D M Basso
Affiliation: The Ohio State University
- Descending systems contributing to locomotor recovery after mild or moderate spinal cord injury in rats: experimental evidence and a review of literatureD Michele Basso
Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus 43210, USA
Restor Neurol Neurosci 20:189-218. 2002..Greater axonal sparing is associated with more extensive recovery. Therefore, we identified the source and relative proportion of spared axons associated with extensive or limited locomotor recovery after SCI...
- Neuroanatomical substrates of functional recovery after experimental spinal cord injury: implications of basic science research for human spinal cord injuryD M Basso
Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, 306 SAMP, 1583 Perry St, Columbus, OH 43210, USA
Phys Ther 80:808-17. 2000..Body weight supported treadmill step training is discussed as an example of new facilitatory interventions based on basic science research using animal models...
- Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strainsD Michele Basso
Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
J Neurotrauma 23:635-59. 2006..05). The differing behavioral response to SCI suggests inherent genetic factors significantly impact locomotor recovery and must be considered in studies with inbred or genetically engineered mouse strains...
- A sensitive and reliable locomotor rating scale for open field testing in ratsD M Basso
Department of Cell Biology, Neurobiology and Anatomy, Ohio State University, Columbus, USA
J Neurotrauma 12:1-21. 1995..The BBB Locomotor Rating Scale offers investigators a more discriminating measure of behavioral outcome to evaluate treatments after spinal cord injury...
- Physical therapy on trial: the rationale, organization, and impact of a mock trial on physical therapy students' attitudes toward and confidence in researchDeborah Givens Heiss
Physical Therapy Division, School of Allied Medical Professions, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210 1234, USA
J Allied Health 32:202-10. 2003..If attitudes predict behavior, these future practitioners are more likely to be physical therapists who critically appraise and use evidence to determine practice...
- The neuropathological and behavioral consequences of intraspinal microglial/macrophage activationP G Popovich
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine and Public Health and School of Allied Medical Professions, Columbus 43210, USA
J Neuropathol Exp Neurol 61:623-33. 2002..Further development of this model will help to clarify the biological potential of microglia and macrophages and the molecular signals that control their function within the spinal cord...
- Behavioral and histological outcomes following graded spinal cord contusion injury in the C57Bl/6 mouseM Ma
Department of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, USA
Exp Neurol 169:239-54. 2001..The data provide a thorough and quantitative analysis of the effects of contusion injury on long-term behavioral and histological outcome measures in this strain and species...
- Delayed Nogo receptor therapy improves recovery from spinal cord contusionXingxing Wang
Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
Ann Neurol 60:540-9. 2006..Myelin-associated inhibitors play a role in limiting axonal growth in the adult central nervous system. Blocking these inhibitors may promote neurological recovery from spinal cord contusion...
- Voluntary wheel running improves recovery from a moderate spinal cord injuryChristie Engesser-Cesar
Institute for Brain Aging and Dementia, University of California, Irvine, California 92697 4540, USA
J Neurotrauma 22:157-71. 2005..05). Finally, fibronectin staining shows no significant difference in lesion size between the two groups. These data represent the first mouse model showing voluntary exercise improves recovery after SCI...
- Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in ratsAnne D Kloos
Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, 516 Atwell Hall, 1583 Perry Street, Columbus, OH 43210, USA
Exp Neurol 191:251-65. 2005..A hierarchical locomotor recovery based on simple segmental versus complex supraspinal motor control is proposed...
- Behavioral testing after spinal cord injury: congruities, complexities, and controversiesD Michele Basso
Division of Physical Therapy, The Ohio State University, Columbus, Ohio 43210, USA
J Neurotrauma 21:395-404. 2004..Recent work in translating behavioral tests from rats to mice is also provided. The purpose of this article is to provide a framework by which behavioral testing can be standardized within and across spinal cord injury labs...
- Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in ratsT Bucky Jones
The Neuroscience Graduate Studies Program, Division of Physical Therapy, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
J Neurosci 24:3752-61. 2004..These data are consistent with the conventional view of myelin-reactive T-cells as pathological effector cells...
- Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapyT Bucky Jones
The Neuroscience Graduate Studies Program, School of Allied Medical Professions, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
J Neurosci 22:2690-700. 2002..Consequently, the safe implementation of such therapies requires that future studies define the mechanisms that control T-cell function within the injured CNS...
- Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in ratsMegan Ryan Detloff
Center for Brain and Spinal Cord Repair, Neuroscience Graduate Studies Program, The Ohio State University 43210, USA
Exp Neurol 212:337-47. 2008..Although the mechanisms of remote microglial activation are unknown, this response may be a viable target for limiting or preventing neuropathic pain after SCI in humans...
- Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in ratsKaren J Hutchinson
Division of Physical Therapy, The Ohio State University, 516 Atwell Hall, 1583 Perry Street, Columbus, OH 43210, USA
Brain 127:1403-14. 2004..These findings suggest that rhythmic, weight-bearing exercise may be an effective intervention to counter SCI-induced allodynia...
- Validity of the walking scale for spinal cord injury and other domains of function in a multicenter clinical trialJohn F Ditunno
Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Neurorehabil Neural Repair 21:539-50. 2007..To demonstrate criterion (concurrent and predictive) and construct validity of the Walking Index for Spinal Cord Injury (WISCI) scale and other walking measures in the Spinal Cord Injury Locomotor Trial (SCILT)...
- SPARING AND EXERCISE TRAINING PROMOTE RECOVERY IN SCIMichele Basso; Fiscal Year: 2006..abstract_text> ..