L Eugene Arnold

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment
    Monica Shaw
    Clinical Development and Medical Affairs, Shire Pharmaceuticals, Ltd, Basingstoke, UK
    BMC Med 10:99. 2012
  2. doi request reprint EEG neurofeedback for ADHD: double-blind sham-controlled randomized pilot feasibility trial
    L Eugene Arnold
    The Ohio State University, Columbus, OH, USA
    J Atten Disord 17:410-9. 2013
  3. doi request reprint Attention-deficit/hyperactivity disorder: dietary and nutritional treatments
    L Eugene Arnold
    Nisonger Center, Ohio State University, McCampbell 395E, 1581 Dodd Drive, Columbus, OH 43210, USA
    Child Adolesc Psychiatr Clin N Am 22:381-402, v. 2013
  4. pmc Research Units of Pediatric Psychopharmacology (RUPP) Autism Network randomized clinical trial of parent training and medication: one-year follow-up
    L Eugene Arnold
    Nisonger Center, Ohio State University, Sunbury, OH 43074, USA
    J Am Acad Child Adolesc Psychiatry 51:1173-84. 2012
  5. pmc Pediatric bipolar disorder and ADHD: family history comparison in the LAMS clinical sample
    L Eugene Arnold
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, Columbus, OH, United States
    J Affect Disord 141:382-9. 2012
  6. pmc Artificial food colors and attention-deficit/hyperactivity symptoms: conclusions to dye for
    L Eugene Arnold
    Department of Psychiatry, The Ohio State University, Columbus, OH 43210, USA
    Neurotherapeutics 9:599-609. 2012
  7. pmc Placebo-controlled pilot trial of mecamylamine for treatment of autism spectrum disorders
    L Eugene Arnold
    Nisonger Center, The Ohio State University, Columbus, OH 43210, USA
    J Child Adolesc Psychopharmacol 22:198-205. 2012
  8. pmc Pediatric bipolar spectrum disorder and ADHD: comparison and comorbidity in the LAMS clinical sample
    L Eugene Arnold
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
    Bipolar Disord 13:509-21. 2011
  9. pmc The treatment of severe child aggression (TOSCA) study: Design challenges
    Cristan A Farmer
    Nisonger Center, Ohio State University, Columbus, USA
    Child Adolesc Psychiatry Ment Health 5:36. 2011
  10. pmc Characteristics of children with elevated symptoms of mania: the Longitudinal Assessment of Manic Symptoms (LAMS) study
    Robert L Findling
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Psychiatry 71:1664-72. 2010

Collaborators

Detail Information

Publications50

  1. pmc A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment
    Monica Shaw
    Clinical Development and Medical Affairs, Shire Pharmaceuticals, Ltd, Basingstoke, UK
    BMC Med 10:99. 2012
    ....
  2. doi request reprint EEG neurofeedback for ADHD: double-blind sham-controlled randomized pilot feasibility trial
    L Eugene Arnold
    The Ohio State University, Columbus, OH, USA
    J Atten Disord 17:410-9. 2013
    ....
  3. doi request reprint Attention-deficit/hyperactivity disorder: dietary and nutritional treatments
    L Eugene Arnold
    Nisonger Center, Ohio State University, McCampbell 395E, 1581 Dodd Drive, Columbus, OH 43210, USA
    Child Adolesc Psychiatr Clin N Am 22:381-402, v. 2013
    ..There is a need to flesh out the evidence base, which could be done cost effectively for supplements or off-label agents that are amenable to placebo control. ..
  4. pmc Research Units of Pediatric Psychopharmacology (RUPP) Autism Network randomized clinical trial of parent training and medication: one-year follow-up
    L Eugene Arnold
    Nisonger Center, Ohio State University, Sunbury, OH 43074, USA
    J Am Acad Child Adolesc Psychiatry 51:1173-84. 2012
    ..The COMB treatment had shown a significant advantage for child behavioral noncompliance (p = .006, d = 0.34), irritability (p = .01, d = 0.48), and hyperactivity/noncompliance (p = .04, d = 0.55) with a lower medication dose...
  5. pmc Pediatric bipolar disorder and ADHD: family history comparison in the LAMS clinical sample
    L Eugene Arnold
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, Columbus, OH, United States
    J Affect Disord 141:382-9. 2012
    ..Transgenerational association of bipolar spectrum disorder (BPSD) and attention deficit/hyperactivity disorder (ADHD) has been reported, but inconclusively...
  6. pmc Artificial food colors and attention-deficit/hyperactivity symptoms: conclusions to dye for
    L Eugene Arnold
    Department of Psychiatry, The Ohio State University, Columbus, OH 43210, USA
    Neurotherapeutics 9:599-609. 2012
    ..A table clarifying the Food and Drug Administration and international naming systems for AFCs, with cross-referencing, is provided...
  7. pmc Placebo-controlled pilot trial of mecamylamine for treatment of autism spectrum disorders
    L Eugene Arnold
    Nisonger Center, The Ohio State University, Columbus, OH 43210, USA
    J Child Adolesc Psychopharmacol 22:198-205. 2012
    ..To explore possible benefits of a nicotinic acetylcholine receptor (nAChR) agent for autistic symptoms based on postmortem observation of nAChR abnormalities (deficient α4β2 nAChRs, excess α7 nAChRs) in brains of patients with autism...
  8. pmc Pediatric bipolar spectrum disorder and ADHD: comparison and comorbidity in the LAMS clinical sample
    L Eugene Arnold
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
    Bipolar Disord 13:509-21. 2011
    ..To compare attention-deficit hyperactivity disorder (ADHD), bipolar spectrum disorders (BPSDs), and comorbidity in the Longitudinal Assessment of Manic Symptoms (LAMS) study...
  9. pmc The treatment of severe child aggression (TOSCA) study: Design challenges
    Cristan A Farmer
    Nisonger Center, Ohio State University, Columbus, USA
    Child Adolesc Psychiatry Ment Health 5:36. 2011
    ..abstract:..
  10. pmc Characteristics of children with elevated symptoms of mania: the Longitudinal Assessment of Manic Symptoms (LAMS) study
    Robert L Findling
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Psychiatry 71:1664-72. 2010
    ..This article describes the initial demographic information, diagnostic and symptom prevalence, and medication exposure for the LAMS cohort that will be followed longitudinally...
  11. pmc Phenomenology of bipolar disorder not otherwise specified in youth: a comparison of clinical characteristics across the spectrum of manic symptoms
    Danella Hafeman
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 15:240-52. 2013
    ....
  12. ncbi request reprint Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Biol Psychiatry 61:538-44. 2007
    ....
  13. pmc Cognitive effects of risperidone in children with autism and irritable behavior
    Michael G Aman
    Nisonger Center, Ohio State University, Columbus, OH, USA
    J Child Adolesc Psychopharmacol 18:227-36. 2008
    ..The objective of this research was to explore the effects of risperidone on cognitive processes in children with autism and irritable behavior...
  14. pmc Medication and parent training in children with pervasive developmental disorders and serious behavior problems: results from a randomized clinical trial
    Michael G Aman
    The Nisonger Center UCEDD, Ohio State University, Columbus, OH 43210 1257, USA
    J Am Acad Child Adolesc Psychiatry 48:1143-54. 2009
    ..We tested whether combined treatment (COMB) with risperidone and parent training (PT) in behavior management is superior to medication alone (MED) in improving severe behavioral problems in children with PDDs...
  15. ncbi request reprint Acute and long-term safety and tolerability of risperidone in children with autism
    Michael G Aman
    The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1296, USA
    J Child Adolesc Psychopharmacol 15:869-84. 2005
    ..Most AEs were mild to moderate and failed to interfere with therapeutic changes; there were no unanticipated AEs. The side effects of most concern were somnolence and weight gain...
  16. ncbi request reprint Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trial
    L Eugene Arnold
    The Ohio State University Nisonger Center, Columbus, OH, USA
    J Child Adolesc Psychopharmacol 17:791-802. 2007
    ..Trials in Down's syndrome, migraine, and Alzheimer's disease showed benefit for attention. A preliminary trial in ADHD using L-carnitine reported significant benefit...
  17. pmc Zinc for attention-deficit/hyperactivity disorder: placebo-controlled double-blind pilot trial alone and combined with amphetamine
    L Eugene Arnold
    The Nisonger Center, Ohio State University, Columbus, Ohio, USA
    J Child Adolesc Psychopharmacol 21:1-19. 2011
    ..To explore effects of zinc supplementation in American children with attention-deficit/hyperactivity disorder (ADHD). Mideastern trials reported significant benefit from 13-40 mg elemental zinc as the sulfate...
  18. ncbi request reprint Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 162:1142-8. 2005
    ..The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior...
  19. pmc What differentiates children visiting outpatient mental health services with bipolar spectrum disorder from children with other psychiatric diagnoses?
    Mary A Fristad
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
    Bipolar Disord 14:497-506. 2012
    ....
  20. ncbi request reprint Validity of the autism diagnostic interview-revised
    Luc Lecavalier
    Nisonger Center, The Ohio State University, Columbus, USA
    Am J Ment Retard 111:199-215. 2006
    ..They indicated some similarities between constructs, but also that the ADI-R measures autism in a unique fashion...
  21. pmc Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritability
    L Eugene Arnold
    Department of Psychiatry, Ohio State University, Columbus, Ohio, USA
    J Child Adolesc Psychopharmacol 20:83-93. 2010
    ..2 in favor of risperidone on the main outcome measure in an 8-week double-blind, placebo-controlled trial for irritability in autistic disorder. This paper explores moderators and mediators of this effect...
  22. ncbi request reprint Parent satisfaction in a multi-site acute trial of risperidone in children with autism: a social validity study
    Elaine Tierney
    Department of Psychiatry, Kennedy Krieger Institute, Baltimore, MD, USA
    Psychopharmacology (Berl) 191:149-57. 2007
    ..Designing studies that consider the consumer's perspective will help to forge a better alliance between participants and researchers...
  23. ncbi request reprint Treatment-related changes in objectively measured parenting behaviors in the multimodal treatment study of children with attention-deficit/hyperactivity disorder
    Karen C Wells
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    J Consult Clin Psychol 74:649-57. 2006
    ..The authors discuss the importance of changes in parenting behavior for families of children with ADHD and the need for reliable and objective measures in evaluating treatment outcome...
  24. pmc Early-onset bipolar spectrum disorders: diagnostic issues
    Stephanie Danner
    Ohio State University, Columbus, OH, USA
    Clin Child Fam Psychol Rev 12:271-93. 2009
    ..Research findings concerning these challenges and relevant recommendations are offered. Areas for further research to guide clinicians' assessment of children with early-onset BPSD are highlighted...
  25. pmc Patterns and predictors of adolescent academic achievement and performance in a sample of children with attention-deficit/hyperactivity disorder
    Joshua M Langberg
    Department of Pediatrics University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, OH, USA
    J Clin Child Adolesc Psychol 40:519-31. 2011
    ..Childhood predictors of adolescent achievement differed from those for performance. Classroom performance and homework management mediated the relationship between symptoms of inattention and academic outcomes...
  26. ncbi request reprint Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trial
    L Eugene Arnold
    The authors are with Ohio State University s Nisonger Center, Columbus, OH 43210, USA
    J Am Acad Child Adolesc Psychiatry 45:1196-205. 2006
    ..To explore placebo-controlled efficacy and safety of atomoxetine (ATX) for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorders (ASD)...
  27. pmc Relation between outcomes on a continuous performance test and ADHD symptoms over time
    Aaron J Vaughn
    Cincinnati Children s Hospital and Medical Center, Cincinnati, OH, USA
    J Abnorm Child Psychol 39:853-64. 2011
    ..Findings are discussed in relation to neuropsychological development including recommendations for future research...
  28. doi request reprint Feasibility of a nutritional supplement as treatment for pediatric bipolar spectrum disorders
    Elisabeth A Frazier
    Department of Psychiatry, The Ohio State University, Columbus, OH, USA
    J Altern Complement Med 18:678-85. 2012
    ..This open-label study explored the feasibility of testing therapeutic effects of a multinutrient supplement, EMPowerplus™ (EMP+), for pediatric BPSD...
  29. doi request reprint Effects of risperidone on cognitive-motor performance and motor movements in chronically medicated children
    Michael G Aman
    The Ohio State University, USA
    Res Dev Disabil 30:386-96. 2009
    ..02, eta(P)(2)=0.36) occurred in the risperidone condition. The findings suggest a beneficial effect of risperidone after several months of treatment on efficiency of responding, activity level, static tremor, and aspects of behavior...
  30. ncbi request reprint Delinquent behavior and emerging substance use in the MTA at 36 months: prevalence, course, and treatment effects
    Brooke S G Molina
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 46:1028-40. 2007
    ....
  31. ncbi request reprint Serum zinc correlates with parent- and teacher- rated inattention in children with attention-deficit/hyperactivity disorder
    L Eugene Arnold
    Department of Psychiatry, Ohio State University, Columbus, Ohio 43074, USA
    J Child Adolesc Psychopharmacol 15:628-36. 2005
    ..Previous reports of zinc in ADHD, including two positive clinical trials of supplementation, have come mainly from countries and cultures with different diets and/or socioeconomic realities...
  32. pmc Serum ferritin and amphetamine response in youth with attention-deficit/hyperactivity disorder
    Chadi Calarge
    Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Child Adolesc Psychopharmacol 20:495-502. 2010
    ..The study aim was to explore whether iron stores, as reflected by serum ferritin concentration, predicted response to psychostimulants...
  33. pmc Treatment of inattention, overactivity, and impulsiveness in autism spectrum disorders
    Michael G Aman
    Department of Psychology, Ohio State University, 225 Psychology Building, 1835 Neil Avenue, Columbus, OH 43210, USA
    Child Adolesc Psychiatr Clin N Am 17:713-38, vii. 2008
    ..Evidence for efficacy seems weakest for newer antidepressants, anxiolytics, and mood stabilizers...
  34. doi request reprint Vestibular Stimulation for ADHD: randomized controlled trial of Comprehensive Motion Apparatus
    David L Clark
    Ohio State University, Ohio, USA
    J Atten Disord 11:599-611. 2008
    ..This research evaluates effects of vestibular stimulation by Comprehensive Motion Apparatus (CMA) in ADHD...
  35. doi request reprint Dietary and nutritional treatments for attention-deficit/hyperactivity disorder: current research support and recommendations for practitioners
    Elizabeth A Hurt
    Nisonger Center, The Ohio State University, Columbus, OH 43210, USA
    Curr Psychiatry Rep 13:323-32. 2011
    ..Consequences of delayed proven treatments need consideration in the risk-benefit assessment of dietary/nutritional treatments...
  36. pmc Psychopharmacological and other treatments in preschool children with attention-deficit/hyperactivity disorder: current evidence and practice
    Jaswinder K Ghuman
    Department of Psychiatry, University of Arizona, Tucson, Arizona 85724 5002, USA
    J Child Adolesc Psychopharmacol 18:413-47. 2008
    ..This article reviews rational approaches to treating attention-deficit/hyperactivity disorder (ADHD) in preschool children, including pharmacological and nonpharmacological treatments. Implications for clinical practice are discussed...
  37. ncbi request reprint Treating attention-deficit/hyperactivity disorder with a stimulant transdermal patch: the clinical art
    L Eugene Arnold
    Department of Psychiatry, Ohio State University, Columbus, Ohio, USA
    Pediatrics 120:1100-6. 2007
    ..This article summarizes clinical principles that physicians may find useful in managing this new addition to the attention-deficit/hyperactivity disorder treatment armamentarium...
  38. doi request reprint Multinutrient supplement as treatment: literature review and case report of a 12-year-old boy with bipolar disorder
    Elisabeth A Frazier
    Department of Psychiatry, The Ohio State University, Columbus, OH 43210 1250, USA
    J Child Adolesc Psychopharmacol 19:453-60. 2009
    ..EMP+ resulted in outcome superior to conventional treatment. This report adds to accumulating preliminary evidence that further basic science and clinical studies of multinutrient supplements are warranted...
  39. doi request reprint Current status of neurofeedback for attention-deficit/hyperactivity disorder
    Nicholas Lofthouse
    Department of Psychiatry, The Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
    Curr Psychiatry Rep 14:536-42. 2012
    ..Most recently, a collaborative NF research group has been planning a definitive double-blind well-controlled trial...
  40. doi request reprint A review of neurofeedback treatment for pediatric ADHD
    Nicholas Lofthouse
    Department of Psychiatry, The Ohio State University, 1670 Upham Drive, Columbus, OH 43210 1250, USA
    J Atten Disord 16:351-72. 2012
    ..The aim of this paper was to review all randomized published trials and unpublished conference presentations on the neurofeedback (NF) treatment of pediatric ADHD, and their relevance, strengths, and limitations...
  41. ncbi request reprint Nine months of multicomponent behavioral treatment for ADHD and effectiveness of MTA fading procedures
    L Eugene Arnold
    The Ohio State University, Columbus, Ohio, USA
    J Abnorm Child Psychol 32:39-51. 2004
    ....
  42. ncbi request reprint A double-blind, placebo-controlled withdrawal trial of dexmethylphenidate hydrochloride in children with attention deficit hyperactivity disorder
    L Eugene Arnold
    Ohio State University, Columbus, Ohio 43210 1296, USA
    J Child Adolesc Psychopharmacol 14:542-54. 2004
    ..This study complements that report by studying the effect of placebo-controlled discontinuation and retesting the duration of action...
  43. ncbi request reprint The role of children's ethnicity in the relationship between teacher ratings of attention-deficit/hyperactivity disorder and observed classroom behavior
    Jeffrey N Epstein
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    J Consult Clin Psychol 73:424-34. 2005
    ..Differences in classroom behavior were attenuated when the behavior of an average child in the classroom was taken into account. Multiple explanations for this pattern of results are discussed...
  44. pmc A review of complementary and alternative treatments for autism spectrum disorders
    Nicholas Lofthouse
    Department of Psychiatry, The Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
    Autism Res Treat 2012:870391. 2012
    ..We conclude this paper with recommendations for future research and ten clinical recommendations for practitioners...
  45. pmc Nutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders
    Elisabeth A Frazier
    Department of Psychiatry, Department of Human Nutrition, The Ohio State University, Columbus, Ohio
    J Child Adolesc Psychopharmacol 23:558-67. 2013
    ....
  46. ncbi request reprint Zinc in attention-deficit/hyperactivity disorder
    L Eugene Arnold
    Department of Psychiatry, Ohio State University, Columbus, OH 43074, USA
    J Child Adolesc Psychopharmacol 15:619-27. 2005
    ..The aim of this study was to review the published evidence for a role of zinc nutrition in attention-deficit/hyperactivity disorder (ADHD)...
  47. ncbi request reprint Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptoms
    Christopher J Kratochvil
    Department of Psychiatry, Nebraska Medical Center, Omaha 68198 5581, USA
    J Am Acad Child Adolesc Psychiatry 44:915-24. 2005
    ..The authors assessed the safety and effectiveness of atomoxetine monotherapy compared with combined atomoxetine/fluoxetine therapy in a population of children and adolescents with ADHD and concurrent symptoms of depression or anxiety...
  48. ncbi request reprint Ethical issues in child psychopharmacology research and practice: emphasis on preschoolers
    Lacramioara Spetie
    Department of Psychiatry, Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
    Psychopharmacology (Berl) 191:15-26. 2007
    ..Within the past few decades, several ethical principles guiding pediatric psychopharmacological research have been developed. The same principles could effectively guide the treatment of these patients...
  49. ncbi request reprint Empirical evaluation of the generalizability of the sample from the multimodal treatment study for ADHD
    Jack Stevens
    Department of Pediatrics, The Ohio State University, 899 East Broad Street, 3rd Floor, Columbus, OH 43205, USA
    Adm Policy Ment Health 34:221-32. 2007
    ..On the whole, we found no compelling evidence against the representativeness of the MTA sample, but the limited power from MECA and NHANES may have lead to noteworthy differences between datasets being statistically nonsignificant...
  50. ncbi request reprint Parent-defined target symptoms respond to risperidone in RUPP autism study: customer approach to clinical trials
    L Eugene Arnold
    Ohio State University, 479 S Galena Road, Sunbury, OH 43074, USA
    J Am Acad Child Adolesc Psychiatry 42:1443-50. 2003
    ..A consumer-oriented efficacy assessment in clinical trials should measure changes in chief complaint and consumer request (symptoms of most concern to patient/caregiver), which may be diluted in change scores of multisymptom scales...