Genomes and Genes
Marjorie A Ariano
Affiliation: The Chicago Medical School
- Striatal neurochemical changes in transgenic models of Huntington's diseaseMarjorie A Ariano
Department of Neuroscience, The Chicago Medical School, North Chicago, Illinois 60064, USA
J Neurosci Res 68:716-29. 2002..These findings suggest modifications in the striatal DA system and that its downstream signaling through cyclic AMP mechanisms is disrupted severely in HD following onset of motor symptoms...
- Neuronal vulnerability in mouse models of Huntington's disease: membrane channel protein changesMarjorie A Ariano
Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 3095, USA
J Neurosci Res 80:634-45. 2005..Together our data suggest that changes in these proteins and their modification may predispose striatal projection neurons to dysfunction and then degeneratation in HD and provide a mechanism for LAN resistance in the disease...
- Partial dopamine loss enhances activated caspase-3 activity: differential outcomes in striatal projection systemsMarjorie A Ariano
Department of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
J Neurosci Res 82:387-96. 2005..These observations could be capitalized upon to develop therapeutic interventions in the preclinical phases of the disorder...
- D1 dopamine receptor stimulation increases GluR1 surface expression in nucleus accumbens neuronsSteven Z Chao
Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
J Neurochem 83:704-12. 2002..When dopamine receptors are over-stimulated during chronic drug administration, this regulation may be disrupted, leading to inappropriate plasticity in neuronal circuits governing motivation and reward...
- Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtypeElizabeth Hernandez-Echeagaray
Mental Retardation Research Center, Room 58 258 David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
Neurochem Res 32:229-40. 2007..We conclude that D(1) receptors are the main D1-like receptor subtype involved in the modulation of GABA currents and that D(5) receptors contribute to the normal expression of these currents in the striatum...
- Striatal potassium channel dysfunction in Huntington's disease transgenic miceMarjorie A Ariano
Mental Retardation Research Center, NPI Room 58 258, 760 Westwood Plaza, University of California, Los Angeles, CA 90095, USA
J Neurophysiol 93:2565-74. 2005..Attenuation in K+ conductances and channel subunit expression contribute to altered electrophysiological properties of MSNs and may partially account for selective cellular vulnerability in the striatum...
- Increased GABAergic function in mouse models of Huntington's disease: reversal by BDNFCarlos Cepeda
Mental Retardation Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
J Neurosci Res 78:855-67. 2004..In conjunction, both changes will severely alter striatal outputs to target areas involved in the control of movement...
- Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's diseaseCarlos Cepeda
Mental Retardation Research Center, University of California at Los Angeles, Los Angeles, California 90095, USA
J Neurosci 23:961-9. 2003..These alterations are likely to contribute to the selective vulnerability of striatal medium-sized spiny neurons...
- Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensiveTom R Hollon
Molecular Neuropharmacology Section and Basic Neurosciences Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1406, USA
J Neurosci 22:10801-10. 2002....
- Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitizationOk jin Kim
Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1406, USA
J Neurosci 22:5920-30. 2002..These results suggest that NF-M interacts with the D(1) receptor in vivo and may modify its expression and regulation...
- D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIPOk jin Kim
Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, Kansas 66045 7582, USA
J Neurochem 106:83-95. 2008..These results suggest that ZIP can physically interact with the D(2) DAR leading to increased intracellular trafficking to lysosomes with subsequent down-regulation of receptor expression and function...