T Bartfai

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. doi request reprint Pharma TARP: a troubled asset relief program for novel, abandoned projects in the pharmaceutical industry
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    ScientificWorldJournal 11:454-7. 2011
  2. ncbi request reprint Positive allosteric modulators to peptide GPCRs: a promising class of drugs
    Tamas Bartfai
    Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Acta Pharmacol Sin 34:880-5. 2013
  3. pmc Drug targets: single-cell transcriptomics hastens unbiased discovery
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10 550N Torrey Pines Road, SR307, La Jolla, CA, 92037, USA
    Trends Pharmacol Sci 33:9-16. 2012
  4. pmc A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
    Tamas Bartfai
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7971-6. 2003
  5. pmc Fever
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    ScientificWorldJournal 10:490-503. 2010
  6. ncbi request reprint From lab bench to Wall Street
    Tamas Bartfai
    Department of Molecular and Integrative Neurosciences, The Harold L Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, California, USA
    FASEB J 20:1578-80. 2006
  7. ncbi request reprint Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
    Ann N Y Acad Sci 1113:173-7. 2007
  8. ncbi request reprint Pharmacogenomics in drug development: societal and technical aspects
    T Bartfai
    Department of Neuropharmacology, Harold L Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Pharmacogenomics J 4:226-32. 2004
  9. ncbi request reprint Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons
    I V Tabarean
    Harold L Dorris Neurological Research Center, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscience 141:1685-95. 2006
  10. pmc Night eating and obesity in the EP3R-deficient mouse
    Manuel Sanchez-Alavez
    The Harold L Dorris Neurological Research Institute and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:3009-14. 2007

Detail Information

Publications75

  1. doi request reprint Pharma TARP: a troubled asset relief program for novel, abandoned projects in the pharmaceutical industry
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    ScientificWorldJournal 11:454-7. 2011
    ..The investment required is small compared to the Troubled Asset Relief Program bank bail out, but the return on investment in financial terms and in satisfying societal needs makes this proposal attractive...
  2. ncbi request reprint Positive allosteric modulators to peptide GPCRs: a promising class of drugs
    Tamas Bartfai
    Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Acta Pharmacol Sin 34:880-5. 2013
    ....
  3. pmc Drug targets: single-cell transcriptomics hastens unbiased discovery
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10 550N Torrey Pines Road, SR307, La Jolla, CA, 92037, USA
    Trends Pharmacol Sci 33:9-16. 2012
    ..Here, we compare SBSCT to other single-cell profiling methods. We argue that the unbiased nature of SBSCT makes it a powerful tool for the identification of new drug targets...
  4. pmc A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
    Tamas Bartfai
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7971-6. 2003
    ..p.). Inhibition of the TIR domain-mediated MyD88/IL1-RI interaction by a low molecular weight, cell-penetrating TIR domain mimic suggests an intracellular site for antiinflammatory drug action...
  5. pmc Fever
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    ScientificWorldJournal 10:490-503. 2010
    ..We also show how fever research provided new insights into temperature and energy homeostasis, and into treatment of infection and inflammation...
  6. ncbi request reprint From lab bench to Wall Street
    Tamas Bartfai
    Department of Molecular and Integrative Neurosciences, The Harold L Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, California, USA
    FASEB J 20:1578-80. 2006
  7. ncbi request reprint Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
    Ann N Y Acad Sci 1113:173-7. 2007
    ..Selective induction or pharmacological application of IL-1ra may be sparing neurons in seizures and neurotrauma...
  8. ncbi request reprint Pharmacogenomics in drug development: societal and technical aspects
    T Bartfai
    Department of Neuropharmacology, Harold L Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Pharmacogenomics J 4:226-32. 2004
  9. ncbi request reprint Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons
    I V Tabarean
    Harold L Dorris Neurological Research Center, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscience 141:1685-95. 2006
    ..Taken together our data suggest that IL-1beta inhibits the activity of preoptic area/anterior hypothalamus neurons by increasing the presynaptic release of GABA...
  10. pmc Night eating and obesity in the EP3R-deficient mouse
    Manuel Sanchez-Alavez
    The Harold L Dorris Neurological Research Institute and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:3009-14. 2007
    ..The findings add to the growing literature on links between inflammatory signaling and obesity...
  11. ncbi request reprint Galanin, galanin receptors, and drug targets
    K Mitsukawa
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    EXS 102:7-23. 2010
    ....
  12. pmc Bidirectional regulation of stress responses by galanin in mice: involvement of galanin receptor subtype 1
    K Mitsukawa
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscience 160:837-46. 2009
    ..In GalR1KO mice, a high dose of galanin failed to induce any of the above effects, suggesting the pivotal role of GalR1 in decreased locomotor activity and stress-resistant effects caused by galanin i.c.v. injection studied here...
  13. ncbi request reprint Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice
    H Badie-Mahdavi
    The Scripps Research Institute, Harold L Dorris Neurological Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, SR307, La Jolla, CA 92037, USA
    Neuropeptides 39:249-51. 2005
    ..In summary, these data indicate that the systemically active, non-peptide galanin receptor agonist, galnon can exert similar effects to galanin (1-29) in attenuation of DG LTP in mice...
  14. pmc Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge
    E P Zorrilla
    The Harold L Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Physiol Behav 91:479-85. 2007
    ..p. 1 IU/kg) in vivo. The results support the hypotheses that galanin-GALR1 systems help adapt food intake and metabolism to changes in dietary fat and modulate glucose disposition in mice...
  15. ncbi request reprint Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:147-52. 2005
    ....
  16. pmc Hypothalamic and dietary control of temperature-mediated longevity
    Iustin Tabarean
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Ageing Res Rev 9:41-50. 2010
    ....
  17. pmc Ceramide mediates the rapid phase of febrile response to IL-1beta
    Manuel Sanchez-Alavez
    Harold L Dorris Neurological Research Center, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2904-8. 2006
    ..These in vivo and in vitro data suggest that ceramide fulfills the criteria for an endogenous pyrogen...
  18. ncbi request reprint Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus
    Andrey Mazarati
    West Los Angeles VA Medical Center, and Department of Neurology, D Geffen Medical School, UCLA, Los Angeles, CA, USA
    Eur J Neurosci 19:3235-44. 2004
    ..These results are important for understanding the role of galanin and galanin receptor subtypes in the hippocampus both under normal conditions and in excitotoxic injury...
  19. ncbi request reprint IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons
    Christopher N Davis
    The Harold L Dorris Neurological Research Institute and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 98:1379-89. 2006
    ....
  20. ncbi request reprint Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:165-7. 2005
    ..For now one needs to interpret the data obtained at lower galanin (2-11) concentrations as effects mediated by non-GalR1 type galanin receptors, i.e., GalR2 and/or GalR3...
  21. pmc Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity
    Joel N Buxbaum
    Division of Rheumatology Research, W M Keck Autoimmune Disease Center, and Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:2681-6. 2008
    ..The interaction may represent a unique normal host defense mechanism, enhancement of which could be therapeutically useful...
  22. pmc MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics
    Christopher N Davis
    The Harold L Dorris Neurological Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2953-8. 2006
    ....
  23. pmc Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
    Eric P Zorrilla
    Harold L Dorris Neurological Research Institute, Committee on the Neurobiology of Addictive Disorders, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:11097-102. 2007
    ..The data suggest that endogenous IL-18 signaling modulates food intake, metabolism, and adiposity during adulthood and might be a central or peripheral pharmacological target for controlling energy homeostasis...
  24. ncbi request reprint Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance
    Olivia Osborn
    The Harold L Dorris Neurological Research Institute, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Swiss Med Wkly 138:665-73. 2008
    ..This review highlights results of studies in mice which indicate important roles for these proinflammatory cytokines during the development of obesity and insulin resistance, and in the treatment of type 2 diabetes...
  25. ncbi request reprint Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 93:493-501. 2005
    ..Our data suggest that UCP2 may represent a drug target for slowing the progression of Parkinson's disease...
  26. pmc Metabolic characterization of a mouse deficient in all known leptin receptor isoforms
    Olivia Osborn
    Molecular and Integrative Neurosciences Department, The Harold L Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Mol Neurobiol 30:23-33. 2010
    ....
  27. pmc Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons
    Manuel Sanchez-Alavez
    The Harold L Dorris Neurological Research Institute, Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California, USA
    Diabetes 59:43-50. 2010
    ..The objective is to examine the role of the metabolic signal insulin in the control of core body temperature (CBT)...
  28. pmc Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests
    Xiaoying Lu
    The Harold L Dorris Neurological Institute, Department of Molecular and Integrative Neurosciences, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 42:387-97. 2008
    ..The present findings are consistent with a predicted antidepressant-like effect of GalR2 signaling, suggesting that GalR2 might be a valid drug target for depressive disorders...
  29. pmc GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models
    Xiaoying Lu
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:15229-34. 2010
    ..CYM2503 also attenuated electroshock-induced seizures in mice. Thus, CYM2503 provides a starting point for the development of anticonvulsant therapy using the galanin R2 receptor as target...
  30. ncbi request reprint Transgenic mice with a reduced core body temperature have an increased life span
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 314:825-8. 2006
    ..Thus, modest, sustained reduction of core body temperature prolonged life span independent of altered diet or CR...
  31. pmc A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus
    Xiaoying Lu
    Department of Neuropharmacology and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:874-9. 2005
    ....
  32. pmc Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue
    Olivia Osborn
    The Harold L Dorris Neurological Research Institute, Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cytokine 53:311-9. 2011
    ..We describe a novel role to the ligand Ccl22 and its receptor Ccr4 in the anterior hypothalamus in temperature regulation that depends on the synthesis of the endogenous pyrogen, prostaglandin E2...
  33. ncbi request reprint Galanin, galanin receptors and drug targets
    K Mitsukawa
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Cell Mol Life Sci 65:1796-805. 2008
    ....
  34. ncbi request reprint Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture
    I V Tabarean
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Neuroscience 135:433-49. 2005
    ..Therefore, and despite obvious differences in their networks, cultured and slice preparations of hypothalamic neurons can complement each other for further studies of warm-sensitivity at the cellular and molecular level...
  35. ncbi request reprint Cytokines and fever
    Bruno Conti
    Harold L Dorris Neurological Research Center, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Front Biosci 9:1433-49. 2004
    ....
  36. ncbi request reprint Mechanisms of antinociception of spinal galanin: how does galanin inhibit spinal sensitization?
    X Y Hua
    Anesthesia Research Laboratory, Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Neuropeptides 39:211-6. 2005
    ....
  37. ncbi request reprint Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine
    B Conti
    Molecular and Integrative Neuroscience Department, Harold L Dorris Neurological Research Institute, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Psychiatry 12:167-89. 2007
    ..The novel transcripts, concomitantly regulated by several antidepressant treatments, may represent novel targets for fast onset, long-duration antidepressants...
  38. ncbi request reprint The brain galanin receptors: targets for novel antidepressant drugs
    Xiaoying Lu
    Molecular and Integrative Neuroscience Department MIND and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Rd SR 307, La Jolla, CA 92037, USA
    CNS Neurol Disord Drug Targets 6:183-92. 2007
    ..Since both GalR2 and GalR3 are G-protein coupled receptors (GPCRs), a favorite target class for drug development, we believe that the pace of developing galaninergic antidepressants will increase significantly from now on...
  39. pmc Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests
    Tamas Bartfai
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:10470-5. 2004
    ..These data further implicate brain and spinal cord galanin receptors as drug targets and provide an example of a systemically active compound based on a scaffold that mimics protein surfaces...
  40. ncbi request reprint A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests
    Alasdair M Barr
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA, United States
    Neurosci Lett 405:111-5. 2006
    ..These combined data from two species indicate that GalR3 receptor antagonists may exhibit antidepressant-like effects...
  41. pmc Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity
    O Osborn
    The Harold L Dorris Neurological Research Institute and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cytokine 44:141-8. 2008
    ..024). While there was no improvement of obesity, a significant improvement of glycemic control and of beta cell function is achieved by this pharmacological treatment which may slow/prevent disease progression in Type 2 Diabetes...
  42. ncbi request reprint Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3',5'-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: studies with a galanin receptor 2 agonist and galanin receptor 1 kn
    H Badie-Mahdavi
    The Scripps Research Institute, Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, La Jolla, CA 92037, USA
    Neuroscience 133:591-604. 2005
    ....
  43. ncbi request reprint Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5
    Xiao Ying Hua
    Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92103 0818, USA
    J Pharmacol Exp Ther 308:574-82. 2004
    ..t. morphine and AP-5-induced antinociception...
  44. ncbi request reprint Galanin alters GABAergic neurotransmission in the dorsal raphe nucleus
    Lisa M Sharkey
    Molecular and Integrative Neurosciences Department, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurochem Res 33:285-91. 2008
    ..These findings may enhance understanding of the cellular mechanisms underlying the effects of antidepressant treatments on galanin and galanin receptors in DRN...
  45. ncbi request reprint TLR2 is required for the altered transcription of p75NGF receptors in gram positive infection
    Sebastian A Wirz
    The Harold L Dorris Neurological Research Center, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Neurochem Res 31:297-301. 2006
    ..This observation provides a link between Gram-positive infection and neurotrophic responses, which may be important in preserving neurons at sites of the infection...
  46. pmc Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition
    Iustin V Tabarean
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:2590-5. 2004
    ....
  47. ncbi request reprint Galanin receptor ligands
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:143-6. 2005
    ..The present paper summarizes the properties of the galanin ligands used at the end of 2004 in the ca. 2000 publications and complements their pharmacological characterization with new data...
  48. pmc Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice
    Xiaoying Lu
    The Harold L Dorris Neurological Research Institute, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, SR 307, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Naunyn Schmiedebergs Arch Pharmacol 379:417-20. 2009
    ..These findings argue for taking precaution when using antibodies to galanin receptors...
  49. ncbi request reprint Homodimerization and internalization of galanin type 1 receptor in living CHO cells
    Sebastian A Wirz
    Department of Neuropharmacology, Harold L Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropeptides 39:535-46. 2005
    ..Internalization and dimerization of GalR1 is shown, contributing to the regulation of galanergic signaling...
  50. pmc It all happens between Toll receptors and caspase 1
    Manuel Sanchez-Alavez
    The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:7733-4. 2007
  51. ncbi request reprint Adipose tissue as a modulator of clinical inflammation: does obesity reduce the prevalence of rheumatoid arthritis?
    Tamas Bartfai
    Department of Molecular and Integrative Neurosciences and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Rheumatol 34:488-92. 2007
    ..We wished to determine if extremely obese individuals were overrepresented among a group of patients with RA...
  52. doi request reprint Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Novum, Floor 5, Division of Neurodegeneration and Neuroinflammation, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Eur J Neurosci 27:549-58. 2008
    ..Taken together, our results indicate that IL-1 is crucial for the adaptability of the brain to acute and chronic neuroinflammation...
  53. ncbi request reprint Effect of interleukin-18 on mouse core body temperature
    Silvia Gatti
    Pharmaceutical Division, CNS Preclinical Research, F Hoffmann LaRoche, CH 4070 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 282:R702-9. 2002
    ..We conclude that IL-18 is not pyrogenic when injected intraperitoneally in C57BL/6 mice. Furthermore, a pretreatment with IL-18, 30 min before IL-1beta, attenuates the febrile response induced by IL-1beta...
  54. ncbi request reprint Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions
    Linda Lundström
    Department of Neurochemistry, Stockholm University, Stockholm, Sweden
    J Neurochem 103:1774-84. 2007
    ..The presented observations could be of major importance for the design and development of new and improved peptide and non-peptide ligands, selectively activating the GalR2 subtype...
  55. ncbi request reprint Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes
    Massimo Locati
    Istituto di Patologia Generale, Universita degli Studi di Milano, Milan, Italy
    J Immunol 168:3557-62. 2002
    ..Chemokine-induced chemokines production could represent a novel amplification loop of leukocyte recruitment, while a subset of chemokine-inducible transcripts could be involved in monocyte extravasation and tissue invasion...
  56. ncbi request reprint Galanin overexpressing transgenic mice
    Jacqueline N Crawley
    Section on Behavioral Genomics, National Institute of Mental Health, Bethesda, MD 20815, USA
    Neuropeptides 36:145-56. 2002
    ..GAL-tg represent a new model for investigating the biological actions of endogenous galanin, and for testing novel therapeutics based on galanin receptor ligands...
  57. pmc Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test
    Takashi Yoshitake
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:354-9. 2004
    ..The present findings support a role of galanin in the regulation of release of NA and 5-HT, two neurotransmitters involved in mood control...
  58. ncbi request reprint Regulation of feeding by galnon
    Urho Abramov
    Department of Physiology, Tartu University, Ravila 19, Tartu 50 411, Estonia
    Neuropeptides 38:55-61. 2004
    ..These data demonstrate that galnon is a promising tool for studies of the involvement of galanin in feeding disorders and other behavioral processes...
  59. ncbi request reprint Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse
    Mircea Oprica
    Neurotec Department, Division of Experimental Geriatrics, Karolinska Institutet, Novum, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden
    Acta Neuropathol 108:69-80. 2004
    ....
  60. ncbi request reprint Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist
    Roya Tehranian
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, Sweden
    J Neurotrauma 19:939-51. 2002
    ....
  61. pmc Interleukin-1beta contributes to the generation of experimental febrile seizures
    Celine Dube
    Department of Anatomy and Neurobiology, University of California at Irvine, Medical Science I, ZOT 4475, Irvine, CA 92697 4475, USA
    Ann Neurol 57:152-5. 2005
    ..These data indicate that IL-1beta signaling contributes critically to fever-induced hyperexcitability underlying FS, constituting a potential target for their prevention...
  62. ncbi request reprint Neuropeptide expression in rats exposed to chronic mild stresses
    Valeriy Sergeyev
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Psychopharmacology (Berl) 178:115-24. 2005
    ....
  63. ncbi request reprint Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury
    Ingo Bechmann
    Department of Anatomy and Cell Biology, Humboldt University, Charite, Berlin, Germany
    Biochem Pharmacol 64:363-7. 2002
    ....
  64. ncbi request reprint Transgenic overexpression of interleukin-1 receptor antagonist in the CNS influences behaviour, serum corticosterone and brain monoamines
    Mircea Oprica
    Division of Experimental Geriatrics, Neurotec Department, Karolinska Institutet, Novum, KFC, 4th Floor, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Brain Behav Immun 19:223-34. 2005
    ..Finally, the activation of hypothalamo-pituitary-adrenal (HPA)-axis was comparable in the two genotypes, however Tg hsIL-1ra(+/+) mice had a modified metabolism of brain monoamines as compared to WT mice...
  65. ncbi request reprint Important pharmacophores for binding to galanin receptor 2
    Linda Lundström
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Svante Arrheniusv 21A, 106 91 Stockholm, Sweden
    Neuropeptides 39:169-71. 2005
    ..This information is useful in the rational design of non-peptide type GalR2 receptor ligands...
  66. ncbi request reprint Age-related impairments of synaptic plasticity in the lateral perforant path input to the dentate gyrus of galanin overexpressing mice
    Kang Zheng
    Department of Neuroscience, Karolinska Institutet, S 171 71, Stockholm, Sweden
    Neuropeptides 39:259-67. 2005
    ..Galaninergic mechanisms may therefore represent therapeutic targets for treatment of age-related memory deficits and Alzheimer's disease...
  67. pmc Anticonvulsant activity of a nonpeptide galanin receptor agonist
    Külliki Saar
    Department of Neurochemistry and Neurotoxicology, Stockholm University, SE 10691 Stockholm, Sweden
    Proc Natl Acad Sci U S A 99:7136-41. 2002
    ..These findings introduce a systemically active nonpeptide galanin agonist anticonvulsant...
  68. ncbi request reprint Multiple interaction sites of galnon trigger its biological effects
    Anders Floren
    Department of Neurochemistry, Stockholm University, Sweden
    Neuropeptides 39:547-58. 2005
    ..We conclude that galnon has multiple sites of interaction within the GPCR signaling cascade which mediate its physiological effects...
  69. ncbi request reprint Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour
    Tie Jun Sten Shi
    Department of Neuroscience, Karolinska Institutet, S171 77 Stockholm, Sweden
    Eur J Neurosci 23:627-36. 2006
    ..These data are in line with earlier observations from the peripheral and central nervous system, suggesting that galanin actions mediated by GalR2 subtype are of importance in neurodevelopment and neuroprotection...
  70. pmc The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal
    Venetia Zachariou
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 100:9028-33. 2003
    ..These studies suggest that galanin normally acts to counteract opiate withdrawal and that small molecule galanin agonists could be effective in diminishing the physical signs of withdrawal...
  71. ncbi request reprint Neuropeptides: opportunities for drug discovery
    Tomas Hokfelt
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Lancet Neurol 2:463-72. 2003
    ..Several other neuropeptide receptor ligands are in clinical trials for various indications...
  72. ncbi request reprint Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity
    Adrian Brunkhorst
    Group of Transcriptional Networks, Unit of Functional Genomics, Center for Genomics and Bioinformatics CGB, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Biochem Biophys Res Commun 325:574-9. 2004
    ..Our results indicate an additional level of complexity in TAF4-mediated regulation of transcription and suggest context-specific roles for these new TAF4 isoforms in transcriptional regulation in vivo...
  73. ncbi request reprint Evaluation of transportan 10 in PEI mediated plasmid delivery assay
    Kalle Kilk
    Department of Neurochemistry and Neurotoxicology, Stockholm University, S 10691 Stockholm, Sweden
    J Control Release 103:511-23. 2005
    ..In conclusion, TP10 can enhance PEI mediated transfection at relatively low concentrations and may help to develop future gene delivery systems with reduced toxicity...
  74. ncbi request reprint Galanin and its receptors in neurological disorders
    Linda Lundström
    Department of Neurochemistry and Neurotoxicology, Stockholm University, S 106 91 Stockholm, Sweden
    Neuromolecular Med 7:157-80. 2005
    ....
  75. ncbi request reprint Galnon--a low-molecular weight ligand of the galanin receptors
    Ulla Sollenberg
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Svante Arrhenius Väg 21A, SE 106 91 Stockholm, Sweden
    Neuropeptides 39:161-3. 2005
    ..In this review, we will summarize what is known about galnon to date...

Research Grants14

  1. Function of galanin receptor subtypes in the hippocampus
    Tamas Bartfai; Fiscal Year: 2002
    ..Also, because galanin has been shown to have anti-epileptic actions, understanding how this peptide regulates seizures could have clinical applications in the treatment of epilepsy. ..
  2. Galanin and GalR2 Receptors in Antidepressant Treatments
    Tamas Bartfai; Fiscal Year: 2007
    ..The planned work will deepen our knowledge of the galanin/5-HT system in the DRN and its contribution to the effects of antidepressant treatments. ..
  3. Galanin and GalR2 Receptors in Antidepressant Treatments
    Tamas Bartfai; Fiscal Year: 2006
    ..The planned work will deepen our knowledge of the galanin/5-HT system in the DRN and its contribution to the effects of antidepressant treatments. ..
  4. Transciption-independent Signaling by IL1 in Neurons
    Tamas Bartfai; Fiscal Year: 2006
    ..hypothalamus, defining their molecular mechanisms of action will contribute to a better understanding of the neuronal effects of IL-1Beta in the hypothalamus, where it regulates the HPA axis, the temperature setpoint, and fever response ..
  5. Function of galanin receptor subtypes in the hippocampus
    Tamas Bartfai; Fiscal Year: 2006
    ..Also, because galanin has been shown to have anti-epileptic actions, understanding how this peptide regulates seizures could have clinical applications in the treatment of epilepsy. ..
  6. Transciption-independent Signaling by IL1 in Neurons
    Tamas Bartfai; Fiscal Year: 2005
    ..hypothalamus, defining their molecular mechanisms of action will contribute to a better understanding of the neuronal effects of IL-1Beta in the hypothalamus, where it regulates the HPA axis, the temperature setpoint, and fever response ..
  7. Function of galanin receptor subtypes in the hippocampus
    Tamas Bartfai; Fiscal Year: 2005
    ..Also, because galanin has been shown to have anti-epileptic actions, understanding how this peptide regulates seizures could have clinical applications in the treatment of epilepsy. ..
  8. Function of galanin receptor subtypes in the hippocampus
    Tamas Bartfai; Fiscal Year: 2004
    ..Also, because galanin has been shown to have anti-epileptic actions, understanding how this peptide regulates seizures could have clinical applications in the treatment of epilepsy. ..
  9. Transciption-independent Signaling by IL1 in Neurons
    Tamas Bartfai; Fiscal Year: 2004
    ..hypothalamus, defining their molecular mechanisms of action will contribute to a better understanding of the neuronal effects of IL-1Beta in the hypothalamus, where it regulates the HPA axis, the temperature setpoint, and fever response ..
  10. Function of galanin receptor subtypes in the hippocampus
    Tamas Bartfai; Fiscal Year: 2003
    ..Also, because galanin has been shown to have anti-epileptic actions, understanding how this peptide regulates seizures could have clinical applications in the treatment of epilepsy. ..
  11. Transciption-independent Signaling by IL1 in Neurons
    Tamas Bartfai; Fiscal Year: 2003
    ..hypothalamus, defining their molecular mechanisms of action will contribute to a better understanding of the neuronal effects of IL-1Beta in the hypothalamus, where it regulates the HPA axis, the temperature setpoint, and fever response ..
  12. Galanin and GalR2 Receptors in Antidepressant Treatments
    Tamas Bartfai; Fiscal Year: 2009
    ..The planned work will deepen our knowledge of the galanin/5-HT system in the DRN and its contribution to the effects of antidepressant treatments. ..