Stanley H Appel

Summary

Affiliation: The Methodist Hospital
Country: USA

Publications

  1. pmc The microglial-motoneuron dialogue in ALS
    S H Appel
    Methodist Neurological Institute, Methodist Hospital Research Institute, Houston, TX, USA
    Acta Myol 30:4-8. 2011
  2. doi request reprint T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
    Stanley H Appel
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, TX, USA
    Trends Immunol 31:7-17. 2010
  3. ncbi request reprint Novel therapeutic targets in neurodegenerative diseases: lessons from amyotrophic lateral sclerosis
    Stanley H Appel
    Department of Neurology, Methodist Neurological Institute, 6560 Fannin, Suite 802, Houston, TX 77030, USA
    Curr Neurol Neurosci Rep 8:353-5. 2008
  4. pmc CD4+ T cells mediate cytotoxicity in neurodegenerative diseases
    Stanley H Appel
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    J Clin Invest 119:13-5. 2009
  5. doi request reprint Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
    S H Appel
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    Neurology 71:1326-34. 2008
  6. ncbi request reprint Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
    Qin Xiao
    Department of Neurology, Methodist Neurological Institute, Houston, Texas 77030, USA
    J Neurochem 102:2008-19. 2007
  7. ncbi request reprint Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism
    Weihua Zhao
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, NB 302, Houston, TX, 77030, USA
    J Neuropathol Exp Neurol 63:964-77. 2004
  8. ncbi request reprint Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia
    Weihua Zhao
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital, Houston, Texas 77030, USA
    J Neurochem 99:1176-87. 2006
  9. pmc Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
    David R Beers
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, TX 77030, USA
    Brain Behav Immun 25:1025-35. 2011
  10. pmc Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:16021-6. 2006

Collaborators

Detail Information

Publications46

  1. pmc The microglial-motoneuron dialogue in ALS
    S H Appel
    Methodist Neurological Institute, Methodist Hospital Research Institute, Houston, TX, USA
    Acta Myol 30:4-8. 2011
    ..A greater understanding of how to restore the imbalance between neuroprotection and cytotoxicity will depend upon a greater understanding of the motor neuron-microglial dialogue...
  2. doi request reprint T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
    Stanley H Appel
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, TX, USA
    Trends Immunol 31:7-17. 2010
    ..A greater understanding of the T cell population that mediates these effects, as well as the molecular signals involved should provide targets for neuroprotective immunomodulation to treat these devastating neurodegenerative diseases...
  3. ncbi request reprint Novel therapeutic targets in neurodegenerative diseases: lessons from amyotrophic lateral sclerosis
    Stanley H Appel
    Department of Neurology, Methodist Neurological Institute, 6560 Fannin, Suite 802, Houston, TX 77030, USA
    Curr Neurol Neurosci Rep 8:353-5. 2008
  4. pmc CD4+ T cells mediate cytotoxicity in neurodegenerative diseases
    Stanley H Appel
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    J Clin Invest 119:13-5. 2009
    ..The results implicate the adaptive immune system in the pathogenesis of Parkinson neurodegeneration and provide a meaningful rationale for immune-based therapies for PD...
  5. doi request reprint Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
    S H Appel
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    Neurology 71:1326-34. 2008
    ..Amyotrophic lateral sclerosis (ALS), an inexorably progressive motoneuron disease, is accompanied by significantly increased markers of inflammation. These inflammatory constituents could protect, harm, do neither, or do both...
  6. ncbi request reprint Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
    Qin Xiao
    Department of Neurology, Methodist Neurological Institute, Houston, Texas 77030, USA
    J Neurochem 102:2008-19. 2007
    ..Thus, relative to wild-type microglia, mSOD1(G93A) microglia were more neurotoxic and induced more motoneuron injury than similarly treated wild-type microglia...
  7. ncbi request reprint Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism
    Weihua Zhao
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, NB 302, Houston, TX, 77030, USA
    J Neuropathol Exp Neurol 63:964-77. 2004
    ..These data suggest that free radicals released from activated microglia may initiate MN injury by increasing the susceptibility of the MN AMPA/kainate receptor to the toxic effects of glutamate...
  8. ncbi request reprint Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia
    Weihua Zhao
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital, Houston, Texas 77030, USA
    J Neurochem 99:1176-87. 2006
    ..These data suggest that IL-4 may provide a significant immunomodulatory signal which can protect against microglia-mediated neurotoxicity by suppressing the production and release of free radicals...
  9. pmc Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
    David R Beers
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, TX 77030, USA
    Brain Behav Immun 25:1025-35. 2011
    ....
  10. pmc Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:16021-6. 2006
    ..This study confirms the importance of microglia as a double-edged sword, and focuses on the importance of targeting microglia to minimize cytotoxicity and maximize neuroprotection in neurodegenerative diseases...
  11. pmc CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Houston, TX, USA
    Proc Natl Acad Sci U S A 105:15558-63. 2008
    ..These glial/T-cell interactions establish a novel target for therapeutic intervention in ALS and possibly other neurodegenerative diseases...
  12. pmc Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Suite ST 802, 6560 Fannin Street, Houston, TX 77030, USA
    Brain 134:1293-314. 2011
    ....
  13. pmc Extracellular mutant SOD1 induces microglial-mediated motoneuron injury
    Weihua Zhao
    Department of Neurology, Methodist Neurological Institute, The Methodist Research Institute, The Methodist Hospital, Houston, Texas, USA
    Glia 58:231-43. 2010
    ..This link between mSOD1 and innate immunity may offer novel therapeutic targets in ALS...
  14. doi request reprint Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
    Bing Liao
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China
    Exp Neurol 237:147-52. 2012
    ..Thus, harnessing the neuroprotective potential of microglia may provide novel avenues for ALS therapies...
  15. ncbi request reprint The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS
    Jenny S Henkel
    Department of Neurology, Methodist Research Institute, 6560 Fannin St, Suite 902, Houston, TX 77030, USA
    Mol Cell Neurosci 31:427-37. 2006
    ..CD68+ cells were present at 39 days of age. Although it is not clear if these responses are protective or injurious, the early increased MCP-1 expression and CD68+ cell presence indicate early preexisting injury...
  16. ncbi request reprint Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
    Jenny S Henkel
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Ann Neurol 55:221-35. 2004
    ..These results support the involvement of immune/inflammatory responses in amplifying motor neuron degeneration in ALS...
  17. doi request reprint Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
    Weihua Zhao
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital, Houston, TX 77030, USA
    Neurobiol Dis 48:418-28. 2012
    ..These data suggest that mSOD1 Tregs contribute to the slowly progressing phase in ALS mice and may offer a novel therapeutic option for ALS patients...
  18. pmc Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival
    Jenny S Henkel
    Department of Neurology, The Methodist Hospital Research Institute, Houston, TX, USA
    EMBO Mol Med 5:64-79. 2013
    ..Collectively, these data suggest that Tregs and Th2 lymphocytes influence disease progression rates. Importantly, early reduced FoxP3 levels could be used to identify rapidly progressing patients...
  19. doi request reprint Microglia in ALS: the good, the bad, and the resting
    Jenny S Henkel
    Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, 6560 Fannin Street, Houston, TX 77030, USA
    J Neuroimmune Pharmacol 4:389-98. 2009
    ..Thus, the cumulative evidence suggests that inflammation plays a central role in ALS and manipulating these microglial effector functions may potentially modify the outcome of this devastating disease...
  20. ncbi request reprint Role of nitric oxide in rotenone-induced nigro-striatal injury
    Yi He
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 86:1338-45. 2003
    ..Our data suggest that chronic rotenone administration can lead to significant injury to the nigro-striatal system, mediated by increased generation of nitric oxide...
  21. ncbi request reprint Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigra
    Yi He
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Exp Neurol 176:322-7. 2002
    ....
  22. ncbi request reprint Major stressors facing patients with amyotrophic lateral sclerosis (ALS): a survey to identify their concerns and to compare with those of their caregivers
    Marilyn Trail
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Houston, TX 77030, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:40-5. 2004
    ....
  23. ncbi request reprint PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients
    Seung H Kim
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neuropathol Exp Neurol 62:88-103. 2003
    ....
  24. ncbi request reprint Slower disease progression and prolonged survival in contemporary patients with amyotrophic lateral sclerosis: is the natural history of amyotrophic lateral sclerosis changing?
    Adam Czaplinski
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Neurol 63:1139-43. 2006
    ..However, despite the increased use of supportive measures, controversy still exists about overall trends in disease progression and survival...
  25. ncbi request reprint Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease
    Ira L Goldknopf
    Power3 Medical Products, Inc, The Woodlands, TX, USA
    Biochem Biophys Res Commun 342:1034-9. 2006
    ..The differential expression of the complement proteins provides potentially useful biomarkers as well as evidence for the involvement of inflammatory processes in the pathogenesis of ALS and PD...
  26. ncbi request reprint Mutant genes responsible for Parkinson's disease
    Weidong Le
    Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Curr Opin Pharmacol 4:79-84. 2004
    ....
  27. ncbi request reprint Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection
    Arabinda Das
    Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci Res 81:551-62. 2005
    ..Inhibition of the activities of both NMDA and AMPA receptors protected VSC4.1 cells from glutamate toxicity and preserved whole-cell membrane potential...
  28. ncbi request reprint Amyotrophic lateral sclerosis: early predictors of prolonged survival
    Adam Czaplinski
    Dept of Neurology, Baylor College of Medicine, Houston, TX, USA
    J Neurol 253:1428-36. 2006
    ..In order to define the predictors of prolonged survival available at the time of first examination we performed a historical cohort study of amyotrophis sclerosis (ALS) patients referred to our ALS Clinic over the last 20 years...
  29. ncbi request reprint Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis
    Ericka P Simpson
    Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Curr Opin Rheumatol 15:730-6. 2003
    ....
  30. ncbi request reprint Mutations in NR4A2 associated with familial Parkinson disease
    Wei Dong LE
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Genet 33:85-9. 2003
    ..Additionally, mutations in NR4A2 affect transcription of the gene encoding tyrosine hydroxylase. These data suggest that mutations in NR4A2 can cause dopaminergic dysfunction, associated with Parkinson disease...
  31. doi request reprint Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis
    Weihua Zhao
    Department of Neurology, Methodist Neurological Institute, Methodist Research Institute, The Methodist Hospital, Houston, TX, USA
    J Neuroimmune Pharmacol 8:888-99. 2013
    ..The better we understand the dynamic changes that occur within the immune system over the course of disease, the better we will be able to develop effective therapeutic regimens in ALS. ..
  32. ncbi request reprint Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons
    Habib A Mohamed
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 69:110-6. 2002
    ..These data suggest that FcgammaRs appear to participate in IgG uptake into motor neurons as well as IgG-mediated increases in intracellular calcium and acetylcholine release from motor axon terminals...
  33. ncbi request reprint Is ALS a systemic disorder? Evidence from muscle mitochondria
    Stanley H Appel
    Department of Neurology, Methodist Neurological Institute, Houston, TX 77030, USA
    Exp Neurol 198:1-3. 2006
  34. ncbi request reprint A study comparing patients with amyotrophic lateral sclerosis and their caregivers on measures of quality of life, depression, and their attitudes toward treatment options
    Marilyn Trail
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030, USA
    J Neurol Sci 209:79-85. 2003
    ..To compare amyotrophic lateral sclerosis (ALS) patients and their caregivers on measures of quality of life (QOL), depression, and their attitudes toward treatment options...
  35. ncbi request reprint Mechanisms of disease pathogenesis in amyotrophic lateral sclerosis. A central role for calcium
    Ericka P Simpson
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Adv Neurol 88:1-19. 2002
  36. ncbi request reprint Predictability of disease progression in amyotrophic lateral sclerosis
    Adam Czaplinski
    Department of Neurology, University of Basel, Basel, Switzerland
    Muscle Nerve 34:702-8. 2006
    ..Identification of predictors of disease progression will facilitate better design of therapeutic trials, permitting the use of disease progression as a primary endpoint and improving baseline stratification of patient populations...
  37. ncbi request reprint Serum anti-Fas antibody levels in amyotrophic lateral sclerosis
    Ihsan S Sengun
    Department of Neurology, Medical School, Dokuz Eylul University, Balcova, Izmir 35340, Turkey
    J Neuroimmunol 142:137-40. 2003
    ..These data demonstrate that the peripheral immune system is activated as reflected by anti-Fas antibodies in ALS, but this activation is not specific to ALS...
  38. ncbi request reprint Promoting excellence in end-of-life care in ALS
    Hiroshi Mitsumoto
    The Elenor and Lou Gehrig MDA ALS Research Center, Columbia University Neurological Institute, New York, NY 10032, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:145-54. 2005
    ..Several public policy changes that will improve coverage for medical care, hospice, and caregiver costs are also reviewed. More clinical evidence is needed on how to provide optimal end-of-life care specifically in ALS...
  39. doi request reprint ALSFRS and appel ALS scores: discordance with disease progression
    Andrei Voustianiouk
    Department of Neurology and the MDA ALS Center, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1052, New York, New York 10029, USA
    Muscle Nerve 37:668-72. 2008
    ..001). Questionnaire-based measurements should be compared against objective scales at all stages of disease severity before they are accepted as primary endpoint measures...
  40. ncbi request reprint Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals
    Seong Ho Koh
    Department of Neurology, College of Medicine, Hanyang University, 17 Haengdang dong, Seongdong Ku, Seoul, Republic of Korea
    Toxicology 202:213-25. 2004
    ....
  41. ncbi request reprint Euthanasia and physician-assisted suicide in ALS: a commentary
    Stanley H Appel
    Am J Hosp Palliat Care 21:405-6. 2004
  42. ncbi request reprint 2D gel blood serum biomarkers reveal differential clinical proteomics of the neurodegenerative diseases
    Essam A Sheta
    Power3 Medical Products, Inc, The Woodlands, TX 77381, USA
    Expert Rev Proteomics 3:45-62. 2006
    ..The potential for pathway measurement in blood tests for differential diagnosis, disease burden and therapeutic monitoring is also outlined...
  43. ncbi request reprint Whole-genome analysis of sporadic amyotrophic lateral sclerosis
    Travis Dunckley
    Translational Genomics Research Inst, Phoenix, AZ 85004, USA
    N Engl J Med 357:775-88. 2007
    ..Approximately 90% of persons with amyotrophic lateral sclerosis (ALS) have the sporadic form, which may be caused by the interaction of multiple environmental factors and previously unknown genes...
  44. ncbi request reprint "Individual and health-related quality of life assessment in amyotrophic lateral sclerosis patients and their caregivers" by Lo Coco G, Lo Coco D, Cicero V, Oliveri A, Lo Verso G, Piccolo F, La Bella V
    Ericka P Simpson
    J Neurol Sci 238:1-2. 2005
  45. ncbi request reprint Incidence and characteristics of spinal decompression surgery after the onset of symptoms of amyotrophic lateral sclerosis
    Daniel Yoshor
    Department of Neurosurgery Baylor College of Medicine Houston, Texas 77030, USA
    Neurosurgery 57:984-9; discussion 984-9. 2005
    ..The high incidence of spondylosis in patients at the mean age of onset (55.7 yr) of amyotrophic lateral sclerosis (ALS) can make recognition of ALS as a cause of weakness difficult...
  46. ncbi request reprint Sublethal dose of 4-hydroxynonenal reduces intracellular calcium in surviving motor neurons in vivo
    Lóránd Vigh
    Institute of Biophysics, Biological Research Center, P O Box 521, 6701, Szeged, Hungary
    Acta Neuropathol 109:567-75. 2005
    ..The reduced intracellular calcium in the surviving motor neurons with no morphological features of degeneration may reflect an impaired ionic homeostasis, which may indicate a residual damage of an incomplete degenerative process...