Research Topics
| L Eugene ArnoldSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Research Units of Pediatric Psychopharmacology (RUPP) Autism Network Randomized Clinical Trial of Parent Training and Medication: One-Year Follow-UpL Eugene Arnold
Nisonger Center at the Ohio State University Electronic address
J Am Acad Child Adolesc Psychiatry 51:1173-84. 2012..The COMB treatment had shown a significant advantage for child behavioral noncompliance (p = .006, d = 0.34), irritability (p = .01, d = 0.48), and hyperactivity/noncompliance (p = .04, d = 0.55) with a lower medication dose...
Pediatric bipolar disorder and ADHD: family history comparison in the LAMS clinical sampleL Eugene Arnold
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, Columbus, OH, United States
J Affect Disord 141:382-9. 2012..Transgenerational association of bipolar spectrum disorder (BPSD) and attention deficit/hyperactivity disorder (ADHD) has been reported, but inconclusively...- Artificial food colors and attention-deficit/hyperactivity symptoms: conclusions to dye forL Eugene Arnold
Department of Psychiatry, The Ohio State University, Columbus, OH 43210, USA
Neurotherapeutics 9:599-609. 2012..A table clarifying the Food and Drug Administration and international naming systems for AFCs, with cross-referencing, is provided... - Placebo-controlled pilot trial of mecamylamine for treatment of autism spectrum disordersL Eugene Arnold
Nisonger Center, The Ohio State University, Columbus, OH 43210, USA
J Child Adolesc Psychopharmacol 22:198-205. 2012..To explore possible benefits of a nicotinic acetylcholine receptor (nAChR) agent for autistic symptoms based on postmortem observation of nAChR abnormalities (deficient α4β2 nAChRs, excess α7 nAChRs) in brains of patients with autism... - Pediatric bipolar spectrum disorder and ADHD: comparison and comorbidity in the LAMS clinical sampleL Eugene Arnold
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
Bipolar Disord 13:509-21. 2011..To compare attention-deficit hyperactivity disorder (ADHD), bipolar spectrum disorders (BPSDs), and comorbidity in the Longitudinal Assessment of Manic Symptoms (LAMS) study... - The treatment of severe child aggression (TOSCA) study: Design challengesCristan A Farmer
Nisonger Center, Ohio State University, Columbus, USA
Child Adolesc Psychiatry Ment Health 5:36. 2011..abstract:.. - Characteristics of children with elevated symptoms of mania: the Longitudinal Assessment of Manic Symptoms (LAMS) studyRobert L Findling
Department of Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
J Clin Psychiatry 71:1664-72. 2010..This article describes the initial demographic information, diagnostic and symptom prevalence, and medication exposure for the LAMS cohort that will be followed longitudinally... 
Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measuresDavid J Posey
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
Biol Psychiatry 61:538-44. 2007....- Cognitive effects of risperidone in children with autism and irritable behaviorMichael G Aman
Nisonger Center, Ohio State University, Columbus, OH, USA
J Child Adolesc Psychopharmacol 18:227-36. 2008..The objective of this research was to explore the effects of risperidone on cognitive processes in children with autism and irritable behavior... - Medication and parent training in children with pervasive developmental disorders and serious behavior problems: results from a randomized clinical trialMichael G Aman
The Nisonger Center UCEDD, Ohio State University, Columbus, OH 43210 1257, USA
J Am Acad Child Adolesc Psychiatry 48:1143-54. 2009..We tested whether combined treatment (COMB) with risperidone and parent training (PT) in behavior management is superior to medication alone (MED) in improving severe behavioral problems in children with PDDs... - Acute and long-term safety and tolerability of risperidone in children with autismMichael G Aman
The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1296, USA
J Child Adolesc Psychopharmacol 15:869-84. 2005..Most AEs were mild to moderate and failed to interfere with therapeutic changes; there were no unanticipated AEs. The side effects of most concern were somnolence and weight gain... - Zinc for attention-deficit/hyperactivity disorder: placebo-controlled double-blind pilot trial alone and combined with amphetamineL Eugene Arnold
The Nisonger Center, Ohio State University, Columbus, Ohio, USA
J Child Adolesc Psychopharmacol 21:1-19. 2011..To explore effects of zinc supplementation in American children with attention-deficit/hyperactivity disorder (ADHD). Mideastern trials reported significant benefit from 13-40 mg elemental zinc as the sulfate... - Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trialL Eugene Arnold
The Ohio State University Nisonger Center, Columbus, OH, USA
J Child Adolesc Psychopharmacol 17:791-802. 2007..Trials in Down's syndrome, migraine, and Alzheimer's disease showed benefit for attention. A preliminary trial in ADHD using L-carnitine reported significant benefit... - What differentiates children visiting outpatient mental health services with bipolar spectrum disorder from children with other psychiatric diagnoses?Mary A Fristad
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
Bipolar Disord 14:497-506. 2012.... - Validity of the autism diagnostic interview-revisedLuc Lecavalier
Nisonger Center, The Ohio State University, Columbus, USA
Am J Ment Retard 111:199-215. 2006..They indicated some similarities between constructs, but also that the ADI-R measures autism in a unique fashion... - Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacologyChristopher J McDougle
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
Am J Psychiatry 162:1142-8. 2005..The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior... - Treatment-related changes in objectively measured parenting behaviors in the multimodal treatment study of children with attention-deficit/hyperactivity disorderKaren C Wells
Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
J Consult Clin Psychol 74:649-57. 2006..The authors discuss the importance of changes in parenting behavior for families of children with ADHD and the need for reliable and objective measures in evaluating treatment outcome... - Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritabilityL Eugene Arnold
Department of Psychiatry, Ohio State University, Columbus, Ohio, USA
J Child Adolesc Psychopharmacol 20:83-93. 2010..2 in favor of risperidone on the main outcome measure in an 8-week double-blind, placebo-controlled trial for irritability in autistic disorder. This paper explores moderators and mediators of this effect... - Parent satisfaction in a multi-site acute trial of risperidone in children with autism: a social validity studyElaine Tierney
Department of Psychiatry, Kennedy Krieger Institute, Baltimore, MD, USA
Psychopharmacology (Berl) 191:149-57. 2007..Designing studies that consider the consumer's perspective will help to forge a better alliance between participants and researchers... - Early-onset bipolar spectrum disorders: diagnostic issuesStephanie Danner
Ohio State University, Columbus, OH, USA
Clin Child Fam Psychol Rev 12:271-93. 2009..Research findings concerning these challenges and relevant recommendations are offered. Areas for further research to guide clinicians' assessment of children with early-onset BPSD are highlighted... - Patterns and predictors of adolescent academic achievement and performance in a sample of children with attention-deficit/hyperactivity disorderJoshua M Langberg
Department of Pediatrics University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, OH, USA
J Clin Child Adolesc Psychol 40:519-31. 2011..Childhood predictors of adolescent achievement differed from those for performance. Classroom performance and homework management mediated the relationship between symptoms of inattention and academic outcomes... - Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trialL Eugene Arnold
The authors are with Ohio State University s Nisonger Center, Columbus, OH 43210, USA
J Am Acad Child Adolesc Psychiatry 45:1196-205. 2006..To explore placebo-controlled efficacy and safety of atomoxetine (ATX) for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorders (ASD)... - Relation between outcomes on a continuous performance test and ADHD symptoms over timeAaron J Vaughn
Cincinnati Children s Hospital and Medical Center, Cincinnati, OH, USA
J Abnorm Child Psychol 39:853-64. 2011..Findings are discussed in relation to neuropsychological development including recommendations for future research... - Effects of risperidone on cognitive-motor performance and motor movements in chronically medicated childrenMichael G Aman
The Ohio State University, USA
Res Dev Disabil 30:386-96. 2009..02, eta(P)(2)=0.36) occurred in the risperidone condition. The findings suggest a beneficial effect of risperidone after several months of treatment on efficiency of responding, activity level, static tremor, and aspects of behavior... - Delinquent behavior and emerging substance use in the MTA at 36 months: prevalence, course, and treatment effectsBrooke S G Molina
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 46:1028-40. 2007.... - Feasibility of a nutritional supplement as treatment for pediatric bipolar spectrum disordersElisabeth A Frazier
Department of Psychiatry, The Ohio State University, Columbus, OH, USA
J Altern Complement Med 18:678-85. 2012..This open-label study explored the feasibility of testing therapeutic effects of a multinutrient supplement, EMPowerplus™ (EMP+), for pediatric BPSD... - Serum zinc correlates with parent- and teacher- rated inattention in children with attention-deficit/hyperactivity disorderL Eugene Arnold
Department of Psychiatry, Ohio State University, Columbus, Ohio 43074, USA
J Child Adolesc Psychopharmacol 15:628-36. 2005..Previous reports of zinc in ADHD, including two positive clinical trials of supplementation, have come mainly from countries and cultures with different diets and/or socioeconomic realities... - Serum ferritin and amphetamine response in youth with attention-deficit/hyperactivity disorderChadi Calarge
Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
J Child Adolesc Psychopharmacol 20:495-502. 2010..The study aim was to explore whether iron stores, as reflected by serum ferritin concentration, predicted response to psychostimulants... - Treatment of inattention, overactivity, and impulsiveness in autism spectrum disordersMichael G Aman
Department of Psychology, Ohio State University, 225 Psychology Building, 1835 Neil Avenue, Columbus, OH 43210, USA
Child Adolesc Psychiatr Clin N Am 17:713-38, vii. 2008..Evidence for efficacy seems weakest for newer antidepressants, anxiolytics, and mood stabilizers... - Vestibular Stimulation for ADHD: randomized controlled trial of Comprehensive Motion ApparatusDavid L Clark
Ohio State University, Ohio, USA
J Atten Disord 11:599-611. 2008..This research evaluates effects of vestibular stimulation by Comprehensive Motion Apparatus (CMA) in ADHD... - Dietary and nutritional treatments for attention-deficit/hyperactivity disorder: current research support and recommendations for practitionersElizabeth A Hurt
Nisonger Center, The Ohio State University, Columbus, OH 43210, USA
Curr Psychiatry Rep 13:323-32. 2011..Consequences of delayed proven treatments need consideration in the risk-benefit assessment of dietary/nutritional treatments... - Treating attention-deficit/hyperactivity disorder with a stimulant transdermal patch: the clinical artL Eugene Arnold
Department of Psychiatry, Ohio State University, Columbus, Ohio, USA
Pediatrics 120:1100-6. 2007..This article summarizes clinical principles that physicians may find useful in managing this new addition to the attention-deficit/hyperactivity disorder treatment armamentarium... - Psychopharmacological and other treatments in preschool children with attention-deficit/hyperactivity disorder: current evidence and practiceJaswinder K Ghuman
Department of Psychiatry, University of Arizona, Tucson, Arizona 85724 5002, USA
J Child Adolesc Psychopharmacol 18:413-47. 2008..This article reviews rational approaches to treating attention-deficit/hyperactivity disorder (ADHD) in preschool children, including pharmacological and nonpharmacological treatments. Implications for clinical practice are discussed... - Nine months of multicomponent behavioral treatment for ADHD and effectiveness of MTA fading proceduresL Eugene Arnold
The Ohio State University, Columbus, Ohio, USA
J Abnorm Child Psychol 32:39-51. 2004.... - A double-blind, placebo-controlled withdrawal trial of dexmethylphenidate hydrochloride in children with attention deficit hyperactivity disorderL Eugene Arnold
Ohio State University, Columbus, Ohio 43210 1296, USA
J Child Adolesc Psychopharmacol 14:542-54. 2004..This study complements that report by studying the effect of placebo-controlled discontinuation and retesting the duration of action... - The role of children's ethnicity in the relationship between teacher ratings of attention-deficit/hyperactivity disorder and observed classroom behaviorJeffrey N Epstein
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
J Consult Clin Psychol 73:424-34. 2005..Differences in classroom behavior were attenuated when the behavior of an average child in the classroom was taken into account. Multiple explanations for this pattern of results are discussed... - Current status of neurofeedback for attention-deficit/hyperactivity disorderNicholas Lofthouse
Department of Psychiatry, The Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
Curr Psychiatry Rep 14:536-42. 2012..Most recently, a collaborative NF research group has been planning a definitive double-blind well-controlled trial... - A review of complementary and alternative treatments for autism spectrum disordersNicholas Lofthouse
Department of Psychiatry, The Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
Autism Res Treat 2012:870391. 2012..We conclude this paper with recommendations for future research and ten clinical recommendations for practitioners... - A review of neurofeedback treatment for pediatric ADHDNicholas Lofthouse
Department of Psychiatry, The Ohio State University, 1670 Upham Drive, Columbus, OH 43210 1250, USA
J Atten Disord 16:351-72. 2012..The aim of this paper was to review all randomized published trials and unpublished conference presentations on the neurofeedback (NF) treatment of pediatric ADHD, and their relevance, strengths, and limitations... - Multinutrient supplement as treatment: literature review and case report of a 12-year-old boy with bipolar disorderElisabeth A Frazier
Department of Psychiatry, The Ohio State University, Columbus, OH 43210 1250, USA
J Child Adolesc Psychopharmacol 19:453-60. 2009..EMP+ resulted in outcome superior to conventional treatment. This report adds to accumulating preliminary evidence that further basic science and clinical studies of multinutrient supplements are warranted... - Zinc in attention-deficit/hyperactivity disorderL Eugene Arnold
Department of Psychiatry, Ohio State University, Columbus, OH 43074, USA
J Child Adolesc Psychopharmacol 15:619-27. 2005..The aim of this study was to review the published evidence for a role of zinc nutrition in attention-deficit/hyperactivity disorder (ADHD)... - Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptomsChristopher J Kratochvil
Department of Psychiatry, Nebraska Medical Center, Omaha 68198 5581, USA
J Am Acad Child Adolesc Psychiatry 44:915-24. 2005..The authors assessed the safety and effectiveness of atomoxetine monotherapy compared with combined atomoxetine/fluoxetine therapy in a population of children and adolescents with ADHD and concurrent symptoms of depression or anxiety... - Empirical evaluation of the generalizability of the sample from the multimodal treatment study for ADHDJack Stevens
Department of Pediatrics, The Ohio State University, 899 East Broad Street, 3rd Floor, Columbus, OH 43205, USA
Adm Policy Ment Health 34:221-32. 2007..On the whole, we found no compelling evidence against the representativeness of the MTA sample, but the limited power from MECA and NHANES may have lead to noteworthy differences between datasets being statistically nonsignificant... - Ethical issues in child psychopharmacology research and practice: emphasis on preschoolersLacramioara Spetie
Department of Psychiatry, Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
Psychopharmacology (Berl) 191:15-26. 2007..Some of these challenges are general to medical treatment and research with children, and others are particular to child psychopharmacological treatment and research... - Parent-defined target symptoms respond to risperidone in RUPP autism study: customer approach to clinical trialsL Eugene Arnold
Ohio State University, 479 S Galena Road, Sunbury, OH 43074, USA
J Am Acad Child Adolesc Psychiatry 42:1443-50. 2003..A consumer-oriented efficacy assessment in clinical trials should measure changes in chief complaint and consumer request (symptoms of most concern to patient/caregiver), which may be diluted in change scores of multisymptom scales...