Genomes and Genes
Michael J Barnes
Affiliation: The Scripps Research Institute
- Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the peripheryMichael J Barnes
Department of Genetics, The Scripps Research Institute, La Jolla, CA, USA
PLoS Biol 7:e51. 2009..Furthermore, we show that peripheral T(reg) cells are a dynamic population that may expand to limit immunopathology or promote chronic infection...
- NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responsesPhilippe Krebs
Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Blood 113:6593-602. 2009..We think that the recognition and killing of target cells by NK cells represents an important pathway for the generation of robust CD8+ T and humoral responses that may be exploited for vaccine development...
- Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient miceMichael J Barnes
Department of Genetics, Scripps Research Institute, La Jolla, CA, USA
J Immunol 184:3743-54. 2010..These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis...