Manzar Ashtari

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc The human visual cortex responds to gene therapy-mediated recovery of retinal function
    Manzar Ashtari
    Diffusion Tensor Image Analyses and Brain Morphometry Center, Department of Radiology, Children s Hospital of Philadelphia CHOP, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:2160-8. 2011
  2. ncbi request reprint Disruption of white matter integrity in the inferior longitudinal fasciculus in adolescents with schizophrenia as revealed by fiber tractography
    Manzar Ashtari
    Department of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York, USA
    Arch Gen Psychiatry 64:1270-80. 2007
  3. pmc Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use
    Manzar Ashtari
    The Children s Hospital of Philadelphia, Philadelphia, PA, United States
    J Psychiatr Res 43:189-204. 2009
  4. ncbi request reprint White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study
    Philip R Szeszko
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 162:602-5. 2005
  5. ncbi request reprint Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 33:976-84. 2008
  6. ncbi request reprint White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study
    Sanjiv Kumra
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 44:934-41. 2005
  7. ncbi request reprint Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Br J Psychiatry 190:230-6. 2007
  8. ncbi request reprint White matter development during late adolescence in healthy males: a cross-sectional diffusion tensor imaging study
    Manzar Ashtari
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neuroimage 35:501-10. 2007
  9. ncbi request reprint Lack of normal association between cerebellar volume and neuropsychological functions in first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, NY 11004, USA
    Am J Psychiatry 160:1884-7. 2003
  10. pmc Medial temporal structures and memory functions in adolescents with heavy cannabis use
    Manzar Ashtari
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA 19102, USA
    J Psychiatr Res 45:1055-66. 2011

Detail Information

Publications28

  1. pmc The human visual cortex responds to gene therapy-mediated recovery of retinal function
    Manzar Ashtari
    Diffusion Tensor Image Analyses and Brain Morphometry Center, Department of Radiology, Children s Hospital of Philadelphia CHOP, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:2160-8. 2011
    ..In addition, these data suggest that gene therapy resulted in not only sustained and improved visual ability, but also enhanced contrast sensitivity...
  2. ncbi request reprint Disruption of white matter integrity in the inferior longitudinal fasciculus in adolescents with schizophrenia as revealed by fiber tractography
    Manzar Ashtari
    Department of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York, USA
    Arch Gen Psychiatry 64:1270-80. 2007
    ..There is increasing evidence that schizophrenia is characterized by abnormalities in white matter...
  3. pmc Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use
    Manzar Ashtari
    The Children s Hospital of Philadelphia, Philadelphia, PA, United States
    J Psychiatr Res 43:189-204. 2009
    ....
  4. ncbi request reprint White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study
    Philip R Szeszko
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 162:602-5. 2005
    ..The goal of this study was to investigate brain white matter abnormalities by using diffusion tensor imaging in patients with schizophrenia or schizoaffective disorder close to illness onset...
  5. ncbi request reprint Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 33:976-84. 2008
    ..These abnormalities have clinical and neuropsychological correlates, which may be useful in further characterizing structure-function relations in schizophrenia and constraining neurobiological models of the disorder...
  6. ncbi request reprint White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study
    Sanjiv Kumra
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 44:934-41. 2005
    ..To investigate abnormalities in the structural integrity of brain white matter as suggested by diffusion tensor imaging in adolescents with early-onset schizophrenia (onset of psychosis by age 18)...
  7. ncbi request reprint Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Br J Psychiatry 190:230-6. 2007
    ..Despite the high prevalence of cannabis use in schizophrenia, few studies have examined the potential relationship between cannabis exposure and brain structural abnormalities in schizophrenia...
  8. ncbi request reprint White matter development during late adolescence in healthy males: a cross-sectional diffusion tensor imaging study
    Manzar Ashtari
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neuroimage 35:501-10. 2007
    ..The authors investigated WM development in healthy adolescent males through age-associated changes in fractional anisotropy (FA), radial (lambda( perpendicular)) and axial (lambda(||)) diffusivity...
  9. ncbi request reprint Lack of normal association between cerebellar volume and neuropsychological functions in first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, NY 11004, USA
    Am J Psychiatry 160:1884-7. 2003
    ..Few studies, however, have examined the relationship between cerebellar size and neuropsychological functioning in schizophrenia. The authors' goal was to examine this relationship in patients and healthy comparison subjects...
  10. pmc Medial temporal structures and memory functions in adolescents with heavy cannabis use
    Manzar Ashtari
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA 19102, USA
    J Psychiatr Res 45:1055-66. 2011
    ....
  11. pmc Brain morphometry using diffusion-weighted magnetic resonance imaging: application to schizophrenia
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Neuroreport 16:1455-9. 2005
    ..Affected areas included the bilateral insular cortex, hippocampus, temporal lobe, and occipital areas. These results largely concur with previous findings of cortical volume deficits in schizophrenia...
  12. ncbi request reprint White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 62:782-90. 2005
    ....
  13. ncbi request reprint Increased stress and smaller anterior hippocampal volume
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Neuroreport 17:1825-8. 2006
    ..Our results may also have implications for neuropsychiatric disorders that have implicated stress and hippocampal abnormalities in their pathogenesis...
  14. ncbi request reprint Reduced frontal white matter integrity in early-onset schizophrenia: a preliminary study
    Sanjiv Kumra
    Department of Research, Zucker Hillside Hospital, Glen Oaks, New York 11004, USA
    Biol Psychiatry 55:1138-45. 2004
    ..Diffusion tensor imaging provides a relatively new approach for quantifying possible connectivity of WM in vivo...
  15. ncbi request reprint Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 160:2190-7. 2003
    ..The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects...
  16. ncbi request reprint Sex differences in frontal lobe white matter microstructure: a DTI study
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neuroreport 14:2469-73. 2003
    ..Our findings may be indicative of increased directional coherence and/or density of left hemisphere white matter fibers and a leftward asymmetry of this structural integrity among women compared to men...
  17. pmc Gray matter structural alterations in obsessive-compulsive disorder: relationship to neuropsychological functions
    Christopher J Christian
    Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, NY, United States
    Psychiatry Res 164:123-31. 2008
    ..Moreover, our data suggest that gray matter structural alterations in OCD have neuropsychological correlates, which may be useful in further characterizing structure-function relations in this disorder...
  18. doi request reprint AAV2 gene therapy readministration in three adults with congenital blindness
    Jean Bennett
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 309 Stellar Chance Labs, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Sci Transl Med 4:120ra15. 2012
    ....
  19. ncbi request reprint Reversed cerebellar asymmetry in men with first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Biol Psychiatry 53:450-9. 2003
    ..In this study, we investigated whether patients experiencing first-episode schizophrenia differed from healthy comparison subjects in regional cerebellar volumes or cerebellar asymmetry...
  20. ncbi request reprint Left middle temporal gyrus activation during a phonemic discrimination task
    Manzar Ashtari
    Department of Radiology, North Shore Long Island Jewish Health System, New Hyde Park, NY 11004, USA
    Neuroreport 15:389-93. 2004
    ..This study also demonstrates the advantage of tone discrimination control blocks as opposed to conventional rest periods to isolate the pure language component of phonemic discrimination...
  21. ncbi request reprint Mapping the functional anatomy of sentence comprehension and application to presurgical evaluation of patients with brain tumor
    Manzar Ashtari
    Department of Radiology and Neurology, Long Island Jewish Division of the North Shore Long Island Jewish Health System, New Hyde Park, New York, NY 11040, USA
    AJNR Am J Neuroradiol 26:1461-8. 2005
    ..The aim of this study was to develop a language task with an adequate control task to engage the areas of the posterior temporal lobe responsible for sentence comprehension...
  22. ncbi request reprint fMRI of retina-originated phosphenes experienced by patients with leber congenital amaurosis
    Manzar Ashtari
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e86068. 2014
    ..fMRI has proven to be a sensitive, non-invasive, and reproducible test paradigm for these purposes and can complement standard visual function testing. ..
  23. ncbi request reprint Neuropsychological correlates of hippocampal volumes in patients experiencing a first episode of schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, Hillside Hospital, a division of North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 159:217-26. 2002
    ..This study investigated the neuropsychological correlates of hippocampal volume in 43 men and 32 women experiencing a first episode of schizophrenia...
  24. ncbi request reprint Basal ganglia volumes in first-episode schizophrenia and healthy comparison subjects
    Handan Gunduz
    Department of Psychiatry Research, Hillside Hospital of the North Shore, Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Biol Psychiatry 51:801-8. 2002
    ..We conducted a magnetic resonance imaging (MRI) study to examine basal ganglia structures and the limbic forebrain in first episode schizophrenia and healthy comparison subjects...
  25. ncbi request reprint Attention-deficit/hyperactivity disorder: a preliminary diffusion tensor imaging study
    Manzar Ashtari
    Departments of Radiology, North Shore Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Biol Psychiatry 57:448-55. 2005
    ..Based upon the literature, we predicted decreased fractional anisotropy (FA) findings in the frontal and cerebellar regions...
  26. ncbi request reprint Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia
    Handan Gunduz-Bruce
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Res 94:281-7. 2007
    ..Larger scale studies are needed to conclude a link between the two measures, yet it is possible that the negative association that was previously shown in other disorders may not apply to schizophrenia...
  27. ncbi request reprint Neuroimaging studies of children with serious emotional disturbances: a selective review
    Jane Avery Serene
    Harvard Medical School, Boston, Massachusetts, USA
    Can J Psychiatry 52:135-45. 2007
    ....
  28. pmc CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia
    Handan Gunduz-Bruce
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychiatry Res 155:57-66. 2007
    ..These results suggest that plasma osmolality is related to ventricle size in healthy volunteers and that this physiological link is impaired in patients with first episode schizophrenia...