Rami I Aqeilan

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint WWOX in biological control and tumorigenesis
    Rami I Aqeilan
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Physiol 212:307-10. 2007
  2. pmc The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
    Rami I Aqeilan
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    J Biol Chem 283:21629-39. 2008
  3. pmc Targeted deletion of Wwox reveals a tumor suppressor function
    Rami I Aqeilan
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:3949-54. 2007
  4. pmc Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo
    Rami I Aqeilan
    Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 67:5606-10. 2007
  5. ncbi request reprint WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function
    Rami I Aqeilan
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43220, USA
    Cancer Res 65:6764-72. 2005
  6. pmc Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis
    Rami I Aqeilan
    Department of Molecular Virology, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Endocrinology 150:1530-5. 2009
  7. ncbi request reprint Association of Wwox with ErbB4 in breast cancer
    Rami I Aqeilan
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 67:9330-6. 2007
  8. ncbi request reprint Physical association with WWOX suppresses c-Jun transcriptional activity
    Eugenio Gaudio
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 66:11585-9. 2006
  9. pmc MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis
    Flavia Pichiorri
    Department of Molecular Virology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:12885-90. 2008
  10. pmc Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells
    Francesco Trapasso
    Ohio State University, Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    J Biol Chem 283:13736-44. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint WWOX in biological control and tumorigenesis
    Rami I Aqeilan
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Physiol 212:307-10. 2007
    ..This review focuses on the most recent progress in understanding WWOX function as a tumor suppressor...
  2. pmc The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
    Rami I Aqeilan
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    J Biol Chem 283:21629-39. 2008
    ..Our results demonstrate an essential requirement for the WWOX tumor suppressor in postnatal survival, growth, and metabolism and suggest a central role for WWOX in regulation of bone tissue formation...
  3. pmc Targeted deletion of Wwox reveals a tumor suppressor function
    Rami I Aqeilan
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:3949-54. 2007
    ..Intriguingly, these tumors still express Wwox protein, suggesting haploinsuffiency of WWOX itself is cancer predisposing. These results indicate that WWOX is a bona fide tumor suppressor...
  4. pmc Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo
    Rami I Aqeilan
    Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 67:5606-10. 2007
    ....
  5. ncbi request reprint WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function
    Rami I Aqeilan
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43220, USA
    Cancer Res 65:6764-72. 2005
    ..In summary, our data indicate that WWOX antagonizes the function of YAP by competing for interaction with ErbB-4 and other targets and thus affect its transcriptional activity...
  6. pmc Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis
    Rami I Aqeilan
    Department of Molecular Virology, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Endocrinology 150:1530-5. 2009
    ..These results demonstrate the essential requirement for the Wwox tumor suppressor in proper steroidogenesis...
  7. ncbi request reprint Association of Wwox with ErbB4 in breast cancer
    Rami I Aqeilan
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 67:9330-6. 2007
    ..These results suggest that expression of Wwox is associated with ErbB4 expression and that their coexpression has prognostic significance in breast cancer...
  8. ncbi request reprint Physical association with WWOX suppresses c-Jun transcriptional activity
    Eugenio Gaudio
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 66:11585-9. 2006
    ..Our findings reveal a novel functional cross-talk between c-Jun transcription factor and WWOX tumor suppressor protein...
  9. pmc MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis
    Flavia Pichiorri
    Department of Molecular Virology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:12885-90. 2008
    ..In summary, we have described a MM miRNA signature, which includes miRNAs that modulate the expression of proteins critical to myeloma pathogenesis...
  10. pmc Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells
    Francesco Trapasso
    Ohio State University, Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    J Biol Chem 283:13736-44. 2008
    ..Characterization of Fhit interacting proteins has identified direct effectors of the Fhit-mediated apoptotic pathway that is lost in most cancers through loss of Fhit...
  11. ncbi request reprint Tal1 transgenic expression reveals absence of B lymphocytes
    Alexey Palamarchuk
    Comprehensive Cancer Center, Human Cancer Genetics Program, OSU School of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 66:6014-7. 2006
    ..Our results suggest that Tal1 overexpression in B cells results in a phenotype similar to that of B cells of E47/E2A knockout animals. This represents first in vivo evidence that Tal1 can completely inhibit E47/E2A function...
  12. pmc Common fragile site tumor suppressor genes and corresponding mouse models of cancer
    Alessandra Drusco
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Biomed Biotechnol 2011:984505. 2011
    ..This paper summarizes our present knowledge on mouse models of cancer generated by knocking out tumor suppressors of CFS...
  13. pmc Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development
    Flavia Pichiorri
    Department of Molecular Virology, Comprehensive Cancer Center, Ohio State University, Columbus, 43210, USA
    Cancer Cell 18:367-81. 2010
    ..The results suggest that these miRNAs are positive regulators of p53 and that their downregulation plays a key role in MM development...
  14. pmc Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas
    Eugenio Gaudio
    Department of Molecular Immunology, Virology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Blood 121:351-9. 2013
    ..These findings suggest that inhibition of Hsp70 may represent an alternative effective therapy for chronic lymphocytic leukemia and lymphomas via its ability to inhibit the oncogenic functions of Tcl1...
  15. pmc Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignancies
    Eugenio Gaudio
    Department of Molecular Immunology, Virology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Blood 119:180-7. 2012
    ..Our findings reveal functional cross-talk between Atm and Tcl1 and provide evidence for a novel pathway that could be targeted in leukemias and lymphomas...
  16. pmc MiR-15a and miR-16-1 cluster functions in human leukemia
    George A Calin
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:5166-71. 2008
    ..By examining the Gene Ontology (GO) database, a significant enrichment in cancer genes (such as MCL1, BCL2, ETS1, or JUN) that directly or indirectly affect apoptosis and cell cycle was found...
  17. ncbi request reprint Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35
    Flavia Pichiorri
    Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    Clin Cancer Res 12:3494-501. 2006
    ..We have generated a chimeric FHIT-containing adenovirus composed of Ad5 and the group B adenovirus called F35 with which we have been able to efficiently infect hematopoietic cells...
  18. ncbi request reprint Akt phosphorylates and regulates Pdcd4 tumor suppressor protein
    Alexey Palamarchuk
    Comprehensive Cancer Center, Human Cancer Genetics Program, and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University School of Medicine, Columbus, 43210, USA
    Cancer Res 65:11282-6. 2005
    ..Using luciferase assay, we show that phosphorylation of Pdcd4 by Akt also causes a significant decrease of the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoter by c-Jun...
  19. doi request reprint Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro
    Francesco Trapasso
    Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    DNA Cell Biol 28:161-7. 2009
    ..Restoration of wild-type HIPK2 expression in Hipk2(-/-) cells rescues the normal phenotype supporting a role for HIPK2 in the regulation of cell proliferation...
  20. pmc WWOX gene restoration prevents lung cancer growth in vitro and in vivo
    Muller Fabbri
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43201, USA
    Proc Natl Acad Sci U S A 102:15611-6. 2005
    ..This study confirms that WWOX is a tumor suppressor gene and is highly effective in preventing growth of lung cancer xenografts, whether introduced through viral infection or by induction of a silent WWOX transgene...
  21. pmc MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme
    Sung Suk Suh
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 109:5316-21. 2012
    ..The results define miR-25 and -32 as positive regulators of p53, underscoring their role in tumorigenesis in glioblastoma...
  22. ncbi request reprint Akt phosphorylates Tal1 oncoprotein and inhibits its repressor activity
    Alexey Palamarchuk
    Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 65:4515-9. 2005
    ..2) promoter. Thus, these data indicate that Akt interacts with Tal1 and regulates Tal1 by phosphorylation at Thr90 in a phosphatidylinositol 3-kinase-dependent manner...
  23. ncbi request reprint Animal models for chronic lymphocytic leukemia
    Yuri Pekarsky
    Comprehensive Cancer Center, Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, OSU School of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 100:1109-18. 2007
    ..In this article, we present what has been learned from mice with B-CLL phenotype and how these mouse models of B-CLL were used to test therapeutic treatments for this common leukemia...
  24. pmc MicroRNAs: New Players in Multiple Myeloma
    Flavia Pichiorri
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Columbus, OH, USA
    Front Genet 2:22. 2011
    ..The aberrant role of miRNAs has been reported in a number of hematopoietic malignancies including multiple myeloma (MM). In this review we summarize the current knowledge on roles of miRNAs in the pathogenesis of MM...
  25. pmc miR-15 and miR-16 induce apoptosis by targeting BCL2
    Amelia Cimmino
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA
    Proc Natl Acad Sci U S A 102:13944-9. 2005
    ..BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors...
  26. pmc WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels
    Jenny C Lee
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 83:180-92. 2008
    ..In conclusion, analyses of 9,798 subjects show significant association between HDL-C and a WWOX variant with an allele-specific cis-regulatory function...
  27. doi request reprint Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells
    Shunji Nakayama
    Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cancer Sci 99:1370-6. 2008
    ..These findings suggest that down-modulation of Wwox expression is an early event and may be associated with the down-regulation of Smad4 protein levels during pancreatic duct carcinogenesis...
  28. ncbi request reprint The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis
    Tamotsu Kuroki
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 10:2459-65. 2004
    ..We showed previously that WWOX is frequently altered in human lung and esophageal cancers. The purpose of this study was to delineate more precisely the role of WWOX in pancreatic carcinogenesis...
  29. ncbi request reprint Loss of WWOX expression in gastric carcinoma
    Rami I Aqeilan
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 10:3053-8. 2004
    ..3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox...
  30. ncbi request reprint Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor
    Rami I Aqeilan
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 64:8256-61. 2004
    ..Our results suggest that Wwox tumor suppressor protein inhibits AP-2gamma oncogenic activity by sequestering it in the cytoplasm...
  31. ncbi request reprint Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis
    Francesco Trapasso
    Dipartimento di Medicina Sperimentale e Clinica, Universita Magna Graecia di Catanzaro, Campus Germaneto, Catanzaro, Italy
    DNA Cell Biol 25:376-82. 2006
    ..Furthermore, neither changes in life span nor spontaneous tumor appearance were observed in Ptprj-null mice. Our results indicate that Ptprj is dispensable for normal growth and development in mice...
  32. pmc Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis
    Berna S Sayan
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 104:10871-6. 2007
    ..We also used a model system in which TAp63 expression was induced by trichostatin-A treatment in HCT116 cells. Trichostatin-A sensitized these cells to apoptosis, and this sensitization was associated with cleavage of up-regulated p63...
  33. pmc The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
    Andrew Oberst
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 104:11280-5. 2007
    ....
  34. pmc Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms
    Maria Sundvall
    MediCity Research Laboratory and Department of Medical Biochemistry and Molecular Biology, University of Turku, FIN 20520 Turku, Finland
    Proc Natl Acad Sci U S A 105:4162-7. 2008
    ..These data indicate that ErbB4 isoforms differ in endocytosis and degradation by a mechanism mediated by CYT-1-specific PPXY motif interacting with a WW domain-containing E3 ubiquitin ligase...
  35. pmc Functional association between Wwox tumor suppressor protein and p73, a p53 homolog
    Rami I Aqeilan
    Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:4401-6. 2004
    ..In addition, we show that cytoplasmic p73 contributes to the proapoptotic activity of Wwox. Our findings reveal a functional cross-talk between p73 and Wwox tumor suppressor protein...
  36. pmc The E3 ubiquitin ligase Itch controls the protein stability of p63
    Mario Rossi
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 103:12753-8. 2006
    ..These data suggest that Itch has a fundamental role in the mechanism that controls endogenous p63 protein levels and therefore contributes to regulation of p63 in physiological conditions...