Ralph Arlinghaus


Affiliation: The University of Texas
Country: USA


  1. Tao W, Leng X, Chakraborty S, Ma H, Arlinghaus R. c-Abl activates janus kinase 2 in normal hematopoietic cells. J Biol Chem. 2014;289:21463-72 pubmed publisher
    ..c-Abl kinase activity induced by IL-3 is required for IL-3-stimulated Jak2 and Jak1 activation. Our findings reveal a novel regulatory role of c-Abl in Jak2 activation induced by IL-3 cytokine growth factor in 32D hematopoietic cells. ..
  2. request reprint
    Ling X, Ma G, Sun T, Liu J, Arlinghaus R. Bcr and Abl interaction: oncogenic activation of c-Abl by sequestering Bcr. Cancer Res. 2003;63:298-303 pubmed
  3. Arlinghaus R, Leng X. Requirement of lipocalin 2 for chronic myeloid leukemia. Leuk Lymphoma. 2008;49:600-3 pubmed publisher
    ..Our new findings indicate that lipocalin 2 is required for leukemia induction, as prevention of expression of lipocalin 2 by BCR-ABL+ mouse marrow cells totally blocks leukemia induction in a mouse model. ..