    Christine E Beattie; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. ncbi Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding
    Michelle L McWhorter
    Center for Molecular Neurobiology, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 162:919-31. 2003
    ..These results show for the first time, in vivo, that Smn functions in motor axon development and suggest that these early developmental defects may lead to subsequent motoneuron loss...
  2. ncbi Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2 gene
    Le T Hao
    Dept of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Rd, Columbus OH 43210, USA
    Mol Neurodegener 6:24. 2011
    ..abstract:..
  3. ncbi Mutations in the stumpy gene reveal intermediate targets for zebrafish motor axons
    C E Beattie
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 127:2653-62. 2000
    ..These results reveal a series of intermediate targets involved in motor axon guidance and suggest that stumpy function is required for motor axons to progress from proximally located intermediate targets to distally located ones...
  4. ncbi Control of motor axon guidance in the zebrafish embryo
    C E Beattie
    Neurobiotechnology Center and Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Brain Res Bull 53:489-500. 2000
    ..Knowledge gained from this body of work not only relates to zebrafish, but to vertebrate axon guidance in general...
  5. ncbi Fishing for a mechanism: using zebrafish to understand spinal muscular atrophy
    Christine E Beattie
    Ohio State University Center for Molecular Neurobiology, Department of Neuroscience, Columbus, OH, USA
    J Child Neurol 22:995-1003. 2007
    ..The use of animal models, however, offers a crucial tool in determining the function of SMN in this disease. In this review, we discuss our efforts to develop a zebrafish model of spinal muscular atrophy...
  6. ncbi Attraction versus repulsion: modular receptors make the difference in axon guidance
    M A Seeger
    Department of Molecular Genetics, Ohio State University, Columbus 43210, USA
    Cell 97:821-4. 1999
  7. ncbi Notochord alters the permissiveness of myotome for pathfinding by an identified motoneuron in embryonic zebrafish
    C E Beattie
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Development 124:713-20. 1997
    ..This change participates in restricting the CaP pathway to the ventral myotome and thus to neuromuscular specificity...
  8. ncbi Zebrafish deadly seven functions in neurogenesis
    M Gray
    Neurobiotechnology Center, Ohio State University, Columbus, Ohio 43210, USA
    Dev Biol 237:306-23. 2001
    ....
  9. ncbi Identification and characterization of roundabout orthologs in zebrafish
    A K Challa
    Neurobiotechnology Center, The Ohio State University, Columbus, OH 43210, USA
    Mech Dev 101:249-53. 2001
    ..robo1 nervous system expression appears later in development and is more restricted. Moreover, both genes are expressed in non-neuronal tissues consistent with additional roles for these genes during development...
  10. ncbi Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis
    Tessa L Carrel
    Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 26:11014-22. 2006
    ..Thus, we have dissociated the snRNP function of SMN from its function in motor axons. These data indicate that SMN has a novel function in motor axons that is relevant to SMA and is independent of snRNP biosynthesis...
  11. ncbi Embryonic motor axon development in the severe SMA mouse
    Vicki L McGovern
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 17:2900-9. 2008
    ..This indicates that in severe SMA mice there are no defects in motor axon formation however, we find evidence of denervation in embryogenesis...
  12. ncbi Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy
    Gabriela E Oprea
    Institute of Human Genetics, University of Cologne, 50931 Cologne, Germany
    Science 320:524-7. 2008
    ..Our study suggests that defects in axonogenesis are the major cause of SMA, thereby opening new therapeutic options for SMA and similar neuromuscular diseases...
  13. ncbi The SMN binding protein Gemin2 is not involved in motor axon outgrowth
    Michelle L McWhorter
    Center for Molecular Neurobiology, The Ohio State University, Columbus, OH 43210, USA
    Dev Neurobiol 68:182-94. 2008
    ..Since Gemin2 and SMN both function in snRNP biogenesis yet only SMN knockdown causes motor axon defects, these data are consistent with an additional role for SMN that is snRNP independent...
  14. ncbi Cellular, genetic and molecular mechanisms of axonal guidance in the zebrafish
    Christine E Beattie
    Neurobiotechnology Center/Department of Neuroscience, Ohio State University, 115 Rightmire Hall, 1060 Carmack Road, Columbus, Ohio 43210, USA
    Results Probl Cell Differ 40:252-69. 2002
  15. ncbi Robo3 isoforms have distinct roles during zebrafish development
    Anil K Challa
    Center for Molecular Neurobiology, Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    Mech Dev 122:1073-86. 2005
    ..This study reveals a novel function for Robo receptors in specifying ventral cell fates during vertebrate development...
  16. ncbi Zebrafish topped is required for ventral motor axon guidance
    Louise R Rodino-Klapac
    Center for Molecular Neurobiology, The Ohio State University, Columbus, OH 43210, USA
    Dev Biol 273:308-20. 2004
    ..These data suggest that Topped functions in the ventromedial fast muscle and is essential for motor axon outgrowth into the ventral myotome...
  17. ncbi Mutations in deadly seven/notch1a reveal developmental plasticity in the escape response circuit
    Katharine S Liu
    Department of Neurobiology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    J Neurosci 23:8159-66. 2003
    ..Such plasticity may be key to the evolution of the startle responses in mammals, which use larger populations of neurons in circuits similar to those in the fish escape response...
  18. ncbi Cloning and expression of zebrafish neuronal nicotinic acetylcholine receptors
    Jeffrey M Zirger
    Department of Neuroscience, College of Medicine and Public Health, The Ohio State University, 4068 Graves Hall, 333 West Tenth Avenue, Columbus, OH 43210, USA
    Gene Expr Patterns 3:747-54. 2003
    ..6pM and 29.7nM and in 5dpf embryos with IC(50) values of 28.4pM and 8.9nM. These studies are consistent with the involvement of neuronal nAChRs in early zebrafish development...

Research Grants9

  1. Spinal Muscular Atrophy: Is it a motor axon disease?
    CHRISTINE BEATTIE; Fiscal Year: 2009
    ..Experiments outlined in this proposal will directly test the hypothesis that SMA is a motor axon disease and will reveal whether SMN functions in a complex crucial for localized protein translation in motor axon growth cones. ..
  2. Spinal Muscular Atrophy: Is it a motor axon disease?
    Christine E Beattie; Fiscal Year: 2010
    ..The proposed experiments will elucidate the interaction and function of plastin 3 as it relates to SMN and has the potential to reveal novel therapeutic targets. ..