ROBERTO G BACCALA

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Tumor immunity via homeostatic T cell proliferation: mechanistic aspects and clinical perspectives
    Roberto Baccala
    Department of Immunology, IMM 3, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Springer Semin Immunopathol 27:75-85. 2005
  2. pmc Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus
    Roberto Baccala
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:2940-5. 2013
  3. pmc Anti-IFN-α/β receptor antibody treatment ameliorates disease in lupus-predisposed mice
    Roberto Baccala
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 189:5976-84. 2012
  4. ncbi request reprint Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:4606-12. 2005
  5. pmc T cell homeostatic proliferation elicits effective antitumor autoimmunity
    Wolfgang Dummer
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 110:185-92. 2002
  6. pmc Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
    Marie Laure Santiago-Raber
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 197:777-88. 2003
  7. ncbi request reprint TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    Roberto Baccala
    The Scripps Research Institute, Department of Immunology, La Jolla, California 93037, USA
    Nat Med 13:543-51. 2007
  8. pmc Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity
    Brian R Lawson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 199:547-57. 2004
  9. ncbi request reprint Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system
    Brian R Lawson
    Diazyme Laboratories Division, General Atomics, San Diego, CA 92186, USA
    J Immunol 178:5366-74. 2007
  10. ncbi request reprint Type I interferons (alpha/beta) in immunity and autoimmunity
    Argyrios N Theofilopoulos
    Immunology Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Immunol 23:307-36. 2005

Research Grants

Detail Information

Publications16

  1. ncbi request reprint Tumor immunity via homeostatic T cell proliferation: mechanistic aspects and clinical perspectives
    Roberto Baccala
    Department of Immunology, IMM 3, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Springer Semin Immunopathol 27:75-85. 2005
    ..In its simplicity, this approach is likely to have application in humans, since it relies on conventional lymphopenia-inducing cancer therapies, infusion of autologous lymphocytes and, optimally, tumor-specific vaccination...
  2. pmc Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus
    Roberto Baccala
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:2940-5. 2013
    ..Thus, IRF8 and SLC15A4 may provide important targets for therapeutic intervention in human lupus...
  3. pmc Anti-IFN-α/β receptor antibody treatment ameliorates disease in lupus-predisposed mice
    Roberto Baccala
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 189:5976-84. 2012
    ..The combined findings suggest that IFN-α/β receptor blockade, particularly when started at early disease stages, may be a useful treatment approach for human systemic lupus erythematosus and other autoimmune syndromes...
  4. ncbi request reprint Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:4606-12. 2005
    ..Thus, gamma delta T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, gamma delta-specific factors...
  5. pmc T cell homeostatic proliferation elicits effective antitumor autoimmunity
    Wolfgang Dummer
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 110:185-92. 2002
    ..The results indicate that concomitant induction of the physiologic processes of homeostatic T cell proliferation and tumor antigen presentation in lymph nodes triggers a beneficial antitumor autoimmune response...
  6. pmc Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
    Marie Laure Santiago-Raber
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 197:777-88. 2003
    ..The data indicate that type-I IFNs are important mediators in the pathogenesis of murine lupus, and that reducing their activity in the human counterpart may be beneficial...
  7. ncbi request reprint TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    Roberto Baccala
    The Scripps Research Institute, Department of Immunology, La Jolla, California 93037, USA
    Nat Med 13:543-51. 2007
    ....
  8. pmc Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity
    Brian R Lawson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 199:547-57. 2004
    ..Thus, modulation of the cell cycle pathway may be a novel approach to reduce apoptosis-resistant pathogenic lymphocytes and to ameliorate systemic autoimmunity...
  9. ncbi request reprint Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system
    Brian R Lawson
    Diazyme Laboratories Division, General Atomics, San Diego, CA 92186, USA
    J Immunol 178:5366-74. 2007
    ..The data suggest that transmethylation is required for CD4 T cell activation, and its inhibition may be a novel approach in the treatment of multiple sclerosis, and other CD4-mediated autoimmune diseases...
  10. ncbi request reprint Type I interferons (alpha/beta) in immunity and autoimmunity
    Argyrios N Theofilopoulos
    Immunology Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Immunol 23:307-36. 2005
    ....
  11. pmc Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12061-6. 2009
    ..Importantly, this helps provide an explanation for the high frequency of anti-nucleic acid Abs in lupus-like systemic autoimmunity...
  12. doi request reprint Sensors of the innate immune system: their link to rheumatic diseases
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Rev Rheumatol 6:146-56. 2010
    ..These findings have resulted in a critical reappraisal of pathogenetic mechanisms, and provide a basis for the development of novel diagnostic and therapeutic modalities for these diseases...
  13. ncbi request reprint Inhibition of lupus by genetic alteration of the interferon-alpha/beta receptor
    Dwight H Kono
    Department of Immunology IMM3, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Autoimmunity 36:503-10. 2003
    ..These findings strongly support the targeting of IFN-alphabeta in SLE and suggest that definition of the specific pathways critical for disease induction will be important for optimal intervention...
  14. ncbi request reprint The new paradigm of T-cell homeostatic proliferation-induced autoimmunity
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Immunol 26:5-8. 2005
    ..A recent study in a diabetes-prone mouse model has provided strong evidence to support this hypothesis...
  15. ncbi request reprint Interferons as pathogenic effectors in autoimmunity
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 204:9-26. 2005
    ....
  16. doi request reprint Sensors of the innate immune system: their mode of action
    Roberto Baccala
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Rev Rheumatol 5:448-56. 2009
    ..Although this sensing is beneficial to the host, excessive activation and/or engagement by self molecules might induce autoimmune and other inflammatory disorders...

Research Grants4

  1. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2007
    ..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. ..